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Post by avichen on May 18, 2016 8:52:20 GMT -5
I don't want to pump or speculate anything... i got a feeling that something is going to be approved... for the kidz...
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Post by Deleted on May 18, 2016 8:55:47 GMT -5
I don't want to pump or speculate anything... i got a feeling that something is going to be approved... for the kidz... You don't have to. The truth is pediatric trials are suspended until qtr 4 with new protocol finalized by qtr 3
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Post by peppy on May 18, 2016 8:59:06 GMT -5
The main disadvantages of pump therapy are: Risk of skin infections at the catheter site. Risk of diabetic ketoacidosis (DKA) from pump malfunction or absorption problems. Cost: pumps are expensive, plus the continuing cost of supplies. Checking blood glucose at least 4 times per day. Letting others know that you have diabetes. Is pump therapy for you? Ask yourself these questions: Are you ready to be attached to a device that lets people know you have diabetes? Do you have realistic expectations? It is not the "magic bullet" that will solve all your blood glucose problems. Hey! If you are going to quote from Joslin at least quote all of it - The Advantages and Disadvantages of an Insulin PumpFrom the same article: The main advantages of pump therapy are: Increased flexibility in lifestyle. Predictable insulin delivery. Precise insulin delivery. Ability to accurately deliver 1/10th of a unit of insulin. Tighter blood glucose control, while reducing the risk of low blood glucose. Reducing episodes of severe hypoglycemia. Reducing wide fluctuations in blood glucose. Helping manage the "dawn phenomenon."On top of those if you are talking about children you can add the ability to deliver insulin without them forgetting, being distracted, or simply not bothering. That's one of the main reasons, aside from all the advantages Joslin mentions, that children are on pumps. Likewise with CGMs as you can monitor their levels over the Internet. Of the disadvantages the big one is the DKA risk from pump malfunction. The delivery tubing occasionally (once a year or so) get obstructed. The pump starts bleeping wildly and you have to fix it or get to insulin within a couple of hours. Fixing it is uncoupling the tubing from the site and repriming which flushes the delivery path. This is not really a problem with patch pumps for obvious reasons! In a world where I am treated like an adult, and I get to choose, I would choose afrezza and a basal. People have a choice now. Many users like technosphere insulin, Mattdownunder can eat. This is huge. The endos I have seen dig in, because they are nervous about delivery system need to open their eyes to choice. With afrezza you do not need, Predictable insulin delivery. Precise insulin delivery. Ability to accurately deliver 1/10th of a unit of insulin.
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Post by kbrion77 on May 18, 2016 9:15:17 GMT -5
Intarcia Therapeutics CEO was on Squawk Box this morning talking about their implantable device for Type 2's this morning. Direct quote, "Injectable therapies are used as last line because people don't like to self inject." But but but I thought needles are so small now a days that it doesn't even phase patients? Will be interesting to keep tabs on this company and see if they have to battle the evil forces as MNKD has.
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Post by agedhippie on May 18, 2016 9:25:57 GMT -5
In a world where I am treated like an adult, and I get to choose, I would choose afrezza and a basal. People have a choice now. Many users like technosphere insulin, Mattdownunder can eat. This is huge. The endos I have seen dig in, because they are nervous about delivery system need to open their eyes to choice. With afrezza you do not need, Predictable insulin delivery. Precise insulin delivery. Ability to accurately deliver 1/10th of a unit of insulin.
I wouldn't argue. My view is that there should be as many choices as possible. Personally I switch between using a pump and not because I find it helps with burnout. I undoubtedly do better on a pump (being able to tailor the basal makes a huge difference - no 3am dip and 5am spike) but sometimes you need a change. The thing is I eat what I want now, Afrezza doesn't give me anything extra there. It would give me a smoother response but it wouldn't change the fundamentals. Oddly the big thing about Afrezza is precisely that is does give predictable and precise insulin delivery! Neither pens nor pumps give reliably predictable delivery although pumps can give precise delivery. The ability to deliver to 1/10th of a unit is extremely important for basals, not really for mealtimes. All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move.
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Post by lakon on May 18, 2016 12:55:07 GMT -5
That's a hard way for the kid to break into modeling. Too bad they didn't use a pen. I heard that doesn't hurt at all. Even stranger that they didn't use a pump since that's what most kids are on which is one injection every 3 days - but that's not going to help their fund raising... Most kids where? I'll settle for a statistic on the diabetic population of children under 18 years of age as internationally accepted on planet Earth. Can you provide a source that shows statistics indicating what you said? I would think that 'most' would be a simple majority at the very least, many might expect a larger percentage. I don't know what the number is so I am serious, but I also think that it is fair to wager that it is less than most.
