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Post by yossarian on Jul 14, 2016 16:01:39 GMT -5
How it effects Mannkind is potentially huge. If Technosphere can be shown to allow the taking of drugs without the need for refrigeration, that has a huge impact. Not only for third world countries but for a potential military application. Military medicine would be much simpler if one could get drugs to the battlefield without refrigeration worries. Has application for travelers who need not worry about refrigeration problems. This makes the Technosphere platform potentially much more valuable than previously given credit for. It increases the value of Mannkind to a potential suitor. So it immediate impact is not financial, it is for the potential that is created.
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Post by kbrion77 on Jul 14, 2016 17:17:51 GMT -5
How it effects Mannkind is potentially huge. If Technosphere can be shown to allow the taking of drugs without the need for refrigeration, that has a huge impact. Not only for third world countries but for a potential military application. Military medicine would be much simpler if one could get drugs to the battlefield without refrigeration worries. Has application for travelers who need not worry about refrigeration problems. This makes the Technosphere platform potentially much more valuable than previously given credit for. It increases the value of Mannkind to a potential suitor. So it immediate impact is not financial, it is for the potential that is created. This word has done a lot of damage. I bear full responsibility for my investment in MNKD but I can't help but to brush off that word right about now. Way too many times I got caught up in the potential conversation.
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Post by prosper on Jul 15, 2016 8:37:06 GMT -5
Several references to this new combo talk about the importance in third world areas. While I am sure that any application for sale in the US or much of Euro land would require years of FDA or other first world agencies approval, I wonder if it is possible to eliminate that long drawn out process and go into much faster roll out. Since d O is already approved in most countries, and T has FDA approval in the US, could we begin to save lives thousands of lives in those other areas very quickly. As for military application, does O have a use for battlefield bleeding injuries?
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Post by liane on Jul 15, 2016 8:46:12 GMT -5
As for military application, does O have a use for battlefield bleeding injuries? No. Oxytocin causes smooth muscle in the uterus to contract, thus stemming the bleeding. I don't think it has an effect on clotting factors.
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Post by anderson on Jul 15, 2016 8:59:49 GMT -5
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Post by mnholdem on Jul 15, 2016 10:52:26 GMT -5
As for military application, does O have a use for battlefield bleeding injuries? No. Oxytocin causes smooth muscle in the uterus to contract, thus stemming the bleeding. I don't think it has an effect on clotting factors. I did a post quite some time ago (Oct-2014) that deals with military applications of Technosphere. Here is an excerpt and link if you want to read up on it:
Publication number US6991779 B2 Publication date Jan 31, 2006 Original assignee Mannkind Corporation
Abstract
Compositions containing biologically active molecules encapsulated in self-assembling, diketopiperazine microspheres (TECHNOSPHEREs™) and methods for making and administering such compositions are described herein. The compositions can be used to immunize individuals against agents of biological warfare. The biologically active molecules include atropine, antibodies, antigens, and antibiotics. The compositions can be placed in an inhalation device for self-administration.
DESCRIPTION
The present invention is generally in the field of methods and compositions to neutralize or treat biologicals used especially in bioterrorism or biological warfare.
Prevention of death and disease from biological warfare agents is a concern for people serving the military and for civilians. Agents used in biological warfare include nerve gases, anthrax, ricin, botulinus, cholera, tularemia, and bubonic plague.
Atropine is a nerve gas antidote. Presently, it is delivered either by injection or via the pulmonary route employing a pressurized metered dose inhaler (PMDI). Individuals who are not practiced in self-injection frequently show reluctance to self-administer a drug via injection, let alone during times of stress, such as when under attack with a chemical agent. More importantly, pulling such a device out of a pack and moving all of the clothing and other paraphernalia to reach an appropriate site for injection incurs an unacceptable delay in time of treatment.
Read more: mnkd.proboards.com/thread/1402/wait-cricket#ixzz4EUcV4rUO
I think that this particular MannKind patent also elaborates on the issue of not needing refrigeration as well.
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Post by mydogskip on Jul 22, 2016 7:02:41 GMT -5
Not breaking news. There is no relationship between Mannkind and the Gates Foundation. The Gates Foundation has seeded money to many groups trying to solve this problem and this non profit is one of them. Looking at their website, Mannkind has been gracious to provide Technosphere to produce the inhaled oxy but that's it. For anyone to say that there is some secret relationship between Gates and Mannkind is only making it up in their head. Mannkind's only focus is on Afrezza for their survival. It 's not going to waste its time on a non profit working on inhaled oxytocin that is years away from ever seeing any third world using it. ok. I want to talk about the gates foundation for a second. My take is it never hurts to have friends in high places.
Regarding the gates foundation, the news media reports their number one objective malaria. It would seem the problem has been solved. Gene editing can now change an entire species -- forever | Jennifer Kahn www.youtube.com/watch?v=OI_OhvOumT0 malaria engineered out of mosquito. spread the word
The Gates Foundation deals with many entities. It is not dealing with Mannkind at all. It is a stretch to say there is any relationship between the two. And even if there is, how exactly do you think the GATES foundation is going to help Mannkind and keep it solvent if Afrezza never materializes?
