Post by hopingandwilling on May 22, 2021 14:35:33 GMT -5
First let me state that I do not have a dog in this hunt, I washed my hands of MannKind years ago and have not posted here in probably two years.
However, if the following is true, and I have not read or seen what Dr. Hoffman stated in his promotion of clofazimine, his knowledge of how the lungs and heart function is scary.
“What Hofman said, as you noted, was that direct inhalation would reduce "systemic side effects of taking a drug orally" which I believe is not the same thing as what LFD is talking about.
(I think) Systemic side effects of taking a (any) drug orally are not the same as specific side-effects tied to taking Clofazimine in particular.
That does not mean LFD is correct, but I do not think Hofman's statement addressed what LFD said. “
For seven years, MannKind has promoted the advantage of Afrezza and it being inhaled increased the rapidity of getting systemic benefit of using Afrezza. Now it appears Dr. Hofmann is suggesting clofazimine has the unique ability of being inhaled and then having it blocked from entering the systemic system. The lungs do not have this selectivity capability for any drug—you inhale it into the lungs, and they immediately put it into the systemic system that spreads the drug throughout the body. Thus, every round trip the drug is accumulating in the liver, spleen, and LUNGS. Therefore, every time the blood containing clofazimine makes it round trip—the lungs are exposed to the drug! And the empirical data collected for clofazimine show that the drug will crystallize in this person’s organs(aka-the lungs are organs.) The only difference between taking a drug orally or by inhalation is that orally it takes longer to be digested into the stomach, converted so it can enter the circulatory (blood) system). So contrary to Dr. Hofmann, by inhaling clofazimine it is merely speeding up the onset of adverse side effects. And if I remember correctly, the SA article indicated that clofazimine has a half-life of nearly three days --- that is a lot of time for a drug to negatively impact a human’s body.
The good new for clofazimine---the only human body part that does not have a blood supply are the eye’s corneas. Therefore, no worry about clofazimine accumulating and crystalizing there.
However, if the following is true, and I have not read or seen what Dr. Hoffman stated in his promotion of clofazimine, his knowledge of how the lungs and heart function is scary.
“What Hofman said, as you noted, was that direct inhalation would reduce "systemic side effects of taking a drug orally" which I believe is not the same thing as what LFD is talking about.
(I think) Systemic side effects of taking a (any) drug orally are not the same as specific side-effects tied to taking Clofazimine in particular.
That does not mean LFD is correct, but I do not think Hofman's statement addressed what LFD said. “
For seven years, MannKind has promoted the advantage of Afrezza and it being inhaled increased the rapidity of getting systemic benefit of using Afrezza. Now it appears Dr. Hofmann is suggesting clofazimine has the unique ability of being inhaled and then having it blocked from entering the systemic system. The lungs do not have this selectivity capability for any drug—you inhale it into the lungs, and they immediately put it into the systemic system that spreads the drug throughout the body. Thus, every round trip the drug is accumulating in the liver, spleen, and LUNGS. Therefore, every time the blood containing clofazimine makes it round trip—the lungs are exposed to the drug! And the empirical data collected for clofazimine show that the drug will crystallize in this person’s organs(aka-the lungs are organs.) The only difference between taking a drug orally or by inhalation is that orally it takes longer to be digested into the stomach, converted so it can enter the circulatory (blood) system). So contrary to Dr. Hofmann, by inhaling clofazimine it is merely speeding up the onset of adverse side effects. And if I remember correctly, the SA article indicated that clofazimine has a half-life of nearly three days --- that is a lot of time for a drug to negatively impact a human’s body.
The good new for clofazimine---the only human body part that does not have a blood supply are the eye’s corneas. Therefore, no worry about clofazimine accumulating and crystalizing there.
