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Post by digger on Apr 29, 2018 1:32:09 GMT -5
Please review "agehippie"'s comment about six posts ago and if you don't believe him, email Mannkind and ask them. Digger I am drunk. hahahaha I must have been as well -- that or early Alzheimers -- since I was meaning to reply to the earlier comment by "sayhey."
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Post by liane on Apr 29, 2018 5:01:51 GMT -5
Not many I agree, however the Bydureon is expensive so maybe it be easy to switch out? I'll try my best to get on Afrezza! You have to be your own advocate. Show him/her that you've done your homework. If necessary, suggest a trial of several months to demonstrate you can get equal or better numbers.
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Post by sayhey24 on Apr 29, 2018 6:35:32 GMT -5
Not many I agree, however the Bydureon is expensive so maybe it be easy to switch out? I'll try my best to get on Afrezza! Money aside Bydureon is in a class of drugs which causes serious issues. Is the risk worth it especially when you can address the root cause of your high BG, your body not making enough insulin for your needs and at the same time afrezza will stop the spike which is huge for heart health. The 9th circuit case is back on - www.drugnews.net/news/januvia-trulicity-victoza-2018-pancreatic-cancer-lawsuits/?gclid=EAIaIQobChMIk4jKprDf2gIVw1mGCh1s2wIrEAAYBCAAEgLji_D_BwEIn the case BP does not deny these drugs cause serious issues but rather blamed the FDA for not requiring these issues disclosed on the label.
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Post by sayhey24 on Apr 29, 2018 6:52:33 GMT -5
Say Hey, I love you! Nice work. No one will tell us better us then Kendall. mango , I will pay for your uber/taxi from LAX to the Hotel!. Weehaw Report Please review "agehippie"'s comment about six posts ago and if you don't believe him, email Mannkind and ask them. Digger - OK I reviewed Aged's comments. What I can say is you guys make me dizzy going in cirlce's. Simple question - Where did the requirement for spirometry come from? If I remember correctly from the days of the Adcom it was part of the risk mitigation strategy, aka the REMS. Long story short - Pfizer tried to stop afrezza by putting out FUD and associating it to Exubera. As Aged use to say in not so many words - afrezza will make your lungs explode. Now, aside from the REMS document which requires it, I can not find another FDA document requiring it. Its mention in the black box is part of the REMS communication requirements. Please point me to another FDA document requiring it if you know of one. Simple question 2 - If the REMS is gone, we know the communication plan also gone but is the requirement for spirometry gone too? It sure seems so. I am sure MNKD will address this soon, in the next month or so but lets assume it is gone. That seems like a HUGE deal. Wouldn't you agree?
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Post by nadathing on Apr 29, 2018 7:04:06 GMT -5
Not many I agree, however the Bydureon is expensive so maybe it be easy to switch out? I'll try my best to get on Afrezza! I was on Bydureon for 6 -8 years, which included a P3 trial. My insurance plan would not cover Bydureon without prior authorization. I switched to Trulicity a year ago and have the same great results I had on Bydureon. I've talked to my Endo about Afrezza. When I brought it up 2 years ago she had not heard of Afrezza. She said she is not going to prescribe insulin for any T2 unless they are insulin dependent. Her department is also not allowed to see pharma reps. The clinic I go to is connected to The International Diabetes Center in St. Louis Park, MN. I wonder how many at the IDC even know Afrezza exists.
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Post by golfeveryday on Apr 29, 2018 7:22:44 GMT -5
Not many I agree, however the Bydureon is expensive so maybe it be easy to switch out? I'll try my best to get on Afrezza! I was on Bydureon for 6 -8 years, which included a P3 trial. My insurance plan would not cover Bydureon without prior authorization. I switched to Trulicity a year ago and have the same great results I had on Bydureon. I've talked to my Endo about Afrezza. When I brought it up 2 years ago she had not heard of Afrezza. She said she is not going to prescribe insulin for any T2 unless they are insulin dependent. Her department is also not allowed to see pharma reps. The clinic I go to is connected to The International Diabetes Center in St. Louis Park, MN. I wonder how many at the IDC even know Afrezza exists. everyone ‘depends’ on insulin. Some of these docs crack me up. T2’s have lost their ability to produce adequate insulin to cover a meal leading to a spike in blood sugar. Most T2’s have actually lost this ability for almost a decade before they are diagnosed. So, what do they do then? Give patients some crappy oral therapy that doesn’t solve the true problem very well, lack of enough insulin to cover blood sugar spikes with meals. Afrezza is ideal here.
