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Post by peppy on Sept 2, 2019 21:29:36 GMT -5
So I have been conversing with a board member who started Afrezza. Perhaps 6 weeks ago? may be 2 months. TYPE 2 (TWO)
He mentioned to me in an email that he is losing weight. So you know me in my know it all fashion said, well water weighs 8 pounds a gallon. sweedee79 remember dad felt better on afrezza. remember when he got off afrezza and went back on subq he gained weight. So I continued with my friend, the glucose is moving into the cell. The osmolarity of the plasma changing and the water weight can be lost? liane , check my thinking. Lung wise, if a diabetic in congestive heart failure? ..... ========================================================= joeypotsandpans , I have been waiting patiently for weight wise report. ======================================================== TYPE ONE TYPE 1Added, shawnonafrezza, how you feel? what is your take? Do you physically feel better when using afrezza over how you feel when physically when using subq? agedhippie |
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Post by shawnonafrezza on Sept 2, 2019 23:30:16 GMT -5
Well I use both subq (good ol' R) and Afrezza together so maybe I'm not the best to ask. But on an average day of say me using a closed loop (with humalog) eating low carb or an average day of me going Afrezza/R I don't feel particularly different. On higher carb days, days I binge, holidays, etc I feel better on Afrezza because I feel like as soon as I get over ~5-6U on board of novolog/humalog I start to feel jittery almost like a pre-crash (that never comes) type jitter.
How much of that is mental I don't know. My heart is in good health, I don't hold water unless I'm taking fitness supplements that will cause to to hold water, my joints are good, lungs are (obviously) good.
I think people eating more of a SAD style diet, the less physically active, and those with worse (lets say >7%) A1C will notice the biggest benefit and that'll because they start to achieve more euroglycemia which itself helps a lot of the above issue.
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Post by agedhippie on Sept 3, 2019 11:47:31 GMT -5
So I have been conversing with a board member who started Afrezza. Perhaps 6 weeks ago? may be 2 months. TYPE 2 (TWO)
He mentioned to me in an email that he is losing weight. So you know me in my know it all fashion said, well water weighs 8 pounds a gallon. sweedee79 remember dad felt better on afrezza. remember when he got off afrezza and went back on subq he gained weight. So I continued with my friend, the glucose is moving into the cell. The osmolarity of the plasma changing and the water weight can be lost? liane , check my thinking. Lung wise, if a diabetic in congestive heart failure? ..... ========================================================= joeypotsandpans , I have been waiting patiently for weight wise report. ======================================================== TYPE ONE TYPE 1Added, shawnonafrezza , how you feel? what is your take? Do you physically feel better when using afrezza over how you feel when physically when using subq? agedhippie I would have thought that you lost more water weight when your control was poor because your kidneys are dumping glucose and that takes water. It's why SGLT2 has the dehydration warning. |
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Post by peppy on Sept 3, 2019 12:02:19 GMT -5
" I would have thought that you lost more water weight when your control was poor because your kidneys are dumping glucose and that takes water. It's why SGLT2 has the dehydration warning. touche, and that is why I love you. What is your take on the reported weight loss? Also remember blindhog1 .... he reported the same. I have seen a few reports of weight loss. What is your take? Think type two here. why are they losing weight? they were not on insulin before? (Blindhog even in some obscure reference, posts ago, time past, mentioned he had lost a lot of weight in those moments and mentioned he was eating rice. I think he was pretty happy.) |
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Post by sweedee79 on Sept 3, 2019 12:31:03 GMT -5
I am no expert.. but from what I gather insulin is the main fat storage hormone in the body.. RAA hangs in the body and isn't the way the body reacts normally... So yes I believe it creates imbalance, not to mention that RAA is also synthetic..
Not so with Afrezza.. it is the closest thing we have to the normal process.. so to me it is just common sense that the body would respond accordingly.. and it isn't synthetic insulin..
In today's world with all of the processed.. genetically modified etc... our bodies are craving back to nature.. I truly believe it cuz I saw it.. and that is why I adamantly defend Afrezza..
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Post by peppy on Sept 3, 2019 12:37:17 GMT -5
I am no expert.. but from what I gather insulin is the main fat storage hormone in the body.. RAA hangs in the body and isn't the way the body reacts normally... So yes I believe it creates imbalance, not to mention that RAA is also synthetic.. Not so with Afrezza.. it is the closest thing we have to the normal process.. so to me it is just common sense that the body would respond accordingly.. and it isn't synthetic insulin.. In today's world with all of the processed.. genetically modified etc... our bodies are craving back to nature.. I truly believe it cuz I saw it.. and that is why I adamantly defend Afrezza.. sweedee. Dad. when he went off afrezza, his health deteriorated a bit? Is my recall correct? When Dad went back on subq. Is dad type one or type two? Did dad's breathing change? Did dad develop congestive heart failure? |
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Post by sweedee79 on Sept 3, 2019 12:40:22 GMT -5
He has had no congestive heart failure that I'm aware of.. but after quitting Afrezza he lost energy.. and gained the weight back.. I saw him get depressed again.. and they say his stroke was caused by his heart..
My dad will be 79 in a couple of months.. he has Lada.. so I call it type 1. His pancreas failed in his 50s.. but I also believe he has insulin resistance.. he is on metformin..
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Post by sweedee79 on Sept 3, 2019 12:54:39 GMT -5
Since Afrezza is a more natural form of insulin why can't the company use this aspect in their marketing.. surely the FDA or BP couldn't stop that cuz it's the truth!!!! Come on!!!
I'm so tired of hearing about fake insulin dominating our market when there is something way better!!
