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Post by coco on Feb 15, 2015 0:57:49 GMT -5
Diabetics will only listen to other diabetics or their endo's and pcp's. My sister in law has this very question of how to dose the in hailed insulin. I referred her to afrezzauser and only then did she understand it. I could not tell her about it. She said that I did not understand cause I was not a diabetic, but when she saw afrezzauser she was in awe. So afrezzauser is a very important resource for us to refere other diabetics to. Coco
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Post by cybergym66 on Feb 15, 2015 8:03:35 GMT -5
Diabetics will only listen to other diabetics or their endo's and pcp's. My sister in law has this very question of how to dose the in hailed insulin. I referred her to afrezzauser and only then did she understand it. I could not tell her about it. She said that I did not understand cause I was not a diabetic, but when she saw afrezzauser she was in awe. So afrezzauser is a very important resource for us to refere other diabetics to. Coco So can I assume your sister-in-law is an Afrezza believer & future convert?! I would love if Afrezzuser did a webcast with an Endo! I think many diabetics would get their questions answered since like you said, we're non-diabetic so we really don't understand...kind of like trying to explain to soon-to-be parents how their lives would be FOREVER changed!
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Post by babaoriley on Feb 15, 2015 18:36:47 GMT -5
Has anyone seen Afrezzauser's bona fides questioned on any diabetes blogs - anyone asking whether he's a diabetic at all or just a shill? I think I remember a time a couple of years ago, his genuineness was examined quite thoroughly on some message boards.
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Post by mannmade on Feb 15, 2015 21:42:15 GMT -5
Baba believe you are right but recently I have not. And On his web site is a letter of cert from our favorite Mannkind General Counsel validating AU's claim to have participated in the trials (and he is in the FDA AdCom video)
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Post by papihoyos on Feb 15, 2015 22:49:58 GMT -5
I am a T2 diabetic and I am and will continue to post on these boards, not to promote MNKD but to promote a great product for diabetics. I only invest in products I believe will make the world a better place not in the next handbag trend. Sorry!!!
Biggest issue I find is the tritration which I'm not articulate enough to explain properly. I sort of understand it but many diabetics especially T1 get caught up on the 4 unit is too much and will cause them to consume a larger meal to justify the dosage.
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Post by BD on Feb 15, 2015 23:14:53 GMT -5
papa, I think the intent of the thread was to dissuade non-diabetic members from posting on the diabetic boards. So, you have no need to justify your posting there. Go forth and prosthelytize (just not as an investor )
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Post by ezrasfund on Feb 16, 2015 0:49:43 GMT -5
I am a T2 diabetic and I am and will continue to post on these boards, not to promote MNKD but to promote a great product for diabetics. I only invest in products I believe will make the world a better place not in the next handbag trend. Sorry!!!
Biggest issue I find is the tritration which I'm not articulate enough to explain properly. I sort of understand it but many diabetics especially T1 get caught up on the 4 unit is too much and will cause them to consume a larger meal to justify the dosage. The thread on this board about why Afrezza does not need precise titration answered the question for me, but I would like to see it confirmed by an Endo or other expert. Basically glucose metabolism is limited by the number of insulin receptors in the cells, so after a certain point excess insulin does not bind with insulin receptors in the cells and does not metabolize more glucose. Because insulin in the blood is broken down after about an hour, the excess insulin also disappears quickly and will not effect blood glucose levels in the longer term. In contrast subcutaneous insulin finds it's way into the bloodstream more gradually, and so it is more fully utilized by the system even when it would lower glucose levels too much. So dosing is more important. Another way of saying this is that insulin does not metabolize glucose, instead it enables the cells to metabolize glucose; so the limiting factor is the capacity of the cells, not the amount of insulin. But the capacity of the cells is a rate of absorption, not an absolute amount. So RAA's that are present in the blood for a longer time mean more glucose metabolism. Excess levels of insulin in the blood do have an important function however, as they signal the liver to stop producing glucose. Again I hope that a doctor or biochemist do a better job of explaining this. And finally an analogy: Imagine a restaurant that can serve 100 meals per hour. If 40 people show up for lunch hour, they serve 40 people. If 80 or 100 people show up they all get served. But if 120 people or even 400 people show up, only 100 are fed. If those who can't get served during lunch hour go away (Afrezza) the restaurant only serves 100. But if those excess people beyond the first 100 hang around all afternoon to get a table (Novolog) now the restaurant has served as many as 400 people in 4 hours. So much business may have depleted the storeroom (glucose) and they may have to call their supplier for extra food (that diabetic snack). And the restaurant's bank account is getting fat.
