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Post by mango on Mar 17, 2020 10:34:48 GMT -5
I'm going with a dry powder surfactant, myself, but I am very excited/eager to see what it is. if MNKD would produce surfactant, just the COPD clients would take us to the moon. surfactant worked for the meconium aspiration and RDS. The difference was HUGE> remember we would hear about the children in the hospital, no more, because they do not have to live on a ventilator for 9 months - year. They got weaned off and went home. Surfactant would send MNKD to the moon. I agree. But, if MannKind develops a successful ARDS treatment then it will send MNKD out of our solar system. 🤞 |
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Post by uvula on Mar 17, 2020 10:45:59 GMT -5
Don't premature babies already get surficant? Why would a powder version be better?
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Post by peppy on Mar 17, 2020 10:49:57 GMT -5
Don't premature babies already get surficant? Why would a powder version be better? I saw the study I think it was 1987, it may have been 1984. I was double blind. HOWEVER, some of the premmies got well instead of getting sicker. WE are not blind, we can see. The study was so obvious, anyway, intubate and give surfactant yes. see the intubate part? |
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Post by mango on Mar 17, 2020 10:50:37 GMT -5
Don't premature babies already get surficant? Why would a powder version be better? Premies are administered a liquid surfactant via ETT. The advantages of a dry powder surfactant formulation using MannKind's technology and inhalation devices should be obvious. The patient would not require intubation and administration via ETT. Instead, a simple inhalation via a discreet, patient-friendly inhaler that even a 4 year old can use will be preferred over the former. |
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Post by ktim on Mar 17, 2020 10:51:03 GMT -5
It would most definitely be fast-tracked. ARDS is a very serious, life-threatening condition. I've seen a lot of people die from it. There is currently no FDA approved treatment for ARDS. It would be fast-tracked and granted orphan status. MannKind could be the very first to have a treatment approved for this horrendous medical condition. Way to go, MannKind! This is the kind of thing we want you to do! certainly much better that what a shortie was insisting that we should do which was give away free Afrezza. Note indeed the question is how quick we can get sonething in front if the FDA. If this works out, it will blow thre limitations if what this innovative system can tackle and it will have a MEANINGFUL positive and long term impact on the valuation. So now prcgorman2 is a short? Are you referring to his post here mnkd.proboards.com/post/200300/thread ? You can post your thoughts without unfounded lashing out at other members of the forum. |
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Post by peppy on Mar 17, 2020 10:57:43 GMT -5
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Post by mango on Mar 17, 2020 11:00:20 GMT -5
Most people use a glidescope now. liane is that what you use or do you prefer the old fashion way? |
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Post by peppy on Mar 17, 2020 11:03:02 GMT -5
Most people use a glidescope now. liane is that what you use or do you prefer the old fashion way? I am old. I have never seen a glidescope. However, it may have been used on me a few times, (surgery.) Don't they still need the larynx scope for the slide? a camera, to visualize the split. In babies back then, measurements were taken and then an x-ray. |
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Post by mango on Mar 17, 2020 11:05:26 GMT -5
Most people use a glidescope now. liane is that what you use or do you prefer the old fashion way? I am old. I have never seen a glidescope. However, it may have been used on me a few times, (surgery.) throw one up for me? They are nice. Makes it a lot easier. There is also throw away, one time use bronchoscopes too, been out for a while now though. |
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Post by peppy on Mar 17, 2020 11:09:37 GMT -5
those tubes seem so long.
heh, we had tubes for 450 gram babies.
Do I remember correctly, 750 grams is a pound?
