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Post by mnkdfann on May 22, 2021 14:59:31 GMT -5
So contrary to Dr. Hofmann, by inhaling clofazimine it is merely speeding up the onset of adverse side effects. And if I remember correctly, the SA article indicated that clofazimine has a half-life of nearly three days --- that is a lot of time for a drug to negatively impact a human’s body. The good new for clofazimine---the only human body part that does not have a blood supply are the eye’s corneas. Therefore, no worry about clofazimine accumulating and crystalizing there. I think you misread something. The SA article says: "Clofazimine was discovered in the 1950s ... The drug was marketed under the name—Lamprene ... it would be relevant to note that the biological elimination half-live is 70 days—not 70 hours, but seventy days –going on three (3) months. What could this drug be being doing to a human’s lungs when it could remain in their lungs and body for seventy days and maybe several years?"
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Post by mnkdfann on May 21, 2021 19:00:12 GMT -5
The article embellishes the side-effects of clofazimine. Interestingly, in yesterday’s meeting, Dr. Hofman, the Chief Medical Officer addressed this directly (starting at 18:45 on the recording) about how the direct inhalation of clofazimine goes directly to the point of infection while avoiding the systemic side effects. He says that 120,000 people a year die of this and he referred to it as a substantial unmet need. FROM NEIL36 ..keeping me sane... What Hofman said, as you noted, was that direct inhalation would reduce " systemic side effects of taking a drug orally" which I believe is not the same thing as what LFD is talking about. (I think) Systemic side effects of taking a (any) drug orally are not the same as specific side-effects tied to taking Clofazimine in particular. That doesn't mean LFD is correct, but I don't think Hofman's statement addressed what LFD said.
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Post by mnkdfann on May 21, 2021 15:29:42 GMT -5
FROM LFD's last piece, written in June 2020: It is my sincere hope and desire that by some means Afrezza can remain available for those patients who need options in treating their medical condition. The same applies for Tre-t. Any new drug that is FDA approved, patients needing options should have it available. He usually (always?) includes a comment like that. From today's article: "It is my sincere wish that Afrezza remains available for those patients needing options for treating their diabetic condition. I hope that any drug addressing the debilitating PAH condition will be a successful drug—whether in DPI delivery format or delivered by a nebulizer."
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Post by mnkdfann on May 17, 2021 12:32:28 GMT -5
Mannkind can salvage this yet ... "Just like Conor racing in the NTT IndyCar Series, Afrezza insulin is fast in and fast out!"
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Post by mnkdfann on May 17, 2021 12:24:27 GMT -5
"Appropriate" is not forbidden... The box warning was not appropriate either so I see no problem with going ahead with it anyways, except that antagonizing this authoritarian monster may not be the best policy at this point in time. I'm pretty sure I am over-thinking it but ... Assuming it is allowed, how about maybe Mannkind doesn't want to put 'Afrezza' on the side of a driver's car until it can afford to put it on the side of a car it knows is more likely to be a serious contender than a possible embarrassment? According to this site, Ed Carpenter racing was tied as the worst Indy Car team at the start of the season. (Yes, I know it won last week.) the-race.com/indycar/rating-the-2021-indycar-driver-line-ups/And Conor, I'm afraid to say, is tied as one of the lowest ranked drivers this season: www.espn.com/racing/standings/_/series/irl In order not to risk hurting the 'Afrezza' brand, maybe Mannkind is happier to go with 'lifestyle' campaign type marketing (when it comes to race cars) for now.
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Post by mnkdfann on May 16, 2021 21:16:33 GMT -5
We're hobbled by the FDA no matter what advertising medium we use. Those black box warnings are a HUGE problem, in so many ways. Not trying to pick a fight here, just asking what is the difference between this car in the Indy Grand Prix this weekend and a car that would have "Afrezza" on it? Maybe a difference is this? (IOTW, maybe if the car only said Afrezza and had nothing remotely hinting at diabetes it would be okay?) www.sponsorship.com/iegsr/2016/02/08/Inside-The-Evolving-Pharmaceutical-Category.aspx Lilly sponsored Chris Buescher in 2014 at the NASCAR Nationwide Series race at Homestead-Miami Speedway on behalf of Humalog Kwikpen and Greg Biffle in 2015 at the NASCAR Sprint Cup Series race at Phoenix International Raceway on behalf of Jardiance, a drug for type 2 diabetes.
