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Post by peppy on Oct 11, 2024 15:28:13 GMT -5
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Post by peppy on Oct 11, 2024 13:18:23 GMT -5
MNKD had epinephrine up for a partner sale for years, shown in quarterly earning presentations.... no partner stepped in. Epinephrine used to be shown on the products list. MNKD Epinephrine needed to be FDA approved secondary to the powder formation and approval for the inhaler.... a two part FDA approval. That was my understanding. ? sayhey24 . ? was that the case? Here is epinephrine, at the bottom of page 7. 2018.. investors.mannkindcorp.com/static-files/6e3651fe-2c56-4b5f-b1e2-528113e3048f |
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Post by peppy on Oct 11, 2024 10:58:11 GMT -5
MNKD had epinephrine up for a partner sale for years, shown in quarterly earning presentations.... no partner stepped in. Epinephrine used to be shown on the products list. MNKD Epinephrine needed to be FDA approved secondary to the powder formation and approval for the inhaler.... a two part FDA approval. That was my understanding. ? sayhey24. ? was that the case? |
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Post by peppy on Oct 7, 2024 14:32:13 GMT -5
www.inbrija.com/prescribing-information.pdfINBRIJA is an aromatic amino acid indicated for the intermittent treatment of OFF episodes in patients with Parkinson’s disease treated with carbidopa/levodopa (1) ______________ DOSAGE FORMS AND STRENGTHS _____________ Inhalation powder: INBRIJA capsules contain 42 mg levodopa for use with the INBRIJA inhaler (3)
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Post by peppy on Oct 6, 2024 9:45:39 GMT -5
I get a little confused when I hear of the concept of Beta Cells resting. I get that they’re overloaded when a person over eats, and eventually worked to failure, but I think of it like Testosterone. Your balls shrink when you take steroids (not that I would know, never done it, going on what I’ve heard) because they are resting, as you’re replacing what they would normally produce. After repeated abuse many can’t produce Testosterone on their own any more and for some Testosterone replacement becomes for life. Wouldn’t that be the same with insulin and Beta Cells? This caught my attention. Testosterone has my attention. Also making testosterone levels go down are Phthalates, which get into the androgen receptors, once in the androgen receptors the feed back system thinks there is enough testosterone. Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene pubmed.ncbi.nlm.nih.gov/36104915/weehaw,  .https://www.sciencedirect.com/science/article/abs/pii/S1532045622002332 ars.els-cdn.com/content/image/1-s2.0-S1532045622002332-ga1_lrg.jpg |
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Post by peppy on Oct 4, 2024 12:07:02 GMT -5
Type 2's gain weight on subq insulin.
I don't think type two's want to be on Rapid Acting Mealtime subq insulin.
They don't want to.
They don't see the pay off?
(*type two's do not gain as much weight using afrezza? Probably secondary to the first phase.)
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Post by peppy on Oct 4, 2024 10:17:25 GMT -5
The reason GLP-1 are in the demand they are in, is the weight loss.
*they are generic."
Another commercial has shown up for GLP-1 on cable television. this one for 99 dollars a month.
I asked a person on GLP-1 on it for weight loss, insurance through employer. I asked if they ever tested their blood glucose level. They replied no.
One other thing, you know I like charts, LLY even with the buy backs seems to have topped and has a measured move to $700. I was wondering if that is secondary to generics hitting the market.
My understanding is, once off the GLP-1 the weight comes back.
