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Post by itellthefuture777 on Aug 10, 2017 12:59:30 GMT -5
"Afrezza — can deliver improved health outcomes at a fraction of the cost of current standards of care."
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Post by itellthefuture777 on Aug 10, 2017 13:34:01 GMT -5
I like how the most advanced APPs technology found Afrezza to be the choice insulin to demonstrate their ability to lower A1C with their approved device combo...they didn't select anyone else..speaks volumes...
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Post by dh4mizzou on Aug 10, 2017 14:01:58 GMT -5
Not seeing any possible completion date(s) for this. Any educated guesses as to when we might expect to hear anything?
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Post by itellthefuture777 on Aug 10, 2017 14:32:58 GMT -5
Both are FDA approved ..I imagine people can just do it...now..but there is a link in the thing to join the trial..probably a cheaper way to do this as things maybe provided..for free in a trial..hmm
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Post by Deleted on Aug 10, 2017 17:55:43 GMT -5
I passed on the information to a T2 on Metformin with elevated A1c. Hopefully, he qualifies to enroll.
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Post by itellthefuture777 on Aug 10, 2017 21:15:54 GMT -5
Metformin..doesn't halt progression...and there are some interesting findings from the scripts institute about Metformin..I will see if I can dig it up..hold on a second
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Post by itellthefuture777 on Aug 10, 2017 21:24:34 GMT -5
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Post by itellthefuture777 on Aug 10, 2017 21:33:50 GMT -5
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Post by itellthefuture777 on Aug 10, 2017 21:34:48 GMT -5
Basically...Afrezza imho should be frontline..not Metformin..
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Post by agedhippie on Aug 10, 2017 21:54:56 GMT -5
Metformin..doesn't halt progression...and there are some interesting findings from the scripts institute about Metformin..I will see if I can dig it up..hold on a second To the best of my knowledge nobody has ever claimed Metformin will stop progression, and if they have the medical establishment will tell them that they are wrong. If Metformin stopped progression then that would be the end point in the standard of care which it isn't. Now for some people Metformin will be all they ever need simply because their disease is progressing slowly enough for them to die of old age before they need anything else. However if your version of diabetes is more aggressive you could blow through what Metformin can do for you in a couple of years. It is not one size fits all hence the liberal use of YMMV when people talk about this in diabetes forums. I have great difficulty envisioning a future where Afrezza displaces Metformin as the first line drug. My view is that because of cost and compliance (convenience) Metformin will remain the first choice for the foreseeable future. Afrezza may well displace other drugs (personally I think sulfas should be banned). |
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Post by itellthefuture777 on Aug 10, 2017 22:05:07 GMT -5
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Post by careful2invest on Aug 10, 2017 23:55:07 GMT -5
Great article! It needs to get exposure in current media. Published in November of 2009. Al addressed dosage quite clearly, "three times the amount" of injectable insulin. Interesting also to read the comments. While reading it, one can see why we longs invested in MNKD in the first place and are so very dedicated to AFREZZA'S success! Sad that Al is no longer here to see it through, but I think that we will! GLTA! |
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Post by sayhey24 on Aug 11, 2017 5:41:07 GMT -5
Metformin..doesn't halt progression...and there are some interesting findings from the scripts institute about Metformin..I will see if I can dig it up..hold on a second To the best of my knowledge nobody has ever claimed Metformin will stop progression, and if they have the medical establishment will tell them that they are wrong. If Metformin stopped progression then that would be the end point in the standard of care which it isn't. Now for some people Metformin will be all they ever need simply because their disease is progressing slowly enough for them to die of old age before they need anything else. However if your version of diabetes is more aggressive you could blow through what Metformin can do for you in a couple of years. It is not one size fits all hence the liberal use of YMMV when people talk about this in diabetes forums. I have great difficulty envisioning a future where Afrezza displaces Metformin as the first line drug. My view is that because of cost and compliance (convenience) Metformin will remain the first choice for the foreseeable future. Afrezza may well displace other drugs (personally I think sulfas should be banned). The future is nearly here. Its all about technology. Prior to CGMs PWDs had no idea what was going on, most doctors also had no idea and the ones which did hid behind the numbers. Once CGMs are widely used it will be difficult for doctors to hide behind the numbers and to keep prescribing something which does not work to address the main problem T2s have which is first phase insulin release and meal time spikes. Many of the T2 are spiking 180+, some 250+ at meal time and 90% are not meeting a 6.0 A1c. So no, metformin is not currently working. Heck, 70+% are not even meeting a target of 7.0 However, I misjudged the market a few years ago as I was focused on the T1/T2 market. When Tim Cook introduces the CGM IWatch it takes everything to a new level. "Non-diabetics" who are spiking over 130 at lunch are going to start looking to address their pre-diabetes. If VDex is correct on the hypo safety of afrezza, this market is way beyond anything I anticipated. The IWatch will not be about the PWD market, it will be about everyone else. The spiking guy at the lunch group is going to be saying "give me that little blue cartridge". Now, I have always thought keeping BG levels non-diabetic is directly tided to longevity. If they can show keeping a 70-130 range greatly improves heart health people will start taking afrezza just like the statins. Bottom line metformin is doomed along with the other T2 meds. As the good doctor who worked hard years ago to get metofrmin FDA approved Dr. Ralph DeFronzo from the University of Texas Health Science Center said at the BeyondA1c forum a few weeks ago “The most waste in type 2 diabetes is to continuously put people on metformin and sulfonylureas (glyburide, glimepiride, etc.). These drugs have no protective effect on the beta cell, and by the time you figure out what you’re doing, there are no beta cells left to save.” diatribe.org/the-diatribe-foundation-and-tcoyd-11th-annual-forum |
