|
|
Post by joeypotsandpans on Jun 29, 2015 11:41:27 GMT -5
I think everyone now has seen the multitudes of ads that have hit the TV's, this past weekend NVO had their Levemir commercial (latest that I've seen in their series including Novolog, flex pen, etc.) also saw the "once a week" ad with another "cute" character doing exercises for Tanzeum (see potential side effects here) www.drugs.com/tanzeum.html ...basically this arena is getting more crowded and the competition for those $$$ are fighting for their pieces... Where this got driven home this past weekend was when I was out with the family at dinner and I noticed a gentleman at a table pricking his finger measuring his BG and taking a pen injector out. He seemed rather comfortable enough where I had no qualms walking over and asking if he knew about "the best alternative out there". Not to my surprise, he had not. So I gave him the 5 minute version, wrote down the usual links and hashtags and he shook my hand and sincerely thanked me. He was a T1 and mentioned he was on the pump as well. So for those that don't think DTC will make much difference, think again because Sanofi has the mother of all in their arsenal (just ask our 5 star General Spiro) and their gloves are about to come off....can't happen soon enough! Speaking of the gloves coming off, can't happen soon enough Ted & Evan, looks like you hit a nerve with AF lol |
|
|
|
Post by 1 percenter on Jun 29, 2015 11:54:58 GMT -5
I think everyone now has seen the multitudes of ads that have hit the TV's, this past weekend NVO had their Levemir commercial (latest that I've seen in their series including Novolog, flex pen, etc.) also saw the "once a week" ad with another "cute" character doing exercises for Tanzeum (see potential side effects here) www.drugs.com/tanzeum.html ...basically this arena is getting more crowded and the competition for those $$$ are fighting for their pieces... Where this got driven home this past weekend was when I was out with the family at dinner and I noticed a gentleman at a table pricking his finger measuring his BG and taking a pen injector out. He seemed rather comfortable enough where I had no qualms walking over and asking if he knew about "the best alternative out there". Not to my surprise, he had not. So I gave him the 5 minute version, wrote down the usual links and hashtags and he shook my hand and sincerely thanked me. He was a T1 and mentioned he was on the pump as well. So for those that don't think DTC will make much difference, think again because Sanofi has the mother of all in their arsenal (just ask our 5 star General Spiro) and their gloves are about to come off....can't happen soon enough! Speaking of the gloves coming off, can't happen soon enough Ted & Evan, looks like you hit a nerve with AF lol DTC will only work if diabetics actually see the ads. How many T2s go out of their way to read diabetic mags? It's a start but I still don't think it will create a watershed moment for the drug just yet. |
|
|
|
Post by traderdennis on Jun 29, 2015 13:27:42 GMT -5
I believe the first part of DTC will be more of a direct to doctors and diabetes professionals. All the DTC in the world will not help of the gatekeepers are not on board.
|
|
|
|
Post by harryx1 on Jun 29, 2015 14:08:00 GMT -5
Attachment DeletedHey James, So after reading your numerous posts on twitter you are against progress of medicine, technology and everything else?!?!. If the majority of people were like you, we would still be living in caves dreaming about living past the average age of 20. It would be a heartwarming tale to wake up tomorrow and see an announcement that every disease known to mankind has been cured. Really that would be great and I for one would be willing to take my loss in any investment for that but it's not the real world and it's not going to happen. It's obvious that you have a burning hatred for investors but without investors there wouldn't be many life saving/altering drugs that we have today. So what if Afrezza is the closet thing to cure that you or your children will see in your lifetime?  You are just going to keep bashing it? What if Afrezza was an injectable and mimicked the pancreas, would you love it and use it? I just don't understand how someone with any disease would not want medicine to progress, whether it's ease of use, better performance or provides a better quality of life. Why don't you signup for the board and ask all the investors why they are so passionate about Afrezza?
