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Post by porkini on Nov 16, 2023 20:22:06 GMT -5
There is no evidence of toxicity (this has been through all three phases of FDA trials). The API quantity argument is the same one that LFD has been used against Afrezza in the past and has the same flaw, it goes Afrezza takes more insulin than RAA to get the same effect so therefore Afrezza is bad. That is flatly wrong since what matters is the outcome and not the quantity of API used as Afrezza shows. Liquidia print specifically sized and shaped particles to act as carriers so they get deep lung reach via that route rather than the inhaler. In some ways Liquidia is not unlike Mannkind in that with Print they have come up with a carrier mechanism to deliver drugs deep into the lung. Their first drug is Tyvaso though rather than insulin. Aged - do you think it has gone through all the studies Al Mann did prior to afrezza/Technosphere product approval? I doubt it. He did a ton of safety studies before he spent that $1B. Yet for years and years you told us it was going to cause serious lung damage. Why would you not take the same position with LQDA that you did with afrezza? Thats kind of a head scratcher to me. Great - it went through three FDA trials and how many separate safety trials? What did it take, 5 years after approval for your endos to give the thumbs up that they were wrong on afrezza lung safety? For Tyvaso DPI, Technosphere was a time proven safe product. This one, at this point is a wildcard. Wait, what!? Where was this said for years and years, please? Thank you. |
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Post by peppy on Nov 16, 2023 21:19:57 GMT -5
... No feedback on the advantages MNKD is discovering with their Technosphere platform? That is, they're finding pharmacokinetic advantages with Technosphere during dose escalation studies. Less drugs, less toxicity, better tolerance. ... . Some drugs either cannot be taken orally because the stomach destroys them, insulin being a prime example, or the side effects are so nasty you can only use the drug in extremis although you want to use it far more often. There is a whole market sitting there waiting. Insulin is also nice IV aged, and I know you know it because you told me.  |
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Post by longliner on Nov 16, 2023 21:31:19 GMT -5
Aged - do you think it has gone through all the studies Al Mann did prior to afrezza/Technosphere product approval? I doubt it. He did a ton of safety studies before he spent that $1B. Yet for years and years you told us it was going to cause serious lung damage. Why would you not take the same position with LQDA that you did with afrezza? Thats kind of a head scratcher to me. Great - it went through three FDA trials and how many separate safety trials? What did it take, 5 years after approval for your endos to give the thumbs up that they were wrong on afrezza lung safety? For Tyvaso DPI, Technosphere was a time proven safe product. This one, at this point is a wildcard. Wait, what!? Where was this said for years and years, please? Thank you. Well, with over 5,500 aged posts sayhey, you have your work cut out for you!  I think if you put in the time you can document what you say. This may pre-date Porky. You gotta ask yourself though...is it worth it...?  |
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Post by sayhey24 on Nov 17, 2023 5:59:04 GMT -5
Wait, what!? Where was this said for years and years, please?theydrom Thank you. Well, with over 5,500 aged posts sayhey, you have your work cut out for you! I think if you put in the time you can document what you say. This may pre-date Porky. You gotta ask yourself though...is it worth it...? Ha - he/she knows what was said. Lately I have been calling it ELS (exploding lung syndrome) Aged corrected me the other day and said it was IPF. All I know was his/her endo said afrezza "may" cause IPF and it was not worth that risk to try it, let alone use it on a daily basis. Aged said that position changed 5 years ago but he/she never mentioned that here until the other day and still won't try it. IDK, I would think he/she would have the same concern about "Print". The thing is afrezza for mealtime control is hands-down better than any RAA. CGMs don't lie. I think at best this "Print" thing will be almost as good as Tyvaso DPI. Why would any doctor prescribe this with all the "risk" and no benefit? |
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Post by uvula on Nov 17, 2023 8:59:47 GMT -5
Sayhey, please stop. Your obsession with aged is not healthy for you and is annoying the rest of us.
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Post by BD on Nov 17, 2023 9:28:47 GMT -5
Just for the record, folks, "bash" is a charged word on financial message boards because it implies a concerted effort to get people to sell so someone can make money shorting. Even if just meant in the sense of "disparage", I'd highly suggest everyone avoid using it.
If I were a member opposing another member's negative take on, say, Afrezza, I would address specific issues that member has and steer clear from "Have you stopped beating your wife?"-type queries such as "Why do you bash?"
