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Post by sayhey24 on Jun 3, 2019 20:30:06 GMT -5
Aged - I firmly believe the Endo at the ADCOM was correct and once T2s at first diagnosis are prescribe afrezza following the VDex "afrezza first afrezza always" protocol, afrezza will significantly impact Endo's business. So at least that Endo and I believe afrezza is so good it will affect the market. After 5 years, time has proved him right in that afrezza really is as good as he thought. We will start seeing an impact in a few years.
Your Endo who "has good ideas" does not seem to have the best idea - prescribe afrezza to all PWDs for meal time control. Its shocking your good idea endo is not prescribing to all T1s for occasional use for out of control high BGs. Thats the best idea in over 10 years for diabetes control.
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Post by shawnonafrezza on Jun 3, 2019 20:49:55 GMT -5
Yes, Afrezza will put endos out of business for T2? It is a very complicated disease but I'd hazard at least half could go off meds with a low carb diet yet endos are still in business and that business is booming. Also that fact people here want Afrezza before lifestyle changes shows where their priorities are. You'd fit in well with the docs though, always drugs before lifestyle. No question on the patient, just Afrezza is the answer. sayhey24, looking for a problem to their solution. I wonder how many of you talk to endos about compliance. Even IF all patients got given Afrezza do you think they'd all comply? They don't right now with their current options so why would they then? Seriously, this is why I bothered to make an account. I don't know if I want to laugh or cry. Pretend your a Afrezza rep, you're trying to pitch this to an endo practicing for 5 years. Why will this fix their patients? To be able to answer this you need to know what is wrong with their current regiments and sadly that is not a single bucket problem. You all are treating this like you have a hammer looking for a nail.
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Post by ezmit on Jun 3, 2019 21:10:36 GMT -5
I appreciate your input but no need to be rude shawn. On the topic of lifestyle changes vs initiating insulin/medication. Most endos I've talked to do recommend a lifestyle change initially. They also say most patients change for only a couple weeks then revert back to their previous lifestyle. In a perfect world every patient would change but these sweeping changes are very difficult to maintain over long periods of time.
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Post by brotherm1 on Jun 3, 2019 21:12:58 GMT -5
Regarding changing lifestyle. Many are not able to do sufficient exercise. Many have large eating disorders. People are different. Some it appears are not even capable of expressing themselves with proper speech.
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Post by shawnonafrezza on Jun 3, 2019 21:17:52 GMT -5
But do you all not see what you just did? (sorry to set you up for it) Suddenly diabetes isn't one size fits all. "Afrezza first afrezza always" maybe is just a bit too narrow. If a patient can't comply to the diet why would the comply to the meds? If they don't take their metformin why would they take their afrezza? Are you starting to see the problem endos face now? Afrezza is a tool, you have to sell on **why** is it needed and/or better?
This is really all I want, because I want Afrezza to succeed but people need to realize what space they're dealing with.
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Post by sportsrancho on Jun 3, 2019 21:38:31 GMT -5
It’s the same with exercise, people start an exercise routine, they do it for two weeks and they stop because they want instant gratification..you get them on a personal training regimen for six weeks, where they are actually paying upfront for a conscience, they see results and they’re hooked. I’ve got a client who’s been with me 20 years and many who have gone on to train on their own. Once they see how their mood level is enhanced, their skin glows, and how much better they feel they don’t go back. It’s coaching them through that period that does the trick.
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Post by buyitonsale on Jun 3, 2019 22:06:01 GMT -5
So many here “want Afrezza to succeed but”... Don’t worry, I know Afrezza will succeed
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Post by longliner on Jun 3, 2019 22:37:02 GMT -5
But do you all not see what you just did? (sorry to set you up for it) Suddenly diabetes isn't one size fits all. "Afrezza first afrezza always" maybe is just a bit too narrow. If a patient can't comply to the diet why would the comply to the meds? If they don't take their metformin why would they take their afrezza? Are you starting to see the problem endos face now? Afrezza is a tool, you have to sell on **why** is it needed and/or better? This is really all I want, because I want Afrezza to succeed but people need to realize what space they're dealing with. Metaformin is not a tool, it is an excuse, an excuse to not change behavior. Afrezza is a solution, quite different than an excuse. I enjoyed Amsterdam (for other reasons than Kuka might) and was impressed by the weight (or lack thereof) of the average individual. Biking is the norm and walking is normal for getting around. So in this discussion I will admit to being torn, but do not conflate Metaformin and Afrezza.
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Post by shawnonafrezza on Jun 3, 2019 22:38:43 GMT -5
So many here “want Afrezza to succeed but”... Don’t worry, I know Afrezza will succeed I believe it will too, but the "but" is important. Maybe not for you because getting it into the hands of PWD isn't your scope but for others it is important. Knowing the why matters. Why has their been resistance and how does one overcome that resistance? Why do PWD fail to use Afrezza correctly? Those are important questions that only comes if you understand the "but". But do you all not see what you just did? (sorry to set you up for it) Suddenly diabetes isn't one size fits all. "Afrezza first afrezza always" maybe is just a bit too narrow. If a patient can't comply to the diet why would the comply to the meds? If they don't take their metformin why would they take their afrezza? Are you starting to see the problem endos face now? Afrezza is a tool, you have to sell on **why** is it needed and/or better? This is really all I want, because I want Afrezza to succeed but people need to realize what space they're dealing with. Metaformin is not a tool, it is an excuse, an excuse to not change behavior. Afrezza is a solution, quite different than an excuse. So in this discussion I will admit to being torn, but do not conflate Metaformin and Afrezza. How is Metformin not a tool and Afrezza is? Pretend I'm a doctor asking you. What is the problem? Why is it the answer? It's not that I'm comparing the drugs, they're not even the same classification. However this ties in to the "but" above. If patients are non compliant with diet, exercise, and taking their metformin, why would an endo bother with Afrezza? Why will it be different? Why should the endo/PWD try?
