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Post by lynn on Jul 22, 2015 23:38:44 GMT -5
I wasn't sure which thread would fit my post , so I figured this would maybe fit here .
I want to share a convo I recently had with one of our Pharmacists at work . Many of us Nurses have told her about Afrezza .
Last week , she approached me and said " did you hear that there's a new Insulin patch that's in Phase 3 trials ? I think it'll be great because it will be the Only Insulin patch on the market " me " yes , I've heard of it ( from this board ) I believe it's years away from becoming available but it does sound great " me again , "you know Afrezza is the Only inhaled insulin on the market Now , I'm following several users on social media who are experiencing non diabetic blood glucose levels and lowering their A1C's for the first time in their Diabetic Lives " she then said again without acknowledging what I just said " but this will be the only insulin patch !" She was quite excited .
I am just sharing an experience I've witnessed . I consider her to be the best Pharmacist at my Hospital . All she remembers is Exubera . We have a lot of misconceptions to overcome . But we'll get there . I searched more about the insulin patch after the convo ( half a** effort ,)) & it looks to me like they've only tested on animals thus far .
If Exubera had never existed , I think this journey ( paradigm shift ) would be alittle easier . But since it did & failed for reasons that have nothing to do w/ Afrezza (we All know the differences , but most do not and are so busy they easily write it off as another failure ) .
That conversation has stuck with me , so I thought I'd share it with you all . I have the utmost respect for her and will not Judge .
It reminds me of having a bad experience with something , or a memory of it . I used to Love Grape Gatorade ! Then I had Salmonella food poisoning and drank way to much of it . I was 24 , it's been almost 2 decades , but the thought of it still puts a bad taste in my mouth . In fact , most grape type juices do the same . I " know " intellectually that I only drank it to hydrate myself & it had nothing to do with my food poisoning experience . But it doesn't matter .
That's a total Segway , but those who remember Exubera & it's initial promise ( then flop ) may associate Afrezza as one and the same . It will take time for that mindset to change .
Still long and strong , I just feel like I'm watching grass grow these days ./
Lynn
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Post by beardawg on Jul 23, 2015 6:30:35 GMT -5
I wasn't sure which thread would fit my post , so I figured this would maybe fit here . I want to share a convo I recently had with one of our Pharmacists at work . Many of us Nurses have told her about Afrezza . Last week , she approached me and said " did you hear that there's a new Insulin patch that's in Phase 3 trials ? I think it'll be great because it will be the Only Insulin patch on the market " me " yes , I've heard of it ( from this board ) I believe it's years away from becoming available but it does sound great " me again , "you know Afrezza is the Only inhaled insulin on the market Now , I'm following several users on social media who are experiencing non diabetic blood glucose levels and lowering their A1C's for the first time in their Diabetic Lives " she then said again without acknowledging what I just said " but this will be the only insulin patch !" She was quite excited . I am just sharing an experience I've witnessed . I consider her to be the best Pharmacist at my Hospital . All she remembers is Exubera . We have a lot of misconceptions to overcome . But we'll get there . I searched more about the insulin patch after the convo ( half a** effort ,)) & it looks to me like they've only tested on animals thus far . If Exubera had never existed , I think this journey ( paradigm shift ) would be alittle easier . But since it did & failed for reasons that have nothing to do w/ Afrezza (we All know the differences , but most do not and are so busy they easily write it off as another failure ) . That conversation has stuck with me , so I thought I'd share it with you all . I have the utmost respect for her and will not Judge . It reminds me of having a bad experience with something , or a memory of it . I used to Love Grape Gatorade ! Then I had Salmonella food poisoning and drank way to much of it . I was 24 , it's been almost 2 decades , but the thought of it still puts a bad taste in my mouth . In fact , most grape type juices do the same . I " know " intellectually that I only drank it to hydrate myself & it had nothing to do with my food poisoning experience . But it doesn't matter . That's a total Segway , but those who remember Exubera & it's initial promise ( then flop ) may associate Afrezza as one and the same . It will take time for that mindset to change . Still long and strong , I just feel like I'm watching grass grow these days ./ Lynn But....It's not comforting that you still hate grape Gatorade...
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Post by kc on Jul 23, 2015 7:40:59 GMT -5
Afrezza is safe for years to Come.
'Smart Insulin Patch' for Diabetes Is Years From Human Trials Medscape › viewarticle Mobile-friendly - Jun 26, 2015 - ... responds to changing blood sugar levels with low risk for hypoglycemia, but human trials are still a distance away. ... "Smart Insulin Patch" for Diabetes Is Years From Human Trials.
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Post by liane on Jul 23, 2015 7:42:37 GMT -5
Even then, a patch would function as a basal insulin, not prandial.
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Post by BD on Jul 23, 2015 7:42:55 GMT -5
It reminds me of having a bad experience with something , or a memory of it . I used to Love Grape Gatorade ! Then I had Salmonella food poisoning and drank way to much of it . I was 24 , it's been almost 2 decades , but the thought of it still puts a bad taste in my mouth . In fact , most grape type juices do the same . I " know " intellectually that I only drank it to hydrate myself & it had nothing to do with my food poisoning experience . But it doesn't matter . I had an all-too-similar experience with gin and tonics followed by champagne at a New Year's party many years ago... couldn't touch either for about 15 years!
