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Post by alethea on Apr 1, 2017 10:14:45 GMT -5
Agree completely. Unfortunately, I'm not an endo or a diabetic. I just take x-rays of foot ulcers on diabetic patients and feel there HAS to be a better way. Afrezza seems so close to that better way, but I hear so much about a second dose after meals. Why not just take a little larger dose at the beginning of the meal? I seem to recall something about waiting until 5 minutes in as a possible solution. Al didn't seem have a problem with that.
Thanks to this recent bear raid, I have an additional 25 calls for 2019 as a last ditch effort to not miss out on the possibility of success. One way or another, we'll know what's up by then. GLTY
One encouraging thing, I finally had a patient come in who knew about Afrezza and was talking to his endo about it. I'm always very careful not to say too much for legal reasons, of course, but I took it as a positive. Maybe I'll get my money back after all. The teenagers take a 8 or 12 unit 10 min in. No follow up dose. I'm so jealous over those calls:-) Which strike did you buy if you don't mind me asking? I start the timer on my watch the moment I begin eating. I always inhale 12 minutes later. Works very, very well for me. I think Al Mann himself was the first to suggest taking Afrezza 10 minutes AFTER eating.
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Post by sportsrancho on Apr 1, 2017 11:40:23 GMT -5
Yes he did! Right you are:-) And now for some reason it has all gotten so complicated..
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nsmyth
Lab Rat
Posts: 43
Sentiment: Long
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Post by nsmyth on Apr 1, 2017 16:23:51 GMT -5
Every week when I see the script numbers it tells me that SNY was right. Afrezza is not commercially viable in the USA for adults. I just don't see it happening for years, if ever. People are not refilling scripts because it is not working for them. I don't accept the excuse that it is the cost. I check pricing on meds BEFORE I get a script filled. I wouldn't even bother starting on a med I knew I couldn't afford. Is it titration? Could be, but MNKD has had 3 years to work on dosing issues with no success. The market is juvenile diabetes. Where are the studies for that market? Why aren't they completed? Were they even started? Who knows. All I know is that we are on life support and so far behind where we should be at this time that I don't see a future for MNKD through the end of the year. Agreed, I informed my bro in law about afrezza about 9 months ago or so. he was very interested and said he would talk to endo on next visit which he did. Endo did not know about afrezza and said she would research it and discuss on next visit. 6 months later, next visit. Endo says that the results are reported as inconsistent due to things like colds or the fact that the dosage seems to change frequently due to varied results. so she says that no endo that she respects is prescribing afrezza. He asked is she saw the online videos of the product and she said yea and dismissed them. she is in the philly area. very discouraging. :-(
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Post by cjm18 on Apr 1, 2017 19:50:39 GMT -5
Every week when I see the script numbers it tells me that SNY was right. Afrezza is not commercially viable in the USA for adults. I just don't see it happening for years, if ever. People are not refilling scripts because it is not working for them. I don't accept the excuse that it is the cost. I check pricing on meds BEFORE I get a script filled. I wouldn't even bother starting on a med I knew I couldn't afford. Is it titration? Could be, but MNKD has had 3 years to work on dosing issues with no success. The market is juvenile diabetes. Where are the studies for that market? Why aren't they completed? Were they even started? Who knows. All I know is that we are on life support and so far behind where we should be at this time that I don't see a future for MNKD through the end of the year. Agreed, I informed my bro in law about afrezza about 9 months ago or so. he was very interested and said he would talk to endo on next visit which he did. Endo did not know about afrezza and said she would research it and discuss on next visit. 6 months later, next visit. Endo says that the results are reported as inconsistent due to things like colds or the fact that the dosage seems to change frequently due to varied results. so she says that no endo that she respects is prescribing afrezza. He asked is she saw the online videos of the product and she said yea and dismissed them. she is in the philly area. very discouraging. :-( Dosage studies can't come soon enough
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Post by goyocafe on Apr 1, 2017 20:22:46 GMT -5
Every week when I see the script numbers it tells me that SNY was right. Afrezza is not commercially viable in the USA for adults. I just don't see it happening for years, if ever. People are not refilling scripts because it is not working for them. I don't accept the excuse that it is the cost. I check pricing on meds BEFORE I get a script filled. I wouldn't even bother starting on a med I knew I couldn't afford. Is it titration? Could be, but MNKD has had 3 years to work on dosing issues with no success. The market is juvenile diabetes. Where are the studies for that market? Why aren't they completed? Were they even started? Who knows. All I know is that we are on life support and so far behind where we should be at this time that I don't see a future for MNKD through the end of the year. Agreed, I informed my bro in law about afrezza about 9 months ago or so. he was very interested and said he would talk to endo on next visit which he did. Endo did not know about afrezza and said she would research it and discuss on next visit. 6 months later, next visit. Endo says that the results are reported as inconsistent due to things like colds or the fact that the dosage seems to change frequently due to varied results. so she says that no endo that she respects is prescribing afrezza. He asked is she saw the online videos of the product and she said yea and dismissed them. she is in the philly area. very discouraging. :-( When I first read this post, i thought "too bad Afrezza isn't perfect". And then it dawned on me, it's just excuses. If they wanted to find a reason not to prescribe Lantus, Toujeo, etc. (any injectable), they could. Scars, inconsistent absorption, inconvenience, compliance... I could keep going. They don't want to change. IMHO.
