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Post by mango on Feb 3, 2020 9:33:34 GMT -5
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Post by sr71 on Feb 3, 2020 11:16:41 GMT -5
Wow, only 15 days from application to approval. Maybe the US Patent Office could learn to be more expeditious as well.
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Post by seanismorris on Feb 3, 2020 11:41:00 GMT -5
I thought this was already patented... I’m looking at the “Office: Australia” and wondering if a (potential) partner wanted this patent done as a competitive edge, on a pipeline opportunity we know nothing. Specifically, I’m hoping for a press release to follow... |
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Post by mango on Feb 3, 2020 14:09:39 GMT -5
I thought this was already patented... I’m looking at the “Office: Australia” and wondering if a (potential) partner wanted this patent done as a competitive edge, on a pipeline opportunity we know nothing. Specifically, I’m hoping for a press release to follow... It has been. Just a continuation or priority patent or something, but I am also hoping for the same! kowtow |
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Post by mango on Feb 19, 2020 8:48:15 GMT -5
New MannKind Granted Patent 2/18/2020 Mouthpiece cover for an inhalerAbstract: A mouthpiece cover for an inhaler is described. The mouthpiece cover is designed for use with a dry powder inhaler and is provided with structural features to prevent a patient from inhaling the cover. Type: Grant Filed: October 1, 2015 Date of Patent: February 18, 2020 Assignee: MannKind Corporation Inventors: Chad C. Smutney, P. Spencer Kinsey patents.justia.com/patent/10561806 |
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Post by Clement on Feb 19, 2020 10:40:39 GMT -5
"with structural features to prevent a patient from inhaling the cover."
---- for pediatrics I assume.
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Post by mango on Feb 19, 2020 11:30:16 GMT -5
"with structural features to prevent a patient from inhaling the cover." ---- for pediatrics I assume. Nice catch. MannKind is always a step ahead! |
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Post by mytakeonit on Feb 19, 2020 13:11:12 GMT -5
I assume the cover is actually the whole inhaler. Has anyone ever inhaled it into their mouth ... and actually swallowed it?
Wow !
But, that's mytakeonit
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Post by mango on Feb 19, 2020 13:18:46 GMT -5
There's 5 pediatric references so I am assuming Clement is correct about it pertaining to Peds.
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Post by mango on Mar 5, 2020 16:54:03 GMT -5
New MannKind Patent Application Published 3/5/20
APPARATUS AND METHOD FOR CRYOGRANULATING A PHARMACEUTICAL COMPOSITION
Abstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.
Type: Application
Filed: November 6, 2019
Publication date: March 5, 2020
Applicant: MannKind Corporation
Inventors: Edwin Amoro, Karel Vanackere, Michael A. White
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Post by seanismorris on Mar 5, 2020 17:20:39 GMT -5
New MannKind Patent Application Published 3/5/20 APPARATUS AND METHOD FOR CRYOGRANULATING A PHARMACEUTICAL COMPOSITIONAbstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing. Type: Application Filed: November 6, 2019 Publication date: March 5, 2020 Applicant: MannKind Corporation Inventors: Edwin Amoro, Karel Vanackere, Michael A. White So, this reduces production costs of TechnoSphere formulations? |
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Post by mango on Mar 10, 2020 14:50:47 GMT -5
New MannKind Granted Patent 3/10/2020 Diketopiperazine salts for drug delivery and related methodsAbstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. Type: Grant Filed:October 4, 2018 Date of Patent: March 10, 2020 Assignee: Mannkind corporation Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson patents.justia.com/patent/10583176----------------------------------- 8. The method of claim 1, wherein said biologically active agent is selected from the group consisting of hormones, anticoagulants, immunomodulating agents, cytotoxic agents, antibiotics, antivirals, antisense, anti-inflammatories, vasoactive agents, neuroactive agents, cannabinoids, antigens, antibodies and active fragments and analogues thereof. |
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Post by longliner on Mar 10, 2020 15:19:49 GMT -5
New MannKind Granted Patent 3/10/2020 Diketopiperazine salts for drug delivery and related methodsAbstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization. Type: Grant Filed:October 4, 2018 Date of Patent: March 10, 2020 Assignee: Mannkind corporation Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson patents.justia.com/patent/10583176----------------------------------- 8. The method of claim 1, wherein said biologically active agent is selected from the group consisting of hormones, anticoagulants, immunomodulating agents, cytotoxic agents, antibiotics, antivirals, antisense, anti-inflammatories, vasoactive agents, neuroactive agents, cannabinoids, antigens, antibodies and active fragments and analogues thereof. That a boy Mike! Don't panic, treat it!! |
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Post by mango on Apr 1, 2020 9:36:04 GMT -5
Two MannKind Patents Granted 3/31/2020 1) High capacity diketopiperazine microparticles and methodsAbstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation. Type: Grant Filed: June 26, 2019 Date of Patent: March 31, 2020 Assignee: MannKind Corporation Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell 8. An inhalable dry powder of claim 1, wherein the drug or active agent is a vasoactive agent, neuroactive agent, hormone, anticoagulant, immunomodulating agent, cytotoxic agent, antibiotic, antiviral agent, antigen, infectious agent, inflammatory mediator, hormone, cell surface antigen, cytokine, lipokine, enkephalin, alkyne, cyclosporin, anti-IL-8 antibodie, IL-8 antagonist including ABX-IL-8; prostaglandin including PG-12, LTB receptor blocker including LY29311, BIIL 284 and CP105696, triptan such as sumatriptan and palmitoleate, insulin and analogs thereof, growth hormone and analogs thereof, parathyroid hormone (PTH) and analogs thereof, parathyroid hormone related peptide (PTHrP), oxytocin, leuprolide, interferon-alpha, RGD peptide, DDAVP peptide, GHR peptide, detirelex human growth hormone, albumin, cyclosporine, ghrelin, obestatin, enterostatin, granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (GCSF), amylin, amylin analogs, glucagon-like peptide 1 (GLP-1), clopidogrel, PPACK (Dphenylalanyl-L-prolyl-L-arginine chloromethyl ketone), oxyntomodulin (OXM), peptide YY(3-36) (PYY), adiponectin, cholecystokinin (CCK), secretin, gastrin, glucagon, motilin, somatostatin, brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), IGF-1, growth hormone releasing factor (GHRF), integrin beta-4 precursor (ITB4) receptor antagonist, nociceptin, nocistatin, orphanin FQ2, calcitonin, CGRP, angiotensin, substance P, neurokinin A, pancreatic polypeptide, neuropeptide Y, delta-sleep-inducing peptide or vasoactive intestinal peptide. patents.justia.com/patent/106033832) Catalysis of diketopiperazine synthesisAbstract: Provided is a method for the synthesis of N-protected 3,6-bis-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ?-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide. Type: Grant Filed: October 4, 2018 Date of Patent: March 31, 2020 Assignee: Mannkind corporation Inventors: John J. Stevenson, Destardi Moye-Sherman patents.justia.com/patent/10604491 |
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Post by mango on Apr 15, 2020 13:51:13 GMT -5
Fresh Granted Patent 4/14/20 Powder dispensing and sensing apparatus and methods for simultaneous filling of cartridgesAbstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges. Type: Grant Filed: September 13, 2017 Date of Patent: April 14, 2020 Assignee: MannKind Corporation Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog patents.justia.com/patent/10620034 |
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