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Post by 1 percenter on Jul 7, 2014 17:18:47 GMT -5
I am sure many of you know who he is. He served as a Director of MannKind Corp., from February 2010 to May 2012. He is now Chief Medical Officer at GlaxoSmithKline PLC.
I post this because I completely forgot about this.
But if anyone knows just how powerful Afrezza and Technosphere is, it would be him.
What are the chances that GSK ends up becoming the partner?
GSK just had Tanzeum (once a week injectable for T2) approved prior to the approval of Afrezza. Would Tanzeum be a possible Technosphere candidate?
Just thinking out loud.
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Post by brentie on Jul 7, 2014 21:00:50 GMT -5
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Post by 1 percenter on Jul 7, 2014 21:31:47 GMT -5
I recall reading that but dismissing it only because there hasn't been any talk about it launching in August. Hakan stated 1Q of 15 would be the launch date. But then again, Hakan comes off as noth always knowing what the hell he's talking about at times.
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Post by jonny80s on Jul 8, 2014 6:22:58 GMT -5
I'm not a scientist, but I don't see the possibility of a long term insulin being inhaled. It would have to dissolve slowly in the lungs. I can't imagine it being a good thing to have something sticking around for a 24hour period in your lungs.
If they were to design some kind of patch system (like nicotine) and the insulin had some sort of carrier that allowed it to be absorbed through the outer layers of skin...... That would be a winning combination.
I looked up transdermal application of insulin and there are a few ways it can be administered; ultrasonic waveforms that enlarge skin pores allowing insulin to pass through the outer layers and transdermal iontophoresis. Concerns with ultrasonic are that it could breakdown the skin over time and iontophoresis...... insulin is pretty large.
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Post by ashiwi on Jul 8, 2014 6:58:01 GMT -5
Al Mann is currently developing a basal insulin patch with another one of his companies. It will be the perfect combo with Afrezzza for prandial insulin. Will ultimately eliminate injections all together. Who says Afrezza sticks around in the lungs for 24 hours?
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Post by bradleysbest on Jul 8, 2014 9:06:09 GMT -5
Per Al it is in & out of the lungs within a couple of minutes. Not sure your info is accurate....
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Post by 4allthemarbles on Jul 8, 2014 11:32:39 GMT -5
There are a few small biotech companies working on product that can be absorbed through certain skin layers. That is not anything new.
Every once in a while someone makes a post saying they are new and not sure of the technology, etc. of course not. Why would it work. It's only been 10 years of development, thousands of patients in numerous trials and approved by both experts in the field (Adcom) and the good ole FDA.
*Sigh*
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Post by cannon5974 on Jul 8, 2014 11:55:55 GMT -5
A company that I invested in years ago called Vyteris had an approved patch. I think they may have been the first company to do so. (don't hold me to that though) Anyways; I thought it was a good investment as a big biotech investor (Kevin Kimberlin) had invested $20M into the company. Needless to say; I lost all my money I invested ($9,639) as the company is out of business. I don't think they filed BK as I don't think they even had money to do so? TD Ameritrade still shows I own 50,000 shares of VYTRQ at 0.00/share! I'm wondering what happened to all their patents though?? I wonder if someone like Al or another investor purchased them or not. Can't find any info on it at all.
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mnkdnyc
Lab Rat
Posts: 48
Sentiment: Long
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Post by mnkdnyc on Jul 8, 2014 12:17:23 GMT -5
I believe that mannkindmillionair is talking about Tanzeum having to stick around in your lungs for 24 hours not Afrezza. He is asking the question about using it with Technosphere technology.
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Post by jpg on Jul 8, 2014 13:50:14 GMT -5
Any drug using Technosphere as a carrier is transferred IV quickly and efficiently. This therefor means that little of the carried drug sticks around the lung and that long acting drugs depending on a 'depo' mediated effect will not be good choices for using Technosphere.
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Post by 4Balance on Jul 9, 2014 15:04:18 GMT -5
Al Mann is currently developing a basal insulin patch with another one of his companies. It will be the perfect combo with Afrezzza for prandial insulin. Will ultimately eliminate injections all together. Who says Afrezza sticks around in the lungs for 24 hours? Ashiwi, could you please elaborate? Which company? Product name? Testing stage...?? TIA!
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Post by ashiwi on Jul 9, 2014 15:20:52 GMT -5
PerQFlo, which is developing drug delivery systems. He had the basal patch in his pocket when I met him. He seemed very enthusiastic about it. It's very early on since it had to take a back seat to Afrezza. Probably years away. Not even sure if it has a name other than the basal insulin patch. I forgot his reason, but he said it will be much better than the artificial pancreas.