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Post by sportsrancho on Apr 1, 2017 20:36:51 GMT -5
They need to be pushed by their patients! And pushed and pushed again..
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Post by cjm18 on Apr 1, 2017 21:17:59 GMT -5
They need to be pushed by their patients! And pushed and pushed again.. The same patients that fight for it will fight to titrate it correctly. They won't give up. Unfortunately a doctor that had a bad experience with it under the sanofi launch won't go through the troubles again. They apparently tell the doctor above about the experience....so it seems.
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Post by agedhippie on Apr 2, 2017 9:43:44 GMT -5
When I first read this post, i thought "too bad Afrezza isn't perfect". And then it dawned on me, it's just excuses. If they wanted to find a reason not to prescribe Lantus, Toujeo, etc. (any injectable), they could. Scars, inconsistent absorption, inconvenience, compliance... I could keep going. They don't want to change. IMHO. Absolutely right. They do not want change. You do not change a patient's treatment unless you think it will produce a better outcome. Right now the data says Afrezza will not give a better outcome so a doctor asked about it will resist change.
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Post by sportsrancho on Apr 2, 2017 17:49:09 GMT -5
If I imagined getting told I had T1 or T2 and had to have meantime shots, there is no way if I knew about Afrezza that I would go with anything else. I don't care if the doctor told me the shots won't hurt, that I'll get used to them. Not a chance! One shot a day is enough. A pump? Are you kidding me? It wouldn't matter to me what the trial results showed. What the black box said! Give me the dreamboat that I can stick in my pocket and don't have to refrigerate. And that won't cause me any pain. That is also kinda cute. I'd want easy!
And it's highly unlikely a Endo would say no to me. If he did I'd call the next one first and tell them I wanted a script for Afrezza before I said yes to the appointment.
That's if I knew about Afrezza!!
And if I found out later that the doctor knew about Afrezza and didn't give me that option. I would be mad as hell!
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Post by agedhippie on Apr 2, 2017 18:03:39 GMT -5
If I imagined getting told I had T1 or T2 and had to have meantime shots, there is no way if I knew about Afrezza that I would go with anything else. I don't care if the doctor told me the shots won't hurt, that I'll get used to them. Not a chance! One shot a day is enough. A pump? Are you kidding me? It wouldn't matter to me what the trial results showed. What the black box said! Give me the dreamboat that I can stick in my pocket and don't have to refrigerate. And that won't cause me any pain. That is also kinda cute. I'd want easy! And it's highly unlikely a Endo would say no to me. If he did I'd call the next one first and tell them I wanted a script for Afrezza before I said yes to the appointment. That's if I knew about Afrezza!! And if I found out later that the doctor knew about Afrezza and didn't give me that option. I would be mad as hell! Wouldn't disagree. I always said new diabetics were the best market. For established diabetics they have a routine so they may well not be keen to change plus they know shots are no big deal. The problem is going to be finding a doctor who knows how to handle Afrezza. You don't have to refrigerate insulin in general either except for long term storage.
