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Post by letitride on Jun 26, 2019 17:32:00 GMT -5
Big differentiation to me is no one has looked at what vaping is doing to your lungs at all while technosphere has been put thru the ringer for years now.
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Post by rockstarrick on Jun 26, 2019 19:00:29 GMT -5
Technosphere quantifies dose more accurately/ as for edibles if that’s what they are called ? Technosphere avoids first pass hepatic metabolism ... I've never indulged in an edible that didn't totally blow my brains out ! Edibles are way to unpredictable. TS will be precise dosing, and will be far better than vaping. I believe a State outlawed Vaping today. en.m.wikipedia.org/wiki/List_of_vaping_bans_in_the_United_StatesThis isn't what I was looking for, but you get the drift. Vaping = smoking = many no fly zones. 😎
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Post by ktim on Jun 26, 2019 23:11:04 GMT -5
Technosphere quantifies dose more accurately/ as for edibles if that’s what they are called ? Technosphere avoids first pass hepatic metabolism ... I've never indulged in an edible that didn't totally blow my brains out ! Edibles are way to unpredictable. TS will be precise dosing, and will be far better than vaping. I believe a State outlawed Vaping today. en.m.wikipedia.org/wiki/List_of_vaping_bans_in_the_United_StatesThis isn't what I was looking for, but you get the drift. Vaping = smoking = many no fly zones. 😎 You seem to be talking about pot rather than the hemp based CBD market that is now federally legal. I probably shouldn't have brought up vaping. Actually all the CBD users I know use some form that is ingested (or topical). I've never heard a single one mention issues with unpredictability. I know for a fact that some are available that lab test the CBD concentration.
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RLS
Jun 27, 2019 1:59:24 GMT -5
via mobile
Post by cretin11 on Jun 27, 2019 1:59:24 GMT -5
sayhey thanks for those links, very informative.
I hope you’re optimism is well placed. I’m just not seeing the mass appeal of TS CBD products. My takeaway from the first article is that sublingual drops are basically equivalent in terms of fast action. Plus they are easy to measure dosages (the dropper has lines showing exactly how many mls).
I’m a regular CBD user. Sublingual drops (tincture), capsules and gummies are super easy to measure dose and easy to take. TS inhaler doesn’t sound appealing by comparison, especially the powder as opposed to nice tasting drops or candies. Contrast that to Afrezza, which offers a huge advantage over sticking yourself with needles, I’d choose Afrezza all day long over needles.
I’m curious about the RLS strategy to tailor its compounds to certain ailments based on THC/CBD ratio. I don’t think it’s that simple, but do you know if terpenes are part of that strategy too (would seem more effective)? Also, it’s easy for any cannabis product producer to adjust the THC/CBD ratios and those products already exist.
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Post by rockstarrick on Jun 27, 2019 8:53:16 GMT -5
I've never indulged in an edible that didn't totally blow my brains out ! Edibles are way to unpredictable. TS will be precise dosing, and will be far better than vaping. I believe a State outlawed Vaping today. en.m.wikipedia.org/wiki/List_of_vaping_bans_in_the_United_StatesThis isn't what I was looking for, but you get the drift. Vaping = smoking = many no fly zones. 😎 You seem to be talking about pot rather than the hemp based CBD market that is now federally legal. I probably shouldn't have brought up vaping. Actually all the CBD users I know use some form that is ingested (or topical). I've never heard a single one mention issues with unpredictability. I know for a fact that some are available that lab test the CBD concentration. Yes, I'm very familiar with CBD, I have a nerve condition in my left arm/hand called RSD, it is also called CRPS, and I use CBD to help with the nerve pain. Unfortunately I am a ”lightweight” when it comes to ”pot”, and THC loaded edibles are way too strong, literally every time. Also, they seem to have a long ”hang time”, 10 to 12 hours. Just speaking from personal experience, and in my opinion, it's incredible that anybody other than a ”pothead” would consider this medicine. Also hard to believe it's legal for recreational in my State, but it is. This could be a different thread because I have some hilarious moments to share from trying to tame the ”edible monster” 😃
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Post by sayhey24 on Jun 27, 2019 9:36:33 GMT -5
sayhey thanks for those links, very informative. I hope you’re optimism is well placed. I’m just not seeing the mass appeal of TS CBD products. My takeaway from the first article is that sublingual drops are basically equivalent in terms of fast action. Plus they are easy to measure dosages (the dropper has lines showing exactly how many mls). I’m a regular CBD user. Sublingual drops (tincture), capsules and gummies are super easy to measure dose and easy to take. TS inhaler doesn’t sound appealing by comparison, especially the powder as opposed to nice tasting drops or candies. Contrast that to Afrezza, which offers a huge advantage over sticking yourself with needles, I’d choose Afrezza all day long over needles. I’m curious about the RLS strategy to tailor its compounds to certain ailments based on THC/CBD ratio. I don’t think it’s that simple, but do you know if terpenes are part of that strategy too (would seem more effective)? Also, it’s easy for any cannabis product producer to adjust the THC/CBD ratios and those products already exist. Some very smart people have been working the pot formulations for a long time. Andrea Leone-Bay has been involved in this from the beginning. They have done a great job in keeping the RLS secret but I hope we are getting closer to hear some news. I have a hard time thinking they are not the real deal when Rubinfeld leaves Starbucks for RLS. We will see.
