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Post by liane on May 17, 2018 17:02:56 GMT -5
Maybe Mnkd will be singing Stealers Wheels. Well I don't know why I came here tonight, I got the feeling that something ain't right, I'm so scared in case I fall off my chair, And I'm wondering how I'll get down the stairs, Clowns to the left of me,
Jokers to the right, here I am, Stuck in the middle with you Gerry Rafferty Yeah! |
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Post by mnholdem on May 17, 2018 18:20:50 GMT -5
Wow, Sports. You obviously are still catching up. Way to party, girl!  |
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Post by sayhey24 on May 17, 2018 18:32:39 GMT -5
mnholdem - Concerning, one of the 2018 AACE Abstracts deals with a favorite subject of mine, one which I've long advocated for Afrezza.
I am with you on wanting to see the official study on early use of afrezza and I just suspect some of that data may be in the "lost studies".
Another study which I would like to see is afrezza's "heart healthy" effects. I am pretty sure Dr. Kendall was involved in the Jardiance study which labeled it "heart healthy" even though people were losing toes and feet.
Many T2s in addition to elevated BG also have elevated LDL. By bringing down the BG to near normal ranges it would be interesting to see how much the LDL is reduced and if the hdl/ldl ratio comes back to normal. If so, afrezza not only obsoletes the anti-glycemics and the RAA but it may also obsolete the need for much of the statins.
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Post by mnholdem on May 17, 2018 18:51:43 GMT -5
I think that spiro could eloquently speak to that issue since Afrezza helped him significantly reduce other adverse health issues. Perhaps some of these studies will be considered by MannKind after Afrezza is generating significant revenue, although there could be some research institutes that could take that baton and run with it.  |
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Post by dreamboatcruise on May 18, 2018 1:37:33 GMT -5
mnholdem - Concerning, one of the 2018 AACE Abstracts deals with a favorite subject of mine, one which I've long advocated for Afrezza. I am with you on wanting to see the official study on early use of afrezza and I just suspect some of that data may be in the "lost studies". Another study which I would like to see is afrezza's "heart healthy" effects. I am pretty sure Dr. Kendall was involved in the Jardiance study which labeled it "heart healthy" even though people were losing toes and feet. Many T2s in addition to elevated BG also have elevated LDL. By bringing down the BG to near normal ranges it would be interesting to see how much the LDL is reduced and if the hdl/ldl ratio comes back to normal. If so, afrezza not only obsoletes the anti-glycemics and the RAA but it may also obsolete the need for much of the statins. While not being able to speculate on whether your hypothesis on cholesterol would pan out, I do think that general idea of bridging Afrezza with longer term results from prior or ongoing non-Mannkind studies is very intriguing. If some shorter/cheaper (perhaps already completed) Mannkind trials can show results in some metric (lipids, PPG, etc.) that other studies link to long term outcomes such as CV, I'm sure Kendall and team are smart enough to already be working on it and know how to maximize the impact. |
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Post by agedhippie on May 18, 2018 9:53:35 GMT -5
Many T2s in addition to elevated BG also have elevated LDL. By bringing down the BG to near normal ranges it would be interesting to see how much the LDL is reduced and if the hdl/ldl ratio comes back to normal. If so, afrezza not only obsoletes the anti-glycemics and the RAA but it may also obsolete the need for much of the statins. That's typically part of a bigger dysfunction called Metabolic Syndrome which also has high blood pressure and obesity as well as diabetes and deranged lipids. There is no evidence I know of that fixing one of those fixes the others (obesity aside - drastically reducing obesity can help reduce or put some into remission but not eliminate them) |
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Post by ilovekauai on May 18, 2018 9:59:46 GMT -5
What about a study for those T2 who have good control, but want to jettison all their other diabetes drugs and go strictly with Afrezza for mealtime control only, because that's all they need due to a healthy lifestyle? Early intervention please! Standard treatment of care has got this backwards IMO.
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Post by brentie on May 18, 2018 10:26:01 GMT -5
Maybe Mnkd will be singing Stealers Wheels. Well I don't know why I came here tonight, I got the feeling that something ain't right, I'm so scared in case I fall off my chair, And I'm wondering how I'll get down the stairs, Clowns to the left of me,
Jokers to the right, here I am, Stuck in the middle with you Hilarious! That's a good song, but I think I found MannKind's theme song.(You'll have to excuse some of the spelling.) |
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Post by joeypotsandpans on May 18, 2018 11:38:58 GMT -5
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS 27th ANNUAL SCIENTIFIC & CLINICAL CONGRESS Boston, MA • May 16-20, 2018
Booth 1524 - Sanofi / Sanofi Regeneron Booth 1417 - MannKind Corporation Booth Booth 1409 - Novo Nordisk - Diabetes Care
www.eventscribe.com/2018/AACE/exhibitors/
This location should be getting some good foot traffic this week, IMO:
Again what stands out to me is the little booth way in the corner in the other room.....booth 132, is it me or does it look like LLY stands ashamed in the corner of the room for having lost some key personnel? Bioexec what say ye? |
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Post by bioexec25 on May 18, 2018 13:27:00 GMT -5
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Post by mnholdem on May 18, 2018 13:30:21 GMT -5
Abbott Diabetes care is just a few spots to the right in Booth 1715. How convenient to have some FreeStyle Libres nearby in case you need one, eh? Dexcom is just a bit north at Booth #1726.
Seems like all the "cutting edge" products are grouped into this area...so what the hell is Sanofi doing in there?  
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Post by peppy on May 18, 2018 13:35:19 GMT -5
That's a good song, but I think I found MannKind's theme song.(You'll have to excuse some of the spelling.) it's been a long time. Peter, Paul and Mary. weehaw. I am still laughing brentie. |
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Post by peppy on May 18, 2018 13:39:37 GMT -5
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Post by mango on May 18, 2018 19:23:33 GMT -5
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Post by mango on May 18, 2018 19:43:09 GMT -5
Snip ----- Many T2s in addition to elevated BG also have elevated LDL. By bringing down the BG to near normal ranges it would be interesting to see how much the LDL is reduced and if the hdl/ldl ratio comes back to normal. If so, afrezza not only obsoletes the anti-glycemics and the RAA but it may also obsolete the need for much of the statins.  |
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