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Post by harleyryder on Aug 6, 2014 18:41:29 GMT -5
"Just to play devil's advocate with the eye/ear example though, how many people have died or had horrendous complications from using eye drops in the ears?" Although I'm not an MD, I play one on the internet, and I'm "hear" to tell you that although there is no record of people dying from eye drops in the ear, in a small percentage of cases, the patient's peripheral vision increases dramatically. I've seen people almost die from anaphylaxis to motrin, so a reaction can happen with any medication. Even if a medicine such as cortisporin ear drops is FDA approved for the ear, there is still a chance it can damage hearing if the eardrum is ruptured and the toxic antibiotic is able to seep into the delicate inner ear. Botox is another great example of off label use. Initially approved for spasm of the eye muscles, it was readily adopted for use in other areas such as to stop armpit sweating, or to improve spasm of the voice box, or to improve wrinkles. Allergan eventually did get FDA approval for some of these additional medical conditions - it allows the company to better market and recommend their product for that indication. PS - someone asked about the harley - I've done Sturgis and Myrtle Beach Bike Weeks, but have cut back on regular riding until the young kids are much older (a risk/benefit analysis on my part). Looking forward to Monday's cc and I appreciate the wisdom shared on this site.
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Post by harleyryder on Aug 6, 2014 18:47:32 GMT -5
YES. Thanks. Got my hearing back a couple of days ago. Great that your hearing is returning! For those who listen to loud music or abuse their hearing, the 70-80 year old hearing impaired patients don't complain about their loss of hearing nearly so much as they complain about the loud whistle or seashell sound in their ears (tinnitus). You can buy a hearing aid (especially if you invest in MNKD), but you can't turn off the tinnitus.
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Post by brentie on Aug 6, 2014 19:09:29 GMT -5
YES. Thanks. Got my hearing back a couple of days ago. Great that your hearing is returning! For those who listen to loud music or abuse their hearing, the 70-80 year old hearing impaired patients don't complain about their loss of hearing nearly so much as they complain about the loud whistle or seashell sound in their ears (tinnitus). You can buy a hearing aid (especially if you invest in MNKD), but you can't turn off the tinnitus. Ah but Al was working on it... SAN DIEGO, Oct. 31, 2013 /PRNewswire/ -- Otonomy, Inc., a clinical stage biopharmaceutical company developing innovative therapeutics for diseases and disorders of the inner and middle ear, today announced that it has completed the acquisition of certain assets and rights to intellectual property (IP) related to the use of gacyclidine for the treatment of tinnitus from an affiliate of NeuroSystec Corporation. Successful serial entrepreneur Alfred Mann founded NeuroSystec to develop a drug-device combination product that could provide sustained delivery of gacyclidine to the inner ear. Gacyclidine is a potent and selective antagonist of the N-Methyl-D-Aspartate (NMDA) receptor. Clinical studies, including pilot studies conducted with gacyclidine, support the use of NMDA antagonists as treatments for tinnitus. The company's third development program, OTO-311, utilizes Otonomy's proprietary drug delivery technology to achieve sustained exposure of gacyclidine in the inner ear from a single intratympanic (IT) injection. www.prnewswire.com/news-releases/otonomy-acquires-assets-and-patent-rights-for-tinnitus-program-230024181.html
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Post by BD on Aug 6, 2014 19:37:58 GMT -5
PS - someone asked about the harley - I've done Sturgis and Myrtle Beach Bike Weeks, but have cut back on regular riding until the young kids are much older (a risk/benefit analysis on my part). Looking forward to Monday's cc and I appreciate the wisdom shared on this site. I understand the risk/benefit thing real well. I ride a BMW R1200RT that I've only owned for a couple of years, but it has become a major component of my stress-reduction repertoire. My house has been a construction (war) zone all summer, and there's nothing I'd love to be able to do more these days than jump on the Beemer...but I had a pulmonary embolism 3 months ago, and I'm on a drug (Xarelto) for six months to keep my blood thin--and with this drug, there's no "quick fix" to get my blood to coagulate if I were to have some sort of serious bike accident, so I agreed to ground myself until I'm off the Xarelto. Trade-offs!
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Post by 4Balance on Aug 6, 2014 19:41:21 GMT -5
Do most insurance companies cover off label use?
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