|
Post by mango on Sept 6, 2018 8:40:44 GMT -5
Tacrolimus is an anti-calcineurinic immunosuppressant making it diabetogenic. Calcineurin is essential for beta cell function and Tacrolimus is an calcineurin inhibitor.
|
|
|
Post by xanet on Sept 6, 2018 11:20:24 GMT -5
Tacrolimus is an anti-calcineurinic immunosuppressant making it diabetogenic. Calcineurin is essential for beta cell function and Tacrolimus is an calcineurin inhibitor. We like to say that every dose of medicine is a little bit of poison. In other words, respect the medicine, know what it does and what the side effects are, and decide if the benefits outweigh the risks for this individual in this situation at this moment in time.
|
|
|
Post by peppy on Sept 6, 2018 19:24:59 GMT -5
Drugs and Supplements Tacrolimus (Oral Route)
US Brand Name Astagraf XL Envarsus XR Hecoria Prograf
Descriptions
Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine (Imuran®), basiliximab (Simulect®), or mycophenolate mofetil (Cellcept®). Tacrolimus belongs to a group of medicines known as immunosuppressive agents.
When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.
Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms: • Capsule • Capsule, Extended Release • Tablet, Extended Release
Source: www.mayoclinic.org/drugs-supplements/tacrolimus-oral-route/description/drg-20068314
I while ago, I tried to under stand what the word, "immunosuppressive" really meant. The word it's self doesn't sound bad. The cells of the immune system can be categorized as lymphocytes (T-cells, B-cells and NK cells), neutrophils, and monocytes/macrophages. These are all types of white blood cells. The major proteins of the immune system are predominantly signaling proteins (often called cytokines), antibodies, and complement proteins. An immune suppressive tries to stop or kill the cells above. These are the cells that fight infection in our bodies. When someone has an infection, a laboratory blood draw can be ordered to see if there is an increase in the above cells. Eosinophils are a type of disease-fighting white blood cell. This condition most often indicates a parasitic infection, an allergic reaction or cancer. You can have high levels of eosinophils in your blood (blood eosinophilia) or in tissues at the site of an infection or inflammation (tissue eosinophilia). Eosinophils are not listed above, although I remember them listed on the laboratory read out. Neutrophils (Polymorphonuclear PMN Cell): A type of cell found in the blood stream that rapidly ingests microorganisms and kills them. www.mayoclinic.org/symptoms/eosinophilia/basics/definition/sym-20050752primaryimmune.org/about-primary-immunodeficiencies/immune-system-and-primary-immunodeficiency
|
|
|
Post by peppy on Sept 7, 2018 4:48:42 GMT -5
First time poster. Curious about the market share shown in TRx slide... 900 scrips is 4%?? This seems like a VERY small market... based on $45M now, 50% share would only be $500M-ish revenue per year. What am I missing? sorry about the brain death here. Here it is.
|
|
|
Post by rayskum on Sept 7, 2018 8:01:12 GMT -5
First time poster. Curious about the market share shown in TRx slide... 900 scrips is 4%?? This seems like a VERY small market... based on $45M now, 50% share would only be $500M-ish revenue per year. What am I missing? The $45M number is a weekly number. You will have to multiply by 52 for annual
|
|