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Post by MnkdWASmyRtrmntPlan on Oct 26, 2017 13:58:57 GMT -5
Here you go Al in his own words 26:50m "pumps are going to be obsolete" www.youtube.com/watch?v=muBuxTqxmQoBut concerning the AP, it works best with afrezza www.youtube.com/watch?v=GGgGjtM5ipg 3minute mark This will also be the conclusion at Yale. Concerning Fiasp there are huge reports of injection site issues and its not currently approved for pump use by the FDA. However some have tried and have reported numerous issues. Wow. Thanks, seyhey. I was compelled to listen to that entire hour-long speech of Al's, in which he basically summarized his incredible career. What an honorable genius. I found it very motivational, as I am seriously considering pursuit of being a Vdex entrepreneur to help bring Al's vision to reality. If anyone else here has any desire to become an Afrezza entrepreneur to help diabetics, please check out the Vdex opportunity if you haven't yet - vdexdiabetes.com, scroll down to the very bottom and fill out the "Interested in helping people beat Diabetes?" form. Everyone here knows that Afrezza needs sales increases more than anything. You can help make it happen. |
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Post by sportsrancho on Oct 26, 2017 14:04:08 GMT -5
Here you go Al in his own words 26:50m "pumps are going to be obsolete" www.youtube.com/watch?v=muBuxTqxmQoBut concerning the AP, it works best with afrezza www.youtube.com/watch?v=GGgGjtM5ipg 3minute mark This will also be the conclusion at Yale. Concerning Fiasp there are huge reports of injection site issues and its not currently approved for pump use by the FDA. However some have tried and have reported numerous issues. Wow. Thanks, seyhey. I was compelled to listen to that entire hour-long speech of Al's, in which he basically summarized his incredible career. What an honorable genius. I found it very motivational, as I am seriously considering pursuit of being a Vdex entrepreneur to help bring Al's vision to reality. If anyone else here has any desire to become an Afrezza entrepreneur to help diabetics, please check out the Vdex opportunity if you haven't yet - vdexdiabetes.com, scroll down to the very bottom and fill out the "Interested in helping people beat Diabetes?" form. Everyone here knows that Afrezza needs sales increases more than anything. You can help make it happen. Good for you! So happy for you and wish you great success!! I’ve been sending people the “open a Vdex” part of their web-sight to fill out. I’ve been getting more and more requests:-) |
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Post by agedhippie on Oct 26, 2017 19:24:23 GMT -5
Concerning Fiasp there are huge reports of injection site issues and its not currently approved for pump use by the FDA. However some have tried and have reported numerous issues. I am in no hurry to use FIasp because I don't like the idea of the additives even if it is vitamin B3. There are definitely reports of site issues but I think huge might be a bit extravagant. One of the dirty little secrets of injected insulin injection is site issues. Some people have a real issue with these with RAA today, never mind with FIasp. Either way it will become clear enough once it hits general use in US. The label is silent on whether pumps can be used or not. If I was going to use it in a pump I would want to see how things go in the EU. Apidra has/had a reputation for gumming up pumps - I would want to make sure FIasp didn't have the same issue. |
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Post by patten1962 on Oct 27, 2017 18:01:50 GMT -5
Wow. Thanks, seyhey. I was compelled to listen to that entire hour-long speech of Al's, in which he basically summarized his incredible career. What an honorable genius. I found it very motivational, as I am seriously considering pursuit of being a Vdex entrepreneur to help bring Al's vision to reality. If anyone else here has any desire to become an Afrezza entrepreneur to help diabetics, please check out the Vdex opportunity if you haven't yet - vdexdiabetes.com, scroll down to the very bottom and fill out the "Interested in helping people beat Diabetes?" form. Everyone here knows that Afrezza needs sales increases more than anything. You can help make it happen. Good for you! So happy for you and wish you great success!! I’ve been sending people the “open a Vdex” part of their web-sight to fill out. I’ve been getting more and more requests:-) One of my Physician friends is looking into it as we speak. 1 in Ct and 1 in Florida. |
