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Post by itellthefuture777 on Feb 2, 2019 11:40:47 GMT -5
The business of Mannkind has lowered prices and on a superior new insulin and is approved only in the U.S. It makes sense that it cost more to get elsewhere..for now..until there is a modular factory in a foreign country..to meet yet another unmet need there. If those countries develoved the drug instead of the U.S...it would have cost Americans more to get..The 3 major pharmas being in America with slow old less clinically effective insulins..will not have any excuse...which like Exubera..isn't Mannkinds drug..those companies..even if they had the pricing..will not be able to make their slow old insulin any better than what it was 90 years ago..Afrezza is disruptive..as we are witnessing..a shift..a change for better..the government trying to prop up older insulins for the poor..so they have something..falls short..and ill conceived..Tesla..is one example of innovation where He left the Earth pennyless..but his invention his legacy..couldn't be stopped..no matter the powerful forces of politicians and their corporate lobbies..in the end it is Market force that weilds supreme..Afrezza is here..lighting up the world..one house at a time..
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Post by agedhippie on Feb 2, 2019 13:30:20 GMT -5
The business of Mannkind has lowered prices and on a superior new insulin and is approved only in the U.S. It makes sense that it cost more to get elsewhere..for now..until there is a modular factory in a foreign country..to meet yet another unmet need there. If those countries develoved the drug instead of the U.S...it would have cost Americans more to get..The 3 major pharmas being in America with slow old less clinically effective insulins..will not have any excuse...which like Exubera..isn't Mannkinds drug..those companies..even if they had the pricing.. will not be able to make their slow old insulin any better than what it was 90 years ago..Afrezza is disruptive..as we are witnessing..a shift..a change for better.. the government trying to prop up older insulins for the poor..so they have something..falls short..and ill conceived..Tesla..is one example of innovation where He left the Earth pennyless..but his invention his legacy..couldn't be stopped..no matter the powerful forces of politicians and their corporate lobbies..in the end it is Market force that weilds supreme..Afrezza is here..lighting up the world..one house at a time.. Lets be honest about this, it doesn't matter where a drug is developed it will always cost more in the U.S. because of the health system here. Hyperbole like " will not be able to make their slow old insulin any better than what it was 90 years ago" is the sort of thing that destroys credibility. Until 1982 insulin was all animal based and trust me even Regular human insulin is better than that. The introduction of RAA 15 years later was a huge improvement on that in turn. This all overlooks the introduction of the basal analogs in 2000 which meant we could get off NPH with all it's odd spikes. The innovation now is in the delivery mechanisms rather than the insulins; Technosphere for Regular insulin (Afrezza), and automated insulin delivery for RAA. Until insulin is reasonably priced I am all in favor of propping up older insulins (Regular and NPH) so people can have a safety net. There are a lot of people who rely on those insulins because they cannot afford RAA or Afrezza. If you look at the older insulin you think the government shouldn't help with, Humulin and Novolin, the NRx on those is about 15,000 each. That's not because they are wonderful insulins, it's because they are what those people can afford. They are keeping people alive.
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Post by sayhey24 on Feb 2, 2019 15:59:44 GMT -5
Aged - at $4 a day and $2.80 for a Libre sensor prices are now less than a Starbucks coffee and doughnut. That seems pretty reasonable to me.
The last I checked no one has insurance for Starbucks. Marrying Humalin from Walmart at $25 along with afrezza with the $4 a day pricing now allows another option for the T1s. It would be nice to see a quick study on TIR using afrezza and humalin
I am also with Itell that on mimicking pancreatic speed no one will do better than afrezza and its human insulin not an analog.
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Post by agedhippie on Feb 2, 2019 16:54:48 GMT -5
Aged - at $4 a day and $2.80 for a Libre sensor prices are now less than a Starbucks coffee and doughnut. That seems pretty reasonable to me. The last I checked no one has insurance for Starbucks. Marrying Humalin from Walmart at $25 along with afrezza with the $4 a day pricing now allows another option for the T1s. It would be nice to see a quick study on TIR using afrezza and humalin I am also with Itell that on mimicking pancreatic speed no one will do better than afrezza and its human insulin not an analog. First $4 per day is a fiction, that's one dose per meal and a limited time offer. If anything has come out of recent debates it's that you need more than one dose per meal. More to the point, if you cannot afford Humalin at less than $1 per day then suggesting they buy Afrezza plus Libre at $6.80 per day is not progress. Humalin is confusing because the same brand cover both meal time (Humalin R), and basal (Humalin N) insulin. If you are suggesting people will get good TIR with NPH you have obviously never used it! It has a profile like a switchback and you have to take it twice a day at the right time because it kicks in periodically with several peaks and dips that decide when you must eat.