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Post by brentie on Jul 9, 2014 16:32:41 GMT -5
PerQFlo, which is developing drug delivery systems. He had the basal patch in his pocket when I met him. He seemed very enthusiastic about it. It's very early on since it had to take a back seat to Afrezza. Probably years away. Not even sure if it has a name other than the basal insulin patch. I forgot his reason, but he said it will be much better than the artificial pancreas. Alfred E. Mann Entrepreneur & Innovator, Founder & Chairman Second Sight Alfred E. Mann has founded and largely funded 17 companies in his career. Two companies became public and ten were acquired at an overall total of almost $8 billion. The companies currently within the family: MannKind Corporation, which develops novel therapeutics and drug delivery technologies for treatment primarily of diabetes, metabolic disease and cancer; Bioness, which develops and manufactures systems to address neural deficits and to restore controlled function of paralyzed limbs to address peripheral pain; Second Sight, which is developing visual prostheses to restore sight to the blind; IncuMed, which is developing novel percutaneous seals for various applications; PerQFlo, which is developing drug delivery systems; and Quallion, which develops, manufactures and markets advanced batteries for medical, aerospace and military applications. Additionally, Mr. Mann founded and served as Chairman and Chief Executive Officer of MiniMed Inc. from its founding in 1993 until August 2001 when it was acquired by Medtronic, Inc. Medtronic MiniMed develops, manufactures and distributes microinfusion systems and continuous glucose monitoring systems that have revolutionized the treatment of type 1 diabetes. Mr. Mann also founded and funded Medical Research Group (MRG) which was developing an artificial pancreas. MRG was also acquired by Medtronic in 2001. Mr. Mann's extensive experience with type 1 diabetes at MiniMed led him to explore therapies to improve outcomes for people with type 2 diabetes which is a pandemic challenging the entire world. Mannkind Corporation has developed an ultra-fast-acting insulin that mimics normal physiology. AFREZZA® will significantly improve care for early stage type 2 diabetics and along with the PerQFlo basal patch pump will more effectively treat type 1 and later type 2 diabetes. ------------------------------------------------------------------------------------------------------- Al: "As I have consistently said in previous calls, I am absolutely convinced that AFREZZA will become widely recognized by patients and clinicians alike as the better, safer and more effective therapy throughout almost the entire diabetes spectrum. For quite a few years in the future, I assert that AFREZZA plus the basal insulin patch pump ought to be the optimum basal-bolus therapy for type 1 and late type 2 diabetic patients. " seekingalpha.com/article/1173611-mannkind-management-discusses-q4-2012-results-earnings-call-transcript?find=basal%20patch%20pump&all=false
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Post by spiro on Jul 9, 2014 21:24:40 GMT -5
Ashiwi, I believe Al Mann said that the artificial pancreas would be too expensive and complex
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Post by babaoriley on Jul 9, 2014 22:58:31 GMT -5
Spiro, don't put too much store into what Al Mann said. Just look at Brentie's post above, containing a partial resume for Mr. Mann. I mean, when you get right down to it, this Mann guy really hasn't done all that much with his life. Frankly, he comes across as somewhat of a ne'er-do-well, heck, I should know, I play golf with those types all the time. And not only that, he's had 89 years to do those things! How many of us have lived 89 years? Give me a little time, that's all I need. I'm feeling my great accomplishments are right around the corner, don't write me off quite yet. I'm planning on having incredibly productive and insightful 8th and 9th decades!
I'm positively flummoxed as to why everyone gets so excited over him. I mean, when he walked into the AGM, a hush went through the crowd, and then the camera flashes started going off. Made me nauseous. What, had Bruce Springsteen or Pee Wee Herman just walked in? I didn't see any Holy Water at the doorway, did I miss a kneeler in front of my seat? I felt I might get tossed if I didn't genuflect and bow my head. Heck, five'll get you ten Al was a constant source of disappointment to his parents. Probably tortured puppies and threw kerosene on cats.
This Mann is a master illusionist, and he's fooled plenty of people in his day. Have any of those universities actually tried cashing those hundred million dollar checks he's written to them? Last thing a university wants is for it to be made public that they gotten taken by Al Mann. I'm thinking Al may be related to Bernie Madoff, I'm seeing the similarities, how about the rest of you, admit it now.
Did he do extraordinary things when he was 8 years old? Did he lift a car off of someone? How was prom night - did he attempt to show his date his prototype inhaler? Did he do well with the ladies when he was in college? Did he even go to college? I'll bet he skipped class to go to the race track. Was higher education even invented when he was 20? Jack Bauer could take care of him, especially now.
I know this post is going to hurt some of you, and I apologize, especially to Chris's young son, who really admires Al Mann. But it's time someone took him down a few pegs, and I might as well be the one to do it. I just couldn't hold it in anymore, Al Mann is not God and you all need to get over it this minute! There, whew, it's off my chest, feels good, like when I helped an elderly lady across the street and ran off with her purse, now I can go back to documenting my loan transaction...
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