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Post by georgethenight2 on Aug 16, 2019 23:34:03 GMT -5
I dont want to say it, but I think we will never see this come to fruition. To many deep pocketed competitors researching and pushing forward. Case in point, $MO investment in $CRON. News is a little old but, www.globenewswire.com/news-release/2019/05/07/1818293/0/en/Cronos-Group-Opens-Cronos-Device-Labs-New-Global-R-D-Center-in-Israel.htmlWith nearly $2b invested in $CRON Altria will be hard to beat IMO. Personally, I am ok with that, as I have been a happy $MO holder for nearly 15 years. If they got something/anything show the world, certainly increases chance of further funding with a product, not just the idea of one. IMO cannabis/ canaboid space is huge, but highly speculative, as valuations are not connected to actually sales but the potential to gain market share and sell. I think we see a dot-com-esk event where only those with cash will survive, and the smaller entities whose real value are tech and ip get bought for pennies on the dollar. My point, RLS NOW has the opportunity to access funding and become relavent. Yet, they like Afrezza sales languish and let the current take them where it may go, instead of being proactive and grasping this amazing chance! But hey. With ALTRIA I am paid to wait. Just put an order in on Thursday. |
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Post by brotherm1 on Aug 17, 2019 0:02:35 GMT -5
Vapes? What? What the hell are you smoking George? 😎
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Post by georgethenight2 on Aug 17, 2019 0:12:26 GMT -5
Vapes? What? What the hell are you smoking George? My point. First to market. Regardless of inhalation method. Jesus, look at Afrezza compared to traditional injectable insulin, we are really winning in that space. |
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Post by sayhey24 on Aug 17, 2019 6:01:30 GMT -5
George - I am not exactly sure why RLS is not announcing more but we will hear more over the next 5 months. When it happens RLS will quickly become the leader of the pack. While Altria is just starting their research MNKD was working on CBD on technosphere even before there was an RLS.
To demonstrate proper dosing to the FDA for various CBD based drugs "the vaporization space" which "is rapidly evolving" is going to find it difficult. In the recreational space "vaping" which was once cool is now starting to take on a bad name.
Now, an Altria purchase of MNKD would be an interesting one but I am not starting that rumor.
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Post by lennymnkd on Aug 17, 2019 6:42:12 GMT -5
My sentiments exactly/ also thought this was about proper dosing .
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Post by nylefty on Sept 8, 2019 12:22:12 GMT -5
www.medpagetoday.com/meetingcoverage/painweek/82033Can Cannabis Replace Opioids for Pain Tx? by Elizabeth Hlavinka, Staff Writer, MedPage Today September 07, 2019 LAS VEGAS -- Can concurrent cannabinoid and opioid use enhance analgesic effects, or should their combined use be avoided? Presenters at the 2019 PAINWeek conference took on this question, agreeing that many of the effects associated with cannabinoids remain unknown. "I feel like I'm speaking to the choir here -- this is something we're all dealing with already," said Chris Herndon, PharmD, of Southern Illinois University in Carbondale, Illinois, at a talk entitled "Cannabis and Opioid Together: Syn or Synergy?" The proportion of patients in primary care clinics that are on chronic opioid therapy and using cannabis has been reported to be anywhere from 16% to 25%, Herndon said. As such, the potential harms and benefits are certainly something that "need to be discussed." There are as many as 400 constituents of the cannabis plant, 66 of which are of the cannabinoid structure, including tetrahydrocannabinol (THC) and cannabidiol (CBD). They each have a number of different pharmacological modalities, many of which support the idea of using these drugs to treat pain, including calcium channel antagonism, downstream effects on lysergic glutamatergic, and potential N-methyl-D-aspartate receptor (NMDA) activity, Herndon said. He cited one recent study that found adding medical cannabis to opioid therapy among fibromyalgia patients was associated with significant improvements in pain, measured through the visual analog scale, fibromyalgia pain severity scales, and disability measures. However, cannabis may affect pain tolerance in a bell or j-shaped curve, in which stimulating pain receptors at certain levels can actually produce a hyperalgesic effect, countered Bradlee Rea, PharmD, of Kaweah Delta Health Care in Visalia, California. "THC may actually reduce a patient's tolerance or ability to tolerate pain," Rea said. Herndon argued that at the right ratio, CBD and THC together have been shown to reduce pain. For example, one study that tested four different cannabis varieties in patients with fibromyalgia found much greater improvements in pain with Bediol -- which contains 13.4 mg THC and 17.8 mg CBD -- than with Bedrocan, which contains mostly THC (22.4 mg THC and <1 mg CBD). But the problem is that in practice, medical marijuana can be a "potpourri surprise," Rea said, and the majority of studies examining analgesic effects of cannabidiol are not standardized in terms of strain, species, or dosing. "We have agonists, we have antagonists, we have inverse agonists," Rea said. "How do we figure out what is going on when we have so many different products in the flower of cannabis? How do we know what product is doing what without more data looking at least in vitro at some of these constituents found in marijuana?" Rea added that cannabidiol could be functioning by changing how patients perceive their pain, reducing pain catastrophizing, or decreasing the amount of other medications they use. Herndon said in a clinical environment that is increasingly encouraging opioid alternatives, this could be one advantage to cannabinoids. In a 2019 study, nearly three-quarters of patients who completed a survey said they were able to completely terminate their opioid use after they started using cannabis for chronic pain, he noted.
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Post by peppy on Sept 16, 2019 10:33:20 GMT -5
This was news to me, although I believed cannabis did effect blood glucose levels, hence the munchies.
"Type two diabetic given cannabis/hemp oil for sore joints. His blood glucose level dropped from mid 200's to mid 90's, it is insulin sensitizing."
This is one interesting video.
