Development deals & international licensing opportunities

[zuegirdor]

Aug 17, 2017 16:05:11 GMT -5 dreamboatcruise said:

Aug 17, 2017 14:20:29 GMT -5 zuegirdor said:

I have to wonder if (or why not)the other Big Pharmas are developing their own incipient/inhalable insulins. Afrezza is great but there is always room for improvement and an expansion of the niche. Yes it takes years for FDA approval (big disincentive for new developments even for Big Pharma?). After all, isn't that why they kept the price of insulin high all these years- to develop the next breakthrough? They just gonna let some upstart like Mannkind dominate with the only major development since GMO insulin?

Could they already have the new and better incipient(technosphere replacement) or the solo dose inhalable candidate in the pipeline, ready to launch a trial in late 2018 without the usual fanfare? Are they trying to eliminate the niche or just derail Afrezza so folks don't get used to it? After all, we know here how hard it is to change a paradigm.

And if they don't have something on deck or in the farm system (what about the GMO safflower/insulin-couldn't somebody also insert the DNA for a little inhalable incipient into that product? Grow it in your back yard. Just pick sniff and go)what is the excuse, or rationale. Seems the BP stockholders could be mad that they did not see this coming, even as Sanofi made its bid to partner on Afrezza.

I don't know. Just seems wierd to gamble so much on scuttling Afrezza while they could be coming up with the next big advancement. I guess they are spending all their money on a REAL CURE? Yeah, that's it.

All other inhalables in the pipeline of BP were killed with the failure of Exubera.  There is one small company working on a pocket nebulizer insulin, but that is considerably larger device than Afrezza and unlikely to match the pk/pd profile, though it might come close.  Still a ways off before it would come to market, if ever.

Not everything can be produced with genetic engineering.  DNA only directly codes for amino acid based molecules (peptides and proteins).  Insulin is a peptide, hence its production through GMO.  Any other types of molecules produced within the body have to come through some metabolic process.   I would not think evolution has created a lot of metabolic processes to generate complex inert substances such as the TS carrier particle, and I wouldn't think artificially creating such metabolic functions through genetic engineering would be feasible.  Though I suspect you were just kidding about growing inhalable insulin bearing plants.

I'm kidding about filling spent vape pen cartridge with $25 human insulin too. Maybe they will rx Afrezza if they think we are that desperate. Maybe we are...? Worked for the Opioid dependent....for a while.