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Post by jpg on Feb 16, 2015 1:15:28 GMT -5
Wiki has a very good, detailed but relatively a bit complex to understand explanation of insulin: en.wikipedia.org/wiki/InsulinI would skip to the sections: Release Beta cells in the islets of Langerhans release insulin in two phases. The first phase release is rapidly triggered in response to increased blood glucose levels. The second phase is a sustained, slow release of newly formed vesicles triggered independently of sugar. The description of first phase release is as follows: etc... and Physiological effects
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Post by liane on Feb 16, 2015 5:26:49 GMT -5
ezra - very good analogy!
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Post by dmb247 on Feb 18, 2015 3:52:16 GMT -5
I dunno, I think posting factual information can be valuable. This keeps repeating itself on a reddit diabetes forum (reddit.com/r/diabetes) w/10k subscribers. Basically the shorts are hitting all the diabetes forums more so than the longs. Posing to be diabetics who don't want to get cancer from this new drug and that someone else should be the guinea pig. I'd rather see factual responses than these statements left unchallenged. Check this thread out: www.reddit.com/r/diabetes/comments/2vc3f3/thoughts_on_afrezza_inhaler_to_possibly_replace/groff200 - Poster for 2 years 5000+ comment karma, definitely a diabetic based on past post history talking about predisone causing DKA dmb247 - obvious pro-mnkd poster, recently created account, he's been posting in every afrezza thread with similar information, definitely a dave matthews band fan EffablyJaded - brand new poster, obviously a basher of afrezza, only 5 posts ever, compares afrezza to thalidomide mattysmitty - obvious mnkd stock investor, more posts in the stocks subreddit than diabetes, very few posts overall larkhills - Type1 diabetic, 22k comment karma, tons of diabetic posts, positive comment about how he doesn't care how he gets his insulin, it's all about cost stakkar - 29k comment karma, definitely an investor based on mnkd investment posts, has a dad w/T2DM who he's been helping for 25 years, providing guidance to larkhills about the discount card/savings "
Couldn't help myself. Had to make a username here and reply after seeing mention of my Reddit thread. PS, I'm not a new reddit user? Been on there a while. Just rarely comment. Just lurk. I learned about Afrezza on a whim. I am dealing with Type 2 and allergic reactions to oral meds, and I needed an answer. Rather than continue to be in denial of my disease, i seeked out alternative treatment options on my own. I happened to find afrezza in this process,and while I have taken injections before, I did not want to do it again. It's so inconvenient. Especially at Dave Matthews Concerts! You had that right. Huge fan here lol. So right now. I'm preparing a plan of action to get my PCP on board. I am doing so much research to prepare myself because I am certain he will have no idea of this new medication. I will be the one educating him. I am not pro mnkd. I didn't know this company existed until a few weeks ago, but I certainly want this medication. That is the only reason I am posting places. I believe in it, and when I believe in something I speak my mind. Especially when I see people posting misinformation to the degree of Fox News. It really bothers me. So yeah. That's me. Just thought I would chime in since I was mentioned.
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Post by liane on Feb 18, 2015 5:22:07 GMT -5
dmb247,
Well it's good to see you here and to hear your thoughts 1st hand. I sincerely hope you are able to get your PCP onboard. Let us know how everything goes. GLTY!
