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Post by dreamboatcruise on Jul 30, 2015 11:25:07 GMT -5
@scotta... and we aren't aware of any trials even outside the U.S. that would seem structured for label improvement.
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Post by mnholdem on Jul 30, 2015 12:19:45 GMT -5
mnkdmillionaire,
Perhaps this clears up the humor: "Americans switching their fork to the left hand (from their right hand) to cut with their knife with the right hand" - then switching the fork back to the right hand again to stab the piece of steak they just cut using that same hand... that is the way most right-handed Americans eat a steak.
The frenchman would keep the fork in his left hand and the knife in his right, give you that arrogant look the French are famous for and then sneer, "Why, monsieur, would every waiter in the world place the fork on the left of your place setting, if you were supposed to use the fork in your right hand?"
So, I taught myself to keep the fork in my left hand and knife in my right hand... which took a bit of practice with the peas (chuckle).
Holdem
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Post by patryn on Jul 30, 2015 12:26:13 GMT -5
mnkdmillionaire, Perhaps this clears up the humor: "Americans switching their fork to the left hand (from their right hand) to cut with their knife with the right hand" - then switching the fork back to the right hand again to stab the piece of steak they just cut using that same hand... that is the way most right-handed Americans eat a steak. The frenchman would keep the fork in his left hand and the knife in his right, give you that arrogant look the French are famous for and then sneer, "Why, monsieur, would every waiter in the world place the fork on the left of your place setting, if you were supposed to use the fork in your right hand?" So, I taught myself to keep the fork in my left hand and knife in my right hand... which took a bit of practice with the peas (chuckle). Holdem Supposedly during WWII, Germans would be able to suss out American spies because they swapped hands when cutting meat, whereas most Europeans would just cut with the right hand and eat with the fork in the left hand. |
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Post by notamnkdmillionaire on Jul 30, 2015 12:26:35 GMT -5
mnkdmillionaire, Perhaps this clears up the humor: "Americans switching their fork to the left hand (from their right hand) to cut with their knife with the right hand" - then switching the fork back to the right hand again to stab the piece of steak they just cut using that same hand... that is the way most right-handed Americans eat a steak. The frenchman would keep the fork in his left hand and the knife in his right, give you that arrogant look the French are famous for and then sneer, "Why, monsieur, would every waiter in the world place the fork on the left of your place setting, if you were supposed to use the fork in your right hand?" So, I taught myself to keep the fork in my left hand and knife in my right hand... which took a bit of practice with the peas (chuckle). Holdem ah..got it now. I am a lefty so I guess I'll be ok with the fork in my left hand at all times when I continue to remind my French friends that they'd be speaking German if it weren't for us Yannks. |
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Post by BD on Jul 30, 2015 12:37:39 GMT -5
mnkdmillionaire, Perhaps this clears up the humor: "Americans switching their fork to the left hand (from their right hand) to cut with their knife with the right hand" - then switching the fork back to the right hand again to stab the piece of steak they just cut using that same hand... that is the way most right-handed Americans eat a steak. The frenchman would keep the fork in his left hand and the knife in his right, give you that arrogant look the French are famous for and then sneer, "Why, monsieur, would every waiter in the world place the fork on the left of your place setting, if you were supposed to use the fork in your right hand?" So, I taught myself to keep the fork in my left hand and knife in my right hand... which took a bit of practice with the peas (chuckle). Holdem As a lefty, I've always appreciated the way the knife and fork are exactly where they're supposed to be when I sit down at a place setting. And when setting a table, the way I remember what side to put things on is to ask myself where I'd want them to be... lol Being a lefty also has advantages if you play tennis!  |
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Post by pmikeks on Jul 31, 2015 18:12:52 GMT -5
Results of follow up A1c at the bottom of the page.
I have been on Affrezza three months. When I started my A1c was 9.2 and I fully expect it to be under 6.0 when I have my follow up this week. I was taking 30 units of Lantus nightly when I started and granted I wasn't behaving as I should. But now when I do splurge (example; pizza and homemade ice cream) my peak isn't as high and doesn't last as long.
Many days at bedtime my blood sugar is under 100 so I don't take Lantus and my fasting blood sugar is still under 100 come morning. Other days because my count is under 130 I take a lesser amount of Lantus (15-25 units). Sooo.as a result I'm using less then a third of the Lantus I was taking to start with. It's like my pancreas has decided to jump in and help. It didn't happen immediately or even with consistent improvement
Are my results after three months typical? I don't have the answer to that. If they are typical it may be part of why SNY isn't as enthusiastic as we would like them to be in promoting Affrezza.
I was disappointed with my official A1c results, it came in at 6.6. I was sure I'd be under 6. Dr was impressed since I was down from 9.2 but said it could take a little longer to get under 6. I think somebody on here said 120 days.
