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Post by nemzter on Jan 28, 2014 19:35:43 GMT -5
Ashiwi, thanks so much for your update as well.
Glad both of you guys took the time to attend this and give us an update.
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Post by babaoriley on Jan 28, 2014 19:48:50 GMT -5
Great synopsis, Ashiwi! You and Spiro have done everyone a solid by pulling whatever strings you had to pull in order to be included in the audience. And by sharing your experience, along with your impressions.
Hoping that investors learn of the great opportunities for Afrezza and Technosphere prior to March 28, and decide to bid the stock up moving into that date. If we go there without a partnership, I'll hope for $7.50 to $8.00. And I'm hoping that because, as you said in your post, "all endpoints were met and they are optimistic regarding approval, but you just never know with the FDA." And I (along with most of us) can bear witness to that!
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Post by notamnkdmillionaire on Jan 28, 2014 20:04:16 GMT -5
what, no inhalable viagra?! That's it. I'm selling first thing tomorrow morning!!!!
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Post by spiro on Jan 28, 2014 20:14:48 GMT -5
I am the old guy on the right' t.
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Post by ashiwi on Jan 28, 2014 20:28:58 GMT -5
Nice Dreamboat Spiro.
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Post by Chris on Jan 28, 2014 20:31:45 GMT -5
I am the old guy on the right' t. Great picture! I hope he let you keep the inhaler. haha
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Post by savzak on Jan 28, 2014 21:01:53 GMT -5
Old guy? I don't see any old guys in that photo. What old guy?
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Post by mnkdfan on Jan 28, 2014 21:04:21 GMT -5
Hi Spiro and Ashiwi, I was looking forward to reading your conference update all morning. Like others, I wanted to thank you two for sharing your notes with us very much. It's been a dissapointing pull back from $7.00+ since the Adcom news, but reading your update today and following the discussions from this board have been so re-assuring. I have always been a believer in the science of Afrezza but I know there's more involved to get to the finish line. If nothing else, the DD you folks have put in and willingness to share your knowledge, that good karma has to be rewarded with positive outcome! Wished I could speed up time MNKDFAN
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Post by Stop Naked Shorting on Jan 29, 2014 3:17:28 GMT -5
OK I finally have a few minutes to relate to you all about this morning. WOW, as Spiro already expressed we both left never feeling more confident about MNKD. Remember this was a meeting about Drug Delivery. With lots of big and small pharma companies in attendance. Al Mann delivered a great keynote address giving us a run down of his amazing career. From US gov't aerospace to the Pacemaker, Minmed, insulin pump, Cochlear implant, Retina implant. He has sold 11 companies for something around 8 billion dollars. He was extremely cordial and friendly and we had a few nice conversations. His goal in life is to meet unmet needs. It's what keeps him going. As he was saying that I saw his wife (who was sitting directly in front of me) nodding her head in agreement. It certainly doesn't look like he's about to slow down anytime too soon. Some stats he mentioned that in 10 years 1/2 half of all adults will be either diabetic or pre-diabetic and the cost to healthcare will be 3.5 Trillion dollars. He went on with some of the benefits of Afrezza which most of you reading this already know. He did mention that a post-approval study will be done to show that Afrezza will show superior A1c. The current studies showed that it is non-inferior. He is very confident it it's reduction of A1c. All endpoints were met and they are optimistic regarding approval, but you just never know with the FDA. He is involved with another company that is working on a basal insulin patch. This would compliment the prandial insulin supplied by Afrezza. Still years away. Enormous potential in my opinion. He believes that the deficiencies in the current insulins have brought many oral meds such as Metformin to market. Many of these have side effects and are detrimental in the long run. Afrezza early on could reduce these pills as well. Technosphere has as much if not more potential in the market place as Afrezza. It was very technical, but Dr Leone-Bay gave an excellent presentation on the actual process. Could be a bout 20 different indications for Technosphere with Pain being # 1. This is where the Cricket device will be utilized. It's a one time device which is tiny and very easy to use. Have a migraine? Take a hit on your Cricket. Bam you are feeling relief. Technosphere for pain will compete with Opioids such as Morphine but with no side effects. There are studies taking place now with mice. Another indication was found to decrease food consumption. How big is the weight loss market???$$$. Technosphere will NOT be utilized with Viagra as it would lower blood pressure too fast. Any way just to repeat Al Mann's closing statement as Spiro already stated "... Imagine the Possibilities..." Can you elaborate on what exactly was said about post approval study will be done to show that Afrezza will show superior A1c. In next sentence you stated "current studies showed that it is non-inferior" prior to this conference many were under impression one of the affinity trials was non-inferior and the other was superior. Are you sure he said both trials were non-inferior ?
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Post by ashiwi on Jan 29, 2014 8:03:14 GMT -5
Sorry I rally can't elaborate. He really didn't go into specifics. It was just an over view. If he did, my notes didn't get it.
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Post by spiro on Jan 29, 2014 8:50:10 GMT -5
I believe he said something like, it should be easy show clear superiority in post approval studies. hw did not elaborate on this issue.
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Post by spiro on Jan 29, 2014 11:29:38 GMT -5
Fraser, welcome to the board and of course that question was asked, but not really answered. We asked if they expect a partnership before approval. The response was some are interested pre-approval and some are interested post approval. it was also mentioned that Greenhill was doing a great job. We did not talk with any of the other participants at the conference. But of course, I would have liked to have told some of the major company representatives there, that there CEO is going to look pretty stupid in 2 years or so, if they passed on the opportunity to partner with MNKD. I hope this helps.
Spiro
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Post by relmor on Jan 30, 2014 1:08:37 GMT -5
Sorry I rally can't elaborate. He really didn't go into specifics. It was just an over view. If he did, my notes didn't get it. Just wanted to thank you for the information. Come from another board had to register for taking the time to post what was said and went on at the conference. Been following MNKD since early 2012 on our forums over at kingofalltrades.com. We have about 15 investors over there right now...Hope to read and post on this board all time now...
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