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Post by bones1026 on Jun 14, 2020 21:37:38 GMT -5
I have gone over my reasons both for being here and for not using Afrezza countless times, they are all back there in the old posts. The only reason you've given for not using Afrezza that I could remember was this, from May 2016 - four years ago. Still waiting?
"All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move."
Hold on..he’s thinking of his next reason for not trying the drug..which he will share on a STOCK message board..not a health/diabetes one..makes total sense
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Post by longliner on Jun 14, 2020 21:55:35 GMT -5
That 15 year old kid is now 35. He settled with the SEC in 2000.
The issuers of the manipulated stocks were Manchester Equipment Company, Inc., Just Toys, Inc., Yes Entertainment, Inc., Fotoball USA, Inc., Man Sang Holdings, Inc., West Coast Entertainment, Inc., Havana Republic, Inc., Classica Group, Inc. and Firetector, Inc.
But, but, but how could he possibly affect share price on a message board? There apparently is zero possibility of that.
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Post by awesomo on Jun 14, 2020 22:14:34 GMT -5
That 15 year old kid is now 35. He settled with the SEC in 2000.
The issuers of the manipulated stocks were Manchester Equipment Company, Inc., Just Toys, Inc., Yes Entertainment, Inc., Fotoball USA, Inc., Man Sang Holdings, Inc., West Coast Entertainment, Inc., Havana Republic, Inc., Classica Group, Inc. and Firetector, Inc.
But, but, but how could he possibly affect share price on a message board? There apparently is zero possibility of that. He was a pumper. These messages were generally devoid of substantive content and, in addition to false price predictions, touted the stock by claiming, among other things, that the stock was about to "take off," would be the "next stock to gain 1,000%," and was "the most undervalued stock ever."Well, those do sound like some posters around here and Stocktwits, but it ain't agedhippie.
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Post by cretin11 on Jun 14, 2020 23:15:24 GMT -5
But, but, but how could he possibly affect share price on a message board? There apparently is zero possibility of that. He was a pumper. These messages were generally devoid of substantive content and, in addition to false price predictions, touted the stock by claiming, among other things, that the stock was about to "take off," would be the "next stock to gain 1,000%," and was "the most undervalued stock ever."Well, those do sound like some posters around here and Stocktwits, but it ain't agedhippie. LOL! Hmmm, yeah longliner, I don’t see MannKind listed in that group of stocks there but perhaps i was too quick to dismiss. He sure does look like a couple of people here, not to name names. 😂🥳🤣
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Post by cretin11 on Jun 14, 2020 23:18:00 GMT -5
That 15 year old kid is now 35. He settled with the SEC in 2000.
The issuers of the manipulated stocks were Manchester Equipment Company, Inc., Just Toys, Inc., Yes Entertainment, Inc., Fotoball USA, Inc., Man Sang Holdings, Inc., West Coast Entertainment, Inc., Havana Republic, Inc., Classica Group, Inc. and Firetector, Inc.
But, but, but how could he possibly affect share price on a message board? There apparently is zero possibility of that. Yes, thank you for letting me correct my statement. Zero chance of anybody on this board manipulating our stock DOWN, but there’s always the possibility of a pumper manipulating a stock artificially higher, like this kid did. 😆 But only if people actually fall for it, and I don’t think that’s the case here. For one thing, there’s simply not enough traffic here to make an iota of difference. We’re basically on this board for the entertainment value lately. And occasionally some actual info (thanks to sports and a couple of others). But hold onto your conspiracy theories if they comfort you, as they do provide a different type of entertainment value for some of us.