Thanks.
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Post by stella on Nov 17, 2023 10:35:02 GMT -5
Sayhey, please don't stop debating Aged. It is not annoying the rest of us. Aged has posted 5,550 time since he joined in Feb 2015 with the bulk of those posted in the last 18 months. Who's obsessed? Controlling the narrative on this board is hard work.
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Post by MnkdWASmyRtrmntPlan on Nov 17, 2023 10:49:06 GMT -5
Sayhey, please don't stop debating Aged. It is not annoying the rest of us. Aged has posted 5,550 time since he joined in Feb 2015 with the bulk of those posted in the last 18 months. Who's obsessed? Controlling the narrative on this board is hard work. Ditto |
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Post by uvula on Nov 17, 2023 11:20:25 GMT -5
The substantive debates between sayhey and aged are great. Perhaps the best posts we have here.
The repetitive "why did you say lungs would explode" posts when aged never said that are getting annoying.
To be honest, I would be better off if I spent less time reading the message boards. I apologize for my grumpiness.
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Post by sayhey24 on Nov 17, 2023 11:20:28 GMT -5
Sayhey, please don't stop debating Aged. It is not annoying the rest of us. Aged has posted 5,550 time since he joined in Feb 2015 with the bulk of those posted in the last 18 months. Who's obsessed? Controlling the narrative on this board is hard work. Hey - just put me on ignore. It won't hurt my feelings. Sometimes Aged brings value. Maybe I do too - not sure. Sometimes or more than sometimes he/she posts things which I think need to be challenged. Nothing personal but you may not be qualified and I may not be either to challenge Aged since I don't have a PHD, MD or a PharmD after my name. Then again neither did Al Mann but he was a lot smarter than me. However if no one else is, I plan to continue. Aged doesn't seem to mind me challenging and if he/she did they can put me on ignore too. No one is making Aged respond. Aged was clearly correct about 2024 Medicare coverage and clearly wrong about afrezza causing lung damage. Aged was also wrong about APIs being able to provide better mealtime control than afrezza and wrong based on the trial sign-up that everyone is happy with their pump. Is Aged right about Print, I don't think so but time will tell. UTHR is only a stop gap for MNKD, paying the bills until MNKD gets its act together. Afrezza should be at least a blockbuster and the TS GLP1 patent which they filed could be a super blockbuster. While we hope and wait, Tyvaso DPI is paying the bills. So why don't you want me to challenge and ask questions? Is there some concern on your part that something will be exposed? |
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Post by longliner on Nov 17, 2023 11:35:30 GMT -5
Sayhey, please stop. Your obsession with aged is not healthy for you and is annoying the rest of us. As some here know Aged is one of my favorite posters. He's actually the reason I initially joined. I joined to counter his negative posts regarding Afrezza. So, every year, at least once I jump in his undermining narrative directed at MNKD. Not his bashing BD....the horrors. I'll leave that to cresomo. |
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Post by cretin11 on Nov 17, 2023 11:45:17 GMT -5
Sayhey, please stop. Your obsession with aged is not healthy for you and is annoying the rest of us. As some here know Aged is one of my favorite posters. He's actually the reason I initially joined. I joined to counter his negative posts regarding Afrezza. longliner you're gonna have to step it up then! You haven't countered much, while aged has proven to be the most accurate predictor here on Afrezza (stevil is in that category too). We all learn a lot from aged's posts, at least those of us willing to be open minded. Same goes for sayhey's substantive posts. |
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Post by sayhey24 on Nov 17, 2023 13:56:27 GMT -5
As some here know Aged is one of my favorite posters. He's actually the reason I initially joined. I joined to counter his negative posts regarding Afrezza. longliner you're gonna have to step it up then! You haven't countered much, while aged has proven to be the most accurate predictor here on Afrezza (stevil is in that category too). We all learn a lot from aged's posts, at least those of us willing to be open minded. Same goes for sayhey's substantive posts. Aged has 66% more posts than me. I am going to need to really step it up. |
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Post by agedhippie on Nov 17, 2023 14:00:03 GMT -5
Aged has 66% more posts than me. I am going to need to really step it up. I have been here longer Although not 66%.... |
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Post by BD on Nov 17, 2023 14:03:01 GMT -5
To be honest, I would be better off if I spent less time reading the message boards. Wouldn't we all. |
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I think if you put in the time you can document what you say.