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Post by agedhippie on May 18, 2016 14:24:05 GMT -5
Even stranger that they didn't use a pump since that's what most kids are on which is one injection every 3 days - but that's not going to help their fund raising... Most kids where? I'll settle for a statistic on the diabetic population of children under 18 years of age as internationally accepted on planet Earth. Can you provide a source that shows statistics indicating what you said? I would think that 'most' would be a simple majority at the very least, many might expect a larger percentage. I don't know what the number is so I am serious, but I also think that it is fair to wager that it is less than most. I'm talking about the US. I would need to find the source again.
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Post by brotherm1 on May 18, 2016 17:03:10 GMT -5
Dear Mr. Hippie. You said, "All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move."
Just the other week I asked you why you do not use Afrezza and your answer was because of lack of insurance coverage where you reside. Now it's a different reason. Sometimes I think you are a wolf in sheeps' clothing. Other times I think you are just fairly up in the years, well read, and argue to be realistic. I'm leaning towards the latter right now. I would think the chance of getting cancer from substances natural to the body would be much lower than from breathing in general in this polluted world. If I am correct in that you are getting long in the tooth, why not take one for the team? Try it and let us know how it works for you. Worst case scenario is your doubts come true and with LC you will most likely pass quickly.
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Post by agedhippie on May 18, 2016 17:20:46 GMT -5
Dear Mr. Hippie. You said, "All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move." Just the other week I asked you why you do not use Afrezza and your answer was because of lack of insurance coverage where you reside. Now it's a different reason. Sometimes I think you are a wolf in sheeps' clothing. Other times I think you are just fairly up in the years, well read, and argue to be realistic. I'm leaning towards the latter right now. I would think the chance of getting cancer from substances natural to the body would be much lower than from breathing in general in this polluted world. If I am correct in that you are getting long in the tooth, why not take one for the team? Try it and let us know how it works for you. Worst case scenario is your doubts come true and with LC you will most likely pass quickly. I'm not keen on taking one for any team! And I'm not yet retired but it's in touching distance... For me there are two parts to this. Does Afrezza work as an insulin? Does Afrezza cause lung problems? I think Afrezza most likely works fine as an insulin and I would have liked a sample pack to test that theory out. The lung side is more tricky. I seriously doubt it causes cancer and my endo agrees. His view is that beyond the increased risk all diabetics see there should be no change (I'm paranoid about cancer because there is a family history on my father's side). However he does think it may cause fibrosis but that we will not see evidence until there is a big population and time has passed. It's a common problem with drugs - the trials all look good and then once it gets widely taken up things start to appear. Since there is little penalty for me to wait and see that's what I am doing (and my insurance doesn't cover it anyway which makes the decision easier). I would still like to try a sample pack though...
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Post by sportsrancho on May 18, 2016 17:43:49 GMT -5
age, I'll see if I can buy you a box off my client. I don't think he has any sample packs. He's traveling though so it will be a few weeks. DM me your address if you like. It's on me:-). sports
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Post by therealisaching on May 19, 2016 4:33:20 GMT -5
Mike C's Twitter feed:
A Team is in place! Thank you to everyone who accepted offers this week. One last opening let's see who the lucky person will be! #winning!
5/19/16 1:54 am
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Post by tripoley on May 19, 2016 6:59:26 GMT -5
That's a hard way for the kid to break into modeling. Too bad they didn't use a pen. I heard that doesn't hurt at all. Even stranger that they didn't use a pump since that's what most kids are on which is one injection every 3 days - but that's not going to help their fund raising... Pumps still can't deal with postprandial spikes. So still 3+ injections a day.
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Post by Deleted on May 19, 2016 7:02:54 GMT -5
Even stranger that they didn't use a pump since that's what most kids are on which is one injection every 3 days - but that's not going to help their fund raising... Pumps still can't deal with postprandial spikes. So still 3+ injections a day. Huh? Pump is used for both basal and bolus
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Post by agedhippie on May 19, 2016 7:14:06 GMT -5
Even stranger that they didn't use a pump since that's what most kids are on which is one injection every 3 days - but that's not going to help their fund raising... Pumps still can't deal with postprandial spikes. So still 3+ injections a day. That's simply wrong and I say that as a pump user.
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Post by tripoley on May 19, 2016 7:19:53 GMT -5
Pumps still can't deal with postprandial spikes. So still 3+ injections a day. That's simply wrong and I say that as a pump user. Really? Which pump are you on that totally eliminates the need for mealtime injections? Because that would be the artificial pancreas which isn't commercially available yet.
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