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Post by longliner on Jun 3, 2019 23:09:59 GMT -5
So many here “want Afrezza to succeed but”... Don’t worry, I know Afrezza will succeed I believe it will too, but the "but" is important. Maybe not for you because getting it into the hands of PWD isn't your scope but for others it is important. Knowing the why matters. Why has their been resistance and how does one overcome that resistance? Why do PWD fail to use Afrezza correctly? Those are important questions that only comes if you understand the "but". Metaformin is not a tool, it is an excuse, an excuse to not change behavior. Afrezza is a solution, quite different than an excuse. So in this discussion I will admit to being torn, but do not conflate Metaformin and Afrezza. How is Metformin not a tool and Afrezza is? Pretend I'm a doctor asking you. What is the problem? Why is it the answer? It's not that I'm comparing the drugs, they're not even the same classification. However this ties in to the "but" above. If patients are non compliant with diet, exercise, and taking their metformin, why would an endo bother with Afrezza? Why will it be different? Why should the endo/PWD try? My question to the doctor (in your vernacular) is WTF does metaformin even do to benefit diabetics? ?? (feel free to answer) Afrezza has a wide range of health benefits for diabetics.
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Post by shawnonafrezza on Jun 3, 2019 23:24:21 GMT -5
Kinda weird you'd say it has no benefit without knowing what it does. Metformin pulls sugar out of the blood, increases insulin sensitivity, drops the amount of sugar the liver dumps which in turn helps dietary sugar get absorbed. It has also been shown to help with heart health and there are current studies on it's potential use as a cancer aid.
There are of course problems with it such as giving gastric distress or rare cases of lactic acidosis though both are "rare" for whatever that means. It's also dirt cheap and proven.
Afrezza has it's pros too but I'm curious what wide range of health benefits you can cite because all I know is it's insulin so it'll drop blood sugar. There are gaps that Metformin has that Afrezza can fill but I'm going to hold off on saying what that is out of curiosity if you know it.
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Post by goyocafe on Jun 3, 2019 23:29:30 GMT -5
Kinda weird you'd say it has no benefit without knowing what it does. Metformin pulls sugar out of the blood, increases insulin sensitivity, drops the amount of sugar the liver dumps which in turn helps dietary sugar get absorbed. It has also been shown to help with heart health and there are current studies on it's potential use as a cancer aid. There are of course problems with it such as giving gastric distress or rare cases of lactic acidosis though both are "rare" for whatever that means. It's also dirt cheap and proven. Afrezza has it's pros too but I'm curious what wide range of health benefits you can cite because all I know is it's insulin so it'll drop blood sugar. 1. It’s called Afrezza. 2. Read. So much on this board, so many resources to explore. If you’re attempting to have this debate without any knowledge of the drug and it’s PK/PD profile, you’re doing us all a disservice.
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Post by shawnonafrezza on Jun 3, 2019 23:30:39 GMT -5
Kinda weird you'd say it has no benefit without knowing what it does. Metformin pulls sugar out of the blood, increases insulin sensitivity, drops the amount of sugar the liver dumps which in turn helps dietary sugar get absorbed. It has also been shown to help with heart health and there are current studies on it's potential use as a cancer aid. There are of course problems with it such as giving gastric distress or rare cases of lactic acidosis though both are "rare" for whatever that means. It's also dirt cheap and proven. Afrezza has it's pros too but I'm curious what wide range of health benefits you can cite because all I know is it's insulin so it'll drop blood sugar. 1. It’s called Afrezza. 2. Read. So much on this board, so many resources to explore. If you’re attempting to have this debate without any knowledge of the drug and it’s PK/PD profile, you’re doing us all a disservice. Dude, I take the drug. I probably am more intimately aware of it than you. You're arguing from the stance it is a first line defense. I'm asking you to state the "why". But I did misspell it once so you win.
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Post by goyocafe on Jun 3, 2019 23:32:46 GMT -5
1. It’s called Afrezza. 2. Read. So much on this board, so many resources to explore. If you’re attempting to have this debate without any knowledge of the drug and it’s PK/PD profile, you’re doing us all a disservice. Dude, I take the drug. I probably am more intimately aware of it than you. You're arguing from the stance it is a first line defense. I'm asking you to state the "why". Wow! Not going down this rat hole.
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Post by longliner on Jun 3, 2019 23:33:39 GMT -5
Yes, Afrezza will drop your blood sugar........faster than anything else........and leave your body faster than anything else........allowing your pancreas to recover it's function (according to Al Mann). Hint: it's a switch that only Afrezza (so far) activates. Metaformin belongs in the "Oh my god, I don't know what to prescribe bin" "But it's cheap!!!!!!"ADA Standards!
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