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Post by harryx1 on Jun 22, 2017 8:25:47 GMT -5
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Post by peppy on Jun 22, 2017 10:07:04 GMT -5
Niacinamide (nicotinamide) www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260908.htm The term niacin as adopted by the American Institute of Nutrition, is a generic form including both nicotinic acid and its amide, nicotinamide (or niacinamide), to which it is readily converted in the body. However, niacin as employed by the Code of Federal Regulations refers only to nicotinic acid. Nicotinamide is a component of two essential coenzymes, nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. The body is also able to form nicotinamide from tryptophan (60 mg of tryptophan provide 1 mg of niacin equivalent) and much of the total niacin equivalents of the diet are supplied in this manner.
Young laboratory animals fed diets containing 1 or 2 percent nicotinic acid or nicotinamide (1 to 2 g per kg body weight per day) have demonstrated growth depression in some but not all studies. At levels of 0.1 percent in the diet, fatty livers may occur, reflecting an induced choline deficiency.
Because large doses of nicotinic acid are known to reduce serum concentration of cholesterol, administration of nicotinic acid has been employed in management of patients with hypercholesterolemia. Dosage commonly employed is 3 to 9 g daily (50 to 150 mg per kg). Initially experienced side effects, including cutaneous flushing, pruritis, and nausea, usually subside with continued therapy and the great majority of subjects then appear to experience no adverse effects. However, abnormal values in liver function test have been detected rather frequently and at least a few subjects have developed jaundice. These manifestations generally subside promptly after discontinuation of treatment. Pathologic changes in the liver, possibly irreversible, have been associated with treatment with large daily doses in a few instances.
Although there have been no short- or long-term animal studies defining the greatest no-adverse-effect level of intake of nicotinic and man have been associated with intakes at least a hundredfold greater than those likely to be achieved from fortification of foods.
In the light of these considerations, the Select Committee concludes that:
There is no evidence in the available information on niacin (nicotinic acid) or niacinamide (nicotinamide) that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.
Its onset of action is about 6 minutes earlier, the peak is 7 minutes earlier, and it works 50% harder during the first 30 minutes compared to traditional aspart.
integrateddiabetes.com/review-of-fiasp-insulin-and-how-it-compares-with-other-fast-insulins/
Novo Nordisk recently announced that it has resubmitted its new, faster-acting mealtime insulin (“faster-acting insulin aspart” or “Fiasp”) to the FDA, with a decision expected toward the end of 2017.
--------------------------------------------------------------------------------------------------------------------------------------------------------- My words; fatty liver, jaundice; Love your numbers, miss your liver? Growth depression. pruritus.
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Post by peppy on Jun 22, 2017 12:59:15 GMT -5
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Post by agedhippie on Jun 22, 2017 21:48:57 GMT -5
Frankly it makes me as twitchy as anything. I have no intention of going near it at this point. |
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Post by sayhey24 on Jun 23, 2017 5:22:39 GMT -5
Frankly it makes me as twitchy as anything. I have no intention of going near it at this point. Maybe you want to give afrezza a try? There is nothing better for corrections. |
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Post by agedhippie on Jun 23, 2017 8:40:03 GMT -5
Frankly it makes me as twitchy as anything. I have no intention of going near it at this point. Maybe you want to give afrezza a try? There is nothing better for corrections. In the corner we find a thoroughly beaten dead horse....  My insurance covers one bolus insulin, not two bolus insulins. |
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Post by sayhey24 on Jun 23, 2017 19:11:27 GMT -5
Maybe you want to give afrezza a try? There is nothing better for corrections. In the corner we find a thoroughly beaten dead horse.... My insurance covers one bolus insulin, not two bolus insulins. If I remember correctly at first it was your endo who would not prescribe new drugs. Then you were going to ask your PCP. Then it was your endo was concerned about the lung FUD. Ok, now its insurance. You need insurance to buy one box and give it a try for corrections? I got mine at Costco, I think it was $278 or something like that. |
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Post by sportsrancho on Jun 24, 2017 6:35:16 GMT -5
