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Post by trondisc on Jan 31, 2016 3:56:31 GMT -5
This Vimeo is friggin' epic. For one moment I'm reminded by Technosphere's incredible technology & how it could change modern medicine...then several sad seconds later I realize my $2.99 cost basis is still screwed.
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Post by therealisaching on Jan 31, 2016 5:20:57 GMT -5
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Post by mindovermatter on Jan 31, 2016 10:57:06 GMT -5
That is an awesome test of Afrezza's viability under extreme conditions. Too bad the stock, MNKD, doesn't have that same toughness. And it might be telling that Afrezza might just be able to survive much longer than Mannkind can. We still remain in the danger zone and the reality is that Afrezza's ability to withstand the heat and stress of temp changes has no bearing on the success of it if Mannkind can not find a way to get it to those who need it in an affordable manner with doctor and insurance company consent.
One thing that did stand out to me is why did he bury it in the dirt? Soil would act as a buffer against the changing air temp. He should have just left it out in the open and not had buried it. And I would still love for him to do more food challenegs, sort of like the "will it blend" series but "Will Afrezza work with XXXX food? Let's see!"
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Post by gamblerjag on Jan 31, 2016 11:38:59 GMT -5
With our luck MNKD won't take advantage of Matt's excellent study.. but Ziploc will probably use it in a commercial in the next 7 days stating how well it keeps moisture out!!!
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Post by kball on Jan 31, 2016 11:52:51 GMT -5
The Martian experiment is an interesting choice by Matt.
But a "Castaway" one might also be appropriate?
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Post by tayl5 on Jan 31, 2016 16:35:53 GMT -5
That is an awesome test of Afrezza's viability under extreme conditions. Too bad the stock, MNKD, doesn't have that same toughness. And it might be telling that Afrezza might just be able to survive much longer than Mannkind can. We still remain in the danger zone and the reality is that Afrezza's ability to withstand the heat and stress of temp changes has no bearing on the success of it if Mannkind can not find a way to get it to those who need it in an affordable manner with doctor and insurance company consent. One thing that did stand out to me is why did he bury it in the dirt? Soil would act as a buffer against the changing air temp. He should have just left it out in the open and not had buried it. And I would still love for him to do more food challenegs, sort of like the "will it blend" series but "Will Afrezza work with XXXX food? Let's see!" The soil would buffer the temperature up as well as down, so the Afrezza would stay warmer as things cooled off in the evening. No one would mistake anywhere in an Australian greenhouse for a refrigerator. As a scientist, I would like to see the negative control on Matt's experiments. What happens if he drinks the soda and doesn't take Afrezza? I assume his BG ramps pretty strongly but it would be good to see that effect and not just the absence of it after Afrezza.
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Post by Deleted on Jan 31, 2016 16:51:56 GMT -5
That is an awesome test of Afrezza's viability under extreme conditions. Too bad the stock, MNKD, doesn't have that same toughness. And it might be telling that Afrezza might just be able to survive much longer than Mannkind can. We still remain in the danger zone and the reality is that Afrezza's ability to withstand the heat and stress of temp changes has no bearing on the success of it if Mannkind can not find a way to get it to those who need it in an affordable manner with doctor and insurance company consent. One thing that did stand out to me is why did he bury it in the dirt? Soil would act as a buffer against the changing air temp. He should have just left it out in the open and not had buried it. And I would still love for him to do more food challenegs, sort of like the "will it blend" series but "Will Afrezza work with XXXX food? Let's see!" The soil would buffer the temperature up as well as down, so the Afrezza would stay warmer as things cooled off in the evening. No one would mistake anywhere in an Australian greenhouse for a refrigerator. As a scientist, I would like to see the negative control on Matt's experiments. What happens if he drinks the soda and doesn't take Afrezza? I assume his BG ramps pretty strongly but it would be good to see that effect and not just the absence of it after Afrezza. any doubts?
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Post by tayl5 on Jan 31, 2016 17:10:49 GMT -5
No doubts. Scientists just like controls. For example, how long does it take for the effect to kick in? How high is the BG likely to go given the Tresiba basal insulin? I don't want Matt (or anyone else) to do anything risky but I'm not a diabetic so I'm curious how these things go. I recall someone mentioning that he had a serious hyperglycemic episode because a server at a restaurant gave him regular Coke or Pepsi instead of diet soda so I don't doubt there is an effect.
I'm impressed that Matt chugged the whole can of Coke on camera like Mean Joe Green. If I tried it, either my head would blow off or you'd hear one epic burp.