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Post by notamnkdmillionaire on Jul 23, 2015 8:19:04 GMT -5
I wasn't sure which thread would fit my post , so I figured this would maybe fit here . I want to share a convo I recently had with one of our Pharmacists at work . Many of us Nurses have told her about Afrezza . Last week , she approached me and said " did you hear that there's a new Insulin patch that's in Phase 3 trials ? I think it'll be great because it will be the Only Insulin patch on the market " me " yes , I've heard of it ( from this board ) I believe it's years away from becoming available but it does sound great " me again , "you know Afrezza is the Only inhaled insulin on the market Now , I'm following several users on social media who are experiencing non diabetic blood glucose levels and lowering their A1C's for the first time in their Diabetic Lives " she then said again without acknowledging what I just said " but this will be the only insulin patch !" She was quite excited . I am just sharing an experience I've witnessed . I consider her to be the best Pharmacist at my Hospital . All she remembers is Exubera . We have a lot of misconceptions to overcome . But we'll get there . I searched more about the insulin patch after the convo ( half a** effort ,)) & it looks to me like they've only tested on animals thus far . If Exubera had never existed , I think this journey ( paradigm shift ) would be alittle easier . But since it did & failed for reasons that have nothing to do w/ Afrezza (we All know the differences , but most do not and are so busy they easily write it off as another failure ) . That conversation has stuck with me , so I thought I'd share it with you all . I have the utmost respect for her and will not Judge . It reminds me of having a bad experience with something , or a memory of it . I used to Love Grape Gatorade ! Then I had Salmonella food poisoning and drank way to much of it . I was 24 , it's been almost 2 decades , but the thought of it still puts a bad taste in my mouth . In fact , most grape type juices do the same . I " know " intellectually that I only drank it to hydrate myself & it had nothing to do with my food poisoning experience . But it doesn't matter . That's a total Segway , but those who remember Exubera & it's initial promise ( then flop ) may associate Afrezza as one and the same . It will take time for that mindset to change . Still long and strong , I just feel like I'm watching grass grow these days ./ Lynn You could have just slapped her in the face for not acknowledging your remarks about Afrezza.
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Post by notamnkdmillionaire on Jul 23, 2015 8:19:57 GMT -5
Even then, a patch would function as a basal insulin, not prandial. She must be the most popular pharmacist because she hands out oxy like they are M&Ms and not because of her expertise.
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Post by mnkdnut on Jul 23, 2015 13:08:23 GMT -5
My feeling, from being in the medical industry for many years, is that the established leadership of the Endocrinologist profession remembers Exubra as a miserable failure and has superficially painted Afrezza with the broad brush of "been there, done that, didn't work". In time, a growing army of satisfied patients will force them to reconsider, but right now they are not very motivated to do so. Mannkind has simply not delivered the kind of iron-clad clinical trial evidence of superior efficacy to turn their heads. Sanofi has taken the reigns and should be addressing this, but it can't be done overnight. This theorized dismissive attitude of the Endo KOL (Key Opinion Leader) "establishment" may also explain the demonstrated high confidence of the Short interest. If you were a Hedge Fund looking to bet tens of millions on the early demise of MNKD, wouldn't you go ask the most highly acclaimed Endocrinologists in the Field what they though of Afrezza's potential success first? If they came back with a dismissive, skeptical response, wouldn't that boost your confidence? It's just my gut feeling that this is what's going on. I think Afrezza will catch on first with the Endo "up and comers". These guys will be the KOLs years from now. They don't have such a vested interest in the status quo.
Looking at it realistically, Sanofi has to start with the patients that would benefit most from avoiding needles. Once they start showing their doctors how well it works in controlling their sugars, we'll see doctor's minds changing. Just look at Sanofi's DTC ads so far: everyday diabetics enjoying social mealtimes because they have a fast, easy and painless way to take their insulin. This is the logical start.
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Post by od on Jul 23, 2015 20:52:07 GMT -5
My feeling, from being in the medical industry for many years, is that the established leadership of the Endocrinologist profession remembers Exubra as a miserable failure and has superficially painted Afrezza with the broad brush of "been there, done that, didn't work". In time, a growing army of satisfied patients will force them to reconsider, but right now they are not very motivated to do so. Mannkind has simply not delivered the kind of iron-clad clinical trial evidence of superior efficacy to turn their heads. Sanofi has taken the reigns and should be addressing this, but it can't be done overnight. This theorized dismissive attitude of the Endo KOL (Key Opinion Leader) "establishment" may also explain the demonstrated high confidence of the Short interest. If you were a Hedge Fund looking to bet tens of millions on the early demise of MNKD, wouldn't you go ask the most highly acclaimed Endocrinologists in the Field what they though of Afrezza's potential success first? If they came back with a dismissive, skeptical response, wouldn't that boost your confidence? It's just my gut feeling that this is what's going on. I think Afrezza will catch on first with the Endo "up and comers". These guys will be the KOLs years from now. They don't have such a vested interest in the status quo. Looking at it realistically, Sanofi has to start with the patients that would benefit most from avoiding needles. Once they start showing their doctors how well it works in controlling their sugars, we'll see doctor's minds changing. Just look at Sanofi's DTC ads so far: everyday diabetics enjoying social mealtimes because they have a fast, easy and painless way to take their insulin. This is the logical start. Well said. As a long term industry professional you also know that had Afrezza been incubated by SNY R&D there would have been a commercial team working on the launch 2+ years prior to approval. Time and SNY resources would have optimized postioning to providers and patients and likely accelerated payor formulary uptake. No doubt, not a flawless launch, but considering the time frame, the SNY bashing is unwarranted.