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Post by notamnkdmillionaire on Feb 18, 2015 8:26:01 GMT -5
I dunno, I think posting factual information can be valuable. This keeps repeating itself on a reddit diabetes forum (reddit.com/r/diabetes) w/10k subscribers. Basically the shorts are hitting all the diabetes forums more so than the longs. Posing to be diabetics who don't want to get cancer from this new drug and that someone else should be the guinea pig. I'd rather see factual responses than these statements left unchallenged. Check this thread out: www.reddit.com/r/diabetes/comments/2vc3f3/thoughts_on_afrezza_inhaler_to_possibly_replace/groff200 - Poster for 2 years 5000+ comment karma, definitely a diabetic based on past post history talking about predisone causing DKA dmb247 - obvious pro-mnkd poster, recently created account, he's been posting in every afrezza thread with similar information, definitely a dave matthews band fan EffablyJaded - brand new poster, obviously a basher of afrezza, only 5 posts ever, compares afrezza to thalidomide mattysmitty - obvious mnkd stock investor, more posts in the stocks subreddit than diabetes, very few posts overall larkhills - Type1 diabetic, 22k comment karma, tons of diabetic posts, positive comment about how he doesn't care how he gets his insulin, it's all about cost stakkar - 29k comment karma, definitely an investor based on mnkd investment posts, has a dad w/T2DM who he's been helping for 25 years, providing guidance to larkhills about the discount card/savings "
Couldn't help myself. Had to make a username here and reply after seeing mention of my Reddit thread. PS, I'm not a new reddit user? Been on there a while. Just rarely comment. Just lurk. I learned about Afrezza on a whim. I am dealing with Type 2 and allergic reactions to oral meds, and I needed an answer. Rather than continue to be in denial of my disease, i seeked out alternative treatment options on my own. I happened to find afrezza in this process,and while I have taken injections before, I did not want to do it again. It's so inconvenient. Especially at Dave Matthews Concerts! You had that right. Huge fan here lol. So right now. I'm preparing a plan of action to get my PCP on board. I am doing so much research to prepare myself because I am certain he will have no idea of this new medication. I will be the one educating him. I am not pro mnkd. I didn't know this company existed until a few weeks ago, but I certainly want this medication. That is the only reason I am posting places. I believe in it, and when I believe in something I speak my mind. Especially when I see people posting misinformation to the degree of Fox News. It really bothers me. So yeah. That's me. Just thought I would chime in since I was mentioned. Welcome to the board even though I'd probably ban you for being a Dave Matthew's fan! I kid. It would be great if you could update us with your progress and hopefully you will do so on Reddit. There are many here who have spent almost a decade closely monitoring Afrezza and who can be helpful.
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Post by dmb247 on Feb 18, 2015 14:54:23 GMT -5
Thanks for the welcome. I've lurked around here quite a bit for the last few weeks just trying to find threads about Afrezza rather than what Afrezza is going to do to the stock I've found some really great info to arm myself with, especially in regards to why Afrezza's dosing requirements are as they are, and needn't be so specific like other RAAs. Great info here. It's just such a shame that people on these other boards are shaming/judging others like myself who want to live the most normal life possible by taking a medication. It's as if we should ignore afrezza, take our oral meds, diet and exercise, eat the least carbs possible, and make our lives more about managing diabetes than actually living. Like Sam/AfrezzaUser says, it's the freedom that Afrezza brings to our lives that makes it so wonderful. Sure you need to watch your carbs, diet, and exercise. Everyone needs to do that, not just diabetics. If there is a medicine that can improve overall quality of life without giving me allergic reactions, kidney, liver, and pancreas damage in the long run, why wouldn't I want to take it?
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Post by lynn on Feb 18, 2015 15:08:14 GMT -5
DBM247, Welcome to the board & I hope that Afrezza may be an option for you to live a better & longer life . I also hope that you can tell that most of us here are motivated by more than just a financial gain . For me personally I believe in Al Mann who's responsible for bringing this drug to market and it hasn't been an easy road . His accomplishments in his life time as far as what he's done to help "mankind " are Priceless . God Bless you and I wish you the best of luck Lynn
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Post by mrmookie123 on Feb 21, 2015 12:03:05 GMT -5
I am a T2 diabetic and I am and will continue to post on these boards, not to promote MNKD but to promote a great product for diabetics. I only invest in products I believe will make the world a better place not in the next handbag trend. Sorry!!!
Biggest issue I find is the tritration which I'm not articulate enough to explain properly. I sort of understand it but many diabetics especially T1 get caught up on the 4 unit is too much and will cause them to consume a larger meal to justify the dosage. And I agree with Papihoyos... Here is one reason why. My wife had an appointment with her PCP on Thursday. I loaded her up with Afrezza information to take with her. She is a Type II diabetic. When the question about her current and future treatment was brought up, My wife asked her doctor, "Have you heard of the new Inhaled Insulin, Afrezza?? Doctors answer: "No, and that Inhaled Insulin was tried before in the past." Not even taking the time to look at any of the information I sent in, My wife proudly came home with scripts for Metfromin and Onglyza. So, my point is the more educated the Diabetic Community is about the advantages of Afrezza the better, even if this includes well educated posts to forums etc.. on the Internet. Of course, as her husband I will not take this treatment regimen and I will actually schedule an appointment with her doctor to discuss Afrezza, either that or a switch to an ENDO for treatment. So, the Hurdle with older physicians and the 2007 Exeubera debacle needs addressed by patients themselves when visiting. The old days of "Well the doctor knows best, so I'll take what scripts they've given me" are over. All patients need to do their own due diligence about new Diabetic Treatments. I see nothing wrong with letting the diabetic community know about Afrezza, as long as it posted with Facts and reasons to ask about the drug. Good Luck Everyone, Thanks for reading !! Thoughts, Comments ??
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