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Post by mnholdem on Nov 2, 2018 17:49:36 GMT -5
Lol! Yeah ditch those pills guys where you have to schedule your time, We’ll buy you the Dreamboat. Fast on-set short-tail control. You girls are jesting with the primal jender so I must bring this to your attention: "Boys will be boys, and even that wouldn't matter, if only we could prevent girls form being girls." From the diary of Anne Frank. What a mind this 14 yr old must have had. Timeless!
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Post by brotherm1 on Nov 2, 2018 19:02:59 GMT -5
no. With Viagra off patent there is a pick up in old men interest for old women. I swear. Lol! Yeah ditch those pills guys where you have to schedule your time, We’ll buy you the Dreamboat. Fast on-set short-tail control. Good one Sports. I like that. Ultra fast short/tall control
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Post by mango on Nov 2, 2018 23:06:55 GMT -5
I go back and forth between Epinephrine and PDE5 as the next drug on TS. The more I think about it, PDE5 makes the most sense for UTHR. It's on page 2 on website under pipeline. Personally, an inhaled drug for ED! So many patients have told me how they hate taking an ED drug then striking out with a young lady. These pills are about $50 a pop. Some of you may make fun of my statement but to patients it is a real problem. epinephrine, is available for license from MNKD. viagra is generic now selling for 2 dollars for 20 mg. The tablets were at times dosed 100 milligrams when prescribed. It is a math problem. now put it in an inhaler, patent good? Sildenafil is our Bucket #3
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Post by brotherm1 on Nov 3, 2018 0:48:07 GMT -5
So we do have viagra!
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Post by peppy on Nov 3, 2018 5:10:08 GMT -5
no. With Viagra off patent there is a pick up in old men interest for old women. I swear. Lol! Yeah ditch those pills guys where you have to schedule your time, We’ll buy you the Dreamboat. Fast on-set short-tail control. Little known information. Listening to Marian Diamond university of California Berkeley. "Penis is the Latin or Greek word for tail."
You're welcome.
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Post by patten1962 on Nov 3, 2018 7:02:06 GMT -5
I go back and forth between Epinephrine and PDE5 as the next drug on TS. The more I think about it, PDE5 makes the most sense for UTHR. It's on page 2 on website under pipeline. Personally, an inhaled drug for ED! So many patients have told me how they hate taking an ED drug then striking out with a young lady. These pills are about $50 a pop. Some of you may make fun of my statement but to patients it is a real problem. epinephrine, is available for license from MNKD. viagra is generic now selling for 2 dollars for 20 mg. The tablets were at times dosed 100 milligrams when prescribed. It is a math problem. now put it in an inhaler, patent good? Peppy, Thank you. Last I knew they were paying upwards of $50. I was unaware the price came down so much. With that said, still think PDE5 will be next drug on TS. I thought Mannkind put Epinephrine on hold about a year ago to work on Trepostinil? Thanks.
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Post by akemp3000 on Nov 3, 2018 8:03:45 GMT -5
Al Mann always said ED treatment would not be an option for Technosphere because the ultra-rapid action could cause a dangerous drop in blood pressure too quickly. He was rarely wrong but maybe he was wrong on this one. Or maybe he had not yet realized the control that would become possible with new technology to monitor inhalation. I remain skeptical of this use as intoxicated users might be dissatisfied with the immediate results and decide to take a second hit which could prove Al right. Good discussion though.
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Post by peppy on Nov 3, 2018 8:05:54 GMT -5
epinephrine, is available for license from MNKD. viagra is generic now selling for 2 dollars for 20 mg. The tablets were at times dosed 100 milligrams when prescribed. It is a math problem. now put it in an inhaler, patent good? Peppy, Thank you. Last I knew they were paying upwards of $50. I was unaware the price came down so much. With that said, still think PDE5 will be next drug on TS. I thought Mannkind put Epinephrine on hold about a year ago to work on Trepostinil? Thanks. This is getting to be an old/time screen cast image. Hold is right.
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Post by peppy on Nov 3, 2018 8:09:29 GMT -5
Al Mann always said ED treatment would not be an option for Technosphere because the ultra-rapid action could cause a dangerous drop in blood pressure too quickly. He was rarely wrong but maybe he was wrong on this one. Or maybe he had not yet realized the control that would become possible with new technology to monitor inhalation. I remain skeptical of this use as intoxicated users might be dissatisfied with the immediate results and decide to take a second hit which could prove Al right. Good discussion though. PAH is different. It isn't our fault tadalafil is Cialis. This image from a Gilead study.
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Post by mytakeonit on Nov 3, 2018 14:46:04 GMT -5
Wow, like going back to college listening to Marian Diamond. She seems like a good lecturer and her class seems jammed packed with info.
Seems almost like peppy and sports were in collaboration on the topic of short-tail control especially with the "penis means tail" topic. (26 minutes)
But Latin is Greek to me and I don't think that I am walking backwards. If I was ... it would give me "hysteria" about what's chasing me ...
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Post by mango on Nov 16, 2018 13:46:16 GMT -5
METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION Type: Application Filed: January 9, 2018 Publication date: November 15, 2018 Applicant: United Therapeutics Corporation Inventor: Martine A. Rothblatt The present invention relates to compositions and methods for treating pulmonary hypertension based on administering to a subject in need thereof a nitric oxide (NO)-releasing compound and a phosphodiesterase type-5 (PDE5) inhibitor. Claims: 40. The method according to claim 37, wherein one or both of the phosphodiesterase type-5 inhibitor and the NO-releasing compound are formulated as a pharmaceutical composition adapted for nebulization into liquid or dry powder medical aerosols for delivery by inhalation to the subject. 41. The method according to claim 40, wherein the pharmaceutical composition is administered to the subject with a metered dose inhaler such as a dry powder inhaler or a soft mist inhaler capable of delivering a fixed amount of the pharmaceutical composition per pulse. patents.justia.com/patent/20180325908
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