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Post by sayhey24 on Oct 27, 2017 18:55:51 GMT -5
Concerning Fiasp there are huge reports of injection site issues and its not currently approved for pump use by the FDA. However some have tried and have reported numerous issues. I am in no hurry to use FIasp because I don't like the idea of the additives even if it is vitamin B3. There are definitely reports of site issues but I think huge might be a bit extravagant. One of the dirty little secrets of injected insulin injection is site issues. Some people have a real issue with these with RAA today, never mind with FIasp. Either way it will become clear enough once it hits general use in US. The label is silent on whether pumps can be used or not. If I was going to use it in a pump I would want to see how things go in the EU. Apidra has/had a reputation for gumming up pumps - I would want to make sure FIasp didn't have the same issue. If you don't like the idea of the Fiasp additives maybe you should give afrezza a try. Whats in Novalog besides a genetically modified insulin? Let me see, glycerin 16 mg/mL, phenol 1.50 mg/mL, metacresol 1.72 mg/mL, zinc 19.6 mcg/mL, disodium hydrogen phosphate dihydrate 1.25 mg/mL, sodium chloride 0.58 mg/mL and water. According to medscape it is not pump approved www.medscape.com/viewarticle/886341 "Fiasp will be available in a prefilled delivery device, the FlexTouch pen, and a 10-mL vial. It is not approved for use in insulin pumps in the United States." But does it really matter as a week later the afrezza label obsoleted Fiasp? Still you gotta love that phenol. The last I checked it was pretty toxic to humans. I am not sure which is worse the phenol or the metacresol. |
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Post by dreamboatcruise on Oct 27, 2017 19:47:33 GMT -5
I am in no hurry to use FIasp because I don't like the idea of the additives even if it is vitamin B3. There are definitely reports of site issues but I think huge might be a bit extravagant. One of the dirty little secrets of injected insulin injection is site issues. Some people have a real issue with these with RAA today, never mind with FIasp. Either way it will become clear enough once it hits general use in US. The label is silent on whether pumps can be used or not. If I was going to use it in a pump I would want to see how things go in the EU. Apidra has/had a reputation for gumming up pumps - I would want to make sure FIasp didn't have the same issue. If you don't like the idea of the Fiasp additives maybe you should give afrezza a try. Whats in Novalog besides a genetically modified insulin? Let me see, glycerin 16 mg/mL, phenol 1.50 mg/mL, metacresol 1.72 mg/mL, zinc 19.6 mcg/mL, disodium hydrogen phosphate dihydrate 1.25 mg/mL, sodium chloride 0.58 mg/mL and water. According to medscape it is not pump approved www.medscape.com/viewarticle/886341 "Fiasp will be available in a prefilled delivery device, the FlexTouch pen, and a 10-mL vial. It is not approved for use in insulin pumps in the United States." But does it really matter as a week later the afrezza label obsoleted Fiasp? Still you gotta love that phenol. The last I checked it was pretty toxic to humans. I am not sure which is worse the phenol or the metacresol. The last I checked it was something your body produces itself as a metabolite. Though as with many things it indeed is toxic in large doses, hence why your kidneys expel it into urine. The phenol in the amount of insulin taken daily would be a fraction of what the body naturally produces. Whether it might contribute in some way to the known injection site issues of insulin might be a valid question... but those aren't systemic, nor serious for most patients. |
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Post by sayhey24 on Oct 27, 2017 19:54:52 GMT -5
Here is what we know. Diabetics have a higher rate of cancer than non-diabetics. Is it their high BG levels, the GMO insulins, the additives in the insulins or something else? We can keep doing the same thing over and over or maybe we can try something different. Just saying.
