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Post by peppy on Jul 5, 2018 0:04:41 GMT -5
STAT trial was not designed for FDA approval. Even though size is small, it still provides informative data for physicians to provide proper dosing guidance to the patients and the expected results they could observe from the patients. Why did the trial have a Novolog arm then? If STAT was for dosing and guidance all they needed to show was that the STAT protocol outperformed the 171 protocol. The ADD 1 dynamic dosing is being done for dosing guidance. Kendall pointed out, regarding STAT the RAA and Afrezza dose needed to be comparable, so 4 unit doses were used hence the increased dosing. Regarding ADD1 Paraphrasing Mike C, and Sports " Take a larger dose to begin with, no follow up needed."  |
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Post by sweedee79 on Jul 5, 2018 0:52:41 GMT -5
Anyone defending Novalog... Humolog or the like, hasn't used Afrezza..
I am confident that Mike and Dr. Kendall knows the appropriate steps we need to take and the STAT study is part of it..
Afrezza was a miracle for my dad.. it totally was.. it's the system that is the problem..
I have also noticed that docs now days seem to want to prescribe cheaper meds believing they are helping their patients save money due to the high cost of health care.. even when they know their are better drugs out there.. I just finally got my dad on Tresiba.. doc was prescribing basaglar just because it was less expensive.. even though he admittedly believed Tresiba was far better..
I'm thinking back to ASM.. and everything that was said there.. guess we just have to wait and see.. But both Mike and Dr. Kendall are well aware of what we need to do..
I too question the motives of some people who post here..
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Post by wgreystone on Jul 5, 2018 1:18:07 GMT -5
Aged - No one is buying this. PWDs want to stack RAAs? Are you kidding me? You also must like playing Russian Roulette. Here is what they said in the "Clinical Results of an Automated Artificial Pancreas Using Technosphere Inhaled Insulin to Mimic First-Phase Insulin Secretion" ... Now here is what Gary Schiener has to say about "angry bolusing" - "Another major limitation to “rapid” insulin is the time it takes to bring above-target blood sugars down to normal. Nobody likes to spend long periods of time with high blood sugar; it turns us into zombies with a major urge to urinate, and drives the A1c up. Many people don’t have the patience to wait 3-5 hours for their high readings to come down, and administer even more insulin before the original correction dose has finished working. “Angry bolusing,” as this is often called, tends to lead to hypoglycemia." You know, if people don't want to believe that diabetics routinely stack insulin I am fine with that. End of the day people will believe what they want. The truth is that you have to stack, it's not optional. You even have to stack with Afrezza (that pesky second dose). Anger bolusing is irrelevant. It's in the same class as overeating when you are low. You know that you shouldn't do it and that it is a bad idea, but sometimes you still do it anyway (actually I overeat when I am low, but I don't anger bolus). Of course, PWD would like to stack insulin to bring down highs. The problem is with stacking RAA. The long tail makes it difficult to bring down the high without the risk of going down to hypo. With Afrezza, the quick in and quick out makes it easier to stack. It seems not too hard to understand. |
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Post by sayhey24 on Jul 5, 2018 7:55:48 GMT -5
Of course they did, in general over a long period of time insulin will remove sugar from the blood about equally. However that is the issue. The healthy body gets it out asap and not over 24hrs.
Now what Dr. Kendall said the other week was he can show afrezza is different than the other insulins and he called it superior at removing sugar. Maybe he is right or maybe its because afrezza signals the liver so you don't get the additional liver sugar.
Either way A1c is like an odometer and what the PWD needs after a meal is a speedometer.