Each car featured the name of a medication, but not the condition it treats. Promoting medical conditions would prompt the need for product disclaimers, said Cammack.
“If you only have the name of the product and do not talk about the disease, you don’t need a disclaimer. Combining the name of a product and the disease that it treats is when those requirements come into play.”
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Post by mnkdfann on May 16, 2021 21:14:20 GMT -5
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Post by mnkdfann on May 16, 2021 13:53:13 GMT -5
Daly made the race highlights! Was that a Sanofi sponsored car that clipped Daly? (Yellow car is Simon Pagenaud. He's French. Sanofi is headquartered in Paris. Just saying. Follow the money.) [*] Video: youtu.be/aFf56KRhkBU?t=17[*] Note to conspiracy theorists, I kid.
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Post by mnkdfann on May 16, 2021 11:49:44 GMT -5
IMO that’s sorta sad. (Note, Ruetir is NOT Reuters.) Unless we consider the Mannkind money well spent that it got Conor a poorly translated mention (tired of bites?) on some random guy’s personal news site (based somewhere in Euroland, I think). www.ruetir.com/contact-us/Hello Friends Welcome To Ruetir
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We’re dedicated to providing you the best of News Website , with a focus on dependability and .
We’re working to turn our passion for News Website into a booming online website. We hope you enjoy our News Website as much as we enjoy offering them to you.
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Post by mnkdfann on May 15, 2021 21:58:09 GMT -5
I taped the race and just watched the start. Conor got more TV time than he would have if he stayed in the race. And since the car wasn't moving it was easy to read the website. The announcer even called his car the mannkind Chevrolet. With this publicity, it is a lock that next week we'll have TRx of 1000+ !!! Sadly, judging from the current status of the Symphony Script thread, we'll never know.
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Post by mnkdfann on May 15, 2021 15:34:16 GMT -5
Maybe: "Thanks for the loot, Mike. Same time, next year?"
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Post by mnkdfann on May 14, 2021 18:49:40 GMT -5
He’s an athlete that is going to go around and talk about his experience with the drug. If anything there’s concern that he’s not well known enough. So by that logic those complainers would rather spend more on advertising? But, does he? Doesn't really seem like it. Maybe he needs a Mannkind media coach to tell him to take advantage of opportunities, like the donut interview above, to mention / use Afrezza.
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Post by mnkdfann on May 14, 2021 18:45:15 GMT -5
Here is Conor from earlier this week, featured on Drivers Eating Donuts. He mentioned his diabetes. Seems like a perfect opportunity to mention Afrezza, at least a throwaway comment, or even take a puff before the donut. Did he do anything like either of those? (If he did, I missed it.) Well, at least he hawked Jack's Donuts, Duvin Shirts, his U.S. Air Force sponsor, merchandise for his mullet cut, etc. BTW, the 'Carb Day' they are talking about is "Carburetion Day" (shortened to "Carb Day" since 2000). Nothing to do with dietary carbs or diabetes. youtu.be/w36S8unaLKU
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Post by mnkdfann on May 14, 2021 18:44:36 GMT -5
He actually uses the drug. Conor did tweet about using it for about a month, back in 2019. It was never clear to me how MUCH he used it. Or whether he stuck with it. I think he mentioned it in a print interview around the time. Since then, I really never heard him say anything about Afrezza or Mannkind. Until this week, of course.
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Post by mnkdfann on May 14, 2021 16:27:07 GMT -5
I’d love to be proven wrong. But somehow, as a target audience, I’m not convinced that NASCAR fans are a good investment. When I think of patients with diabetes who are likely to demand a new approach from their Endo or PCP, this is not the group that pops into my mind. And if they do notice the slogan as the car speeds by, I can’t imagine that they will make a mental note to google it as soon as they get home. Racing fans talk to each other and "Tired of Pricks?" is a subject that will be discussed among many of them. Do you really believe that? I'm friends with a lot of racing fans, and I can't say I've ever heard them talk about anything to do with advertising on a car.
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