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Post by sayhey24 on Feb 2, 2019 17:09:46 GMT -5
Aged - what I am suggesting is a study. You always seem to want studies to change the Standard of Care even though clinical usage tells us there is no better way to get back to baseline than afrezza. Now you know the answer. No study is needed. I just read a guy saying he was using 70/30 with afrezza and having great control. We could call it the Penny Pinching Study.
Now $4 a day with the 12u box is more than fiction. If you are really looking to save money and only need the 8u split the 12u. If you need a 4u follow-up then use the left over. Fiction its not. A great option it is for those with no insurance and limited funds.
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Post by itellthefuture777 on Feb 2, 2019 17:32:15 GMT -5
Aged - at $4 a day and $2.80 for a Libre sensor prices are now less than a Starbucks coffee and doughnut. That seems pretty reasonable to me. The last I checked no one has insurance for Starbucks. Marrying Humalin from Walmart at $25 along with afrezza with the $4 a day pricing now allows another option for the T1s. It would be nice to see a quick study on TIR using afrezza and humalin I am also with Itell that on mimicking pancreatic speed no one will do better than afrezza and its human insulin not an analog. First $4 per day is a fiction, that's one dose per meal and a limited time offer. If anything has come out of recent debates it's that you need more than one dose per meal. More to the point, if you cannot afford Humalin at less than $1 per day then suggesting they buy Afrezza plus Libre at $6.80 per day is not progress. Humalin is confusing because the same brand cover both meal time (Humalin R), and basal (Humalin N) insulin. If you are suggesting people will get good TIR with NPH you have obviously never used it! It has a profile like a switchback and you have to take it twice a day at the right time because it kicks in periodically with several peaks and dips that decide when you must eat. Mike said in interview that Mannkind is reviewing the demand..could be 1000 maybe 10000 dunno yet..if that program will be expanded..as I recall..guess we'll know..when they have done anaylsis..until then..Afrezza is the worlds only active monomeric human insulin..as fast as Mothernatures own within 30 seconds of the pacreas..so..fastest in..fastest out with thee least hypo risk out there with thee superior glycemic control..no site scaring..most type 2's only need Afrezza at meal time as that is the point where control is lost...and can be potentially halted..all other insulins..are inactive hexomeric insulins..way to slow..and all pharma is in agreement..otherwise they wouldn't be trying to speed up..their wheel and buggies..or whipping their horses..to catch up to a rocket..
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Post by porkini on Feb 2, 2019 18:08:43 GMT -5
While I cannot speak for any specific aged person, I can attest to there being aged persons out there that will not change or try something better simply because they still believe the Great Depression is going to do them in. Those aged persons would rather have toilet tissue that fingers readily penetrate when used in order to save a penny or two . Even if a "go fund me" campaign was mounted for these aged people to provide an appropriate or better solution for them, we would still hear complaints from them about how wasteful it is and they would still insist on using their same product from the depression era letting the newer/better product wither in the corner of the room. Aged folk, truth, I've known at least one in real life and they were not on this message board. And then there is MythBusters www.discovery.com/tv-shows/mythbusters/mythbusters-database/teach-old-dog-new-tricks/.
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Post by mytakeonit on Feb 2, 2019 18:45:01 GMT -5
Great Depression? That was like 1930? The stock market crashed in 1929 ! So you are talking about people 90 years old. So ... only that agedhippie guy fits this scenario. Ask him if he uses that old toilet paper ... and you do know that you can use more than one sheet at a time. BTW, in the military during field training ... they said that you just use one sheet and tear a small piece out of the middle. Stick your finger thru the hole and wipe your butt, then pull up the sheet and wipe your finger. Then you can use that tear off piece to clean under your fingernail. I always wondered if anyone tried it ... or it's just another mythbuster.
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Post by mango on Feb 2, 2019 19:20:01 GMT -5
Great Depression? That was like 1930? The stock market crashed in 1929 ! So you are talking about people 90 years old. So ... only that agedhippie guy fits this scenario. Ask him if he uses that old toilet paper ... and you do know that you can use more than one sheet at a time. BTW, in the military during field training ... they said that you just use one sheet and tear a small piece out of the middle. Stick your finger thru the hole and wipe your butt, then pull up the sheet and wipe your finger. Then you can use that tear off piece to clean under your fingernail. I always wondered if anyone tried it ... or it's just another mythbuster. 🥴
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Post by porkini on Feb 2, 2019 19:23:48 GMT -5
Great Depression? That was like 1930? The stock market crashed in 1929 ! So you are talking about people 90 years old. So ... only that agedhippie guy fits this scenario. Ask him if he uses that old toilet paper ... and you do know that you can use more than one sheet at a time. BTW, in the military during field training ... they said that you just use one sheet and tear a small piece out of the middle. Stick your finger thru the hole and wipe your butt, then pull up the sheet and wipe your finger. Then you can use that tear off piece to clean under your fingernail. I always wondered if anyone tried it ... or it's just another mythbuster. LMAO dude!
