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Post by rrtzmd on Oct 20, 2015 11:08:50 GMT -5
I am not really sure what the argument is here. Surely rrtzmd is not suggesting that Afrezza does not reach the deep lungs. Is the suggestion that the dreamboat design is somehow inferior and substandard? It is well know that some of the TI powder is left in the mouth and throat, but that is accounted for in the cartridges that do not contain 4 units of insulin, but a 4 unit equivalent, for example. I am not a scientist, but that bong gif did remind me of a certain device made by Nektar Therapeutics. The OP made the assertion, "So if you wanted maximum disbursement of your drug that has to go through a bunch of twists and turns, would you want it shot out of a cannon...or would you want it as slow as possible to get where it needs to go." He further asserted that afrezza had specific qualities that made it "non-aerodynamic" and which resulted in it somehow "slowing down." However, that's simply incorrect. The afrezza particles are TINY relative to the total mass of air. Once they are suspended in the airflow, they move at the same speed as the air! Hand someone a baseball and time a 100 yard dash. Then hand them a football or an egg -- would that affect how fast they ran the 100 yards? The "disbursement" is determined primarily by turbulence at each bifurcation. That's why so much afrezza gets deposited at the back of the throat -- the air flow slamming into the back of the throat not only causes direct impaction of the afrezza particles, but also generates a great deal of turbulence which contributes to the particles getting "tossed out" of the air flow and against the walls of the airway. That's why 60% of the afrezza in each cartrdige NEVER reaches the alveoli. The "energy" of the airflow is dissipated by turbulence at each bifurcation. A "bong" would be more effective than a simple inspiration, because it would generate a larger amount of energy that overcomes the reduction caused by the turbulence. Like I said, the particle's shape, etc, IS important in effective "de-agglomeration" of afrezza while inhaling but otherwise but does little to affect the distribution. |
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Post by rrtzmd on Oct 20, 2015 11:24:42 GMT -5
"Airways have distinct and very important laminar and turbulent properties."  Yes! To the flow of AIR! I agree entirely! You DO understand that the OP was talking about the specific properties of the afrezza particles and how their shape, etc, made them "non-aerodynamic" and thereby affected distribution? The relatively TINY amount of TINY afrezza particles CANNOT affect the "laminar and turbulent properties" of the AIR FLOW and, therefore, are practically irrelevant to the particles' distribution. You would get about the same distribution if you inhaled smoke or any other fine particulate. "...basis of gas exchange..." No! Gas exchange is determined by the PARTIAL pressures of the gases. Partial pressure is analogous to concentration and has nothing to do with the airway pressure. Oxygen, for example, simply moves down a gradient from an area of higher partial pressure/concentration in the alveolus to an area of lower partial pressure/concentration in the blood. As far as "gibberish," are you referring to this: "The only IMPORTANT place where particle properties matter is in the "de-agglomeration" from inside the cartridge. It's important that afrezza gets broken up as much as possible into the smallest fragments possible in order to assure maximum distribution. Consequently, things like electrostatic attraction, geometry, weight, etc, contribute to how well it "de-agglomerates." But once broken into its smallest fragments and in the air flow, nothing specific to the particles matters much in terms of affecting distribution to the distal lung." That is not "gibberish." "De-agglomeration" is "The process of breaking up or dispersing that which has agglomerated, or aggregated, or clustered together." That is what happens to the afrezza in the cartridge as the Venturi effect produces a vacuum to suck the afrezza up. I would think it would be obvious that the specific properties of the particles could have significant effects on that process. Sorry, but there is no "gibberish" there. |
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Yes! To the flow of AIR! I agree entirely! You DO understand that the OP was talking about the specific properties of the afrezza particles and how their shape, etc, made them "non-aerodynamic" and thereby affected distribution? The relatively TINY amount of TINY afrezza particles CANNOT affect the "laminar and turbulent properties" of the AIR FLOW and, therefore, are practically irrelevant to the particles' distribution. You would get about the same distribution if you inhaled smoke or any other fine particulate.