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Post by lorcan458 on Oct 1, 2015 20:49:30 GMT -5
Here are the pieces of technology that I would be putting together with Afrezza, with the help of Sanofi, Google Life Sciences and a company with a product like Glucowise. I'd combine non-invasive realtime glucose monitoring that sends data to a phone, an app that allows you to enter what foods you are eating and a smartwatch to monitor exercise activity. All this data is stored and analyzed by Google. Mannkind would develop a smart inhaler that would be able to deliver a precise enough range of doses so that when the app looks at your current blood glucose level and the meal you intend to have, the dose of Afrezza is custom measured. Then, after the meal, the app learns how accurate it's guess was and improvements are made. Google analytics combines everyone's anonymous data to further refine its dosing algorithm. The app would also suggest menu changes, exercise changes, etc.
Afrezza being a dry powder and quick acting I think is the ideal mealtime insulin for this type of customized treatment. I believe if the above could be implemented, those diabetics will live very close to normal lives and may even have better control over their blood sugar levels than pre-diabetics. I don't see any technical hurdles to this. It just needs vision and money, as far as I can tell. I just provided the vision, Google and Sanofi have the money. Let's change the world.
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Post by trondisc on Oct 1, 2015 21:04:26 GMT -5
Sanofi is the boring lame duck player as I have been saying for several weeks since the Google partnership. Google and MannKind could challenge the entire medical software/hardware industry forever. It would be incredible to witness Google software analytics store data on a global scale, combine everyone's research data to further refine dosing algorithms & allowing the MannKind/Afrezza app to also suggest menu changes, exercise changes, etc as you stated! Getting digital integration into Technosphere is paramount especially when developing future devices to help and monitor different ailments/diseases/etc.
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Post by harrys on Oct 1, 2015 21:11:02 GMT -5
If I were the CEO of MNKD I'd be working on my resume and LinkedIn for when I'm rightfully booted. Hakan is literally incompetent, I mean what does it say about the company that the CFO is the official spokesperson... anything other than this all culminating in a buyout should absolutely warrant management being ultimately replaced, maybe under the guidance of Al.
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Post by 1 percenter on Oct 1, 2015 21:31:51 GMT -5
If I were the CEO of MNKD I'd be working on my resume and LinkedIn for when I'm rightfully booted. Hakan is literally incompetent, I mean what does it say about the company that the CFO is the official spokesperson... anything other than this all culminating in a buyout should absolutely warrant management being ultimately replaced, maybe under the guidance of Al. You have to remember that hakaloogie was hand picked by Al himself. He isnt going anywhere. And remember, hakan said we are going to make a lot of money.
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Post by peppy on Oct 1, 2015 22:04:25 GMT -5
Here are the pieces of technology that I would be putting together with Afrezza, with the help of Sanofi, Google Life Sciences and a company with a product like Glucowise. I'd combine non-invasive realtime glucose monitoring that sends data to a phone, an app that allows you to enter what foods you are eating and a smartwatch to monitor exercise activity. All this data is stored and analyzed by Google. Mannkind would develop a smart inhaler that would be able to deliver a precise enough range of doses so that when the app looks at your current blood glucose level and the meal you intend to have, the dose of Afrezza is custom measured. Then, after the meal, the app learns how accurate it's guess was and improvements are made. Google analytics combines everyone's anonymous data to further refine its dosing algorithm. The app would also suggest menu changes, exercise changes, etc. Afrezza being a dry powder and quick acting I think is the ideal mealtime insulin for this type of customized treatment. I believe if the above could be implemented, those diabetics will live very close to normal lives and may even have better control over their blood sugar levels than pre-diabetics. I don't see any technical hurdles to this. It just needs vision and money, as far as I can tell. I just provided the vision, Google and Sanofi have the money. Let's change the world. quote; "non-invasive realtime glucose monitoring (that sends data to a phone") "I don't see any technical hurdles to this." reply: we not have a non-invasive glucose monitoring system. Do we?
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Post by lorcan458 on Oct 1, 2015 22:18:34 GMT -5
Glucowise has a non-invasive (no puncturing the skin) glucose monitor that sends data to a phone. They are a UK company. I don't know if Mannkind has a relationship with them, but the technology exists.
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Post by peppy on Oct 1, 2015 22:23:17 GMT -5
Glucowise has a non-invasive (no puncturing the skin) glucose monitor that sends data to a phone. They are a UK company. I don't know if Mannkind has a relationship with them, but the technology exists. oh man, thank you. I see you mentioned the company on your first post. let's look. thanks www.gluco-wise.com/
The glucose levels are extracted by a non-invasive technique which transmits low-power radio waves through a section of the human body, such as the area between the thumb and forefinger or the earlobe. These areas have adequate blood supply and are thin enough for waves to pass through the tissue. These signals are then received by a sensor on the opposite side of the GlucoWise device, where the data about the characteristics of the blood within the flesh are collected and analysed
GlucoWise™ utilised two unique technologies to achieve unprecedented accuracy in non-invasive glucose measurements. First, we utilise high-frequency radio waves around the 65 GHz range. These waves are large enough to allow penetration through the tissue, yet simultaneously small enough to provide sufficient resolution of the blood regions inside the tissue. Second, our sensors have integrated nano-composite films which temporarily make the skin transparent to the radio waves when a measurement is initiated. This ensures consistent readings across all people independent of age, or skin type and colour.
now I remember, I had been to the link once before; GlucoWise™ is currently in development and will be available to purchase once clinical trials are completed. We expect to start taking pre-orders in late 2016.
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Post by peppy on Oct 1, 2015 22:50:14 GMT -5
lorcan, if they could get a reading from the forearm, a watch with a continuous read out.