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Post by dreamboatcruise on Jul 31, 2015 18:20:30 GMT -5
pmikeks... while not being what you had hoped, that is still great improvement. Undoubtedly will continue lower. Congrats. Hope you're helping to convert your doc to a strong Afrezza advocate. à Votre Santé
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Post by babaoriley on Jul 31, 2015 21:13:59 GMT -5
Results of follow up A1c at the bottom of the page. I have been on Affrezza three months. When I started my A1c was 9.2 and I fully expect it to be under 6.0 when I have my follow up this week. I was taking 30 units of Lantus nightly when I started and granted I wasn't behaving as I should. But now when I do splurge (example; pizza and homemade ice cream) my peak isn't as high and doesn't last as long. Many days at bedtime my blood sugar is under 100 so I don't take Lantus and my fasting blood sugar is still under 100 come morning. Other days because my count is under 130 I take a lesser amount of Lantus (15-25 units). Sooo.as a result I'm using less then a third of the Lantus I was taking to start with. It's like my pancreas has decided to jump in and help. It didn't happen immediately or even with consistent improvement Are my results after three months typical? I don't have the answer to that. If they are typical it may be part of why SNY isn't as enthusiastic as we would like them to be in promoting Affrezza. I was disappointed with my official A1c results, it came in at 6.6. I was sure I'd be under 6. Dr was impressed since I was down from 9.2 but said it could take a little longer to get under 6. I think somebody on here said 120 days. pmikeks, I think you're doing great! I mentioned the 120 days, I learned that from Dr. Spiro, but I've heard it from smart people since, so I believe it! Just kidding, Spiro, glad to see you posting again, you're apparently home, safe and sound! |
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Post by mannmade on Aug 1, 2015 0:11:36 GMT -5
Baba I believe Sam posted that Dr. Bode told him the same re: 120 days.
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Post by dallasfan on Aug 1, 2015 20:54:20 GMT -5
Probably has to do with the fact that afrezza users are more aggressive with their treatment and keep their average blood sugars lower than someone who doesn't.
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Post by compound26 on Sept 18, 2015 19:16:10 GMT -5
I have been on Affrezza three months. When I started my A1c was 9.2 and I fully expect it to be under 6.0 when I have my follow up this week. I was taking 30 units of Lantus nightly when I started and granted I wasn't behaving as I should. But now when I do splurge (example; pizza and homemade ice cream) my peak isn't as high and doesn't last as long. Many days at bedtime my blood sugar is under 100 so I don't take Lantus and my fasting blood sugar is still under 100 come morning. Other days because my count is under 130 I take a lesser amount of Lantus (15-25 units). Sooo.as a result I'm using less then a third of the Lantus I was taking to start with. It's like my pancreas has decided to jump in and help. It didn't happen immediately or even with consistent improvement Are my results after three months typical? I don't have the answer to that. If they are typical it may be part of why SNY isn't as enthusiastic as we would like them to be in promoting Affrezza. pmikeks, I am neither a doctor nor a diabetic but my understanding from reading posts from people who are both, suggests your results are very much in line with the vast majority of other diabetics on Afrezza. Namely they see the reversal of insulin resistance requiring lower basal doses and the elimination/disappearance of the "dawn effect." In effect Afrezza restores the normal communication between the pancreas and the liver and your body acts as if it were normal (non-diabetic). Take a read of Compounds article that he drafted of SA under the thread for Articles and Media. You will find many other benefits from Afrezza that users are experiencing. Continued good health to you... I think we got carried away on this thread at some point. Back to the original message posted by pmikeks, I think by this point, it appears there is now ample evidence that Afrezza will reduce the usage of basal, at least to a large group of users. See: www.afrezzajustbreathe.com/afrezza-reduced-basal-insulin-need/Aslo, as I posted in this thread previously, ML (Granger, who has been on Afrezza for over five year)'s case also illustrate this regenerative effect of Afrezza. Here is what she says (under the user name: bob_marylou_granger) on tudiabetes.org: “I have been a Type 1 diabetic for 58 years. After 52 years of thousands of injections, I became needle-phobic. The OUCH you think is minor to you is not minor to millions of others. ….Spent 5 1/2 years in a research study trial using AFREZZA inhaled insulin. I have not had to take an insulin injection during those 5 1/2 years. Believe me, I know that is not a cure. But for now it is the best out there for those of us struggling physically and emotionally with injections.” www.tudiabetes.org/forum/t/insulin-independence-revolutionary-phase-3-trial-giving-type-1-diabetics-the-promise-of-a-needle-free-life/46721/15Here is what she says in this forum: "When I first joined the MannKind trial, I was injecting Lantus in the morning at breakfast and inhaling Exubera with each meal. Before Exubera had been taken off the market, I had stockpiled quite a large supply. It could be stored on a shelf at room temperature, no refrigeration was needed. In the beginning, I still took my Lantus at breakfast and then began using the Technosphere {Afrezza as it is now called} with each meal. My BG levels began to drop. My doctor kept lowering the Lantus until he suggested I drop the injections completely. It took me a couple of days to work up my courage, but the idea of not taking ANY shots was