Diabetesmine article about Dance Biopharm mentions afrezza

[peppy]

www.dancebiopharm.com/inhaled-insulin

Here is what I think. I think the 'Dance" aerosol  will make it to the bronchials rather than the alveoli.
totally different.
the alveoli is where the gas exchange takes place.

It is like this, we do not get gas exchange in our bronchioles. its epithelium I believe. 
The gas exchange is in the alveoli.
covered in capillaries.

[xoxoxoxo]

I thought the whole magic part of what MNKD has is this FKDP particle which magically allows drugs of certain sizes to easy get across the pleural membrane. Our entire inhaled drug delivery pipeline is based on that technology so when other companies come in with inhaled stuff I’m asking why is our tech superior? With dance it sounds like they’re using the same RAAs so it gets into the bloodstream super fast, and then takes a longer amount of time to clear out which they’re saying makes it better than afrezza. I still don’t understand if there’s something special about afrezza’s tech or if any insulin can just go through the lung membrane with no issues

[mango]

Nov 4, 2018 12:56:02 GMT -5 xoxoxoxo said:

I thought the whole magic part of what MNKD has is this FKDP particle which magically allows drugs of certain sizes to easy get across the pleural membrane. Our entire inhaled drug delivery pipeline is based on that technology so when other companies come in with inhaled stuff I’m asking why is our tech superior? With dance it sounds like they’re using the same RAAs so it gets into the bloodstream super fast, and then takes a longer amount of time to clear out which they’re saying makes it better than afrezza. I still don’t understand if there’s something special about afrezza’s tech or if any insulin can just go through the lung membrane with no issues

The dry powder formulations and the inhalers work synergistically together, that's how the magic is created. 

[mango]

Nov 4, 2018 12:56:02 GMT -5 xoxoxoxo said:

I thought the whole magic part of what MNKD has is this FKDP particle which magically allows drugs of certain sizes to easy get across the pleural membrane. Our entire inhaled drug delivery pipeline is based on that technology so when other companies come in with inhaled stuff I’m asking why is our tech superior? With dance it sounds like they’re using the same RAAs so it gets into the bloodstream super fast, and then takes a longer amount of time to clear out which they’re saying makes it better than afrezza. I still don’t understand if there’s something special about afrezza’s tech or if any insulin can just go through the lung membrane with no issues

The insulin in Afrezza is trapped onto FDKP particles and stablized in their monomeric molecular structure. The insulin is delivered in its active form so there is no dissociation phase, just immediate absorption.
The inhaler is actually a marvel of engineering, and this little device is needed to function properly in order for the powders to effectively navigate anatomical airway, down to the deep lung. If the inhalers sucked, then the powders would be useless. Instead, Afrezza is able to restore post-prandial glucose homeostasis by matching physiologic insulin.

[liane]

I'll also add that the size / form of the Technosphere particles allow them to get deep into the lungs. Aqueous droplets are necessarily larger in size and are more likely to get hung up in the bronchial tree.

[mango]

Xoxoxoxo—

This breaks it down really well & is a worth reading anyway:
www.annualreports.com/HostedData/AnnualReportArchive/m/NASDAQ_MNKD_2006.pdf

And this one shows you what it takes to manufacture Afrezza and produce Technosphere:
www.mannkindcorp.com/Collateral/Documents/English-US/PharmPro%20-%20capturing%20lightning%20in%20a%20bottle.pdf

[tomtabb]

The way I understand the device, it is basically a nebulizer that uses a "vibrating mesh" instead of air pressure to produce the aerosol:

"...utilizes ultrasonic power in order to produce micron-scaled inhalable particles; ultrasonic nebulizers break down the drug solution into small droplets via piezoelectric vibration. There is a baffle within the inhaler, as well as jet nebulizers, to remove large droplets and return them to the main chamber of device."

The device itself actually looks quite similar to Aradigm's: www.aradigm.com/technologies.html

It's interesting that they boast: "PK profile: faster onset and longer duration than Humalog." I suspect that's because they are targeting the type 2 population, so using their product would mimic a single long acting dose while enabling the type 2 diabetic to treat meals more individually.