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Post by mnholdem on Sept 17, 2018 7:25:49 GMT -5
Has the Hrs/Min been corrected? I hate to create account just to check.. Onset is 12 min but it's under the hour header so either should be changed from "12" to "12(min)" or probally more correct changed to "0.2" No. If you click the link (above) you now get a sign in / registration page, but if you google "MPR Insulin Chart" and change the google search filter to Past Month, you can view the chart, which still displays the Onset in Hrs rather than Mins.
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Post by mnholdem on Sept 17, 2018 6:05:52 GMT -5
Which is why agedhippie has argued himself into a corner. An AP / smart pump would administer a follow on dose 2 hours after an initial mealtime dose if indicated by BG levels.
That’s the protocol which was used in the STAT trial. You would take a follow on dose with a simple (click, snap, inhale), faster (onset), safer (shorter duration of insulin on board = less post-prandial glucose excursions) and much less expensive treatment for optimum BG control.
Expense aside, a smart pump would come with its own set of problems and, because it would administer SQ insulin, would not be safer.
Speaking personally (and allegorically), I would never put my life or the lives of my family at risk by getting behind the console of a $60k-$100k computer-guided vehicle. Until I see decades of safety data, I would continue to manually drive a $30k vehicle - a simple and safe vehicle with a dashboard display that gives drivers the information they want, which provides navigation advice when asked for and alerts drivers to immediate problems/dangers when needed.
This is one man’s opinion, but if you think it’s viable to get an expensive computer-guided car to every driver around the world (or even just the USA) then go for it. Find that cutting-edge automaker and invest in it.
I have applied the same logic to managing diabetes, so I choose to invest in a company whose cutting-edge technology can save thousands of lives and livelihoods that are lost every year - even though the treatment is administered manually.
Good fortune to you.
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Post by mnholdem on Sept 16, 2018 14:37:14 GMT -5
You seem to be a highly responsible and intelligent diabetic/ for those who don’t fall in that category discipline included / which I am willing to believe is great number of the patient population , a quick reading and breath seems like a very small price to pay for what you might consider an inconvenience more than anything. I would have loved to know the reason why the non-compliant people in the STAT study were non-compliant. Dr Kendall speculates that it is because of fear of hypos, I suspect it was a feeling that they have taken their insulin for the meal. I think not ask why was an opportunity missed because it is almost certainly reflected in the wider community. If you know what the issue is you can address it. "Compliance with TI use was based on using TI per protocol at 1- and 2-h postmeal based on PPG values. Patients were defined as compliant if ±90% of postmeal TI dosages were taken per protocol, with at least one of the postmeal inhalations taken if indicated per meal. "Four patients in the TI group were excluded from the final analysis (two dropped out the study due to non-side-effects-related reasons, and one had no CGM data and the other had incomplete CGM data (with the first 2 weeks of the study data missing)." Out of 22 patients in the TI group, 15 (68%) were compliant and 7 were noncompliant, with average compliance in the whole group of 91% ± 11%. Source: www.liebertpub.com/doi/10.1089/dia.2018.0200--- I happen to think that Dr Kendall's speculation about reasons for STAT noncompliance carries much more weight than yours. Your posts may seem educational, for some ProBoards members and nonmembers, but you never seem to post much data which supports your repeated implication that others manage their diabetes like you manage yours and have similar concerns (or lack thereof) about various treatments or their daily blood glucose levels. You may be a fine person but I have concerns about your theme (which you convey in dozens of posts) that somehow your experiences with this disease are reflective of the millions of unique human beings who deal with diabetes every day, each in his or her own way. IMO, your viewpoint should carry the same weight as each of the blogs posted by sportsrancho or harryx1, which they share with ProBoards member from men, women and children who share their experiences with Afrezza and diabetes management on the Internet. David Kendall MD has worked with thousands, if not tens of thousands, of patients with diabetes. You are one person.
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Post by mnholdem on Sept 16, 2018 13:08:27 GMT -5
Well how about that? A squeaky wheel got greased!
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Post by mnholdem on Sept 14, 2018 13:30:45 GMT -5
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Post by mnholdem on Sept 13, 2018 7:01:13 GMT -5
UTC’s conference call could simply be about their buyout of PAH competitor SteadyMed. The M&A just closed the other day.