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Post by longliner on Jun 15, 2020 0:27:04 GMT -5
But, but, but how could he possibly affect share price on a message board? There apparently is zero possibility of that. Yes, thank you for letting me correct my statement. Zero chance of anybody on this board manipulating our stock DOWN, but there’s always the possibility of a pumper manipulating a stock artificially higher, like this kid did. 😆 But only if people actually fall for it, and I don’t think that’s the case here. For one thing, there’s simply not enough traffic here to make an iota of difference. We’re basically on this board for the entertainment value lately. And occasionally some actual info (thanks to sports and a couple of others). But hold onto your conspiracy theories if they comfort you, as they do provide a different type of entertainment value for some of us. I'm quite certain you will correct your statement many more times than once.
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Post by longliner on Jun 15, 2020 12:49:38 GMT -5
Strength of conviction.
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Post by alethea on Jun 15, 2020 13:03:07 GMT -5
Why would ANYONE spend so much effort on the stock board of a Company that they have no investment in? Each post a negative bent on all news related to the product and Company? Go long! This post is WELL WORTH repeating. I echo your sentiments times ten.
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Post by mango on Jun 15, 2020 13:12:03 GMT -5
Interesting the timing of agedhippie's negativity correlating with Looking For Diogenes hit piece.
For two "different people" with supposedly no vested interest in MannKind, "they" sure do share the same views and time commitment with this company!
What will the other side do now that the Seeking Alpha hit pieces are no longer working?
I'm laughing...
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Post by agedhippie on Jun 15, 2020 20:59:03 GMT -5
Interesting the timing of agedhippie's negativity correlating with Looking For Diogenes hit piece. For two "different people" with supposedly no vested interest in MannKind, "they" sure do share the same views and time commitment with this company! What will the other side do now that the Seeking Alpha hit pieces are no longer working? I'm laughing... You think I am LFD and have the same views? You need to stop smoking that stuff.
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Post by agedhippie on Jun 15, 2020 21:02:43 GMT -5
I have gone over my reasons both for being here and for not using Afrezza countless times, they are all back there in the old posts. The only reason you've given for not using Afrezza that I could remember was this, from May 2016 - four years ago. Still waiting?
"All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move."
I thought the primary reason I gave was that I don't see it as necessary for me. My A1c is 6.3 with minimal hypos and that's good enough for me. If it ain't broke don't fix it. Also still waiting for the users to turn up rather than the numbers there are now...
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Post by cretin11 on Jun 15, 2020 22:15:12 GMT -5
Interesting the timing of agedhippie's negativity correlating with Looking For Diogenes hit piece. For two "different people" with supposedly no vested interest in MannKind, "they" sure do share the same views and time commitment with this company! What will the other side do now that the Seeking Alpha hit pieces are no longer working? I'm laughing... You think I am LFD and have the same views? You need to stop smoking that stuff. Aged, it’s not that you and LFD have the same views, you two are the SAME person! Also, you are singlehandedly responsible for suppressing our share price with your manipulation. Please try to keep up. 😂
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Post by sellhighdrinklow on Jun 15, 2020 22:22:11 GMT -5
The only reason you've given for not using Afrezza that I could remember was this, from May 2016 - four years ago. Still waiting?
"All of this said - I would like to move to Afrezza but right now I am going to hold back and see if any lung issues materialize. I want someone else to be the guinea pig. There have been the trials and a years use, but I want bigger numbers of users for a couple of years before I move."
I thought the primary reason I gave was that I don't see it as necessary for me. My A1c is 6.3 with minimal hypos and that's good enough for me. If it ain't broke don't fix it. Also still waiting for the users to turn up rather than the numbers there are now... 6.3 is highest endpoint for pre diabetic. Pre diabetes is 5.7 to 6.3. My latest A1C is 5.3 which equate to non diabetic after being on Afrezza for 4++ years. You lose the argument in perpetuity.