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Post by mango on Jun 27, 2019 10:14:28 GMT -5
Technosphere quantifies dose more accurately/ as for edibles if that’s what they are called ? Technosphere avoids first pass hepatic metabolism ... I've never indulged in an edible that didn't totally blow my brains out ! Edibles are way to unpredictable. TS will be precise dosing, and will be far better than vaping. I believe a State outlawed Vaping today. en.m.wikipedia.org/wiki/List_of_vaping_bans_in_the_United_StatesThis isn't what I was looking for, but you get the drift. Vaping = smoking = many no fly zones. 😎 Too much edibles can be very similar to an acid trip. Often times is done by accident & scares the chit outta people
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Post by cretin11 on Jun 27, 2019 11:04:27 GMT -5
You seem to be talking about pot rather than the hemp based CBD market that is now federally legal. I probably shouldn't have brought up vaping. Actually all the CBD users I know use some form that is ingested (or topical). I've never heard a single one mention issues with unpredictability. I know for a fact that some are available that lab test the CBD concentration. Yes, I'm very familiar with CBD, I have a nerve condition in my left arm/hand called RSD, it is also called CRPS, and I use CBD to help with the nerve pain. Unfortunately I am a ”lightweight” when it comes to ”pot”, and THC loaded edibles are way too strong, literally every time. Also, they seem to have a long ”hang time”, 10 to 12 hours. Just speaking from personal experience, and in my opinion, it's incredible that anybody other than a ”pothead” would consider this medicine. Also hard to believe it's legal for recreational in my State, but it is. This could be a different thread because I have some hilarious moments to share from trying to tame the ”edible monster” 😃 Rick, even for lightweights, they now make edible products with dosage as low as 1 mg of THC, essentially a microdose. I'd bet 1 mg would not "blow your brains out" and you might not even notice it. Then you try 2 mg, etc., to find your subjective sweet spot. Lots of folks are skeptical, as you are, about whether there's any legit medical purpose to THC, but I submit that the evidence is coming in strongly in favor of that proposition. In that respect I agree with sayhey and others who have optimism for RLS to make something good happen for us. Plus, as a bass player, with a little bit of THC you'd have the added effect of a little boost to your creative juices on stage, in rehearsal, and especially just jamming out with buddies. And since you're already familiar with CBD, in case you didn't know this, CBD is the perfect antidote for when one takes too much THC and it's turning "hairy" - CBD will counteract the psychoactive effects of THC so you'll be able to get that sense of disphoria under control quickly. Would enjoy hearing some of those moments of trying to tame the edible monster, I have been with friends in the same boat and it can get interesting...
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RLS
Jun 27, 2019 12:40:20 GMT -5
awesomo likes this
Post by ktim on Jun 27, 2019 12:40:20 GMT -5
sayhey thanks for those links, very informative. I hope you’re optimism is well placed. I’m just not seeing the mass appeal of TS CBD products. My takeaway from the first article is that sublingual drops are basically equivalent in terms of fast action. Plus they are easy to measure dosages (the dropper has lines showing exactly how many mls). I’m a regular CBD user. Sublingual drops (tincture), capsules and gummies are super easy to measure dose and easy to take. TS inhaler doesn’t sound appealing by comparison, especially the powder as opposed to nice tasting drops or candies. Contrast that to Afrezza, which offers a huge advantage over sticking yourself with needles, I’d choose Afrezza all day long over needles. I’m curious about the RLS strategy to tailor its compounds to certain ailments based on THC/CBD ratio. I don’t think it’s that simple, but do you know if terpenes are part of that strategy too (would seem more effective)? Also, it’s easy for any cannabis product producer to adjust the THC/CBD ratios and those products already exist. Some very smart people have been working the pot formulations for a long time. Andrea Leone-Bay has been involved in this from the beginning. They have done a great job in keeping the RLS secret but I hope we are getting closer to hear some news. I have a hard time thinking they are not the real deal when Rubinfeld leaves Starbucks for RLS. We will see. What is your evidence Rubinfeld has anything to do with RLS. His LinkedIn profile lists him as president of a company he founded called Airvision. RLS doesn't list him on their site.
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RLS
Jun 27, 2019 13:02:35 GMT -5
Post by awesomo on Jun 27, 2019 13:02:35 GMT -5
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RLS
Jun 27, 2019 13:04:40 GMT -5
Post by Clement on Jun 27, 2019 13:04:40 GMT -5
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Post by bioexec25 on Jun 27, 2019 13:46:23 GMT -5
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Post by nylefty on Jun 27, 2019 17:10:25 GMT -5
www.statnews.com/2019/06/27/cbd-doctors-uncharted-territory/?utm_source=STAT+Newsletters&utm_campaign=732007eda7-Pharmalot&utm_medium=email&utm_term=0_8cab1d7961-732007eda7-151111657Excerpts from a longer article about doctors and CBD: WASHINGTON — Corner-store cannabidiol “scares the bejesus” out of Dr. Jacqueline French.