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Post by barnstormer on Apr 29, 2018 7:22:45 GMT -5
NADATHING You really should contact Mannkind and ask them to contact your clinic. If the clinic won't see a rep (many don't) Mike or someone on the executive team can contact them. They can't hide from information about new drugs their patients want or could benefit from and call themselves a "Diabetes Center".
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Post by Deleted on Apr 29, 2018 7:40:51 GMT -5
"everyone ‘depends’ on insulin"
Diabetes is the only endocrinology disorder that is mistreated because of false premises. A large and profitable establishment now exists. It will do everything possible to maintain its existence.
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Post by nadathing on Apr 29, 2018 7:45:10 GMT -5
I was on Bydureon for 6 -8 years, which included a P3 trial. My insurance plan would not cover Bydureon without prior authorization. I switched to Trulicity a year ago and have the same great results I had on Bydureon. I've talked to my Endo about Afrezza. When I brought it up 2 years ago she had not heard of Afrezza. She said she is not going to prescribe insulin for any T2 unless they are insulin dependent. Her department is also not allowed to see pharma reps. The clinic I go to is connected to The International Diabetes Center in St. Louis Park, MN. I wonder how many at the IDC even know Afrezza exists. everyone ‘depends’ on insulin. Some of these docs crack me up. T2’s have lost their ability to produce adequate insulin to cover a meal leading to a spike in blood sugar. Most T2’s have actually lost this ability for almost a decade before they are diagnosed. So, what do they do then? Give patients some crappy oral therapy that doesn’t solve the true problem very well, lack of enough insulin to cover blood sugar spikes with meals. Afrezza is ideal here. Of course everyone depends on insulin. I guess I have to spell it out word for word for some: Until a diabetic is not able to produce ANY of their own insulin my Endo will not prescribe insulin therapy.
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Post by nadathing on Apr 29, 2018 7:54:47 GMT -5
NADATHING You really should contact Mannkind and ask them to contact your clinic. If the clinic won't see a rep (many don't) Mike or someone on the executive team can contact them. They can't hide from information about new drugs their patients want or could benefit from and call themselves a "Diabetes Center". Park Nicollet is one of the largest health care systems in MN. I would have to believe that their systems allows pharma reps to access their people at some level, but they do not have direct access to doctors. I had a nurse instruct me on how to use Trulicity and I also asked her if she was aware of Afrezza and she was. She told me she knew of one patient on Afrezza that had experienced good results. That patient was being treated by a physician who practiced general medicine. How that physician or department became aware of Afrezza is unknown to me. Just for kicks, I will email Mike and tell him of my experience and see if I get a response. My A1c is 5.8. That is another factor. I can't imagine a doctor prescribing Afrezza when a T2 has tight control using existing treatment. I knows that Afrezza acts differently and the benefits. Changing the way docs treat diabetes is a slow and arduous process.
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Post by digger on Apr 29, 2018 8:31:29 GMT -5
Please review "agehippie"'s comment about six posts ago and if you don't believe him, email Mannkind and ask them. Digger - OK I reviewed Aged's comments. What I can say is you guys make me dizzy going in cirlce's. Simple question - Where did the requirement for spirometry come from? If I remember correctly from the days of the Adcom it was part of the risk mitigation strategy, aka the REMS. Long story short - Pfizer tried to stop afrezza by putting out FUD and associating it to Exubera. As Aged use to say in not so many words - afrezza will make your lungs explode. Now, aside from the REMS document which requires it, I can not find another FDA document requiring it. Its mention in the black box is part of the REMS communication requirements. Please point me to another FDA document requiring it if you know of one. Simple question 2 - If the REMS is gone, we know the communication plan also gone but is the requirement for spirometry gone too? It sure seems so. I am sure MNKD will address this soon, in the next month or so but lets assume it is gone. That seems like a HUGE deal. Wouldn't you agree? I'm sorry but, no, I can't assume it's gone because it simply isn't. Mannkind no doubt would have made a big deal off it being gone were it truly gone, but it didn't. The market would have made a big deal, but it didn't. Like I said, the only thing that was removed were the REMS requirements that insured broad distribution of the warnings. All the warnings remain the same, just as they are shown on the new website.