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Post by mango on Sept 16, 2019 10:53:53 GMT -5
This was news to me, although I believed cannabis did effect blood glucose levels, hence the munchies. "Type two diabetic given cannabis/hemp oil for sore joints. His blood glucose level dropped from mid 200's to mid 90's, it is insulin sensitizing."This is one interesting video. Cannabis turns on fat burning (apoptosis) via the CB2 receptor and endogenous cannabinoids, Anandamide and 2AG, both play a role in glucose homeostasis (insulin secretion etc). Anandamide is the endogenous cannabinoid which THC mimics. Both are responsible for stimulating hunger via CB1 receptor |
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Post by peppy on Sept 16, 2019 11:08:34 GMT -5
This was news to me, although I believed cannabis did effect blood glucose levels, hence the munchies. "Type two diabetic given cannabis/hemp oil for sore joints. His blood glucose level dropped from mid 200's to mid 90's, it is insulin sensitizing."This is one interesting video. Cannabis turns on fat burning (apoptosis) via the CB2 receptor and endogenous cannabinoids, Anandamide and 2AG, both play a role in glucose homeostasis (insulin secretion etc). Anandamide is the endogenous cannabinoid which THC mimics. Both are responsible for stimulating hunger via CB1 receptor Mango, I want to say, that your understanding of the cannabinoid system in the body was/is way superior to anything I ever thought. It does seem to be a major human body player. My favorite, besides stopping seizures and muscle spams, the cancer stopping properties. wow. Apoptosis is way under estimated. The marijuana legalization is one of the only thing I can be proud of for the people that lived through the sixties and 70's. As pointed out on the video, many medications had cannabis and the attributes were known. So the name was changed and marijuana was made illegal. As the video points out, it would probably not have been made illegal if it was known what the vote was making illegal. We are so brain washed. |
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Post by mango on Sept 16, 2019 11:10:17 GMT -5
Cannabis turns on fat burning (apoptosis) via the CB2 receptor and endogenous cannabinoids, Anandamide and 2AG, both play a role in glucose homeostasis (insulin secretion etc). Anandamide is the endogenous cannabinoid which THC mimics. Both are responsible for stimulating hunger via CB1 receptor Mango, I want to say, that your understanding of the cannabinoid system in the body was/is way superior to anything I ever thought. It does seem to be a major human body player. My favorite, besides stopping seizures and muscle spams, the cancer stopping properties. wow. Apoptosis is way under estimated. The marijuana legalization is one of the only thing I can be proud of for the people that lived through the sixties and 70's. As pointed out on the video, many medications had cannabis and the attributes were know. So the name was changed and marijuana was made illegal. As the video points out, it would probably not have been made illegal if it was known what the vote was making illegal. We are so brain washed. From over 2 years ago The Endocannabinoid System and Diabetes mnkd.proboards.com/post/96983/thread |
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Post by mango on Sept 16, 2019 11:29:37 GMT -5
Cannabis turns on fat burning (apoptosis) via the CB2 receptor and endogenous cannabinoids, Anandamide and 2AG, both play a role in glucose homeostasis (insulin secretion etc). Anandamide is the endogenous cannabinoid which THC mimics. Both are responsible for stimulating hunger via CB1 receptor Mango, I want to say, that your understanding of the cannabinoid system in the body was/is way superior to anything I ever thought. It does seem to be a major human body player.My favorite, besides stopping seizures and muscle spams, the cancer stopping properties. wow. Apoptosis is way under estimated. The marijuana legalization is one of the only thing I can be proud of for the people that lived through the sixties and 70's. As pointed out on the video, many medications had cannabis and the attributes were known. So the name was changed and marijuana was made illegal. As the video points out, it would probably not have been made illegal if it was known what the vote was making illegal. We are so brain washed. The Endocannabinoid System is a homeostatic regulatory system of bodily function. Global cleansing from Reefer Madness? |
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Post by peppy on Sept 16, 2019 11:36:23 GMT -5
CBD blocks opioid receptors?
marijauna stops morphine?
what?
22 min mark.
stops the opiod high and side effects, oh brother.
also CBD receptors are in the immune system. what mark was that?
immune system, lymph nodes. the macrophage and lymphocytes.
"The bone marrow and thymus are considered as primary immune/lymphoid components because they contain the stem cells that will develop into T cells, B cells and natural killer cells of the functioning immune and lymphatic systems."
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Post by mango on Sept 16, 2019 11:39:15 GMT -5
CBD blocks opioid receptors? marijauna stops morphine? what? 22 min mark. stops the opiod high and side effects, oh brother. also CBD receptors are in the immune system. what mark was that? immune system, lymph nodes. the macrophage and lymphocytes. "The bone marrow and thymus are considered as primary immune/lymphoid components because they contain the stem cells that will develop into T cells, B cells and natural killer cells of the functioning immune and lymphatic systems." The CB2 receptor is the immune system cannabinoid receptor |
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Post by mango on Sept 16, 2019 11:41:37 GMT -5
CBD can also be thought of as a buffer...it’s an endocannabinoid tone modulator
meaning...if the system is too high it brings it back down, too low it brings it back up
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Post by peppy on Sept 16, 2019 11:44:33 GMT -5
Cytotoxic to breast cancer cells?
30 min mark.
breast cancer.
all those pink ribbons.
I had a neighbor that had breast cancer ten years ago, went through treatment.
then this seemingly fine neighbor went to the doctor, and was told the cancer was back.
she started chemo, dead a year later.
her physician told her that studies showed, she would live longer if she took the chemo.
added, known to be effective against MRSA.
this is getting ridiculous.
Methicillin-resistant Staphylococcus aureus (MRSA)
added, last but not least, improvement in Alzheimers.
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