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Post by mango on Sept 21, 2020 10:38:42 GMT -5
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Post by parrerob on Sept 21, 2020 13:28:51 GMT -5
[quote author=" brotherm1" timestamp="1596543575" source="/post/208982/thread"Besides, if a patient has COVID and is sick enough to need Aviptadil then they are already going to be in the hospital, likely the ICU or some other special treatment unit, where aerosolized drugs are frequently used as part of respiratory therapy. Treating COVID sequela does not seem to me to be a good target for Technosphere delivery of the drug. Totally disagree on this sentence. What ia really needed to fight this pandemia is a treatment that could be done at home. We need to keep hostipals and specially intensive treatment department free and we need to treat hill people at home with an innovative drug that really treat covid consequences... no way to look for a vax and in the mean time treat people in the hospitals. This will no run fisrt because vax will not run second because we need to keep hospitals free. |
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Post by mango on Aug 5, 2021 5:53:42 GMT -5
This thread is certainly ironic now, eh? OP, you have a magic crystal ball or something? |
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Post by neil36 on Aug 5, 2021 6:33:11 GMT -5
Yes, this thread is very interesting to re-read in light of yesterday’s PR. A couple of you saw this development coming…..over a year ago.
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Post by peppy on Aug 5, 2021 7:25:22 GMT -5
is tadalafil related somehow to aviptadil? Not in a pharmacological sense. Aviptadil is a peptide drug that binds to the VPAC1 receptor of ATII cells. The typical approach to treating hypertension is to inhibit the angiotensin converting enzyme which, as it name suggests, converts angiotensinogen to angiotensin and too much angiotensin (which acts on ATII cells) increases the body's production of aldosterone, causing vasoconstriction and an increase in blood pressure. Aviptadil protects ATII cells from various forms of damage including infectious agents which trigger release of inflammatory cytokines and promotes pulmonary edema, something that happens to many COVID patients. Tadalafil and its cousins (like sildenafil) are phosphodiesterase-5 inhibitors. Various PDE forms break down two biomolecules, cAMP and cGMP, which act as vasodilators. By inhibiting PDE, the action of cAMP and cGMP are prolonged which is good if the patient is hypertensive. All the PDE inhibitors are similar in that they attack a phosphodiester bond in a molecule, but the cyclic versions are the ones that act on cAMP and cGMP to promote lowering of blood pressure. As all these molecules are tissue specific, some PDE inhibitors work better in certain tissues than others. Viagra (sildenafil) was developed as an oral medication for treating systemic hypertension and failed in its Phase III clinical trial, but it did have a certain curious side effect on one specific type of tissue found in men, hence the whole field of erectile dysfunction drugs was borne proving once again that it is better to be lucky than smart. So both drugs can be used to treat PAH, but they have very different mechanisms of action. In theory both can be administered in an inhaled form, but while PAH is a chronic disease COVID is not and I would not expect a drug manufacturer to go to the trouble of reformulating the drug for short term use as an anti-infective. Besides, if a patient has COVID and is sick enough to need Aviptadil then they are already going to be in the hospital, likely the ICU or some other special treatment unit, where aerosolized drugs are frequently used as part of respiratory therapy. Treating COVID sequela does not seem to me to be a good target for Technosphere delivery of the drug. Who would have thought, I miss Matt. I must have miss googled. |
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Post by radgray68 on Aug 5, 2021 20:09:55 GMT -5
The phrase that comes to mind is: "even a blind squirrel finds an acorn once in a while"
To which, I usually respond: "No, the owl gets him." Guess in this case, I was wrong. Good work guys.
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Post by peppy on Aug 5, 2021 20:27:39 GMT -5
Procivni contains the active ingredients Aviptadil (Vasoactive Intestinal Peptide (VIP) and phentolamine intended for the treatment of erectile dysfunction. VIP acts on the veno-occlusive mechanism of erection whilst exerting little effect on the arterial inflow, whereas phentolamine increases arterial flow having little effect on the veno-occlusive mechanism. mri.cts-mrp.eu/download/DK_H_2351_001_PAR.pdf========================================================== I am an idiot. Yes, MannKind already has patents covering Vasoactive Intestinal Peptide. Take this recent patent for example, granted August 25, 2020 (just one of several): 4. The medicament cartridge of claim 2, wherein the active ingredient is insulin, heparin, calcitonin, felbamate, sumatriptan, parathyroid hormone, growth hormone, erythropoietin, AZT, DDI, granulocyte macrophage colony stimulating factor, lamotrigine, chorionic gonadotropin releasing factor, luteinizing releasing hormone, beta-galactosidase, exendin, vasoactive intestinal peptide, follicle stimulating hormone, vasoactive intestinal peptide, parathyroid hormone, parathyroid hormone related protein, glucagon-like peptide-1, exendin, oxyntomodulin, peptide YY, interleukin 2-inducible tyrosine kinase, Bruton's tyrosine kinase, inositol-requiring kinase 1, PC-DAC-modified derivative, or O-glycosylated forms of PC-DAC, parathyroid hormone 1-34, argatroban, or a combination thereof. patents.justia.com/patent/10751488#claimsKowtow, oh great one. |
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