|
|
|
|
Post by joeypotsandpans on Jun 29, 2015 14:36:55 GMT -5
Hey James, So after reading your numerous posts on twitter you are against progress of medicine, technology and everything else?!?!. If the majority of people were like you, we would still be living in caves dreaming about living past the average age of 20. It would be a heartwarming tale to wake up tomorrow and see an announcement that every disease known to mankind has been cured. Really that would be great and I for one would be willing to take my loss in any investment for that but it's not the real world and it's not going to happen. It's obvious that you have a burning hatred for investors but without investors there wouldn't be many life saving/altering drugs that we have today. So what if Afrezza is the closet thing to cure that you or your children will see in your lifetime? You are just going to keep bashing it? What if Afrezza was an injectable and mimicked the pancreas, would you love it and use it? I just don't understand how someone with any disease would not want medicine to progress, whether it's ease of use, better performance or provides a better quality of life. Why don't you signup for the board and ask all the investors why they are so passionate about Afrezza? Harry, If James had done a little due diligence before spouting off, he would know that I am a T2 as well and as such was communicating more on that level than anything else. So I guess while we're taking the gloves off...here goes: what I also left out was the following which up until now have kept discreet about but feel it's time to put it out there. I asked this individual who his current Endo was and suggested two practices that I know of in the area that are PROGRESSIVELY or PROACTIVELY HELPING their patients by subscribing Afrezza. How did this come about? I know my current PA did not attend one of the educational dinners...no showed to be exact, this came from the Sanofi rep that I have come to know over the past month. I called Sanofi to inquire about physicians/Endos in my area that are/have been prescribing Afrezza....Sanofi stated they could not give out that information for various reasons. I did email Matt and mentioned that I was a bit surprised by it and have yet to get a reply...for all I know my email went to spam heaven...and after contacting the rep, did not pursue or bother Matt about it. Then I read Sam's blog this weekend on the week 14 results and emailed him with the idea that he should incorporate a self reported part of the website where one could enter their current physician or practice and location for those that want an easy directory rather than weeks of a "hit or miss" approach. I have not heard back from Sam yet regarding same but sure at some point he will get to it as his schedule allows. Lets talk about AF while we're at it....I know it's hard for many to keep their emotions in check when it comes to his being...but lets keep things in perspective, he is nothing more than a "pawn" and as such has no self worth, and it wouldn't surprise me down the road for him to take his own life some day when he realizes what a waste his life is/was. It is part of the "natural events" of evolution. This past weekend, my wife (ICU-RN) took care of a twenty something who was shot by his buddy at a shooting range. They wanted to check out the "bullet proof" vests they were wearing and the one said to the other..."shoot me"...the other did and the bullet went just below where the vest was joined in the front under the sternum. The bullet went into the spine and the kid is now a paraplegic...wife was discussing it with my oldest son (who started residency this week) and she was initially taken back by his response "natural event"...in other words, survival of the fittest and the idiots taking care of not making it further in life by themselves, welcome to my oldest but he had a point...makes me think of Adam  BTW, for the record...not once did I mention the word stock or Mannkind or ticker symbol for that matter...I did however mention that Sanofi was the company marketing it. |
|
|
|
Post by babaoriley on Jun 29, 2015 15:19:56 GMT -5
So, Joey, first, with respect to you talking to this poor, unsuspecting diner, who had just taken a bunch of insulin in anticipation of a large carb content meal, which you caused him to delay -- did the unfortunate guy go hypo on you? Did you see the initial frozen smile on his face, and then did you notice as it slowly turned to a glassy-eyed look?
Second, I say we find out what docs are refusing to prescribe Afrezza and picket their offices, hopefully, things won't turn violent.
Third, vest guy is a mortal lock for a Darwin award and shooter guy, well, what can you say about him.
Lest there be an iota of doubt, the above, save "Third," is very tongue in cheek.
|
|
|
|
Post by jpg on Jun 29, 2015 16:25:02 GMT -5
Hey James,
From what you seem to he saying every dime not invested the way you want it invested (a complete and total cure for T1) seems to be a waste of time and money?
If I understand this view correctly that is a rather narrow view of medical research. What if Afrezza was a bridge to a cure (for T1 and even T2)? What if Afrezza was part of the cure for both T1 and T2?
It wouldn't be far fetched for basal insulin production to be unregulated (many T1s have some low level residual secretion) in some T1s but that the stress of peak load simply couldn't be handled. Afrezza could be the perfect 'off loading insulin' to augment basal secretion and preserve function. This phenomena seems to be even more meaningful in type 2 diabetics. I refer you to the abundant (but still not mainstream) literature that shows intensive insulin therapy seems to reverse or partially reverse type 2 disease. How meaningful is this? We don't know yet but this could be a partial or complete cure for some.
Tour anger is directed against those who are innovating (and funding these innovations). Focus your energy on convincing the ADA or other non profits to fund the studies (BCG seems to be your favorite?). Why is the ADA (and fellow diabetics) not listening to you? Try harder. From what you seem to post you dislike all Pharma and all those who do research you find not to be your top priorities. This seems to include the ADA and the JDRF. Start your own company or non for profit and get going. It's easy to bash everyone. Much harder to build.
