|
Post by sayhey24 on Oct 26, 2018 17:09:15 GMT -5
I'm not going to bother reading the patents. They are intentionally written to be as difficult to follow as possible. I'm sure I wouldn't understand them even if they were trying to be as clear as possible. One thing that doesn't add up. If MNKD had a potential cure for the opioid crisis, wouldn't the gov't and groups like the Gates Foundation be all over this? Fast track, etc. But we haven't heard anything for years.
Thats a good question. Dealing in the government world is very different than dealing in the private sector. Maybe MNKD does not have anyone with the right experience dealing in that world.
I would think there are numerous contracts worth good money MNKD could be getting with some effort. To answer your question you go to the mountain, the mountain does not typically come to you. The government groups will send out an RFI to players in the field but they need to know you are a player which takes work and why K street exists. Sometimes the best place to start is with a cooperate research and development agreement - CRADA but even getting one of those takes work. By the time it hits the CBD its too late.
Does MNKD have a government group? They only have a couple hundred people. I had that in my small group doing advance technology programs for the government.
|
|
|
Post by brentie on Oct 26, 2018 19:53:55 GMT -5
As I recall this was the subject of the Torrey Pines partnership from several years ago. Specifically a non addictive pain killer that could be taken liberally with no side effects nor addiction issues. For some reason it has faded from the conversation. Yeah, that really sounded promising at the time(2012). I hope something comes from that partnership, there's a huge need for a non addictive pain killer that you can't overdose on and that starts working within a minute. -------------------------------------------------------------------------------- "After the lunch, Houghten expanded on the new drug's possibilities. "It's actually pretty marvelous," Houghten said. "You can't (overdose) on this drug." The drug is being developed in partnership with Mannkind Corp., which has created a small device that allows people to inhale medicine. By inhaling, the medicine can relieve pain quicker than through pill form, Houghten said. "Our pain compound, if it all works out, ... if you can take that pain compound and just inhale within just 30 seconds to a minute, your pain will be alleviated," Houghten said. "So you can see that that can be a real important step." The drug has been tested on two separate animal groups and Houghten said the drug will be tested on a third before going before the U.S. Food and Drug Administration, which must give approval for human trials. Houghten said the unique nature of the drug could make it easier to get approval. "You never really quite know," he said. "Right now, everything's looking really good. ... We can't get a high enough dose that causes a problem." Patients also do not build up a tolerance to the medicine, whereas other pain relievers require patients to take more and more to get the same effect. Houghten said he is thrilled with the drug's progress. "In reality is if it's 2014 (before human testing), I'm still going to be happy," Houghten said. "I don't think it's going to be a problem with the FDA. It's very simple what we want to do, so we can show them clearly here's the effective dose, here's the toxic dose. That's 90 percent of it right there. It's effective and it's not toxic." -------------------------------------------------------------------------------------------- This is kind of interesting, it's from 3 months ago, but I'm not sure if Technosphere is involved in these trials. I would think that we would have heard something about Cara Therapeutics if they were using MNKD's inhaler in their pain trial. Dr. Richard Houghten: "These techniques can be used in virtually all existing bench top assays. Internal use of these techniques resulted in the identification of extra-ordinarily active and specific kappa opiate receptor tetra-peptides which were licensed to CARA Therapeutics and will be entering Phase III trials for peripheral pain management; these compounds have none of the side effects of the opiates such as morphine." www.tpims.org/news
|
|
|
Post by itellthefuture777 on Oct 26, 2018 20:21:25 GMT -5
I aways thought this was a great solution of an unmet need.
|
|
|
Post by rravis1914 on Oct 27, 2018 21:03:22 GMT -5
This sounds like a logical question to be brought up at the CC. Pain killers, oxytocin etc etc.
|
|
|
Post by tmann on Oct 30, 2018 15:03:12 GMT -5
Will bring it to USG attention.
|
|
|
Post by tmann on Nov 2, 2018 9:41:48 GMT -5
Opioid pain killers are effective but are also highly addictive.
Justia is (according to patents granted ) a pain killer that does have an undesirable addictive property.
