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Post by longliner on Jan 21, 2019 22:52:17 GMT -5
Second dose, second poke... and more scar tissue. Is that what people with diabetes really want? The long tail eliminates the need for the second dose because it covers the carbs that arrive later. The focus is on faster onset, not on faster exit - URLI looks identical or slightly longer than ordibary Humalog. How lowwww can you go??
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Post by longliner on Jan 21, 2019 22:55:18 GMT -5
clinicaltrials.gov/ct2/show/NCT03214367Experimental: LY900014 LY900014 given subcutaneously (SC) 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Active Comparator: Insulin Lispro Insulin lispro given SC 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Experimental: LY900014 Open Label LY900014 given SC 20 minutes after the start of each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. They are not using CGM's they are using, Mixed-Meal Tolerance Test (MMTT) agedhippie , what is an MMTT? They used Self-Monitoring Blood Glucose (SMBG) Values (finger pricks) Well of course no CGM....that would be a fair comparison.
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Post by mango on Jan 21, 2019 23:24:06 GMT -5
Hmm maybe I read that wrong. So in that one experimental arm, they didn't administer lispro at all before the meal, and only after 20 minutes after the start of the meal? Or is it a second dose?
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Post by mango on Jan 21, 2019 23:26:15 GMT -5
The long tail eliminates the need for the second dose because it covers the carbs that arrive later. The focus is on faster onset, not on faster exit - URLI looks identical or slightly longer than ordibary Humalog. In the PRONTO-T1D study they required particpants in the URLi arm to administer a second dose 20 minutes after the start of each meal. Only in the T2D study did they not do follow on doses Now I dunno if that's right or not. To me it looks that way, but the whole design is quite confusing. Anyone know?
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Post by peppy on Jan 21, 2019 23:41:47 GMT -5
Hmm maybe I read that wrong. So in that one experimental arm, they didn't administer lispro at all before the meal, and only after 20 minutes after the start of the meal? Or is it a second dose? I do not believe it is a second dose. (It would kill them to have a second dose 20 mins later.). Are they dosing the basal with every meal? experimental: LY900014 LY900014 given subcutaneously (SC) 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Experimental: LY900014 Open Label LY900014 given SC 20 minutes after the start of each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Active Comparator: Insulin Lispro Insulin lispro given SC 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. add to this; If you are a person participating in a clinical trial, the MMTT can provide a more comprehensive physiological stimulus to insulin since the beta cells of the pancreas are responsive to certain amino acids and fatty acids in addition to glucose. For example, research trials may use MMTT tests in drug development, assessing the effectiveness of certain types of therapies, such as insulin pumps, glucagon-like peptide (GLP-1) agonists, and continuous glucose monitors. The Mixed Meal Tolerance Test (MMTT) requires a person to drink a "mixed meal," such as Boost or Ensure, that contains, protein, carbohydrates, and fat. The goal of the test is to measure how much insulin your pancreas can make in response to food. 1-hour Postprandial Glucose (PPG) Excursion during Mixed-Meal Tolerance Test (MMTT) [ Time Frame: Week 26 ] 1-hour PPG excursion during MMTT 2-hour PPG Excursion during MMTT [ Time Frame: Week 26 ] 2-hour PPG excursion during MMTT Rate of Severe Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of severe hypoglycemia *I do not see the protocol for monitoring their extended glucose levels over two hours glucose level Rate of Documented Symptomatic Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of documented symptomatic hypoglycemia This trial tweaked for results? www.verywellhealth.com/what-is-a-mixed-meal-tolerance-test-4151260
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Post by longliner on Jan 21, 2019 23:45:09 GMT -5
In the PRONTO-T1D study they required particpants in the URLi arm to administer a second dose 20 minutes after the start of each meal. Only in the T2D study did they not do follow on doses Now I dunno if that's right or not. To me it looks that way, but the whole design is quite confusing. Anyone know? Hold firm dude, you are on the right side, let them research, the short folk have more on the line (now)!
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Post by mango on Jan 21, 2019 23:46:29 GMT -5
Second dose, second poke... and more scar tissue. Is that what people with diabetes really want? The long tail eliminates the need for the second dose because it covers the carbs that arrive later. The focus is on faster onset, not on faster exit - URLI looks identical or slightly longer than ordibary Humalog. Here's what Lilly actually says, they say the focus of URLi is the "ultra rapid on/off profile." It's highlighted in the yellow box. assets.ctfassets.net/mpejy6umgthp/2dVCYhgahe6qeugw6kIqiY/8b348cbeccff4f233c1851a4dfa2b499/ADA2017_959-P.pdf
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Post by longliner on Jan 21, 2019 23:51:57 GMT -5
Mannkind should request a head to head comparison using a CGM. (Note; Lilly doesn't (wisely) reference inhaled insulin). And again we find ourselves at "Ultra rapid Afrezza, the fastest prandial treatment available". That would be in and out .
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Post by peppy on Jan 22, 2019 0:01:44 GMT -5
thank you. this trial is to obtain this? Mango on your data, Lilly working Treprostinil as an accelerant. Local vasodilation.
