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Post by mango on Jan 4, 2018 17:36:39 GMT -5
New MannKind Patent Application Published 1/4/2017 POWDER DISPENSING AND SENSING APPARATUS AND METHODSType: Application Filed: September 13, 2017 Publication date: January 4, 2018 Applicant: MannKind Corporation Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog patents.justia.com/patent/20180003545
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Post by bioexec25 on Jan 4, 2018 18:14:58 GMT -5
New MannKind Patent Application Published 1/4/2017 POWDER DISPENSING AND SENSING APPARATUS AND METHODSType: Application Filed: September 13, 2017 Publication date: January 4, 2018 Applicant: MannKind Corporation Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog patents.justia.com/patent/20180003545Cool mango. Ok out there by just got this weird visual of a vending style machine dialing up precise doses. Could be insulin or cannabinol who knows. Interesting patent. Applied to manufacturing, HCP, pharmacies, retail who knows. Clearly part of a broader strategy. Just don’t wake up one morning and get the urge to invent such a system. Likely is software driven and connected to the cloud.
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Post by mango on Jan 5, 2018 2:38:24 GMT -5
New MannKind Patent Application Published 1/4/2017 POWDER DISPENSING AND SENSING APPARATUS AND METHODSType: Application Filed: September 13, 2017 Publication date: January 4, 2018 Applicant: MannKind Corporation Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog patents.justia.com/patent/20180003545Cool mango. Ok out there by just got this weird visual of a vending style machine dialing up precise doses. Could be insulin or cannabinol who knows. Interesting patent. Applied to manufacturing, HCP, pharmacies, retail who knows. Clearly part of a broader strategy. Just don’t wake up one morning and get the urge to invent such a system. Likely is software driven and connected to the cloud. Might be able to be connected to the cloud but I didn't see anything hinting at that... The patent application is, however, a continuation and is a small, compact, transportable system for measuring and filing accurate dosages and takes up very little real estate. It can be used for single use inhalers or multiple dose inhalers.
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Post by boca1girl on Jan 5, 2018 9:04:16 GMT -5
I always thought selling bulk Afrezza to PWDs made sense. I’ve seen many complaints about the size of the packages and the amount of frig space it takes to store a three month supply.
PWDs could have an Afrezza dispensing machine much like a Keurig with a refillable k-cup.
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Post by sportsrancho on Jan 5, 2018 10:29:24 GMT -5
That’s a good idea:-)although I know no one personally that refrigerates it.
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Post by mango on Jan 9, 2018 23:58:32 GMT -5
New International MannKind Patent Application Published 1/4/2018 Application Date: 15.09.2017 Publication Date: 04.01.2018 Applicants: MannKind Corporation Inventors: Chad C. Smutney Benoit Adamo Brendan F. Laurenzi P. Spencer Kinsey Title: (EN) DRY POWDER DRUG DELIVERY SYSTEM AND METHODS Abstract: (EN) A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity. patentscope.wipo.int/search/en/detail.jsf?docId=US209520582
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Post by mango on Mar 28, 2018 3:50:55 GMT -5
New MannKind Patent Granted 3/27/2018
Heat-stable dry powder pharmaceutical compositions and methodsType: Grant Filed: July 18, 2014 Date of Patent: March 27, 2018 Assignee: MannKind Corporation Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution. This application is a 371 of PCT/US2014/047304, filed Jul. 18, 2014, which claims benefit under 35 U.S.C. § 119(e) from U.S. Provisional Patent Application Ser. No. 61/847,981, filed Jul. 18, 2013, the content of which is incorporated herein by reference in its entirety. patents.justia.com/patent/9925144
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Post by goyocafe on Mar 28, 2018 8:09:01 GMT -5
New MannKind Patent Granted 3/27/2018
Heat-stable dry powder pharmaceutical compositions and methodsType: Grant Filed: July 18, 2014 Date of Patent: March 27, 2018 Assignee: MannKind Corporation Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution. This application is a 371 of PCT/US2014/047304, filed Jul. 18, 2014, which claims benefit under 35 U.S.C. § 119(e) from U.S. Provisional Patent Application Ser. No. 61/847,981, filed Jul. 18, 2013, the content of which is incorporated herein by reference in its entirety. patents.justia.com/patent/9925144Wouldn’t this be true for insulin then? Reminds me of the video from down under when the guy buried his insulin in the middle of summer for 4 weeks or something like that.
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Post by harryx1 on Mar 28, 2018 9:35:12 GMT -5
Afrezza: Extreme Thermal Stability
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Post by goyocafe on Mar 28, 2018 9:41:27 GMT -5
Afrezza: Extreme Thermal Stability I looked for this, but couldn't find it, even after searching under Mat's entries. Thanks for posting.
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Post by mnholdem on Mar 28, 2018 11:10:46 GMT -5
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Post by mytakeonit on Mar 28, 2018 13:10:07 GMT -5
That video is a fake ... Matt Bendall didn't belch after drinking that phony Coke !!! Ha!
Didn't afrezzauser also leave a box of Afrezza in his hot car for awhile and it was perfectly fine after a month of so. His car would be definitely over 100 degrees in the hot sun.
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Post by mango on Mar 28, 2018 14:46:42 GMT -5
The oxytocin formulation is stable for at least 40 weeks at 100°F and 75% relative humidity.
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Post by mytakeonit on Mar 28, 2018 18:16:50 GMT -5
?? Dare I ask what happens on the 41st week?
It seems like it will last for quite awhile ... and that we have to set limits so that people don't store it away and not use it as designed.
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Post by mango on Apr 23, 2018 9:00:57 GMT -5
Two New MannKind Granted Patents Use of ultrarapid acting insulinAbstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day. Type: Grant Filed: December 10, 2013 Date of Patent: April 17, 2018 Assignee: MannKind Corporation Inventors: Peter Richardson, Robert A. Baughman, Elizabeth Potocka, Anders Hasager Boss, Richard Petrucci patents.justia.com/patent/9943571Formation of N-protected bis-3,6-(4-aminobutyl)-2, 5-diketopiperazine through a cyclic alpha-N-protected amino esterAbstract: A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic ?-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent. Type: Grant Filed: November 16, 2015 Date of Patent: April 17, 2018 Assignee: MannKind Corporation Inventors: John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft patents.justia.com/patent/9944609
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