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Post by mytakeonit on Jan 8, 2019 20:36:38 GMT -5
Ahhh yes ... I understand it perfectly now.
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Post by mango on Jan 8, 2019 20:47:32 GMT -5
In attempting to understand the difference between Treprostinil and Ralinepag, can anyone decipher what this all means: Ralinepag Potent IP Receptor Agonist PAH – Time to Clinical Events Ph3 Initiated PAH – Exercise Capacity (CPET) Ph3 PAH – Exercise Capacity (6MW) Ph3 PAH – Differentiation 1H:19 Initiatio www.arenapharm.com/pipeline/#Ralinpag is a selective prostacyclin receptor agonist. It has a high binding affinity and selectivity for the prostacyclin receptor and a weak binding affinity for other prostanoid receptors.
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Post by travis1953 on Jan 8, 2019 21:01:09 GMT -5
What does it mean "for rescue"? To have as a backup, and to use as needed I'm afraid I still don't understand. How would a person with pulmonary hypertension know when they needed it versus just an additional dose of remodulin or tyvaso? Or for that matter, why not use Mannkind's version of treprostinil as a rescue?
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Post by mnkdfann on Jan 8, 2019 21:02:26 GMT -5
In attempting to understand the difference between Treprostinil and Ralinepag, can anyone decipher what this all means: Ralinepag Potent IP Receptor Agonist PAH – Time to Clinical Events Ph3 Initiated PAH – Exercise Capacity (CPET) Ph3 PAH – Exercise Capacity (6MW) Ph3 PAH – Differentiation 1H:19 Initiatio www.arenapharm.com/pipeline/#If you google the phrases, stuff turns up on the web. CPET is Cardiopulmonary exercise testing, a global test of a patient's cardiorespiratory capacity. 6MWD (you left out the D) is an abbreviation for 6 minute walk distance. A particular exercise test. That's all I got for now.
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Post by lakers on Feb 6, 2019 2:04:23 GMT -5
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Post by peppy on Feb 6, 2019 8:36:45 GMT -5
To have as a backup, and to use as needed I'm afraid I still don't understand. How would a person with pulmonary hypertension know when they needed it versus just an additional dose of remodulin or tyvaso? Or for that matter, why not use Mannkind's version of treprostinil as a rescue? I think these people are probably on all these medications and the physician does prescribe what to take when. They know because they are oxygen starved. They feel like they have run out of breathe. The hypertension of the pulmonary vein which should deliver oxygenated blood to the left atrium. In the presence of oxygen one glucose molecule becomes 32 ATP = aerobic metabolism. In the presence of no oxygen one glucose molecule makes 2 ATP = anaerobic metabolism. liane check me here. a normal Arterial blood gas is in these parameters. Partial pressure of carbon dioxide (PaCO2) - 38 - 42 mmHg. Arterial blood pH of 7.38 - 7.42. Oxygen saturation (SaO2) - 94 - 100% Bicarbonate - (HCO3) - 22 - 28 mEq/L.
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