|
Post by seanismorris on Jul 22, 2014 21:51:42 GMT -5
4allthemarbles,
That's the million dollar question. I'd think within two years.
Where this gets dicey is with intentions...
Does the migraine partner want to create a new formulation to extend their existing patents? Or, use a generic triptan as the base?
Does Mannkind want to do this in house (no partner until after approval)?
If so, I'd probably pick a generic triptan, but which one? Do I do multiple trials to find out which is the most effective? Or, have I already decided that Sumatriptan is the way to go?
Lets say Sumatriptan is the decision, is their one study that covers generic injected Sumatriptan, pill form, and patch? Or, compare it to many other triptans? We also need to look at bioavailability and dosing...
I think Mannkind has already done most of the work, but having a partner could complicate things.
|
|
|
Post by brentie on Jul 22, 2014 21:58:23 GMT -5
Really small Dreamboats?
|
|
|
Post by brentie on Jul 22, 2014 22:11:32 GMT -5
|
|
|
Post by clos22 on Jul 22, 2014 22:16:09 GMT -5
If I recall correctly, it was the Crickett device for migraine pain. I remember Al saying it was non addictive. The Crickett is a one time device. Pre- filled . It was being used on rats at Torrey pines. I just never understood how they got the rats to inhale? Al, Leone-Bay and Jonathan Goldman had visited the Torrey Pines facility in Port St Lucie the day before coming to the Drug Delivery Conference in Boca Raton which is about an hour away.
|
|
|
Post by clos22 on Jul 22, 2014 22:41:55 GMT -5
FYI, Allergan recently bought out MAPP pharmaceuticals which created a device much like the crickett called levadex..for now AGN plans on launching their new inhalable device to treat patients with acute migraines ( with DHE) I believe peak plasma concentration is reached well within 10 min and there is a lot of talk at AGN about using this technology in different therapeutic areas.
They will now have BOTOX for chronic migraine and Levadex for acute migraines.
|
|
|
Post by 4allthemarbles on Jul 22, 2014 22:46:01 GMT -5
Seanismorris, I agree about the work (as far as what they will use and why) has probably already been planned out. To include a partner or try to go it alone may depend on a lot of things they don't know right know (how successful Afrezza is out of the gate, how much of a work force they can dedicate to distro, selling, marketing, etc and how much money is left in the pot) it might just be easier to let a partner do all of the legwork. Either way, if we are looking at a 2 or 3 year window (2 year would be great since I bought some leaps). Either way, this is great to have a potential blockbuster and another drug that works in the fraction of the time for standard applications (cricket/ migraine) that could be pretty good for us. This is a juicy "imagine what could happen" topic. Good post.
Thanks for the info.
|
|
|
Post by seanismorris on Jul 23, 2014 0:13:50 GMT -5
4allthemarbles,
If I was Al (Mannkind) and I received a billion up front from the Afrezza partnership. I'd start a few internal initiatives to expand the product pipeline. This assumes the end game is selling the company in it's entirety in 3-5 years. A migraine drug could be perfect for that purpose.
Quote: The Migraine Drug Market Will Increase from $3.3 Billion in 2011 to $5.8 Billion in 2021 in the United States, France, Germany, Italy, Spain, the United Kingdom ...
A migraine drug, that is just a reformulation of another existing off patent triptan drug is many magnitudes easier to develop than, for example the Torrey Pines (Peptide) pain drug.
The migraine drug would be in many ways just like Afrezza, just replacing a triptan for the insulin.
For the peptide pain drug there is all kinds of other potential complications like unknown drug interactions. Mannkind would need a development partner right out the gate. They just don't have the experience in house to get it done. That's probably a 5-10 year endeavor costing a billion+.
The market size makes it worth it. The patent expirations almost guarantee that someone will step forward.
Quote LONDON--(BUSINESS WIRE)-- The global pain treatment market recorded sales of $22.0bn in 2010, rising at a compound annual growth rate of 8.9% from 2005, according to a new report from companiesandmarkets.com. This growth was supported by the presence of five blockbuster pain drugs - OxyContin, Lyrica, Cymbalta, Celebrex and Lidoderm. However, as patent expiries loom, the global market value is set to contract to $18.7bn by 2016.
|
|
|
Post by chmith27 on Jul 23, 2014 3:23:25 GMT -5
Rapid-acting would be awesome. Right now, when I get a migraine I pop a Maxalt, which takes exactly an hour and 20 minutes to work (on me, anyway). I'm sure whatever they use with Technosphere is going to work a lot faster! i just hope it works for post-coital headaches... i get those like every 6 hours. just horrible.
|
|
|
Post by brentie on Jul 23, 2014 8:19:30 GMT -5
Rapid-acting would be awesome. Right now, when I get a migraine I pop a Maxalt, which takes exactly an hour and 20 minutes to work (on me, anyway). I'm sure whatever they use with Technosphere is going to work a lot faster! i just hope it works for post-coital headaches... i get those like every 6 hours. just horrible. Only in your dreams,Chad.
|
|
|
Post by 4allthemarbles on Jul 23, 2014 10:28:53 GMT -5
Rapid-acting would be awesome. Right now, when I get a migraine I pop a Maxalt, which takes exactly an hour and 20 minutes to work (on me, anyway). I'm sure whatever they use with Technosphere is going to work a lot faster! i just hope it works for post-coital headaches... i get those like every 6 hours. just horrible. Sure, buddy. Perhaps it also works for muscle pain as well, perhaps the tissue surrounding the radius and the ulna. Too funny Chad.
|
|
|
Post by brentie on Jul 23, 2014 22:40:00 GMT -5
If I recall correctly, it was the Crickett device for migraine pain. I remember Al saying it was non addictive. The Crickett is a one time device. Pre- filled . It was being used on rats at Torrey pines. I just never understood how they got the rats to inhale?Al, Leone-Bay and Jonathan Goldman had visited the Torrey Pines facility in Port St Lucie the day before coming to the Drug Delivery Conference in Boca Raton which is about an hour away. Ashiwi, check this out... penncentury.com/wp-content/uploads/InstructionsForUse-PennCentury-DryPowderInsufflator-DP-4.pdf
|
|
|
Post by ashiwi on Jul 24, 2014 4:12:40 GMT -5
Nice find Brentie. I find it amazing that someone comes up with this stuff. Pretty complex mechanism.
|
|