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Post by mango on Jan 22, 2019 0:06:55 GMT -5
Hmm maybe I read that wrong. So in that one experimental arm, they didn't administer lispro at all before the meal, and only after 20 minutes after the start of the meal? Or is it a second dose? I do not believe it is a second dose. (It would kill them to have a second dose 20 mins later.). Are they dosing the basal with every meal? experimental: LY900014 LY900014 given subcutaneously (SC) 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Experimental: LY900014 Open Label LY900014 given SC 20 minutes after the start of each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Active Comparator: Insulin Lispro Insulin lispro given SC 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. add to this; If you are a person participating in a clinical trial, the MMTT can provide a more comprehensive physiological stimulus to insulin since the beta cells of the pancreas are responsive to certain amino acids and fatty acids in addition to glucose. For example, research trials may use MMTT tests in drug development, assessing the effectiveness of certain types of therapies, such as insulin pumps, glucagon-like peptide (GLP-1) agonists, and continuous glucose monitors. The Mixed Meal Tolerance Test (MMTT) requires a person to drink a "mixed meal," such as Boost or Ensure, that contains, protein, carbohydrates, and fat. The goal of the test is to measure how much insulin your pancreas can make in response to food. 1-hour Postprandial Glucose (PPG) Excursion during Mixed-Meal Tolerance Test (MMTT) [ Time Frame: Week 26 ] 1-hour PPG excursion during MMTT 2-hour PPG Excursion during MMTT [ Time Frame: Week 26 ] 2-hour PPG excursion during MMTT Rate of Severe Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of severe hypoglycemia *I do not see the protocol for monitoring their extended glucose levels over two hours glucose level Rate of Documented Symptomatic Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of documented symptomatic hypoglycemia This trial tweaked for results? I think you're right. It's a dose 20 min into a meal to compete with Fiasp. They are very deceptive with their use of words. Just like how Novo did all this crap before them over a lack-luster product, here is Lilly with their Misinfo/Disinfo self-marketing campaign about having an Ultra Rapid insulin that is ultra rapid on/off and that more closely mimics insulin in a non-diabetic. This chit is the work of a con man.
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Post by longliner on Jan 22, 2019 0:08:53 GMT -5
I do not believe it is a second dose. (It would kill them to have a second dose 20 mins later.). Are they dosing the basal with every meal? experimental: LY900014 LY900014 given subcutaneously (SC) 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Experimental: LY900014 Open Label LY900014 given SC 20 minutes after the start of each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. Active Comparator: Insulin Lispro Insulin lispro given SC 0-2 minutes before each meal with either basal insulin glargine given SC once or twice daily or insulin degludec given SC once daily. add to this; If you are a person participating in a clinical trial, the MMTT can provide a more comprehensive physiological stimulus to insulin since the beta cells of the pancreas are responsive to certain amino acids and fatty acids in addition to glucose. For example, research trials may use MMTT tests in drug development, assessing the effectiveness of certain types of therapies, such as insulin pumps, glucagon-like peptide (GLP-1) agonists, and continuous glucose monitors. The Mixed Meal Tolerance Test (MMTT) requires a person to drink a "mixed meal," such as Boost or Ensure, that contains, protein, carbohydrates, and fat. The goal of the test is to measure how much insulin your pancreas can make in response to food. 1-hour Postprandial Glucose (PPG) Excursion during Mixed-Meal Tolerance Test (MMTT) [ Time Frame: Week 26 ] 1-hour PPG excursion during MMTT 2-hour PPG Excursion during MMTT [ Time Frame: Week 26 ] 2-hour PPG excursion during MMTT Rate of Severe Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of severe hypoglycemia *I do not see the protocol for monitoring their extended glucose levels over two hours glucose level Rate of Documented Symptomatic Hypoglycemia [ Time Frame: Baseline through Week 26 ] Rate of documented symptomatic hypoglycemia This trial tweaked for results? I think you're right. It's a dose 20 min into a meal to compete with Fiasp. They are very deceptive with their use of words. Just like how Novo did all this crap before them over a lack-luster product, here is Lilly with their Misinfo/Disinfo self-marketing campaign about having an Ultra Rapid insulin that is ultra rapid on/off and that more closely mimics insulin in a non-diabetic. This chit is the work of a con man. And they populate every board!!!!!!!!!!!
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Post by mango on Jan 22, 2019 0:09:12 GMT -5
thank you. this trial is to obtain this? Mango on your data, Lilly working Treprostinil as an accelerant. Local vasodilation.Local vasodilator, the citrate a vascular permeator
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Post by longliner on Jan 22, 2019 0:11:56 GMT -5
thank you. this trial is to obtain this? Mango on your data, Lilly working Treprostinil as an accelerant. Local vasodilation.Local vasodilator, the citrate a vascular permeator So what concoction will we get with UTHR??
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Post by peppy on Jan 22, 2019 0:12:36 GMT -5
we will have to read the results and see the incidence of migraine. Am I being facetious? We better stop now, we have gone off topic for the thread. I beg for forgiveness now.
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Post by longliner on Jan 22, 2019 0:14:43 GMT -5
we will have to read the results and see the incidence of migraine. Am I being facetious? We better stop now, we have gone off topic for the thread. I beg for forgiveness now. There are a lot more folks on this board, myself included, with a whole lot more begging to do than you Peppy. HOWEVER!!! I am in Alaska pecking away at 8:30 PM on this fine MLK Memorial Day, which makes it .....what time there?? Maybe you should trot off to bed! Or maybe I should quit with the wine. Up to you, (well actually up to my wife)!
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