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Post by mytakeonit on Apr 2, 2017 18:49:24 GMT -5
Okay Sports fans ... Big Hair Day turned out to be a buzz cut ... so, we need a certain female to go to her Rancho or Rancho Mirage and tease her hair. I mean really tease her hair with mousse and hair spray to get it to stand up. She should also add a few nyah nyah nyah in there and really tease it. Then, take a pic and post it. THEN, we will really have a BIG HAIR DAY and maybe a 1,000 script day.
Can't lose for trying. It'll make my day to see that pic also.
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Post by sportsrancho on Apr 2, 2017 19:04:49 GMT -5
There you go mytakeonit :-) Now we better soon have a 1,000 script Friday!
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Post by mytakeonit on Apr 2, 2017 19:21:19 GMT -5
There you go mytakeonit :-) Now we better soon have a 1,000 script Friday! No mousse ... but maybe good enough. If scripts really take off ... I'll buy you that Gambling Cowboy ... and we'll name it ... SPORTS BAR. It won't need any ads for people to know about it.
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Post by mango on Apr 2, 2017 20:55:29 GMT -5
When I first read this post, i thought "too bad Afrezza isn't perfect". And then it dawned on me, it's just excuses. If they wanted to find a reason not to prescribe Lantus, Toujeo, etc. (any injectable), they could. Scars, inconsistent absorption, inconvenience, compliance... I could keep going. They don't want to change. IMHO. Absolutely right. They do not want change. You do not change a patient's treatment unless you think it will produce a better outcome. Right now the data says Afrezza will not give a better outcome so a doctor asked about it will resist change. I assume by "they" you are referring to The Endo Committee? To say no one wants to change the "standards of care" is inaccurate. Why do you suppose billions of dollars are used by the U.S. government, non-profits, independent agencies, researchers, and pharmaceutical companies in finding ways to improve those so called "standards of care". Perhaps the patients are waking up? What are these roadblocks? —Pharmaceutical companies breaking anti-trust laws —Pharmaceutical companies colluding to prevent innovation and new competition within "their domains" —PBMs colluding with pharmaceutical companies —Pharmaceutical companies influencing medical decision making —Insurance companies influencing medical decision making —Committees made up of members with financial relationships with pharmaceutical companies designing management algorithm recommendations that directly influence medical decision making Real evidence or big data? • Here is a direct contradiction to your statement by an Endocrinologist: Effort > results The future generations' quality of health and care will continue to deteriorate if people continue to adhere to these "standards of care"—which have created a downward spiral of disease related epidemic proportions. The "standards of care" have proven to be a failure. Even the data agrees with this. The authorities that create these "standards of care" don't have a clue what health and care actually means. People are reversing T2D naturally, and going against the grain of wisdom that is the "Standards of Care". • The WHO even agrees that diabetes has become an disease epidemic—how has the "standards of care" helped the prevalence of diabetes and diabetes related complications? Perhaps the "standards of care" need to change. #7 leading cause. www.latimes.com/business/la-fi-mannkind-drug-20150603-story.htmlwww.cdc.gov/chronicdisease/resources/publications/aag/diabetes.htmwww.who.int/features/factfiles/diabetes/en/
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Post by agedhippie on Apr 3, 2017 8:41:22 GMT -5
Absolutely right. They do not want change. You do not change a patient's treatment unless you think it will produce a better outcome. Right now the data says Afrezza will not give a better outcome so a doctor asked about it will resist change. I assume by "they" you are referring to The Endo Committee? To say no one wants to change the "standards of care" is inaccurate. Why do you suppose billions of dollars are used by the U.S. government, non-profits, independent agencies, researchers, and pharmaceutical companies in finding ways to improve those so called "standards of care". Lets clear that one up. I am not talking abut the Endo committee I am talking about doctors, the people prescribing. You are confusing the Standards of Care (the ADA issue supplements regularly to the Standard of Care btw.) with following the Standard of Care. You follow the Standard of Care because it is the established best practice and is grounded in hard evidence (trial data). You can argue every other point under the sun but that is not the way things work. Do the superiority trial and get the data - then it changes but until then... And that is why the pediatric trials matter, because they will potentially change the Standard of Care.
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