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Post by dreamboatcruise on Oct 27, 2017 20:15:03 GMT -5
Here is what we know. Diabetics have a higher rate of cancer than non-diabetics. Is it their high BG levels, the GMO insulins, the additives in the insulins or something else? We can keep doing the same thing over and over or maybe we can try something different. Just saying. Science isn't perfect, but applying its principles to actually uncover causation has certainly lead to pretty amazing advances in health sciences. Having some a priori belief that certain things must be safe or other things must be unnatural and unsafe, rarely leads to the best outcomes. And if you want to avoid GMO insulin the only option is animal insulin, and I certainly doubt many would want to go back to that. |
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Post by agedhippie on Oct 27, 2017 20:34:39 GMT -5
I am in no hurry to use FIasp because I don't like the idea of the additives even if it is vitamin B3. There are definitely reports of site issues but I think huge might be a bit extravagant. One of the dirty little secrets of injected insulin injection is site issues. Some people have a real issue with these with RAA today, never mind with FIasp. Either way it will become clear enough once it hits general use in US. The label is silent on whether pumps can be used or not. If I was going to use it in a pump I would want to see how things go in the EU. Apidra has/had a reputation for gumming up pumps - I would want to make sure FIasp didn't have the same issue. If you don't like the idea of the Fiasp additives maybe you should give afrezza a try. Whats in Novalog besides a genetically modified insulin? Let me see, glycerin 16 mg/mL, phenol 1.50 mg/mL, metacresol 1.72 mg/mL, zinc 19.6 mcg/mL, disodium hydrogen phosphate dihydrate 1.25 mg/mL, sodium chloride 0.58 mg/mL and water. According to medscape it is not pump approved www.medscape.com/viewarticle/886341 "Fiasp will be available in a prefilled delivery device, the FlexTouch pen, and a 10-mL vial. It is not approved for use in insulin pumps in the United States." But does it really matter as a week later the afrezza label obsoleted Fiasp? Still you gotta love that phenol. The last I checked it was pretty toxic to humans. I am not sure which is worse the phenol or the metacresol. It's no contest, the metacresol wins by a mile. Happily it doesn't bother me but some people have real problems with it. Phenol can be nasty but there are only trace amounts in RAA. Approval for pump use doesn't really matter. The only reason to produce it in 10mL vials is for pump users so if that's how they selling it that's how it will get used. My position with FIasp is the same as my position with Afrezza; I see no reason to change. That said I would go to Afrezza rather than FIasp if I had to - insurance permitting. |
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Post by agedhippie on Oct 27, 2017 20:46:52 GMT -5
Here is what we know. Diabetics have a higher rate of cancer than non-diabetics. Is it their high BG levels, the GMO insulins, the additives in the insulins or something else? We can keep doing the same thing over and over or maybe we can try something different. Just saying. The EU watches insulins very closely for cancers and they have found no evidence. If you have a Type 1 your immune system is compromised so a higher cancer rate is hardly a surprise. Likewise with Type 2 you have a broken glucose metabolism with diabetes as only one aspect, others like NAFLD are known cancer risks. |
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Post by dreamboatcruise on Oct 27, 2017 21:09:36 GMT -5
Here is what we know. Diabetics have a higher rate of cancer than non-diabetics. Is it their high BG levels, the GMO insulins, the additives in the insulins or something else? We can keep doing the same thing over and over or maybe we can try something different. Just saying. The EU watches insulins very closely for cancers and they have found no evidence. If you have a Type 1 your immune system is compromised so a higher cancer rate is hardly a surprise. Likewise with Type 2 you have a broken glucose metabolism with diabetes as only one aspect, others like NAFLD are known cancer risks. I'm still curious about the recent findings linking autoimmune disorders (I have Hashimoto's) to various cancers. Why do you characterize T1 as having a "compromised" immune system... confused, yes. |
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Post by boca1girl on Oct 28, 2017 6:57:38 GMT -5
