An Investor's View Of Where MannKind Is With Afrezza

[ezrasfund]

Here's a back of the envelope idea for when the MNKD/SNY joint venture will begin to show positive cash flow. MNKD has the ability to draw on a $175 million line of credit from SNY. Al's rule of thumb is to figure out how much money you think you will need and then triple it. From this I conclude that that MNKD expects to show losses in the $60 million range from the JV before becoming cash flow positive,and the total joint venture is prepared to invest over $500 million ($175x3) before throwing in the towel.

[robsacher]

Aug 21, 2015 18:03:33 GMT -5 prosper said:

Your comment implies a reduction in the profitability of A for both S & M.
I think that is worthy of a new discussion of what that implies and means.
The more i think about the situation, the more i think the old "reasons" for slow adoption of A are real, but not the real brick wall we are hitting and will continue to hit. That huge wall is insurance. No matter how good A is, if the discounts for early users disappears after an intro, then the cost will stop any growth now, and sour people that now tried but had to drop out because of costs.
I think the fantastic reports from users are good, but i also think that the more i read the more i am concerned that even these very sophisticated and aware type !'s that are going through the efforts to experiment with trial and error and documented efforts are not indicative of what the giant market of type 2's will be willing to do.
Net result of my thinking this through is that neither S or M are currently prepared to hand hold the type 2's through the increasingly complex process of becoming a knowledgeable and successful user of this wonderful drug.
That means they are either oblivious to what is going to be required, or they have been prescient in their awareness that we need a documented experiential record of actual users in order to write the "manual" of how to actually use this wonderful invention.
There are three goals for A. An operating manual (detailed, including "tweaking hints"), higher level insurance coverage, and going back to the first point, education of doctors on all levels on how to manage A.
As great as A is, it is not "take a puff before your meal".

Prosper,

T1 and T2 populations are quite different and we 've seen mostly T1s using Afrezza, so far. Insurance issues will have to be ironed out next year and when that happens we will see a lot more T2s begin using Afrezza. T2s do not have to be as vigilant as T1 diabetics in their administration of insulin. It's a different disease. All T2s have to do is take Afrezza at the start of a meal. Follow up is a lot less likely in their case. Therefore, T2s will not have to know about "the manual" in the way T1s must know it.

RS

[suebeeee1]

Aug 22, 2015 7:58:14 GMT -5 kball said:

Aug 21, 2015 23:43:07 GMT -5 suebeeee1 said:

My husband had been on Afrezza for about 2 1/2 weeks.  

*snip

It seems that he can intake 4 units immediately preceding eating, test about two hours later and (usually) correct with an additional 2 to 4 units at that time.  There have been no hypos.  

*snip*.

2 question
1. How is it possible for a 2 unit correction at this time?

2. Has he tried that first puff 5-10 minutes into that meal to see if that would make correction dose unnecessary?

Twice now, he had " forgotten" to use his inhaler immediately before eating.  Remember this is all new to him.  Both times his BG was still too high.  He doesn't need to correct after every meal.  Mostly this occurs after a large dinner in which he consumed too much pasta (I do hail from Italian stock).  The only real instructions have been obtained through others and the coach program.  It will be nice when all the docs or technicians have been trained.  It all takes time.  

[compound26]

Here is an update on the insurance coverage based on Formularylookup.

Formularylookup on 08.07.2015.


Insurance Status          Toujeo      Afrezza

Preferred                      28%          4%

Covered                        23%          21%

Restricted                     28%          43%

Not Covered                  22%          32%


Formularylookup on 08.24.2015.


Insurance Status          Toujeo      Afrezza      Lantus      Novolog     Levemir

Preferred                      32%          4%          89%          66%          86%

Covered                       19%          22%          6%           5%           2%

Restricted                     27%          42%          4%          15%          9%

Not Covered                  22%          32%          1%          13%          3%

[prosper]

Rob

Thank you for your reasoned response.

I am not diabetic so have no personal experience with the disease, but I have been a firm long following the initially interesting but now cartoon like yahoo board for over 3 years, with all the growing frustration with the idiots there, but have learned how to filter and not even open the idiot's posts. I have actually given up on that board because unless i monitor daily I miss the good posts and have to wade thru the crap. I still work for a living, so i don't have time to waste. it is really a shame because i really learned a lot from the yahoo board years ago. I am now continuing with this board that is truly worth my time and actually legitimately factual as well as humorous. I think Spiro is worth a reality tv show, and I mean that in a complimentary and serious way. With the real number of diabetics in the usa, that could be a Nielsen hit.

Be that as it may, I now solely rely on this board. Thank you Lianne and the other moderators in your excellent editing. It is a tough job.

I am classified as a newbie because of my low number of posts, but i think they were worth consideration in their serious intent, despite my typo of hypo v hyper.

I really don't care about my "classification" except I hope I can get responses to my questions

[liane]

prosper,

Thanks for the comments! The classifications don't really carry a lot of weight. Just 11 more posts and you'll be a lab rat . There are so many knowledgeable posters here, and they are always willing to answer sincere questions.