As for passionate investors: why do you think we invested in a company with one product? Because we think they have a good revolutionary product. That is why. Many of us have spent years treating patients with the complications of diabetes and feel this will dramatically alter the whole field. A few self appointed research vigilantes will not stop a revolutionary product from helping diabetics.
History will show many to be simply uninformed. it would be sad if the scientifically illiterate '100% cure or nothing' crowd won out. It's unlikely but sadly possible. History is full of examples of the ill informed clutching to the status quo at all cost. You would still be using cow and pig insulin if the 'cure or nothing' crowd ruled.
|
|
|
|
Post by babaoriley on Jun 29, 2015 17:26:38 GMT -5
In my vernacular, jpg, what your calm and well-reasoned post actually is, is.... coiling!! |
|
|
|
Post by suebeeee1 on Jun 29, 2015 17:52:26 GMT -5
It is part of the "natural events" of evolution. This past weekend, my wife (ICU-RN) took care of a twenty something who was shot by his buddy at a shooting range. They wanted to check out the "bullet proof" vests they were wearing and the one said to the other..."shoot me"...the other did and the bullet went just below where the vest was joined in the front under the sternum. The bullet went into the spine and the kid is now a paraplegic...wife was discussing it with my oldest son (who started residency this week) and she was initially taken back by his response "natural event"...in other words, survival of the fittest and the idiots taking care of not making it further in life by themselves, welcome to my oldest but he had a point...makes me think of Adam For true understanding of the "survival of the fittest", if you need a realization check of how bizzare and utterly innane people can be, check out the "Darwin Awards" www.darwinawards.com/ |
|
|
|
Post by _neil on Jun 29, 2015 18:01:09 GMT -5
|
|
|
|
Post by peppy on Jun 29, 2015 18:25:40 GMT -5
quote: the idea that he should incorporate a self reported part of the website where one could enter their current physician or practice and location for those that want an easy directory rather than weeks of a "hit or miss" approach.
Reply: consider a thread on this board, people could type the name of the practice where they received a prescription.
|
|
|
|
Post by liane on Jun 29, 2015 18:33:18 GMT -5
peppy,
I think that idea would be more appropriate on a PWD forum rather than here where the focus is more the investment thesis.
|
|
|
|
Post by peppy on Jun 29, 2015 18:35:02 GMT -5
sounds good
|
|
|
|
Post by jimbering on Jun 29, 2015 18:37:05 GMT -5
"It's obvious that you have a burning hatred for investors but without investors there wouldn't be many life saving/altering drugs that we have today. So what if Afrezza is the closet thing to cure that you or your children will see in your lifetime? You are just going to keep bashing it? What if Afrezza was an injectable and mimicked the pancreas, would you love it and use it? " The hatred for investors is something that galls me. OK, I see the point when investors on diabetic sites and start pontificating about Afrezza. They absolutely shouldn't be doing that unless they are an insulin using diabetic. I agree. However, you have some posters on those sites that have a vitriol hatred of investors. The most amazing one is an investor! Not only an investor but a so called analyst or contributor on Seeking Alpha! This so called analyst will knock investors on TuDiabetes and then turn around and write an article on Seeking Alpha telling everyone why MNKD's financials are a catastrophe waiting to happen! Talk about a hypocrite! Miracle drugs come because people take a chance and invest in small biotechs. That's a fact. |
|
|
|
Post by peppy on Jun 29, 2015 19:03:02 GMT -5
I think everyone now has seen the multitudes of ads that have hit the TV's, this past weekend NVO had their Levemir commercial (latest that I've seen in their series including Novolog, flex pen, etc.) also saw the "once a week" ad with another "cute" character doing exercises for Tanzeum (see potential side effects here) www.drugs.com/tanzeum.html ...basically this arena is getting more crowded and the competition for those $$$ are fighting for their pieces... Where this got driven home this past weekend was when I was out with the family at dinner and I noticed a gentleman at a table pricking his finger measuring his BG and taking a pen injector out. He seemed rather comfortable enough where I had no qualms walking over and asking if he knew about "the best alternative out there". Not to my surprise, he had not. So I gave him the 5 minute version, wrote down the usual links and hashtags and he shook my hand and sincerely thanked me. He was a T1 and mentioned he was on the pump as well. So for those that don't think DTC will make much difference, think again because Sanofi has the mother of all in their arsenal (just ask our 5 star General Spiro) and their gloves are about to come off....can't happen soon enough! Speaking of the gloves coming off, can't happen soon enough Ted & Evan, looks like you hit a nerve with AF lol Television advertisement are costly. Diabetic magazines have limited readership. I have a picture in my mind, Afrezza advertisements on the sides of buses.
|
|
You are just going to keep bashing it?