The EU watches insulins very closely for cancers and they have found no evidence. If you have a Type 1 your immune system is compromised so a higher cancer rate is hardly a surprise. Likewise with Type 2 you have a broken glucose metabolism with diabetes as only one aspect, others like NAFLD are known cancer risks. I'm still curious about the recent findings linking autoimmune disorders (I have Hashimoto's) to various cancers. Why do you characterize T1 as having a "compromised" immune system... confused, yes.*** Pathway Scientist Identifies Possible Trigger for Type 1 Diabetes Dr. Thomas Delong, Pathway to Stop Diabetes Awardee Type 1 diabetes occurs when the body's immune system attacks and destroys the insulin-producing cells in the pancreas. There is no cure for type 1 diabetes, which affects about 1.25 million Americans. In order to prevent or reverse the development of type 1 diabetes, it is essential to understand why and how the immune system attacks the body's own cells. The American Diabetes Association awarded one of its highly-competitive Pathway to Stop Diabetes grants to Thomas Delong, PhD, in 2015 to seek answers to these questions. Dr. Delong coauthored a study published today in the prestigious journal Science describing results from his American Diabetes Association-funded project, which provide a possible explanation for how the immune system goes awry leading to type 1 diabetes. The immune system's "T cells" normally fight infections. T cells identify markers called "antigens" on the surface of viruses and bacteria and then mount an attack. In healthy people, the body's own cells are protected from the immune system because T cells do not recognize self-antigens. However, in type 1 diabetes and other autoimmune diseases, something in this protective system breaks down. Dr. Delong and colleagues isolated T cells from a mouse model of type 1 diabetes to determine what it may be that they recognize as foreign in insulin-producing cells. Using this approach, they identified a modification of insulin that acted as an antigen. They found that the so-called "hybrid insulin peptides" (HIPs) were recognized by immune T cells from pancreatic islets of two organ donors who had type 1 diabetes, as well. This study suggests that these HIPs may play an important role in triggering the immune system to attack the body's insulin-producing cells, causing type 1 diabetes. Understanding the misguided immune attack is a critical first step in identifying possible ways to turn it off, which may offer insight into new therapies to prevent or reverse type 1 diabetes. Dr. Delong, who himself has type 1 diabetes, appeared on CBS Denver News to explain this exciting study. Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K. Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 351(6274): 676-8. Last Reviewed: February 12, 2016 Last Edited: March 8, 2017 |
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Post by agedhippie on Oct 28, 2017 7:12:08 GMT -5
The EU watches insulins very closely for cancers and they have found no evidence. If you have a Type 1 your immune system is compromised so a higher cancer rate is hardly a surprise. Likewise with Type 2 you have a broken glucose metabolism with diabetes as only one aspect, others like NAFLD are known cancer risks. I'm still curious about the recent findings linking autoimmune disorders (I have Hashimoto's) to various cancers. Why do you characterize T1 as having a "compromised" immune system... confused, yes. The base cause of Type 1 is a deranged auto-immune response, but also we have a far higher incidence of other auto-immune diseases in particular rheumatoid arthritis, celiac, lupus, and thyroid disorders. It is also why you get pushed to the front of the queue when things like the bird flu scare happen as infections are more common and tend to be more serious. There are various reasons for this but a major one is a lower level of production of interleukins which is a major component of the auto-immune system. In general auto-immune diseases are associated with a higher incidence of cancer. Statistics aside you can see this in treatments that suppress the immune system and the associated rise in cancers. It's one of the reasons I would not take a Type 1 treatment that relied on immuno-suppressants such as transplants. |
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Post by sayhey24 on Oct 28, 2017 7:12:10 GMT -5
I suspect Aged is saying this because your immune system is attacking your beta cells. This probably also happens in more cases we call T2 today but to a lesser degree and shorter time. We see this big increase in LADAs today why, probably because they are being tested for it as being a T2 is socially unacceptable because people associated it to being fat and lazy. Whats causing the attack is the big question and it may not be one cause.
As far as GMO insulilns there is a huge difference to the body between a genetically created human insulin molecule and a molecule which has been modified so it is nolonger seen as natural to the body. There are some universities in Europe who have been looking at the long term effects of the GMOs. We already know how AspB10 turned out.
The big discussion is risk versus benefit. We still have SGLT-2s on the market and people are losing toes like crazy but the argument is its better than dying.
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