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Post by mnkdfann on Feb 11, 2020 19:18:11 GMT -5
Oh for F'k sake. Now we're debating on how the product gets to Biomm? Are you kidding me? Who cares, did they re-order? That's what matters. Geezus folks c'mon! That discussion had ended two days ago. Nice of you to bump it to create new interest, though.  Mytakeonit, are you there? Your turn, take it away. |
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Post by falconquest on Feb 11, 2020 19:28:53 GMT -5
I have the guy on ignore so I don't see his posts. FYI
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Post by letitride on Feb 11, 2020 19:42:28 GMT -5
I still say its airborne delivery, only fitting given the product.
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Post by mytakeonit on Feb 11, 2020 20:37:59 GMT -5
Why is the size or method of shipment relevant? What matters are orders, who cares about the shipment? You said this several days ago ... how many times are you going to keep repeating yourself? But, that's mytakeonit Oh thanks mnkdfann for telling bird brain for me. And now that I know he can't read my posts ... I can say whatever I want about him. !!! Ha! But, that's mytakeonit |
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Post by cretin11 on Feb 12, 2020 1:46:21 GMT -5
Why is the size or method of shipment relevant? What matters are orders, who cares about the shipment? You said this several days ago ... how many times are you going to keep repeating yourself? But, that's mytakeonit Oh thanks mnkdfann for telling bird brain for me. And now that I know he can't read my posts ... I can say whatever I want about him. !!! Ha! But, that's mytakeonit Imagine that, MTOI is annoyed by another poster repeating himself. Things that make you go hmmm. 😜 |
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Post by matt on Feb 12, 2020 9:15:44 GMT -5
Why would you put it on a ship for a month when you could fly it overnight. Weight is obviously not a restriction. Keeping it cool for a night or a month might be? Lets Go! Shipping does not take a month on the water. I used to manage a portion of the international logistics for a large healthcare company and our longest sailing time was around 12 days which was sufficient to get from Singapore or Malaysia to California. Japan was about 8-9 days, Europe from the east coast to Antwerp or Rotterdam was around 5-6 days. Brazil is about a 10 day sail from Miami, add 1 or 2 days for more northern ports. Those are sailing times so you have to add on the time to dray the container from the origin to the shipping port and from the destination port to the final destination. Drayage can add just a few hours or several days depending on the ports. The reason not to fly the shipment is simply cost. Air freight is calculated two ways, one by actual weight and one by dimensional weight, and the customer pays the higher of the two. If you are shipping something extremely heavy, like machine parts, the customer pays based on actual weight. If the customer ships something that is very light but bulky, the carrier imputes a hypothetical weight based on the cubic volume of the box so that the belly of the aircraft is not full of low value but bulky cargo. There are also concerns with temperature management on an aircraft because gel ice packs will only last for so long and that might not be long enough to get the product onto the plane, fly it to the destination, clear customs, and make final delivery. The alternative that works well is dry ice, but when you ship that way the package is off-gassing carbon dioxide fumes the entire flight and releasing CO2 into an enclosed aircraft cabin is problematic for the health of the crew so dry ice quantities are severely restricted. On a ship, they can simply attach a refrigeration unit to the container. On balance, when shipping high-value perishable commodities (like Afrezza) most companies will opt for air. Often the key is to partner with a good freight forwarder that can mix products on a single pallet to minimize the dimensional weight problem. We were the number two customer for one large air freight forwarder, but the number one customer was Caterpillar Tractor. They would air ship lots of heavy engine parts due to the cost of down-time on a piece of construction equipment, so the forwarder would stack our low weight but bulky medical products on top of their heavy and dense machine parts. We paid less than the dimensional weight for our portion and Caterpillar paid less than the actual weight for their portion so everybody was happy. Mind you that this takes consistent volume with the major air carriers and we shipped several hundred tons of air cargo every month (we were also FedEx's number three customer worldwide after Intel and HP). MNKD will not have that kind of volume and may not be able to avail themselves of specialized services from the freight forwarders and carriers; in that case ocean freight may be their best or only realistic option. |
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Post by sr71 on Feb 12, 2020 13:43:20 GMT -5
matt -
Thank you for your very informative posts from your real-world experience "in the trenches" dealing with many of the same issues as Mannkind. I'm sure I also speak for other ProBoards members in stating that I always learn something from your writings.