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Post by agedhippie on Aug 11, 2017 7:20:15 GMT -5
The future is nearly here. Its all about technology. Prior to CGMs PWDs had no idea what was going on, most doctors also had no idea and the ones which did hid behind the numbers. Once CGMs are widely used it will be difficult for doctors to hide behind the numbers and to keep prescribing something which does not work to address the main problem T2s have which is first phase insulin release and meal time spikes. Many of the T2 are spiking 180+, some 250+ at meal time and 90% are not meeting a 6.0 A1c. So no, metformin is not currently working. Heck, 70+% are not even meeting a target of 7.0 However, I misjudged the market a few years ago as I was focused on the T1/T2 market. When Tim Cook introduces the CGM IWatch it takes everything to a new level. "Non-diabetics" who are spiking over 130 at lunch are going to start looking to address their pre-diabetes. If VDex is correct on the hypo safety of afrezza, this market is way beyond anything I anticipated. The IWatch will not be about the PWD market, it will be about everyone else. The spiking guy at the lunch group is going to be saying "give me that little blue cartridge". Now, I have always thought keeping BG levels non-diabetic is directly tided to longevity. If they can show keeping a 70-130 range greatly improves heart health people will start taking afrezza just like the statins. Bottom line metformin is doomed along with the other T2 meds. As the good doctor who worked hard years ago to get metofrmin FDA approved Dr. Ralph DeFronzo from the University of Texas Health Science Center said at the BeyondA1c forum a few weeks ago “The most waste in type 2 diabetes is to continuously put people on metformin and sulfonylureas (glyburide, glimepiride, etc.). These drugs have no protective effect on the beta cell, and by the time you figure out what you’re doing, there are no beta cells left to save.” diatribe.org/the-diatribe-foundation-and-tcoyd-11th-annual-forumThe CGM iWatch that Tim Cook is wearing is the Dexcom app. To use it you need a Dexcom and if people don't like insulin needles they are going to love a CGM inserter. Contrary to what you think people are not going to want to obsess over their blood glucose levels, they are just not that engaged. You are trying to change lifestyles and that is extremely difficult to do. So no, I am with the good doctor, the future is not single drugs like metformin, as he says it's tailored drug cocktail with metformin as a constituent. Yes insulin will have a role but it's going to be as a last resort. Not that I like that approach, I would move to insulin after monotherapy failure, but it has the virtue of requiring minial change and in the end that approach wins. |
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Post by zuegirdor on Aug 11, 2017 13:11:12 GMT -5
To the best of my knowledge nobody has ever claimed Metformin will stop progression, and if they have the medical establishment will tell them that they are wrong. If Metformin stopped progression then that would be the end point in the standard of care which it isn't. Now for some people Metformin will be all they ever need simply because their disease is progressing slowly enough for them to die of old age before they need anything else. However if your version of diabetes is more aggressive you could blow through what Metformin can do for you in a couple of years. It is not one size fits all hence the liberal use of YMMV when people talk about this in diabetes forums. I have great difficulty envisioning a future where Afrezza displaces Metformin as the first line drug. My view is that because of cost and compliance (convenience) Metformin will remain the first choice for the foreseeable future. Afrezza may well displace other drugs (personally I think sulfas should be banned). The future is nearly here. Its all about technology. Prior to CGMs PWDs had no idea what was going on, most doctors also had no idea and the ones which did hid behind the numbers. Once CGMs are widely used it will be difficult for doctors to hide behind the numbers and to keep prescribing something which does not work to address the main problem T2s have which is first phase insulin release and meal time spikes. Many of the T2 are spiking 180+, some 250+ at meal time and 90% are not meeting a 6.0 A1c. So no, metformin is not currently working. Heck, 70+% are not even meeting a target of 7.0 However, I misjudged the market a few years ago as I was focused on the T1/T2 market. When Tim Cook introduces the CGM IWatch it takes everything to a new level. "Non-diabetics" who are spiking over 130 at lunch are going to start looking to address their pre-diabetes. If VDex is correct on the hypo safety of afrezza, this market is way beyond anything I anticipated. The IWatch will not be about the PWD market, it will be about everyone else. The spiking guy at the lunch group is going to be saying "give me that little blue cartridge". Now, I have always thought keeping BG levels non-diabetic is directly tided to longevity. If they can show keeping a 70-130 range greatly improves heart health people will start taking afrezza just like the statins. Bottom line metformin is doomed along with the other T2 meds. As the good doctor who worked hard years ago to get metofrmin FDA approved Dr. Ralph DeFronzo from the University of Texas Health Science Center said at the BeyondA1c forum a few weeks ago “The most waste in type 2 diabetes is to continuously put people on metformin and sulfonylureas (glyburide, glimepiride, etc.). These drugs have no protective effect on the beta cell, and by the time you figure out what you’re doing, there are no beta cells left to save.” diatribe.org/the-diatribe-foundation-and-tcoyd-11th-annual-forumThat spiking guy would be me! |
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