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Post by agedhippie on Mar 17, 2020 12:28:00 GMT -5
those tubes seem so long. heh, we had tubes for 450 gram babies. Do I remember correctly, 750 grams is a pound? I think 450g would be 1lb based on my quick and dirty use of 500g equals 1lb which I know is slightly high. |
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Post by peppy on Mar 17, 2020 12:28:57 GMT -5
those tubes seem so long. heh, we had tubes for 450 gram babies. Do I remember correctly, 750 grams is a pound? I think 450g would be 1lb based on my quick and dirty use of 500g equals 1lb which I know is slightly high. thank you. yes. My memory/thinking isn't what I hoped. I remember some 450 and 500 gram babies. |
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Post by matt on Mar 17, 2020 13:38:14 GMT -5
those tubes seem so long. heh, we had tubes for 450 gram babies. Do I remember correctly, 750 grams is a pound? The tube length varies, but they are roughly a foot long. The only thing that really matters is that the balloon cuff has to be fully inserted into the trachea and that it is not advanced so far that it is seated in the right or left bronchus. That is why you always see them listening on both sides of the lung after insertion to make sure there are breath sounds in both lung during ventilation. There are a number of ways to insert an ET tube, but all require good visualization of the arytenoid cartilage that guards the entrance to the trachea. You visualize the arytenoid, take aim, and hope that you hit the hole on the first try. It takes a lot of practice to get it right and I assure you that is not as easy as it looks on television! |
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Post by peppy on Mar 17, 2020 13:46:01 GMT -5
those tubes seem so long. heh, we had tubes for 450 gram babies. Do I remember correctly, 750 grams is a pound? The tube length varies, but they are roughly a foot long. The only thing that really matters is that the balloon cuff has to be fully inserted into the trachea and that it is not advanced so far that it is seated in the right or left bronchus. That is why you always see them listening on both sides of the lung after insertion to make sure there are breath sounds in both lung during ventilation. There are a number of ways to insert an ET tube, but all require good visualization of the arytenoid cartilage that guards the entrance to the trachea. You visualize the arytenoid, take aim, and hope that you hit the hole on the first try. It takes a lot of practice to get it right and I assure you that is not as easy as it looks on television! you are a physician. yes. the balloons came in when I was there. we used to tape them prior. very occasionally they would go down the right and the clinician would pull them back. you are a physician. |
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Post by jlaw277 on Mar 17, 2020 13:59:41 GMT -5
It would most definitely be fast-tracked. ARDS is a very serious, life-threatening condition. I've seen a lot of people die from it. There is currently no FDA approved treatment for ARDS. It would be fast-tracked and granted orphan status. MannKind could be the very first to have a treatment approved for this horrendous medical condition. Way to go, MannKind! This is the kind of thing we want you to do! I had to look it up. www.lung.org/lung-health-and-diseases/lung-disease-lookup/ards/learn-about-ards.html============= Learn About ARDSAcute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients. The main complication in ARDS is that fluid leaks into the lungs making breathing difficult or impossible. Key Facts ARDS occurs when there is trauma to the lungs, either directly or indirectly. Most people who get ARDS are already in the hospital for trauma or illness. ARDS causes fluid to leak into the lungs, making it difficult to get oxygen into the blood. ARDS can be associated with an acute medical problem or procedure. What Is ARDS? ARDS is a buildup of fluid in the tiny air sacs in your lungs called alveoli. This means less oxygen can get to your organs, which is very dangerous. ARDS occurs when there is significant trauma that either affects the lungs directly or indirectly. Some examples of trauma include sepsis (a blood infection), breathing in smoke from a house fire, near-drowning, severe pneumonia, major trauma, and shock from any cause. Your body responds to this trauma with an inflammatory reaction that releases numerous natural molecules into the bloodstream. Normally, this inflammatory reaction would be protective and help you fight infection or heal from an injury. However, in some people, these inflammatory molecules lead the smallest blood vessels in the lungs to leak fluid. Fluid leaves these small vessels and goes into the alveoli. The alveoli fill with this fluid making it difficult for oxygen to get into the bloodstream. How ARDS Affects Your Body The fluid that leaks into the lungs makes it very difficult to breathe and leads to low oxygen in the blood, or hypoxemia. The fluid in the lungs makes the lungs stiff and difficult to inflate. This increases the work it takes to breathe and get air into your lungs. When the body can't carry out the work of breathing and has low oxygen levels, it causes respiratory failure. In order to improve the amount of oxygen and reduce the work of breathing, most ARDS patients will be placed on a ventilator to support them while the lungs heal. If the inflammation and fluid in the lung(s) persist, some patients will go on to develop scarring in the lungs. This is known as the fibrotic stage of ARDS. It is during this stage that the lung can "pop" and deflate, leading to a collapsed lung, also called a pneumothorax. How Serious Is ARDS? There are about 200,000 cases of ARDS each year in the United States. Most people who get ARDS are already in the hospital in critical condition from some other health complication or trauma. ARDS is a very serious disease and even with the best medical care between 30 and 50 percent of those diagnosed with ARDS die of it. Those surviving the disease will often have long hospital stays. One of the biggest problems with this disease is that many patients develop additional complications while they are in the intensive care unit. Some of these complications include pneumonia, collapsed lungs, other infections, severe muscle weakness, confusion, and kidney failure. This content was developed in partnership with the CHEST Foundation, the philanthropic arm of the American College of Chest Physicians. |
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