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Post by tripoley on Mar 20, 2015 20:01:23 GMT -5
This is why a HgbA1c <6.0, FBS <109 and 2 hour PP <154 matters: Diabetic retinopathy goes from <5% to ~15% in 40 to 74 year olds above those levels. Does that chart continue to shoot up for A1C over 6.2? That might be a useful tool for me to try to motivate someone to take action. I'm sure it does. I think the point of the chart is just a small increase results in some seriously increased morbidity. I'll see if I can dig up some stats on other diabetic related illnesses. The bean counters will pay attention.
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Post by gwb on Mar 22, 2015 13:55:47 GMT -5
It appears that this lady has Afrezza dialed in now . She like some others had to experiment to dose at the right times with right amounts . Wow ! Nice ,
twitter.com/AmyDBMine
Another good #bgnow morning on #Afrezza
Embedded image permalink
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Post by ezrasfund on Mar 22, 2015 20:56:33 GMT -5
Also on Twitter @doctortranri360 seems to be losing his faith...in Sanofi if not Afrezza.
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Post by spiro on Mar 23, 2015 8:38:45 GMT -5
Updated results, Should Spiro buy a 3rd Blood Glucose monitor?
Fasting Blood Glucose Update
2/26 134 2/27 135 Started Afrezza at breakfast 2/28 131 3/1 119 3/2 115 3/3 114 3/4 113 3/5 100 3/6 101 3/7 116 3/8 105 3/9 99 3/10 106 2/11 94 3/12 100 3/13 93 3/14 106 3/15 97 3/16 104 3/17 94 3/18 99 3/19 88 3/20 98 3/21 95 3/22 95 3/23 88
Spiro's Breathalyzer looks to be working just fine. BTW, at my card game last night, I ate my 8 inch hoagie, some chips and 2 mallomars.
Spiro here
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Post by mnkdorbust on Mar 23, 2015 9:16:42 GMT -5
Also on Twitter @doctortranri360 seems to be losing his faith...in Sanofi if not Afrezza. Everyone has their own opinion but mine is that his opinion doesn't mean anything. I would call him a spammer. To each their own. I've followed him for over a year and he's like water droplets on a hot skillet.
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Post by ezrasfund on Mar 23, 2015 13:06:24 GMT -5
Also on Twitter @doctortranri360 seems to be losing his faith...in Sanofi if not Afrezza. Everyone has their own opinion but mine is that his opinion doesn't mean anything. I would call him a spammer. To each their own. I've followed him for over a year and he's like water droplets on a hot skillet. I agree. I have never followed him. In fact I have considered asking him to stop spamming Twitter #afrezza. I just thought it was perhaps a sign of capitulation bottom if he has joined the chorus of management detractors.
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Post by jpg on Mar 23, 2015 18:23:51 GMT -5
Updated results, Should Spiro buy a 3rd Blood Glucose monitor? Fasting Blood Glucose Update 2/26 134 2/27 135 Started Afrezza at breakfast 2/28 131 3/1 119 3/2 115 3/3 114 3/4 113 3/5 100 3/6 101 3/7 116 3/8 105 3/9 99 3/10 106 2/11 94 3/12 100 3/13 93 3/14 106 3/15 97 3/16 104 3/17 94 3/18 99 3/19 88 3/20 98 3/21 95 3/22 95 3/23 88 Spiro's Breathalyzer looks to be working just fine. BTW, at my card game last night, I ate my 8 inch hoagie, some chips and 2 mallomars. Spiro here Those are some impressive fasting numbers. If other early diabetics consistently get these type of FBGs then Afrezza would qualify as being an insulin sensitizer but in a very different (and possibly much more physiologic way than metformin).
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Post by dreamboatcruise on Mar 23, 2015 18:31:36 GMT -5
Spiro's results would seem to indicate an A1C reduction significantly better than the average trial results wouldn't it? I wonder if this is indicative of starting earlier in the disease progression and therefore the sensitivity is more easily restored.
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Post by jpg on Mar 23, 2015 18:55:47 GMT -5
Spiro's results would seem to indicate an A1C reduction significantly better than the average trial results wouldn't it? I wonder if this is indicative of starting earlier in the disease progression and therefore the sensitivity is more easily restored. The patients included in the trial were much more advanced in their diabetes process. If they would design a trial to show this amazing effect on FBG in early type 2s it would be hugely informative. The speed at which Afrezza restored (or seems to restore) insulin sensitivity in Spiro is much faster then I would have thought. Impressive really. The experience of type 1s who use Afrezza well ('flateliners' near or ideally below the 100 line) would partially validate the rapid speed at which they also become more sensitive to insulin. We don't have enough data (and the data we have is anecdotal) but it certainly would fit the theory of Afrezza being a huge help in restoring physiological insulin sensitivity and not simply a 'whip to churn out more insulin from tired pancreatic cells' or simply spilling glucose in urine like some of the other new drugs. Obviously all of this, if true, is a very big deal. The next step from that would be 'disease modifying drug' and outcome modifying drug.
