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Post by ktim on Mar 11, 2024 12:16:53 GMT -5
What might we expect to hear, if anything, out of the Leerink 1-on-1 meeting today> Unless they choose to do a press release with some new info they plan to discuss, I'd say we won't hear anything. |
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Post by longliner on Mar 13, 2024 15:38:14 GMT -5
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Post by letitride on Mar 13, 2024 15:51:03 GMT -5
Was Good Mike sounds more confident with every call as he should!
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Post by longliner on Mar 13, 2024 16:02:09 GMT -5
Was Good Mike sounds more confident with every call as he should! I particularly liked his reference to currently paying down debt! Be gone with the blood suckers! |
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Post by letitride on Mar 13, 2024 16:12:49 GMT -5
Need this float locked up and the note holders will get out of the way and wait for their money back, in 2026. At 2.5% Mannkind is on the right side of this deal.
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Post by longliner on Mar 13, 2024 16:16:58 GMT -5
Need this float locked up and the note holders will get out of the way and wait for their money back, in 2026. At 2.5% Mannkind is on the right side of this deal. The Midcap loan has be extinguished ASAP. It locks up both our Property / IP and 30 Million dollars, that in addition to 8% interest I believe. I agree, the 2.5%...letitride  |
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Post by sayhey24 on Mar 13, 2024 16:19:13 GMT -5
Mike needs to start talking and explaining TITR when he is talking about Inhale-3. The 24 hour TIR is not going to be ground breaking but the 2 hour TITR tells a great story.
Its also nice to hear someone is including afrezza in a gestational study after seeing the ATTD presentation.
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Post by prcgorman2 on Mar 13, 2024 16:48:47 GMT -5
Mike needs to start talking and explaining TITR when he is talking about Inhale-3. The 24 hour TIR is not going to be ground breaking but the 2 hour TITR tells a great story. Its also nice to hear someone is including afrezza in a gestational study after seeing the ATTD presentation. Afrezza for gestational diabetes could be a literal lifesaver. |
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Post by letitride on Mar 13, 2024 16:53:25 GMT -5
The lack of Hypos is huge and Mike was driving that home today.
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Post by sayhey24 on Mar 13, 2024 17:29:46 GMT -5
Mike needs to start talking and explaining TITR when he is talking about Inhale-3. The 24 hour TIR is not going to be ground breaking but the 2 hour TITR tells a great story. Its also nice to hear someone is including afrezza in a gestational study after seeing the ATTD presentation. Afrezza for gestational diabetes could be a literal lifesaver. We may need another label update - 8.1 Pregnancy Teratogenic Effects: Pregnancy Category C AFREZZA has not been studied in pregnant women. AFREZZA should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus |
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Post by longliner on Mar 13, 2024 18:49:04 GMT -5
MC also spoke of Cipla meeting with regulators in India last week. Maybe an update soon?
There was quite a lot discussed with Oppenheimer today.
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Post by uvula on Mar 13, 2024 20:11:12 GMT -5
Oppenheimer is good but we would get attention if Mike talked to Barbie.
(Sorry. Just watched the Oscars.)
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Post by Thundersnow on Mar 14, 2024 1:47:43 GMT -5
Mike needs to start talking and explaining TITR when he is talking about Inhale-3. The 24 hour TIR is not going to be ground breaking but the 2 hour TITR tells a great story. Its also nice to hear someone is including afrezza in a gestational study after seeing the ATTD presentation. Afrezza for gestational diabetes could be a literal lifesaver. From ST...... Did anyone catch Mike mention they will be seeking approval for Gestational Diabetes and HOSPITAL CARE??? Once PEDS is approved I’m sure they will be going for a MAJOR LABEL CHANGE. Can you imagine a diabetic going to the ER with a 800 BG and staying there for 2 hours instead of 12 hours??? How much of a SAVINGS is that?? |
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Post by casualinvestor on Mar 14, 2024 8:44:42 GMT -5
I think that a study proving superior outcomes that apply to Gestational Diabetes would be a great wedge in the door. Almost 300k cases of gestational diabetes per year in the US.
Chipping away at the cases where TIR control and a better safety profile is more important than for the average diabetic.
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Post by agedhippie on Mar 14, 2024 8:46:19 GMT -5
Afrezza for gestational diabetes could be a literal lifesaver. From ST...... Did anyone catch Mike mention they will be seeking approval for Gestational Diabetes and HOSPITAL CARE??? Once PEDS is approved I’m sure they will be going for a MAJOR LABEL CHANGE. Can you imagine a diabetic going to the ER with a 800 BG and staying there for 2 hours instead of 12 hours??? How much of a SAVINGS is that?? Gestational diabetes would be an interesting as while by no means all women with gestational diabetes are put on insulin those that are currently put on RAA would be strong candidates for Afrezza instead. It would require trials but there is an additional benefit in doing a proper trials which is T1 pregnancies. Doctors want very tight control while you are pregnant and that is a lot of work. I could see a definite role for Afrezza there if it was approved. The ER example wouldn't work for a few reasons. The likelihood if you are in the 800s without DKA and are in ER it's because you cannot afford insulin and almost certainly don't have insurance. This happens more commonly than you would think with a cycle of about a month or so. The biggest problem though is that if you dropped someone from 800 to 100 in the space of a couple of hours there is a strong chance you will kill them with hypokalemia. High insulin doses suck potassium out of the blood so you have to drop that sort of level relatively slowly to void cardiac issues. If they are 800 with DKA then getting their level down is literally the last thing you do. High levels will not kill you, but the electrolyte imbalance caused by DKA will and fast. That means an IV is required and used for everything including insulin. DKA is fatal in about 1:300 cases in the west, couple that with virtually all kids being diagnosed with Type 1 because they are in DKA... In the list of things that scare T1 diabetics DKA is usually top. Everyone I knew who has died from diabetes died because of DKA, never hypos. |
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