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Post by mnholdem on Sept 13, 2018 6:57:43 GMT -5
Good morning mnholdem (and other long time MNKD equity holders) from Ontario Canada. I don't understand what your post is alluding too. Can somebody translate and put into laymen terms? Thanks in advance. Briefly, that website mixed up the name of the partner which could mislead new investors in MNKD. Sloppy on their part.
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Post by mnholdem on Sept 12, 2018 19:58:21 GMT -5
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Post by mnholdem on Sept 12, 2018 19:40:01 GMT -5
Drug Profile Treprostinil dry powder inhalation - MannKind/Receptor Life SciencesAlternative Names: Treprostinil Technosphere®; TreT Latest Information Update: 11 Jun 2018 Originator MannKind Corporation; Receptor Life Sciences Class Antihypertensives; Prostaglandins; Small molecules; Vasodilators Mechanism of Action Epoprostenol receptor agonists; Platelet aggregation inhibitors Orphan Drug Status No New Molecular Entity No Highest Development Phases
Phase I Pulmonary arterial hypertension Most Recent Events07 Jun 2018 MannKind completes a phase I trial in Pulmonary arterial hypertension in USA (NCT03464864) 07 Jun 2018 MannKind plans a clinical trial for Pulmonary arterial hypertension 27 Mar 2018 Chemical structure information added Link: adisinsight.springer.com/drugs/800051419
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Post by mnholdem on Sept 12, 2018 16:00:06 GMT -5
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Post by mnholdem on Sept 12, 2018 15:38:37 GMT -5
One Drop Becomes First Diabetes Blood Glucose Monitoring Platform To Integrate Directly With Apple Watch Published: Sep 12, 2018
NEW YORK, /PRNewswire/ -- One Drop expands their industry leading Apple Watch diabetes management solution by offering the first and only wireless blood glucose monitoring system to connect directly to Apple Watch.
One Drop is as an award-winning, digital diabetes management solution delivering exceptional clinical outcomes, including absolute reduction in A1C, through its evidence-based self-care tools, professional coaching, and data-driven insights. As people with diabetes continue to look for the easiest and most convenient ways to lessen the burden of managing their condition, One Drop continues to innovate and offer the simplest, most elegant, and most accessible solutions to support and empower their users.
Read more at: www.biospace.com/article/releases/one-drop-becomes-first-diabetes-blood-glucose-monitoring-platform-to-integrate-directly-with-apple-watch/
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Post by mnholdem on Sept 11, 2018 13:17:53 GMT -5
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Post by mnholdem on Sept 11, 2018 8:37:51 GMT -5
National Diabetes Coalition Urges People With Diabetes Living Along The East Coast To Prepare For Hurricane Florence Published: Sep 11, 2018
ARLINGTON, Va., Sept. 10, 2018 /PRNewswire/ -- As the U.S. Eastern seaboard braces for Hurricane Florence, a category 4 hurricane that could potentially impact several states including Georgia, South Carolina, North Carolina and Virginia between Thursday and Friday, the diabetes community is rallying to make sure that people living with diabetes--especially those who depend upon insulin--have access to resources and support so they can continue to effectively manage their diabetes. The Diabetes Disaster Response Coalition (DDRC), comprised of the nation's leading diabetes organizations, is urging all people with diabetes and their loved ones to prepare for Hurricane Florence by putting together a diabetes kit and making a plan to stay healthy and safe during the storm and in its aftermath.
Source: www.biospace.com/article/releases/national-diabetes-coalition-urges-people-with-diabetes-living-along-the-east-coast-to-prepare-for-hurricane-florence/
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Post by mnholdem on Sept 10, 2018 21:47:11 GMT -5
FYI - You have up to an hour to go back in to edit your first post and correct those irritating spell-checkers / auto-spells.
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Post by mnholdem on Sept 10, 2018 13:00:56 GMT -5
Years ago MannKind did have trademarks registered for Coffee Kick and Wine Blast for flavored powders that had no therapeutic benefit. I had purged that out of my memory as it was back in the "Embarrassment of Riches" days That being said i'm game for anything that keeps the production lines moving and sales rolling in. That was way before Pfeffer.
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