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Post by peppy on Jan 31, 2016 17:24:49 GMT -5
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Post by liane on Jan 31, 2016 17:28:27 GMT -5
No doubts. Scientists just like controls. For example, how long does it take for the effect to kick in? How high is the BG likely to go given the Tresiba basal insulin? I don't want Matt (or anyone else) to do anything risky but I'm not a diabetic so I'm curious how these things go. I recall someone mentioning that he had a serious hyperglycemic episode because a server at a restaurant gave him regular Coke or Pepsi instead of diet soda so I don't doubt there is an effect. I'm impressed that Matt chugged the whole can of Coke on camera like Mean Joe Green. If I tried it, either my head would blow off or you'd hear one epic burp. That was my question yesterday in this thread.
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Post by stevil on Feb 1, 2016 3:43:22 GMT -5
That is an awesome test of Afrezza's viability under extreme conditions. Too bad the stock, MNKD, doesn't have that same toughness. And it might be telling that Afrezza might just be able to survive much longer than Mannkind can. We still remain in the danger zone and the reality is that Afrezza's ability to withstand the heat and stress of temp changes has no bearing on the success of it if Mannkind can not find a way to get it to those who need it in an affordable manner with doctor and insurance company consent. One thing that did stand out to me is why did he bury it in the dirt? Soil would act as a buffer against the changing air temp. He should have just left it out in the open and not had buried it. And I would still love for him to do more food challenegs, sort of like the "will it blend" series but "Will Afrezza work with XXXX food? Let's see!" You're right about the soil acting as insulation but he pointed the thermometer at the soil both times. So it's safe to say that it was at least 80 degrees during those 3 and a half months. It would be interesting to see if it could survive in the Sahara, but that should be quite sufficient for room temp and short walks outside. Wasn't there another person, maybe afrezzauser, who left their Afrezza in their car for a couple weeks during the CA summer?
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Post by LosingMyBullishness on Feb 1, 2016 5:58:15 GMT -5
Matt's website is impressive. Exactly how a early adopter page should look like. Authentic, structured, to the point. This really deserves donations!
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Post by mindovermatter on Feb 1, 2016 8:45:44 GMT -5
Matt's website is impressive. Exactly how a early adopter page should look like. Authentic, structured, to the point. This really deserves donations! It is why I scratch my head as to why we have seen very little comments from people using Afrezza. After a year, its pretty much the same people who have been discussing their time on Afrezza. I would have thought we'd see many more people comment on their use while on the drug. Maybe I am expecting too much.
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Post by sla55 on Feb 1, 2016 8:50:21 GMT -5
That is an awesome test of Afrezza's viability under extreme conditions. Too bad the stock, MNKD, doesn't have that same toughness. And it might be telling that Afrezza might just be able to survive much longer than Mannkind can. We still remain in the danger zone and the reality is that Afrezza's ability to withstand the heat and stress of temp changes has no bearing on the success of it if Mannkind can not find a way to get it to those who need it in an affordable manner with doctor and insurance company consent. One thing that did stand out to me is why did he bury it in the dirt? Soil would act as a buffer against the changing air temp. He should have just left it out in the open and not had buried it. And I would still love for him to do more food challenegs, sort of like the "will it blend" series but "Will Afrezza work with XXXX food? Let's see!" You're right about the soil acting as insulation but he pointed the thermometer at the soil both times. So it's safe to say that it was at least 80 degrees during those 3 and a half months. It would be interesting to see if it could survive in the Sahara, but that should be quite sufficient for room temp and short walks outside. Wasn't there another person, maybe afrezzauser, who left their Afrezza in their car for a couple weeks during the CA summer? Yes he did. He mentioned it on Facebook: " Matt Bendall is an Afrezza User in Australia. Some call me AU so I suppose we can call him AU in AU. He is the first person on Afrezza in Australia and has run numerous experiments to show how much better Afrezza is to current injectable insulins. Afrezza has not been approved in AU, but he has been able to get it from the USA at a high expense once he realized out what it can do for his life. His latest article proves the longevity of Afrezza in the heat. I can attest to this as I accidently left some Afrezza in my car for two months in the direct sunlight last summer and it still worked like new. By the way, it works in the cold just as well and cannot wait to use it in the frozen winter lands of Sweden and Norway in a few weeks."
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Post by LosingMyBullishness on Feb 1, 2016 9:02:08 GMT -5
Matt's website is impressive. Exactly how a early adopter page should look like. Authentic, structured, to the point. This really deserves donations! It is why I scratch my head as to why we have seen very little comments from people using Afrezza. After a year, its pretty much the same people who have been discussing their time on Afrezza. I would have thought we'd see many more people comment on their use while on the drug. Maybe I am expecting too much. Mind, Nothing good comes out of scratching your head and being constantly pessimistic beside losing all your hair. If you have some ideas how to improve Mary's website I am sure he would be happy to hear from you.
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