In the corner we find a thoroughly beaten dead horse.... My insurance covers one bolus insulin, not two bolus insulins. If I remember correctly at first it was your endo who would not prescribe new drugs. Then you were going to ask your PCP. Then it was your endo was concerned about the lung FUD. Ok, now its insurance. You need insurance to buy one box and give it a try for corrections? I got mine at Costco, I think it was $278 or something like that. I offered to mail him samples months ago ( no charge ). |
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Post by agedhippie on Jun 24, 2017 9:47:24 GMT -5
In the corner we find a thoroughly beaten dead horse.... My insurance covers one bolus insulin, not two bolus insulins. If I remember correctly at first it was your endo who would not prescribe new drugs. Then you were going to ask your PCP. Then it was your endo was concerned about the lung FUD. Ok, now its insurance. You need insurance to buy one box and give it a try for corrections? I got mine at Costco, I think it was $278 or something like that. Not that I owe you an explanation but... 1) My endo is still anti-Afrezza because he thinks there may be a fibrosis risk. However he has now started one patient on it because they have so little subcutaneous fat that injecting is an issue (absorption) so at least he will see how it behaves. 2) I asked my PCP and he would do it if I wanted but it was contingent on being able to get the sample pack for free which people thought it was at the time. Turns out it wasn't available. 3) Insurance was always a problem ( this is the post you are talking about) as I said at the time. 4) I am not paying $350 out of pocket for a box of Afrezza. Besides which if it works (which I expect it will) I cannot afford to sustain that cost so what is the point? |
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Post by brotherm1 on Jun 24, 2017 10:34:08 GMT -5
If I remember correctly at first it was your endo who would not prescribe new drugs. Then you were going to ask your PCP. Then it was your endo was concerned about the lung FUD. Ok, now its insurance. You need insurance to buy one box and give it a try for corrections? I got mine at Costco, I think it was $278 or something like that. Not that I owe you an explanation but... 1) My endo is still anti-Afrezza because he thinks there may be a fibrosis risk. However he has now started one patient on it because they have so little subcutaneous fat that injecting is an issue (absorption) so at least he will see how it behaves. 2) I asked my PCP and he would do it if I wanted but it was contingent on being able to get the sample pack for free which people thought it was at the time. Turns out it wasn't available. 3) Insurance was always a problem ( this is the post you are talking about) as I said at the time. 4) I am not paying $350 out of pocket for a box of Afrezza. Besides which if it works (which I expect it will) I cannot afford to sustain that cost so what is the point? Have you considered a different insurance plan? |
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Post by promann on Jun 24, 2017 10:44:42 GMT -5
Age just obviously does not care to be on Afrezza he is a soft basher. If he really cared about his health he could spend half the time he spends on this message board as a Walmart greeter and be able to have all the Afrezza he needs. But he would rather be here soft bashing pretending he cares.
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Post by agedhippie on Jun 24, 2017 10:57:19 GMT -5
Have you considered a different insurance plan? Yes, however the only plans my employer offers are Cigna so nothing would change. This is one of the problems with the US health system and tying cover to your employer. |
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Post by agedhippie on Jun 24, 2017 11:10:50 GMT -5
Age just obviously does not care to be on Afrezza he is a soft basher. If he really cared about his health he could spend half the time he spends on this message board as a Walmart greeter and be able to have all the Afrezza he needs. But he would rather be here soft bashing pretending he cares. My numbers are pretty good as is my health so I don't see a gain in switching, if I had horrible numbers it would be more compelling. I would like Afrezza for corrections but what I am not going to do is buy Afrezza out of pocket as I already spend about $3,000 a year on diabetes as it is. |
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Post by otherottawaguy on Jun 25, 2017 7:02:02 GMT -5
Sports:
You have pretty good comms with Mike. Wondering if you could reach out to Mike and ask him to set Aged hippie up with a 180 titration pack? That is if Aged is willing to give it a shot (puff)?
OOG
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Post by agedhippie on Jun 25, 2017 11:03:12 GMT -5
Sports: You have pretty good comms with Mike. Wondering if you could reach out to Mike and ask him to set Aged hippie up with a 180 titration pack? That is if Aged is willing to give it a shot (puff)? OOG If Mannkind gives me a sample pack I will definitely give it a shot. |
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