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Post by charlespk on Sept 13, 2015 12:22:47 GMT -5
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Post by peppy on Sept 13, 2015 12:42:21 GMT -5
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Sodium-glucose co-transporter 2 (SGLT2), expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. Canagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, canagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose (RTG), and thereby increases urinary glucose excretion (UGE). Canagliflozin is practically insoluble in aqueous media from pH 1.1 to 12.9. www.invokanahcp.com/prescribing-information.pdf================================================================================================================================================= my personal preference would be spinach salad and beans. |
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Post by liane on Sept 13, 2015 12:45:02 GMT -5
Wow - 1st euglycemic ketoacidosis, now osteoporotic bone fractures. Not to mention UTI's. Sounds like a drug I would love to try (not!).
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Post by kball on Sept 13, 2015 14:34:24 GMT -5
Wow - 1st euglycemic ketoacidosis, now osteoporotic bone fractures. Not to mention UTI's. Sounds like a drug I would love to try (not!). So sanofi reps CANT claim ultra rapid as of now, but it would seem they could bring up these points regarding other drugs? |
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Post by mssciguy on Sept 13, 2015 14:47:08 GMT -5
Wow - 1st euglycemic ketoacidosis, now osteoporotic bone fractures. Not to mention UTI's. Sounds like a drug I would love to try (not!). Yeah I heard that there was an Afrezza ad in Cooking light magazine, went to the library, they had the Sept edition, the warning was for penile and vaginal yeast infections. That magazine has about a dozen drug ads, but not for Afrezza in Sept--- must be the Oct edition. |
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Post by liane on Sept 13, 2015 14:47:24 GMT -5
kball,
Absolutely!! It's fair game.
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Post by notamnkdmillionaire on Sept 13, 2015 14:57:07 GMT -5
Wow - 1st euglycemic ketoacidosis, now osteoporotic bone fractures. Not to mention UTI's. Sounds like a drug I would love to try (not!). Yeah I heard that there was an Afrezza ad in Cooking light magazine, went to the library, they had the Sept edition, the warning was for penile and vaginal yeast infections. That magazine has about a dozen drug ads, but not for Afrezza in Sept--- must be the Oct edition. Some might argue that investing in Mannkind of the last 10 years has had the undesirable side effect of incontinence and IBS. |
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Post by nylefty on Sept 13, 2015 15:38:41 GMT -5
It would be refreshing if we could participate on this message board without being subjected to political propaganda such as the multiple doses of Thomas Sowell that we get here almost every day. Could we dispense with Sowell, or should I post Paul Krugman quotes here each day?
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Post by ripano on Sept 13, 2015 18:31:02 GMT -5
Thomas Sowell is brilliant. He speaks clearly and concisely. How does that offend anyone ?
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Post by nylefty on Sept 13, 2015 19:48:13 GMT -5
Thomas Sowell is brilliant. He speaks clearly and concisely. How does that offend anyone ? Paul Krugman is also brilliant and speaks clearly and concisely. Thomas Sowell is a staunch conservative who opposes Medicare and many other government programs, while Krugman supports Medicare and most of the programs that Sowell opposes. I can understand why conservatives like Sowell and why liberals like Krugman, but the thoughts of neither should be pounded into our consciousnesses on this board on a daily basis. |
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Post by notamnkdmillionaire on Sept 13, 2015 19:48:43 GMT -5
It would be refreshing if we could participate on this message board without being subjected to political propaganda such as the multiple doses of Thomas Sowell that we get here almost every day. Could we dispense with Sowell, or should I post Paul Krugman quotes here each day? Free speech for thee but nor for me. Typical of a NYlefty.  But I will take it down as you are offended by anything that doesn't fit your ideological persuasion. |
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Post by liane on Sept 13, 2015 20:01:48 GMT -5
nota - thank you for keeping this from escalating.
OK - let's keep the politics to a dull roar. I don't want to have to lock the thread.
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Post by nylefty on Sept 13, 2015 20:14:50 GMT -5
It would be refreshing if we could participate on this message board without being subjected to political propaganda such as the multiple doses of Thomas Sowell that we get here almost every day. Could we dispense with Sowell, or should I post Paul Krugman quotes here each day? Free speech for thee but nor for me. Typical of a NYlefty. But I will take it down as you are offended by anything that doesn't fit your ideological persuasion. No, I'm suggesting that both conservatives and liberals refrain from posting divisive political rhetoric. I see that you've now substituted one conservative quote for another, so maybe I should now quote FDR or LBJ. |
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Post by peppy on Sept 13, 2015 20:32:15 GMT -5
when you figure out how to add the quotes, let me know. I am sure I can type something that will offend everyone.  |
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Post by esstan2001 on Sept 14, 2015 8:32:37 GMT -5
when you figure out how to add the quotes, let me know. I am sure I can type something that will offend everyone. ...an equal opportunity offender? I LIKE IT !!!  |
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But I will take it down as you are offended by anything that doesn't fit your ideological persuasion.