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Post by harryx1 on Jul 23, 2015 21:11:45 GMT -5
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Post by newmnkdinvestor on Jul 24, 2015 15:08:58 GMT -5
After my day last week at Mt Sinai I decided to do my own D&D. I am not a finance guru. I am a newb but I am doing pretty well so far! Anyway Spare me the ethics comments.
I decided to spend the end of my day yesterday calling Endo's. I was pretending to be diabetic and wanted to know if they were prescribing Afrezza.I probably made 30 calls. Only a couple were prescribing. While many want instant gratification through magazine and tv ads I would venture to guess SNY is spending money educating Dr's. Unfortunately we do not get to see that aspect. Dr's are the gate keepers.
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Post by notamnkdmillionaire on Jul 24, 2015 15:26:12 GMT -5
After my day last week at Mt Sinai I decided to do my own D&D. I am not a finance guru. I am a newb but I am doing pretty well so far! Anyway Spare me the ethics comments. I decided to spend the end of my day yesterday calling Endo's. I was pretending to be diabetic and wanted to know if they were prescribing Afrezza.I probably made 30 calls. Only a couple were prescribing. While many want instant gratification through magazine and tv ads I would venture to guess SNY is spending money educating Dr's. Unfortunately we do not get to see that aspect. Dr's are the gate keepers. So are insurance companies. It is not unthinkable that in the not so distant future that certain insurance companies will only have Afrezza as their only recommended insulin for certain types of patients. Obviously, other pharmas will fight tooth and nail to stop this but it's happening with other types of drugs where only one is being covered by an insurance company. A doctor would have no choice BUT (edit) to Rx it unless the patient is ok with spending $$$ out of pocket for the alternative.
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Post by newmnkdinvestor on Jul 24, 2015 15:28:36 GMT -5
After my day last week at Mt Sinai I decided to do my own D&D. I am not a finance guru. I am a newb but I am doing pretty well so far! Anyway Spare me the ethics comments. I decided to spend the end of my day yesterday calling Endo's. I was pretending to be diabetic and wanted to know if they were prescribing Afrezza.I probably made 30 calls. Only a couple were prescribing. While many want instant gratification through magazine and tv ads I would venture to guess SNY is spending money educating Dr's. Unfortunately we do not get to see that aspect. Dr's are the gate keepers. So are insurance companies. It is not unthinkable that in the not so distant future that certain insurance companies will only have Afrezza as their only recommended insulin for certain types of patients. Obviously, other pharmas will fight tooth and nail to stop this but it's happening with other types of drugs where only one is being covered by an insurance company. A doctor would have no choice to Rx it unless the patient is ok with spending $$$ out of pocket for the alternative. Actually that's a great point. Lower a1c's help keep medical epxenses down by keeping the patient healthier.
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Post by compound26 on Jul 24, 2015 15:52:02 GMT -5
After my day last week at Mt Sinai I decided to do my own D&D. I am not a finance guru. I am a newb but I am doing pretty well so far! Anyway Spare me the ethics comments. I decided to spend the end of my day yesterday calling Endo's. I was pretending to be diabetic and wanted to know if they were prescribing Afrezza.I probably made 30 calls. Only a couple were prescribing. While many want instant gratification through magazine and tv ads I would venture to guess SNY is spending money educating Dr's. Unfortunately we do not get to see that aspect. Dr's are the gate keepers. newmnkdinvestor, that's great effort on your side. So I guess 3-5 (probably no more than 5) Endos of the 30 you called upon saying they are prescribing? That's probably about 10-15% Endos. Considering that SNY has been focusing on Endos, the GPs will probably be even less educated regarding Afrezza. So the GPs prescribing Afrezza probably will be significantly below 10%. I agree with your observation. I think up to this moment, it probably has been the same group of open-minded Endos that have been prescribing Afrezza over the last several months. The majority of the Endos are still under-educated and to the extent they have some knowledge, they have adopted a wait-and-see attitude towards prescribing Afrezza.
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Post by dreamboatcruise on Jul 24, 2015 15:56:27 GMT -5
compound26... I think from the number of scripts vs number of GPs in U.S. we can assume that the % that have prescribed even 1 script is probably a fraction of 1%. It seems in most likelihood that a very tiny % of docs are writing many scripts and vast majority are writing none.
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