French, a neurologist at New York University’s Langone Health, tries to steer her patients away from sprinting to the neighborhood bodega to buy versions of the hemp derivative that’s better known as CBD.
She, like so many other doctors around the country, is torn — on the one hand, there’s scant guidance for how to treat a patient with a CBD supplement, and there are few reputable sellers who can guarantee what they’re selling. There’s not nearly as much science behind those products as with a typical prescription medicine. On the other hand, there is one FDA-approved drug based on CBD, fully cleared based on the agency’s rules for safety and efficacy, with dosing information at least for the patients who have the two types of epilepsy it treats.
“The last thing that you can do is tell them, ‘Don’t do it,’ because that doesn’t work. You can say, ‘Here’s what I know, and if you decide in any case to do it, please let me know,’” French said. “You have to keep them in the discussion and go with them the best that you can. … The buzz and the intensity of the desire of people to take it is so great.”
French, like so many other doctors around the country whose patients are clamoring to try the supplement, is in uncharted territory.
Related: Dude, where’s my regulatory framework? As CBD gains popularity, Washington struggles to keep up
More than half a dozen neurologists and other physicians around the country spoke with STAT about the difficult decisions and even headaches that CBD — sometimes a supplement, sometimes a drug — and its booming popularity have created for the medical community. Should they encourage a treatment that may not work but also may not hurt their patients, if it gives them hope? Or should they reject any treatment out of hand that hasn’t been proven effective?
For those doctors that do decide to “prescribe” CBD, there’s a whole new set of questions. How can they help a patient get a safe product in a largely unregulated market? How does a doctor dose CBD? And exactly what should that doctor monitor after the patient starts treatment?
“It is [as] if suddenly Prozac was a dietary supplement,” French said.
Twenty-six percent of Americans have tried CBD in the last two years, and the rates are much higher for patients with conditions that seem to respond to CBD treatment. A recent survey of arthritis patients, for example, found that more than 50% of respondents had tried CBD to treat joint pain.
Perhaps no patients are more interested than those with epilepsy, especially after the Food and Drug Administration’s 2018 approval of Epidiolex, from GW Pharmaceuticals.
That approval, in fact, is at the heart of the conflict doctors now face. Right now, the FDA regulates drugs and dietary supplements like vitamins, minerals, or even herbs very differently — in fact, legally, anything regulated as a drug can’t also be regulated as a supplement.
CBD, at least for now, is straddling both worlds. While CBD supplements are technically illegally under current law, the FDA seems intent on fixing that. Top FDA officials have hinted that they will eventually aim for something of a compromise, regulating products with less than a certain amount of CBD as supplements, and those with more as drugs.
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RLS
Jun 27, 2019 17:51:26 GMT -5
Post by lennymnkd on Jun 27, 2019 17:51:26 GMT -5
In Oregon and Washington, Rite Aid shelves display an assortment of CBD products. Rite Aid is running a trial of these new products in the Pacific northwest before rolling them out across the country. This could help boost revenues since CBD is a trend growing very quickly.
Amazon
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Post by sayhey24 on Jun 27, 2019 19:06:00 GMT -5
I don't believe Rubinfeld left Starbucks to start his own branding/marketing consulting firm. Airvision has been around since 2002 when Rubinfeld started it. Prior he was consulting to MSFT on marketing and is how he became friends with Kevin Johnson. www.airvision.com/microsoft Notice Starbucks at the bottom. Rubinfeld was still working at Starbucks for awhile after RLS was announced in 2016. At the time he left Starbucks he was President, Starbucks Coffee - Innovation, Chief Creative Officer and Operational Lead of Starbucks Reserve Roasteries. Why he left when he did we would have to ask him but around the same time is when RLS started to raise money and Rubinfeld is listed on the SEC paperwork. Take at look at this article which says - The SEC filing lists Traci Carman as the president of Receptor. Three other people are listed as directors: patent attorney Gregory Wesner, former high-ranking Starbucks executive Arthur Rubinfeld, who now runs a consumer-focused brand consulting company, and a David Thomson. Its an interesting group. Two from MSFT, two from MNKD. You can call me crazy but IMO the secretive partner not listed is Kevin Johnson who is also from MSFT. Tracking tail number history to DXR is a good place to start. I know if I was about to invest a fortune I would want to see the factory where TS is used. www.geekwire.com/2018/secretive-startup-receptor-life-sciences-raises-7-5m-therapies-based-plant-extracts/Now, I am not trying to be disingenuous but Rubinfeld is up to something and RLS is up to something. Rubinfeld clearly left Starbucks and seems knee deep in RLS. I just hope they start making some announcements real soon. I also hope Rubinfeld is the marketing genius I think he is.
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