They did it, they are reading it with a radio waves. nano composite films,which temporarily make the skin transparent to the radio waves when a measurement is initiated
they are sending some charge through also? they did it
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Post by trenddiver on Oct 1, 2015 23:09:26 GMT -5
I'd be spearheading the insurance coverage effort and assembling a top flight team to accomplish this extremely important task.
Trend
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Post by peppy on Oct 2, 2015 7:05:51 GMT -5
for me for fun a non-invasive technique which transmits low-power radio waves through a section of the human body, such as the area between the thumb and forefinger or the earlobe. These areas have adequate blood supply and are thin enough for waves to pass through the tissue. These signals are then received by a sensor on the opposite side of the GlucoWise device, where the data about the characteristics of the blood within the flesh are collected and analysed
Could the blood glucose level be obtained by an ear ring with this technology. A wearable?
Interesting information and we could watch. eat 8 cookies? an ice cream cone? what are my glucose levels now? how about now? consciousness raising. eat a salad, what did the glucose level do.
it would be a type two revolution if type two's had their blood glucose levels on a monitor. especially a continuous blood glucose monitor that is non evasive and has the potential to be a fashion accessory.
Google wearables.
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Post by lorcan458 on Oct 2, 2015 7:26:21 GMT -5
it would be a type two revolution if type two's had their blood glucose levels on a monitor. especially a continuous blood glucose monitor that is non evasive and has the potential to be a fashion accessory.
I know it may sound like I'm cheerleading this idea, but the more I think about it, the more obvious and inevitable it seems to me that this will happen. Afrezza seems like a perfect fit as the non-invasive insulin. Google's obvious for the data analytics. The phone app is trivial to produce. I'd bet Glucowise would say yes if Google called and said, let's do this. I emailed the idea to Mannkind via their website. I don't know if an exec will see it or if I'll even get a response, but I hope this plan or an even more ambitious one is underway and all the silence on the pipeline and future plans is because they are working on something with this level of ambition.
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Post by cathode on Oct 2, 2015 10:01:01 GMT -5
What I would be working on if I were CEO of MannKind--
EXACTLY WHAT THEY ARE WORKING ON RIGHT NOW!!!! Development of new drugs that are existing APIs coupled to the TS delivery method. I would not be focusing on new Afrezza delivery methods or inhalers (haven't we had problems with that in the past...?). Google Life Sciences has already teamed up with Sanofi and DexCom, likely for similar reasons to what you stated. I think it would be a disservice for MNKD to continue to put manpower on reaching out with Afrezza. That is Sanofi's responsibility. If I were CEO of MNKD I would be focussed on developing the new drug pipeline.
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Post by vissertrades on Oct 2, 2015 10:12:05 GMT -5
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Post by longstocking on Oct 2, 2015 11:58:17 GMT -5
it would be a type two revolution if type two's had their blood glucose levels on a monitor. especially a continuous blood glucose monitor that is non evasive and has the potential to be a fashion accessory.
I know it may sound like I'm cheerleading this idea, but the more I think about it, the more obvious and inevitable it seems to me that this will happen. Afrezza seems like a perfect fit as the non-invasive insulin. Google's obvious for the data analytics. The phone app is trivial to produce. I'd bet Glucowise would say yes if Google called and said, let's do this. I emailed the idea to Mannkind via their website. I don't know if an exec will see it or if I'll even get a response, but I hope this plan or an even more ambitious one is underway and all the silence on the pipeline and future plans is because they are working on something with this level of ambition. I doubt you'll get a response from them. Ever since the GOOG/SNY partnership was announced, I have been thinking the same thing. I wholeheartedly believe this is the reason for the silence. My doctor had me start using the myFitnessPal app to track my calories, exercise and nutrition when he was threatening to put me on pre-diabetes meds. That app combined nicely with RunTastic to merge exercise data with nutrition data. Although Runtastic syncs with many other apps and/or wearables, my use of the technology stopped there as with just these two apps I was able to change my health significantly as I went from about 212lbs down to 153lbs. No more threats of diabetes. A bit of nutrition education, combined with apps that provided a place to track my data, gave ME the tools to track my own health instead of just trusting a doctor's opinion. Although he made the initial threat of diabetes meds, he was of little use when I was trying to learn about diabetes/nutrition and how to take charge of my health. My positive results were achieved through research which inspired change for me. Seeing "real-time" data, (calories consumed, nutrition stats, calories burned through exercise, and daily weigh-in charts), further inspired me to continue because I was seeing success (or failures) based on daily decisions about diet/exercise. After a few weeks it became quite obvious to me that the battle is won in the kitchen, not the gym - both for weight loss and for unnecessary wear and tear on my pancreas. Think about it - if you consume tons of calories all day, (increased insulin needs), then work it all off at the gym after work, you still over worked your pancreas by causing it to store fat all day. Through my iPhone it takes multiple apps to get what I wanted. Who has the motive to wrap it all together for monitoring overall health? Who would love to beat APPL? GOOG!!!! And I don't think it will be limited to diabetes. Many possibilities for GOOG/SNY/MNKD partnerships with TS!! The technology age has set the bar for access to info. Who wants to wait to ask the doctor? I want to know my stats now. If I were diabetic, even more so. IMO Google will not leave this easy $$$ sitting on the table. Just my opinion, for what it's worth.
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Post by lorcan458 on Oct 2, 2015 17:03:03 GMT -5
I just sent the idea with links to Mediwise. Samsung and Google would love to beat Apple. Samsung has facilities to miniaturize the core components of the Glucowise device and they already have the wearables and phones. I don't think developing this would take away from Mannkind because Samsung and Google would fund the scientists and engineers working on the project. Sanofi + Google + Samsung is close to a trillion dollars in market cap. A project like this is a tiny slice of their ordinary R&D budget, but the PR for all the companies involved would be huge.
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