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Post by sayhey24 on Apr 29, 2018 8:41:52 GMT -5
everyone ‘depends’ on insulin. Some of these docs crack me up. T2’s have lost their ability to produce adequate insulin to cover a meal leading to a spike in blood sugar. Most T2’s have actually lost this ability for almost a decade before they are diagnosed. So, what do they do then? Give patients some crappy oral therapy that doesn’t solve the true problem very well, lack of enough insulin to cover blood sugar spikes with meals. Afrezza is ideal here. Of course everyone depends on insulin. I guess I have to spell it out word for word for some: Until a diabetic is not able to produce ANY of their own insulin my Endo will not prescribe insulin therapy. Your endo sounds like Ralph DeFronzo 25 years ago. Here is what he said last summer. He has finally realized you need to save the beta cells not destroy them. Why would anyone want to destroy them when afrezza provides a real chance of saving them and in some cases restore beta cell function? “The most waste in type 2 diabetes is to continuously put people on metformin and sulfonylureas (glyburide, glimepiride, etc.). These drugs have no protective effect on the beta cell, and by the time you figure out what you’re doing, there are no beta cells left to save.” – Dr. Ralph DeFronzo (University of Texas Health Science Center) diatribe.org/the-diatribe-foundation-and-tcoyd-11th-annual-forum
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Post by digger on Apr 29, 2018 8:42:57 GMT -5
NADATHING You really should contact Mannkind and ask them to contact your clinic. If the clinic won't see a rep (many don't) Mike or someone on the executive team can contact them. They can't hide from information about new drugs their patients want or could benefit from and call themselves a "Diabetes Center". Park Nicollet is one of the largest health care systems in MN. I would have to believe that their systems allows pharma reps to access their people at some level, but they do not have direct access to doctors. I had a nurse instruct me on how to use Trulicity and I also asked her if she was aware of Afrezza and she was. She told me she knew of one patient on Afrezza that had experienced good results. That patient was being treated by a physician who practiced general medicine. How that physician or department became aware of Afrezza is unknown to me. Just for kicks, I will email Mike and tell him of my experience and see if I get a response. My A1c is 5.8. That is another factor. I can't imagine a doctor prescribing Afrezza when a T2 has tight control using existing treatment. I knows that Afrezza acts differently and the benefits. Changing the way docs treat diabetes is a slow and arduous process. What a drug rep has to deal with to sell at Park-Nicollet: www.parknicollet.com/About/~/media/Files/pdf/About-Us/HCIRpolicy.ashxA "Health Care Industry Representative (HCIR)...refers to any individual representing any vendor, manufacturer, distributor, contractor, service company or any other organization that sells or provides products or services to PNHS...Examples of HCIRs may include, but are not limited to, marketing and sales roles, such as office product, technology hardware and software, business, support services, pharmaceutical, medical supply or device sale."
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Post by peppy on Apr 29, 2018 8:47:47 GMT -5
Not many I agree, however the Bydureon is expensive so maybe it be easy to switch out? I'll try my best to get on Afrezza! I was on Bydureon for 6 -8 years, which included a P3 trial. My insurance plan would not cover Bydureon without prior authorization. I switched to Trulicity a year ago and have the same great results I had on Bydureon. I've talked to my Endo about Afrezza. When I brought it up 2 years ago she had not heard of Afrezza. She said she is not going to prescribe insulin for any T2 unless they are insulin dependent. Her department is also not allowed to see pharma reps. The clinic I go to is connected to The International Diabetes Center in St. Louis Park, MN. I wonder how many at the IDC even know Afrezza exists. I think what I Have learned is Sanofi (Trulicity) must be giving the Pharmacy Purchasing Managers more of a rebate than AstraZeneca (Bydureon) Bydureon has the same Warning as Trulicity although no black box. www.bydureonhcp.com/bydureon-bcise?source=BYD_N_H_662&umedium=CPC&uadpub=Google&ucampaign=2018___BYDUREON_BCise_HCP_Branded_(Pen)&ucreative=General_Searches_and_FAQs&uplace=BYDUREON&cmpid=1&gclid=Cj0KCQjw2pXXBRD5ARIsAIYoEbc01Pczl5L_Nw4Y_1mb7NPaIf6Faw470N79Y3YNZ4sj9Ebv2Sv3Z7caAqLmEALw_wcB&gclsrc=aw.dsI wonder if Dr. Kendall can make head way in Minnesota. Strange, words like International in front of a Managed Care Facility to make it seem more consequential. Minnesotans are always thinking. In my opinion it is the endocrinologist job/ or the person (MD) on the endocrinologists team that reports new medications to know about a new insulin delivery system. Are we really to believe these people are stupid? The International Diabetes Center? In Saint Louis Park Mn? hahaha
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Post by sportsrancho on Apr 29, 2018 9:17:50 GMT -5
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