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Post by mytakeonit on Feb 12, 2020 14:31:45 GMT -5
I dealt with shipping also ... a long, long, long time ago. In any case, I just checked on www.icontainers.com on their shipping costs, ports, and approximate time on water. If you go from Long Beach to Port of Santos ... direct shipment takes 25 days ... with transshipment to Cartagena it'll take 32 days. If you go from LAX to Port of Santos ... direct shipment takes 35 days. Shipping costs doesn't amount to much so that won't be a problem. Not sure what it costs to rail a container to Miami to do that 10 - 12 days shipment ... and how many days to rail added on. |
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Post by letitride on Feb 12, 2020 20:39:11 GMT -5
I dealt with shipping also ... a long, long, long time ago. In any case, I just checked on www.icontainers.com on their shipping costs, ports, and approximate time on water. If you go from Long Beach to Port of Santos ... direct shipment takes 25 days ... with transshipment to Cartagena it'll take 32 days. If you go from LAX to Port of Santos ... direct shipment takes 35 days. Shipping costs doesn't amount to much so that won't be a problem. Not sure what it costs to rail a container to Miami to do that 10 - 12 days shipment ... and how many days to rail added on. I was about to tell you how its done but its a trade secret. |
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Post by ktim on Feb 12, 2020 20:56:15 GMT -5
mattSo what would be rough estimate for how much it would cost to airfreight one standard pallet where weight is obviously on the low side?
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Post by mytakeonit on Feb 12, 2020 21:58:36 GMT -5
I did a fast check and it seems that they limit the weight to 250kg or about 550 lbs. I assume that also includes the pallet weight. Rates vary, but it seems to be around $5,000. I categories it as perishable goods. Oh, I valued it as $700,000 and added insurance so this could be totally Wong. In addition they said that it'll take 2 - 4 days. Only propeller planes go to Brazil?
Maybe matt will have more accurate numbers.
But, that's mytakeonit
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Post by harryx1 on Feb 13, 2020 10:53:27 GMT -5
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Post by harryx1 on Feb 13, 2020 14:14:16 GMT -5
www.diariodepetropolis.com.br/integra/insulina-inalavel-para-o-tratamento-de-diabetes-chega-ao-mercado-brasileiro-177269Inhalable insulin for the treatment of diabetes reaches the Brazilian market Afrezza®, launched by Brazilian pharmaceutical company Biomm, has innovative technology and offers lower risk of hypoglycemia to patients¹ In the country, 16.8 million people live with diabetes and 500 new cases are diagnosed daily Patients living with diabetes now have an innovative and safe option to improve glycemic control, already available in Brazil, which offers less risk of hypoglycemia to users. Afrezza® inhalable insulin hits the market by Biomm, a Brazilian biotechnology company, in partnership with MannKind Corporation, a North American biopharmaceutical company. Brazil is the second country to make the medication available, after the United States. Approved by Anvisa in 2019, the drug will be marketed in three dosages (4, 8 and 12 international units of insulin), in packs of 90 and 180 refills, and two inhalers per box. The recommended dosage should be indicated by the doctor. Inhalable insulin has an ultra-fast action and is more similar to the hormone naturally produced by the body in healthy individuals³. Afrezza® dissolves through the lung after inhalation and immediately reaches the bloodstream 4, so maximum medication levels are reached between 12 to 15 minutes after administration, which must be carried out before meals. Therapy is indicated for adult patients. Diabetes mellitus is characterized by the body's inability to properly control blood glucose levels. Insulin, a hormone produced by the pancreas, normally regulates the body's glucose levels, but in people with the disease, insufficient insulin levels are produced. The body also does not respond adequately to the little insulin it produces. Currently, the disease affects 425 million people worldwide, according to the International Diabetes Federation (2017), with Brazil being the fourth largest affected population. There are 16.8 million living with diabetes and about 500 new cases diagnosed per day. The numbers are worrying, since 40 million Brazilians are pre-diabetic and 25% are expected to develop it in the next five years, as pointed out by the Brazilian Diabetes Society (SBD). “With Afrezza, we seek to bring greater convenience and quality of life to patients, using a medication that is proven to be safe and effective,” says Heraldo Marchezini, CEO of Biomm. To facilitate the initiation of treatment and increase patient compliance, Biomm offers the Mais Saúde BIOMM program. After registering (through the website www.maissaudebiomm.com or calling 0800-057-2467), the patient will be able to purchase the drug from associated pharmacy chains with a 20% to 35% discount (according to the presentation), in addition to having with educational information and guidance from a qualified team. Through this program, inhalable insulin will cost from R $ 1,900.00 (box with 90 refills of 8 IU each). The commercial value of Afrezza® was defined by the Medicines Market Regulation Chamber (CMED), releasing it for sale. Adherence to treatment is usually a barrier pointed out by specialists, since the person with diabetes needs to control their blood glucose regularly and have discipline to improve their lifestyle. According to Dr. Márcio Krakauer, endocrinologist at the technology center of the Brazilian Diabetes Society, there are habits and facilities that can help with treatment. “Frequent monitoring of blood glucose can facilitate the control of diabetes, as well as more and more adequate drugs to meet the needs of patients. Other facilities that help in the routine of patients with the disease are insulins with a lower risk of hypoglycemia and easier to administer ”, explains the doctor.
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Post by xanet on Feb 13, 2020 14:24:44 GMT -5
$438 USD. Not happy with the pricing. |
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Post by rfogel on Feb 13, 2020 15:26:00 GMT -5
I still don't understand why they decided not to offer the 4U dose.
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