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Post by sweedee79 on Sept 3, 2019 13:27:35 GMT -5
I'm invested in pharmaceuticals.. but I'm not pro pharma.. nor am I pro our medical system in this country.. there is a pill for everything..
My mom has Alzheimer's and my dad diabetes and now a stroke victim.. you should see the aresanal of pills they get fed everyday..
FDA and our medical system in this country really needs to be rethought.. as well as our daily recommended diet .it's almost like they want people to be sick.. lots of money in that. Pretty sad. We are creating our own problems.. in the meantime insurance and BP get rich.
Then you have a solution like Afrezza.. and we are struggling? This has opened my eyes to a lot.
People should be aware that our tax dollars, Medicaid foot the bill for nursing homes.. and all of the pills.. hope someone takes notice someday.
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Post by peppy on Sept 3, 2019 13:30:10 GMT -5
" I would have thought that you lost more water weight when your control was poor because your kidneys are dumping glucose and that takes water. It's why SGLT2 has the dehydration warning. touche, and that is why I love you. What is your take on the reported weight loss? Also remember blindhog1 .... he reported the same. I have seen a few reports of weight loss. What is your take? Think type two here. why are they losing weight? they were not on insulin before? (Blindhog even in some obscure reference, posts ago, time past, mentioned he had lost a lot of weight in those moments and mentioned he was eating rice. I think he was pretty happy.) Can you pin it down, why the weight loss? Also, this was news to me and it made sense when I learned it. Blood plasma and interstitial fluid are the same thing. The name changes depending on fluid location. (Water 8 pounds a gallon, 16 cups.) |
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Post by cjm18 on Sept 3, 2019 13:39:49 GMT -5
I am no expert.. but from what I gather insulin is the main fat storage hormone in the body.. RAA hangs in the body and isn't the way the body reacts normally... So yes I believe it creates imbalance, not to mention that RAA is also synthetic.. Not so with Afrezza.. it is the closest thing we have to the normal process.. so to me it is just common sense that the body would respond accordingly.. and it isn't synthetic insulin.. In today's world with all of the processed.. genetically modified etc... our bodies are craving back to nature.. I truly believe it cuz I saw it.. and that is why I adamantly defend Afrezza.. This and this. There’s a saying that abs are made in the kitchen. Keeping insulin levels down are key. It’s the same reason low carb diets work for a lot of people. 75 % of people are insulin resistant (high insulin levels). |
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Post by ktim on Sept 3, 2019 13:41:56 GMT -5
Since Afrezza is a more natural form of insulin why can't the company use this aspect in their marketing.. surely the FDA or BP couldn't stop that cuz it's the truth!!!! Come on!!! I'm so tired of hearing about fake insulin dominating our market when there is something way better!! The insulin that goes into Afrezza is made from GMO ecoli bacteria. Is exactly the same insulin as Humulin from years ago... just different delivery mechanism. So question would be what value it would have drawing a distinction at the molecular level between it and RAA. I think that distinction would be lost on a vast majority of consumers. Most patients go on basal insulin first, which is modified to slow absorption, so the concept of tweaking the molecule to alter timing is something that is pretty well accepted as useful. However, as long as Mannkind stuck within the verified facts, it would likely be allowed by FDA. Just curious, are you equally opposed to long acting basal insulins? |
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Post by peppy on Sept 3, 2019 13:48:30 GMT -5
Since Afrezza is a more natural form of insulin why can't the company use this aspect in their marketing.. surely the FDA or BP couldn't stop that cuz it's the truth!!!! Come on!!! I'm so tired of hearing about fake insulin dominating our market when there is something way better!! The insulin that goes into Afrezza is made from GMO ecoli bacteria. Is exactly the same insulin as Humulin from years ago... just different delivery mechanism. So question would be what value it would have drawing a distinction at the molecular level between it and RAA. I think that distinction would be lost on a vast majority of consumers. Most patients go on basal insulin first, which is modified to slow absorption, so the concept of tweaking the molecule to alter timing is something that is pretty well accepted as useful. However, as long as Mannkind stuck within the verified facts, it would likely be allowed by FDA. Just curious, are you equally opposed to long acting basal insulins? no one uses Humulin subq anymore. However hospitals still may use it IV. You know that ktim. P.S. leave sweedee alone, she was trying to help me and my thinking. I'll stop thinking.... |
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Post by sweedee79 on Sept 3, 2019 13:49:11 GMT -5
ktim .. no not opposed to basal insulin as at this point we don't have something to replace that.. My dad uses Tresiba which I helped him get.. and it has been amazing. Does it bother you that I defend Afrezza? Even if it is genetically modified per your info.. it is at least not synthetic.. and much more closely mimics physiology.. I think you get my drift.
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Post by ktim on Sept 3, 2019 14:20:07 GMT -5
ktim .. no not opposed to basal insulin as at this point we don't have something to replace that.. My dad uses Tresiba which I helped him get.. and it has been amazing. Does it bother you that I defend Afrezza? Even if it is genetically modified per your info.. it is at least not synthetic.. and much more closely mimics physiology.. I defend Afrezza as well. Certainly the best prandial insulin. Only competition in my view would be RAA in a closed loop pump system, though I wouldn't want an invasive device hanging off me 24/7. I'm just questioning whether molecular level distinctions would make good marketing. In a TV advert there is very little time left over for the actual message after all the warnings and fine print. I used to think the pk profile and comparing to endogenous first phase would be compelling, but I've had the "first phase" discussion with several PWD, as well as some doctors, that had no clue what I was talking about. I wish someone had the magic formula that resonated with patients. I would hope MNKD will do some focus groups to explore the messaging before doing the next advert they've talked about. |
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