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Post by agedhippie on Jul 5, 2018 8:52:24 GMT -5
Anyone defending Novalog... Humolog or the like, hasn't used Afrezza.. I am confident that Mike and Dr. Kendall knows the appropriate steps we need to take and the STAT study is part of it.. Afrezza was a miracle for my dad.. it totally was.. it's the system that is the problem.. I have also noticed that docs now days seem to want to prescribe cheaper meds believing they are helping their patients save money due to the high cost of health care.. even when they know their are better drugs out there.. I just finally got my dad on Tresiba.. doc was prescribing basaglar just because it was less expensive.. even though he admittedly believed Tresiba was far better.. I'm thinking back to ASM.. and everything that was said there.. guess we just have to wait and see.. But both Mike and Dr. Kendall are well aware of what we need to do.. I too question the motives of some people who post here.. To be clear. I believe that Afrezza works really well for your dad and absolutely support his right to have it over RAA. The PBM system that prevents diabetics from receiving the treatment they need is broken. |
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Post by agedhippie on Jul 5, 2018 8:57:50 GMT -5
Of course, PWD would like to stack insulin to bring down highs. The problem is with stacking RAA. The long tail makes it difficult to bring down the high without the risk of going down to hypo. With Afrezza, the quick in and quick out makes it easier to stack. It seems not too hard to understand. You are completely wrong on RAA. If you don't know how to safely correct a high (which means stacking) then you need to run and not walk to your nearest endo and get trained, and I would question how they ever let you on MDI in the first place. |
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Post by agedhippie on Jul 5, 2018 9:07:53 GMT -5
Of course they did, in general over a long period of time insulin will remove sugar from the blood about equally. However that is the issue. The healthy body gets it out asap and not over 24hrs. Now what Dr. Kendall said the other week was he can show afrezza is different than the other insulins and he called it superior at removing sugar. Maybe he is right or maybe its because afrezza signals the liver so you don't get the additional liver sugar. Either way A1c is like an odometer and what the PWD needs after a meal is a speedometer. Lol. RAA does not last 24 hours, that's basal insulin. Insulin suppresses ketosis and diabetic (as opposed to dietary) ketosis happens when there is no insulin in your blood, that's DKA and potentially fatal. There is always insulin in a healthy body and the level is modulated by the glucose level. |
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Post by mnkdfann on Jul 5, 2018 9:28:22 GMT -5
And give up skimmed milk, it's an invention of the devil, regular milk is better for diabetics. Would you please explain that. What makes the one bad, and the other better? |
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Post by peppy on Jul 5, 2018 9:30:12 GMT -5
Of course they did, in general over a long period of time insulin will remove sugar from the blood about equally. However that is the issue. The healthy body gets it out asap and not over 24hrs. Now what Dr. Kendall said the other week was he can show afrezza is different than the other insulins and he called it superior at removing sugar. Maybe he is right or maybe its because afrezza signals the liver so you don't get the additional liver sugar. Either way A1c is like an odometer and what the PWD needs after a meal is a speedometer. Lol. RAA does not last 24 hours, that's basal insulin. Insulin suppresses ketosis and diabetic (as opposed to dietary) ketosis happens when there is no insulin in your blood, that's DKA and potentially fatal. There is always insulin in a healthy body and the level is modulated by the glucose level. aged: love you. More specifically, ketosis happens when fat/lipids are being burned as an energy source. |
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Post by agedhippie on Jul 5, 2018 10:07:56 GMT -5
And give up skimmed milk, it's an invention of the devil, regular milk is better for diabetics. Would you please explain that. What makes the one bad, and the other better? Regular milk has fat which slows the digestion of the carbs smooth the spike. Skimmed milk has the same number of carbs but will spike you because there is no fat. Raw skimmed milk is a water gray and rather unappealing so they dump stuff in it to make it look like regular milk. So one diabetic objection, and one aesthetic objection  |
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Post by ilovekauai on Jul 5, 2018 10:12:43 GMT -5
Well stated Joey. Kendall knows his stuff. I saw him in action at the ASM as you did too, and will take his outlook over anyone on this board who is here only to sow dissent.
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Post by agedhippie on Jul 5, 2018 10:21:06 GMT -5
Lol. RAA does not last 24 hours, that's basal insulin. Insulin suppresses ketosis and diabetic (as opposed to dietary) ketosis happens when there is no insulin in your blood, that's DKA and potentially fatal. There is always insulin in a healthy body and the level is modulated by the glucose level. aged: love you. More specifically, ketosis happens when fat/lipids are being burned as an energy source. Sorry, I should have said that. Lacking glucose the body burns fat for energy and to preserve glucose for the brain (the brain cannot use ketones and must have glucose). In dietary ketosis the continuing presence of low levels of insulin moderate the ketosis and keep you safe. In diabetic ketosis there is no insulin so there is no moderation and you get runaway ketosis that will kill you. The quick check is to test your blood glucose. If you have more than trace ketones and are under 250 that is almost certainly dietary ketones. If you are over 250 and have more than trace ketones start to worry. If you are over 350 and have ketones go to hospital immediately. DKA worries me far more than hypos. All the diabetics I know who have died were killed by DKA. |
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Post by sweedee79 on Jul 5, 2018 11:02:35 GMT -5
Afrezza is superior to any mealtime insulin on the market today.... all of the info and studies support this...
The reason it worked so well for my dad is because it is the most natural form of treatment for any type of diabetes... his body began to function normally again... it was like he was healing from the ravages of diabetes right before my eyes..
With all we know I cannot defend or endorse RAA .. it is now old school IMO .. and I agree with the adjective "barbaric"
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Post by mango on Jul 5, 2018 11:05:23 GMT -5
Localized insulin-derived amyloidosis can also cause DKA due to the significantly low amount of subcutaneous insulin absorbed that was injected into the amyloid mass. Quite prevelant world-wide. Poor absorption of subcutaneous insulin can cause DKA.
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Post by agedhippie on Jul 5, 2018 11:59:43 GMT -5
Localized insulin-derived amyloidosis can also cause DKA due to the significantly low amount of subcutaneous insulin absorbed that was injected into the amyloid mass. Quite prevelant world-wide. Poor absorption of subcutaneous insulin can cause DKA. What does quite prevalent mean in concrete terms, and what is the evidence of the scale? |
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