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Post by Deleted on Aug 5, 2016 23:14:55 GMT -5
Really confused by this thread. Is it breaking news that a grant was awarded to Mintaka from B&M Foundation? Not breaking news. There is no relationship between Mannkind and the Gates Foundation. The Gates Foundation has seeded money to many groups trying to solve this problem and this non profit is one of them. Looking at their website, Mannkind has been gracious to provide Technosphere to produce the inhaled oxy but that's it. For anyone to say that there is some secret relationship between Gates and Mannkind is only making it up in their head. Mannkind's only focus is on Afrezza for their survival. It 's not going to waste its time on a non profit working on inhaled oxytocin that is years away from ever seeing any third world using it. Gates Foundation grant made to Al Mann Foundation: • Alfred Mann FoundationDate: September 2004 Purpose: for general operating support Amount: $25,000 Term: 12 Topic: Communications, Community Grants Regions Served: GLOBAL|NORTH AMERICA Program: Communications Grantee Location: Valencia, California www.gatesfoundation.org/How-We-Work/Quick-Links/Grants-Database/Grants/2004/09/OPP36025• Like dozens of the wealthy Americans who joined Bill Gates and Warren Buffett's campaign last year, Alfred and Claude Mann vowed to give a majority of their estate to philanthropy.• In a commitment to the Gates-Buffett Giving Pledge, Mr. Mann laid out a plan to give $100 million to a number of research universities to create biomedical institutes that can advance medical technology.• "I want to use those resources to make this a better world—and to do as much as I can during my lifetime," Mr. Mann wrote in a letter.www.wsj.com/articles/SB10001424052748704005404576176890363445896
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Post by mydogskip on Aug 9, 2016 12:12:07 GMT -5
Not breaking news. There is no relationship between Mannkind and the Gates Foundation. The Gates Foundation has seeded money to many groups trying to solve this problem and this non profit is one of them. Looking at their website, Mannkind has been gracious to provide Technosphere to produce the inhaled oxy but that's it. For anyone to say that there is some secret relationship between Gates and Mannkind is only making it up in their head. Mannkind's only focus is on Afrezza for their survival. It 's not going to waste its time on a non profit working on inhaled oxytocin that is years away from ever seeing any third world using it. Gates Foundation grant made to Al Mann Foundation: • Alfred Mann FoundationDate: September 2004 Purpose: for general operating support Amount: $25,000 Term: 12 Topic: Communications, Community Grants Regions Served: GLOBAL|NORTH AMERICA Program: Communications Grantee Location: Valencia, California www.gatesfoundation.org/How-We-Work/Quick-Links/Grants-Database/Grants/2004/09/OPP36025• Like dozens of the wealthy Americans who joined Bill Gates and Warren Buffett's campaign last year, Alfred and Claude Mann vowed to give a majority of their estate to philanthropy.• In a commitment to the Gates-Buffett Giving Pledge, Mr. Mann laid out a plan to give $100 million to a number of research universities to create biomedical institutes that can advance medical technology.• "I want to use those resources to make this a better world—and to do as much as I can during my lifetime," Mr. Mann wrote in a letter.www.wsj.com/articles/SB10001424052748704005404576176890363445896We aren't in 2004. It's now 2016. There is no relationship, partnership, funding or collaboration between the two at the present time.
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Post by Deleted on Aug 9, 2016 14:21:06 GMT -5
Gates Foundation grant made to Al Mann Foundation: • Alfred Mann FoundationDate: September 2004 Purpose: for general operating support Amount: $25,000 Term: 12 Topic: Communications, Community Grants Regions Served: GLOBAL|NORTH AMERICA Program: Communications Grantee Location: Valencia, California www.gatesfoundation.org/How-We-Work/Quick-Links/Grants-Database/Grants/2004/09/OPP36025• Like dozens of the wealthy Americans who joined Bill Gates and Warren Buffett's campaign last year, Alfred and Claude Mann vowed to give a majority of their estate to philanthropy.• In a commitment to the Gates-Buffett Giving Pledge, Mr. Mann laid out a plan to give $100 million to a number of research universities to create biomedical institutes that can advance medical technology.• "I want to use those resources to make this a better world—and to do as much as I can during my lifetime," Mr. Mann wrote in a letter.www.wsj.com/articles/SB10001424052748704005404576176890363445896We aren't in 2004. It's now 2016. There is no relationship, partnership, funding or collaboration between the two at the present time. I don't care what year we are in. I just showed you an example of how far back the relationship exists, hence, Gates gave Alfred Mann a grant via his foundation. Which also correlates with the time he established Bioness 😉
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Post by mydogskip on Aug 9, 2016 15:44:08 GMT -5
We aren't in 2004. It's now 2016. There is no relationship, partnership, funding or collaboration between the two at the present time. I don't care what year we are in. I just showed you an example of how far back the relationship exists, hence, Gates gave Alfred Mann a grant via his foundation. Which also correlates with the time he established Bioness 😉 A gift to Al's foundation. Not Mannkind which was my point in the beginning. Again, there is no direct relationship to Mannkind the company and Gates Foundation. You can't be that obtuse not to understand that.
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