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Post by peppy on Oct 3, 2024 17:01:29 GMT -5
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Post by peppy on Oct 3, 2024 10:25:55 GMT -5
From seekingalpha: "MannKind has large long-term liabilities, including $227.577 in senior convertible notes and $135.365 million in liability for sale of future royalties." What is "liability for sale of future royalties"? Thanks. 1% of the Tyvaso DPI royalty./year. |
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Post by peppy on Oct 3, 2024 9:13:55 GMT -5
Is there news? Did India approve? What is going on?  |
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Post by peppy on Oct 2, 2024 20:58:24 GMT -5
Blah blah blah. Did the peak times and the out of system times change on these Rapid Acting Subq insulins? Hard to get the blood glucose control the correct use of Afrezza gives. You know, you keep saying "blah blah blah" at people, they might start taking it personally... aged and I know each other. aged uses multiple daily injection using a pen. You do know that peak on the RAA's is @ 90 mins and out of system 5 to 6 hours correct? Afrezza peak 35 mins out of system 90 mins for a 4 unit cartridge. Subq pumps can not make RAA's work faster. So what happens is the type one goes high and then low using subq rapid acting insulin. A low A1c the lows average the highs. Aged points out a no carb diet blunts highs if people go that route. Don't get me wrong, it is the delivery route that makes RAA's so slow. Put the insulin in an IV bag and run it into a human being IV, it works fast. Better control the amount and rate. . |
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Post by peppy on Oct 1, 2024 19:29:46 GMT -5
Do we know for certain that automated pump refers to AID and not a stand alone insulin pump? We want automated pump to mean AID but even "dumb" pumps are sophisticated computer controlled devices. Another way to look at it: if mnkd wanted to be crystal clear that they were referring only to AIDs, they would have said AID. Press releases are never ambiguous unless it is in the company's advantage for people to make wrong assumptions by interpreting things incorrectly. The inclusion criteria for the trial says, " MDI, an AID system, or an insulin pump without automation. The PR says, "multiple daily injections (MDI), an automated insulin delivery system, (AID) or a pump without automation." I think it's safe to say automated pump means AID. You are correct though, even dumb pumps some automation because they change basal rates on a schedule you give it. Blah blah blah. Did the peak times and the out of system times change on these Rapid Acting Subq insulins? Hard to get the blood glucose control the correct use of Afrezza gives. |
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Post by peppy on Sept 30, 2024 19:34:02 GMT -5
The study proves that a Type-1 can have a better A1C without being tethered to a pump. The study assumes/implies a better Time In Range. ... The trial data shared doesn't show that you can get a better A1c without being tethered to a pump, it shows that Afrezza is better than an aggregate of MDI, dumb pumps, and AID pumps. It may be the case that Afrezza does out-perform AID pumps, but right now we have no way of knowing since they didn't share that data. TIR is implied by A1c, but again there is no breakdown between the treatments so we don't know. I suspect this is all we get until 2025 based on, "We look forward to discussing more details of the 30-week study results at ATTD next March and additional conferences in 2025." Quote time in range is implied by A1c. Lost in the A1c are the lows that average out the highs. A1c's are lazy for the physician, and dangerous for the Subq user, in my opinion. |
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Post by peppy on Sept 24, 2024 15:09:14 GMT -5
quote, Most of them swapped to a low carb high fat (LCHF) diet which gives slow and low peaks RAA can handle. reply, switching the way people eat, what they eat, seems like more work than breathing some Afrezza, twice at meal time. Starting dose and add on dose. What I am saying is this how people actually cope today - mostly a combination of LCHF diets and pumps. The main thing is that these people are highly motivated and will make changes. This is why I think Afrezza is a fit, and because it is theoretically time limited I think insurers may play ball. aged, This is the most positive thing I can remember you saying about Afrezza use. |
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Post by peppy on Sept 24, 2024 13:36:26 GMT -5
... Not going over 125 without afrezza has to be a challenge. Even with afrezza its a challenge but staying under 140 in 2 hours post meal not much of one. I guess my question is why did it take Carol Levy so long to get on the afrezza train? Ten years after approval seems like she was snoozing or something changed. Not going over 125 is definitely a challenge, but can be done and I know people who did it. Most of them swapped to a low carb high fat (LCHF) diet which gives slow and low peaks RAA can handle. The problem, as always, isn't the food it's your body which can decide for no apparent reason that now is a good time to mess with your levels. It is also the reasons why pregnant type 1s got CGMs far ahead of most other people. I am going to ignore your comment about Carol Levy because you know nothing about her, have little idea what she has been doing, and are obviously just trolling. quote, Most of them swapped to a low carb high fat (LCHF) diet which gives slow and low peaks RAA can handle. reply, switching the way people eat, what they eat, seems like more work than breathing some Afrezza, twice at meal time. Starting dose and add on dose. |
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