worth it. It worked for a few weeks, and then my BG levels started to rise. Terribly disappointed, I went back on the morning Lantus shots and inhaling at each meal. Shortly, my BG levels dropped again, and my doctor took me off injections again. From then on, NO SHOTS!!! No one can explain it --- it just is!ML" mnkd.proboards.com/thread/2135/recent-tudiabetes-diabetics-poll#ixzz3hDZioOeeI am not a doctor, so I am not sure how significant this is from a doctor's point of view. doctor.stockpicker seems to be very exercised in his post below. mnholdem • Jun 22, 2015 10:03 PM Everyone should repost this. Flood the board with it. From doctor.stockpicker @yahoo message boards: What I saw today was almost unbelieveable!!!! I have several patients on Afrezza and have seen some very good results, but nothing like the patient I saw today. Previously, I thought I would not post patient data here, but this astonished me. This patient has been a diabetic for over 30 years and has profound insulin resistance. His regimen was Lantus 60 units every 12 hours and at least 30 units of prandial insulin with each meal. His finger stick blood sugars were terrible, so we decided to try 16 units of Afrezza in place of his injectable prandial insulin. Today, he was in for an acute care visit concerning another issue, but he brought in his glucose log and it was truly amazing..The vast majority of his readings were well less then 200 except his readings prior to the evening meal. But the most astounding revelation was that he had stopped taking his morning Lantus. He was ecstatic and so was I. I told him to split his Lantus 30 units every 12 hours to bring his evening sugar down. (Lantus is a lousy once a day basal insulin). Once again, it was astounding. I know you shorts are going to blast this note, but to prove how much this event has made me believe in Afrezza, I will self bump this daily on the message board until I sell my MNKD years from now. It will be there every day for every one to see and if I'm wrong the detractors will have ample opportunity to tell me so I am absolutely convinced that this will be one of the best selling drugs of all time and I believe every diabetic without contraindications will be using Afrezza. _______________________________________________________________________________________ So what doctor.stockpicker (has claimed in his YMB post quoted above to) have observed has now been confirmed by other users. What is the significance of this phenomenon?
Please share your thoughts. |
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Post by peppy on Sept 18, 2015 20:09:08 GMT -5
The first post:
I think the first person stopped by this board and told us her story. I have a picture of her filed in a post. Added: there she is. used exubera first for years. Likes Afrezza. screencast.com/t/jygnHHWxMbD
The second post, I am doubtful that a physician would post.
We need to be careful here.
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Post by liane on Sept 19, 2015 5:29:06 GMT -5
peppy,
I really wish you would learn to use the quote feature on this board. I have no idea what posts you are referencing; and it's a PITA to scroll through the entire thread to try and figure it out.
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Post by peppy on Sept 19, 2015 6:08:19 GMT -5
peppy, I really wish you would learn to use the quote feature on this board. I have no idea what posts you are referencing; and it's a PITA to scroll through the entire thread to try and figure it out. The post directly above; quote: Aslo, as I posted in this thread previously, ML (Granger, who has been on Afrezza for over five year)'s case also illustrate this regenerative effect of Afrezza.
Here is what she says (under the user name: bob_marylou_granger) on tudiabetes.org: “I have been a Type 1 diabetic for 58 years. After 52 years of thousands of injections, I became needle-phobic. The OUCH you think is minor to you is not minor to millions of others. ….Spent 5 1/2 years in a research study trial using AFREZZA inhaled insulin. I have not had to take an insulin injection during those 5 1/2 years. Believe me, I know that is not a cure. But for now it is the best out there for those of us struggling physically and emotionally with injections.”
www.tudiabetes.org/forum/t/insulin-independence-revolutionary-phase-3-trial-giving-type-1-diabetics-the-promise-of-a-needle-free-life/46721/15
Here is what she says in this forum:
"When I first joined the MannKind trial, I was injecting Lantus in the morning at breakfast and inhaling Exubera with each meal. Before Exubera had been taken off the market, I had stockpiled quite a large supply. It could be stored on a shelf at room temperature, no refrigeration was needed.
In the beginning, I still took my Lantus at breakfast and then began using the Technosphere {Afrezza as it is now called} with each meal. My BG levels began to drop. My doctor kept lowering the Lantus until he suggested I drop the injections completely. It took me a couple of days to work up my courage, but the idea of not taking ANY shots was worth it. It worked for a few weeks, and then my BG levels started to rise. Terribly disappointed, I went back on the morning Lantus shots and inhaling at each meal. Shortly, my BG levels dropped again, and my doctor took me off injections again. From then on, NO SHOTS!!! No one can explain it --- it just is!
ML"
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she is the lovely lady who came by the board months ago. told us her story with this picture. You know what I pain in the.... I am about pictures, I have one with her. screencast.com/t/jygnHHWxMbD screencast.com/t/Ab2vH63GqdV
======================================================================================== The rest of the post pertained to the other poster quoted in the post above, the post in question. Very long post. As usual, opps and sorry.
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