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Post by tripoley on Mar 23, 2015 19:06:33 GMT -5
Spiro's results would seem to indicate an A1C reduction significantly better than the average trial results wouldn't it? I wonder if this is indicative of starting earlier in the disease progression and therefore the sensitivity is more easily restored. The patients included in the trial were much more advanced in their diabetes process. If they would design a trial to show this amazing effect on FBG in early type 2s it would be hugely informative. The speed at which Afrezza restored (or seems to restore) insulin sensitivity in Spiro is much faster then I would have thought. Impressive really. The experience of type 1s who use Afrezza well ('flateliners' near or ideally below the 100 line) would partially validate the rapid speed at which they also become more sensitive to insulin. We don't have enough data (and the data we have is anecdotal) but it certainly would fit the theory of Afrezza being a huge help in restoring physiological insulin sensitivity and not simply a 'whip to churn out more insulin from tired pancreatic cells' or simply spilling glucose in urine like some of the other new drugs. Obviously all of this, if true, is a very big deal. The next step from that would be 'disease modifying drug' and outcome modifying drug. The patients in 175 probably had the crap beaten out of their pancreas prior to entering the study by every oral hypoglycemic on the market. They had 40 patients on metformin but they didn't break out the results other than hypoglycemia. Those patients probably would be the closest to a med naive T2 diabetic and it would be interesting to see their results.
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Post by dreamboatcruise on Mar 23, 2015 19:22:10 GMT -5
Spiro... Has your routine so far been to use a single 4u cartridge with each and every meal? What sort of lows have you hit if any? and are you doing routine post meal checks around when activity of afrezza would be peaking? I'm curious because I'm considering recommending Afrezza to a borderline diabetic who has never been on any meds to date.
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Post by mnholdem on Mar 23, 2015 20:21:54 GMT -5
sir spiro,
Since you've either abdicated or have been stripped of your Lead Global Moderator title, and since it was deemed that other titles befitting your contributions are too lengthy to fit within the confines of this forum, I have decided to submit a request to Her Majesty that you be considered for knighthood.
I hope to hear from the nominating committee and hope to have you knighted sometime before Afrezza becomes available in England.
------
Of greater importance to me, if not the entire kingdom, is learning whether you freeze your Mallomars that you are still able to indulge even when they are out of season.
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Post by spiro on Mar 23, 2015 20:55:20 GMT -5
dreamboatcruise,
I take 4 u of Afrezza seconds before starting to eat each meal. I have never taken the Afrezza without my big Greek nose smelling the food on my plate. For the first week or so, I checked my gulcose 1, 2 and sometimes 3 hours after most meals. After the first 6 days or so my 1 hr was always around 130, my 2 hour around 115 and my 3 hour, around 100. My lowest BG reading since starting Afrezza was 82 after a 1 1/2 mile walk taken 2 hours or so after dinner. I have used about 150 test strips on 2 different Glucose monitors, since starting Afrezza. For the last 6 or 7 days, I have cut my BG testing down to about 3 times a day. fasting, before lunch and at bedtime. Low glucose does not appear to be an issue so far.
Spiro here
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Post by spiro on Mar 23, 2015 21:12:33 GMT -5
mnholdem,
Spiro's "Lead Global Moderator" title was just a temporary one weekend position. It took Spiro less than one hour to use his new powers to get into trouble with the big guys. They corrected Spiro's mischief and then let him enjoy the coveted title of " Lead Global Moderator" for the remainder of that weekend. The Mallomars were located at a small neighborhood grocery store. They may have been a couple of years old, like everything else at that store, but a Maalomar is a Mallomar and they were quickly consumed. I got to eat 2 of them before they disappeared.
Spiro
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Post by kball on Mar 23, 2015 21:49:26 GMT -5
mnholdem, Spiro's "Lead Global Moderator" title was just a temporary one weekend position. It took Spiro less than one hour to use his new powers to get into trouble with the big guys. They corrected Spiro's mischief and then let him enjoy the coveted title of " Lead Global Moderator" for the remainder of that weekend. The Mallomars were located at a small neighborhood grocery store. They may have been a couple of years old, like everything else at that store, but a Maalomar is a Mallomar and they were quickly consumed. I got to eat 2 of them before they disappeared. Spiro This. Every once in a while i buy a product where the packaging has DUST on it. its always a "this isn't right" moment
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