If this drug works as claimed, it could replace all addictive pain killers in medical use. (hundreds of drugs from vicodin to fentanyl)
Does Justia work as claimed?
Do you trust Al Mann?
|
|
|
Post by uvula on Nov 2, 2018 9:53:55 GMT -5
Opioid pain killers are effective but are also highly addictive. Justia is (according to patents granted ) a pain killer that does have an undesirable addictive property. If this drug works as claimed, it could replace all addictive pain killers in medical use. (hundreds of drugs from vicodin to fentanyl) Does Justia work as claimed? Do you trust Al Mann? I think you meant "does NOT". Unfortunately no one asked about this during the Web cast. If it is so great then why isn't mnkd doing something with it. Do you think there is a chance that there are secret negotiations with a partner? If so it could be another huge win for Mike.
|
|
|
Post by mnholdem on Nov 2, 2018 16:53:40 GMT -5
IMO, it would have to be a partnership. Pain med trials are VERY expensive.
|
|
|
Post by boca1girl on Nov 2, 2018 17:50:41 GMT -5
Opioid pain killers are effective but are also highly addictive. Justia is (according to patents granted ) a pain killer that does have an undesirable addictive property. If this drug works as claimed, it could replace all addictive pain killers in medical use. (hundreds of drugs from vicodin to fentanyl) Does Justia work as claimed? Do you trust Al Mann? I think you meant "does NOT". Unfortunately no one asked about this during the Web cast. If it is so great then why isn't mnkd doing something with it. Do you think there is a chance that there are secret negotiations with a partner? If so it could be another huge win for Mike. Didn’t Torre Pines get the rights to the pain API years ago?
|
|
|
Post by mnholdem on Nov 2, 2018 17:55:50 GMT -5
Mann had an out in the contract if TP didn’t take the API to trials.
|
|
|
Post by sayhey24 on Nov 2, 2018 17:57:12 GMT -5
If I remember correctly you are right.
Was this what Mike was referring to when he said he does not want to make the same mistake as in the past and partner with someone with no money?
|
|
|
Post by boca1girl on Nov 2, 2018 18:01:10 GMT -5
Mann had an out in the contract if TP didn’t take the API to trials. If that is the case, why doesn’t MNKD claw back the rights?
|
|
|
Post by brotherm1 on Nov 2, 2018 18:47:03 GMT -5
Perhaps because maybe most opioid treatments will soon be a thing of the past ? Don’t know but from the manholdem himself: t's important to understand that Torrey Pines is a partner ONLY in co-developing an opioid pain relief medication with MannKind's Technosphere delivery system. Torrey Pines is NOT a pharmaceutical company that has the cash to develop and/or marketing this co-patented pain medication. It is a research institute. Both Torrey Pines and MannKind Corporation would need to find and sign a big pharmaceutical company (BP) to fund the regulatory (FDA/EMEA) trials and, assuming approval, to market it globally. This happens to be one of the API types - a unique API that has never been approved - that Hakan once said is the most expensive and would take the longest to develop into a marketable product. MannKind has other API that can exit the pipeline much faster and cheaper than this opioid, IMHO. Read more: mnkd.proboards.com/thread/4257/torrey-pines-files-patent-dreamboat?page=2#ixzz5VkC5H7Vq
|
|
|
Post by brotherm1 on Nov 2, 2018 20:52:27 GMT -5
Also, I’m thinking inhaling opioids would be akin to snorting heroin, and we’re all probably aware of the current problems associated with inhaling opioids. It might not go over well with the FDA at this point in time.
|
|
|
Post by seanismorris on Nov 2, 2018 21:40:55 GMT -5
Also, I’m thinking inhaling opioids would be akin to snorting heroin, and we’re all probably aware of the current problems associated with inhaling opioids. It might not go over well with the FDA at this point in time. If I remember correctly the Torrey Pines/MannKind collaboration was for a pain med they called “non addictive”. I don’t think we ever got the details, but whatever it was, it wasn’t an opioid. I agree, a technosphere opioid would never get approved.
|
|