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Post by liane on Feb 2, 2019 19:28:28 GMT -5
I think we need to get back on topic - TMI.
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Post by sellhighdrinklow on Feb 2, 2019 22:03:28 GMT -5
The business of Mannkind has lowered prices and on a superior new insulin and is approved only in the U.S. It makes sense that it cost more to get elsewhere..for now..until there is a modular factory in a foreign country..to meet yet another unmet need there. If those countries develoved the drug instead of the U.S...it would have cost Americans more to get..The 3 major pharmas being in America with slow old less clinically effective insulins..will not have any excuse...which like Exubera..isn't Mannkinds drug..those companies..even if they had the pricing..will not be able to make their slow old insulin any better than what it was 90 years ago..Afrezza is disruptive..as we are witnessing..a shift..a change for better..the government trying to prop up older insulins for the poor..so they have something..falls short..and ill conceived..Tesla..is one example of innovation where He left the Earth pennyless..but his invention his legacy..couldn't be stopped..no matter the powerful forces of politicians and their corporate lobbies..in the end it is Market force that weilds supreme..Afrezza is here..lighting up the world..one house at a time.. 100% !
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Post by sellhighdrinklow on Feb 2, 2019 22:14:13 GMT -5
Aged - at $4 a day and $2.80 for a Libre sensor prices are now less than a Starbucks coffee and doughnut. That seems pretty reasonable to me. The last I checked no one has insurance for Starbucks. Marrying Humalin from Walmart at $25 along with afrezza with the $4 a day pricing now allows another option for the T1s. It would be nice to see a quick study on TIR using afrezza and humalin I am also with Itell that on mimicking pancreatic speed no one will do better than afrezza and its human insulin not an analog. First $4 per day is a fiction, that's one dose per meal and a limited time offer. If anything has come out of recent debates it's that you need more than one dose per meal. More to the point, if you cannot afford Humalin at less than $1 per day then suggesting they buy Afrezza plus Libre at $6.80 per day is not progress. Humalin is confusing because the same brand cover both meal time (Humalin R), and basal (Humalin N) insulin. If you are suggesting people will get good TIR with NPH you have obviously never used it! It has a profile like a switchback and you have to take it twice a day at the right time because it kicks in periodically with several peaks and dips that decide when you must eat. Agedhippie-. You are twisting and pontification nothing but spin. You ( and or your posse?) seem to be here 24/7. Please excuse the following but your twisted, spin is nothing more than silver tongued FUD. You claim to be Type 2, AND sit on this message board (you and your posse?), 24/7 doing nothing but negative rebuttal. Type 2 and could improve your life for a few extra $ but ignore all positivity here. Funny but crystal clear why you're here. You'd have been better off not claiming to be diabetic so your story stayed straight. But hey, that's just my personal opinion on the crystal clear reason you post here.
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Post by peppy on Feb 2, 2019 22:55:01 GMT -5
First $4 per day is a fiction, that's one dose per meal and a limited time offer. If anything has come out of recent debates it's that you need more than one dose per meal. More to the point, if you cannot afford Humalin at less than $1 per day then suggesting they buy Afrezza plus Libre at $6.80 per day is not progress. Humalin is confusing because the same brand cover both meal time (Humalin R), and basal (Humalin N) insulin. If you are suggesting people will get good TIR with NPH you have obviously never used it! It has a profile like a switchback and you have to take it twice a day at the right time because it kicks in periodically with several peaks and dips that decide when you must eat. Agedhippie-. You are twisting and pontification nothing but spin. You ( and or your posse?) seem to be here 24/7. Please excuse the following but your twisted, spin is nothing more than silver tongued FUD. You claim to be Type 2, AND sit on this message board (you and your posse?), 24/7 doing nothing but negative rebuttal. Type 2 and could improve your life for a few extra $ but ignore all positivity here. Funny but crystal clear why you're here. You'd have been better off not claiming to be diabetic so your story stayed straight. But hey, that's just my personal opinion on the crystal clear reason you post here. Aged is a type one. Diabetics make their own decisions.
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Post by mannmade on Feb 2, 2019 23:33:48 GMT -5
I often disagree with Aged’s posts but I respect that he generally backs them with facts and/or well reasoned rationales. Perhaps he is just too aged to change... not enough to call him a short imho...
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