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Post by rockstarrick on Jun 15, 2020 23:33:34 GMT -5
DXCM should care because “real-time, mealtime glucose management” to me, and at least a few people with Diabetes that I know of, means, what is the Mealtime Insulin I just took doing for me now, not an hour from now. I’ll say it again, why Afrezza isn’t breaking trail for all this new technology is beyond stupid!! Why wouldn’t DXCM want to pair their G6 CGM with the fastest mealtime insulin on the planet. Always respect your opinion aged, but you’re missing the real importance of Afrezza. Besides the obvious fact that there is no needle, and the fact that Afrezza will start to move the needle in about 5 minutes, (maybe faster, but the CGM only records a reading every 5 minutes), but the threat of Severe Hypoglycemia is eliminated. I saw Bigfoot aged, I can’t unsee it. With Afrezza, you don’t need to constantly worry about low blood sugar, only high blood sugar. It nearly eliminates the one thing that makes diabetes such a shitty and difficult disease to manage, and quickly takes care of mealtime glucose spikes. It’s so easy, even a caveman can do it. My Father in law was suffering from severe lows every time he took prandial insulin, since starting Afrezza, he hasn’t been low one time. The first night on Afrezza was miserable for him, because he kept waiting to go low, but it never happened. Stayed up all night for nothing. He was afraid to go to sleep at night because he lives alone, and didn’t feel confident enough to hook up his CGM. He was so afraid of going low, that he wasn’t injecting his RAA until after his meal, and his blood sugar was rising. His endos failed him, he didn’t understand why it was important to try and time the rise, and inject before he started his meal, which was compounding his lows. Now all he has to do is keep his BG from going high, and it makes more sense to him because he can take his insulin when he starts his meal, or even after like he was doing with the RAA’s. There is literally no comparison between the two insulin products, they are two completely different products, and Afrezza is beyond superior. I’ve got a brain, I saw it with my own eyes. ✌🏻😎
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Post by rockstarrick on Jun 16, 2020 0:16:51 GMT -5
The HbA1c was a secondary result in a failed study without a comparator arm so that study goes nowhere. To put it in context Dexcom did a study using CGMs with Type 2s and got exactly the same reduction just by using a CGM. Dexcom are going to look at this study and say that on those grounds Afrezza made zero contribution to the HbA1c reduction. This is the bit Shawn and I kept hammering but people don't seem to want to hear. The second dose is a big deal because it doubles the number of times you have to think about and deal with your diabetes. That seriously matters. With CGMs there is no need for an additional comparator arm. The comparator arm are the same PWDs. With CGMs you know exactly how they were performing prior to the introduction of the changed medication - in this case afrezza. In this study - prior to afrezza you had these PWDs on the CGM and RAA. In this study they took 25 people, measured their baseline with the RAA and CGM and then switched them to afrezza. If the previous Dexcom studies are correct these PWDs should have already seen some A1c benefit prior to afrezza since they were already using the CGM with the RAA. IMO, going forward this is the way to do studies as you don't have the variable of different people being compared. Instead you have the exact same person. The failure of this study was measuring TIR during sleeping hours. This needs to be factored out. This study included it which made it a flawed study. The big question is what do the AGPs look like which are not included in the abstract. Concerning the second dose with a T2 you and Shawn are wrong. In the case of a T2 there is a lot of leeway and its really up to the T2 how good they want their numbers to be. If a T2 like Joey wants great numbers looking at his CGM 1hr after eating and second dosing is no big deal. They want to do it. If they miss a second dose every once in a while - oh well. For the T2 who has high A1cs and is being put on a cocktail of poisons like SGLT2s, etc. one puff of afrezza during meal should significantly improve their numbers even if they don't second dose. Afrezza provides the T2 choice and should be used prior to TZDs, SGLT2 and GLP1s and of course metformin as its creates the greatest harm due to the lost time in addressing the problem. Per the abstract - Patients were titrated from pre-meal insulin plus basal insulin to inhaled insulin plus basal insulin over 2 weeks and followed for 14 weeks. At Week 14, mean (±SE) times spent above (>180 mg/dL; -1.7±3.2 mins; P=0.60), in (70 180 mg/dL; -1.2±2.6 mins; P=0.65), and below (<70 mg/dL; +2.9±2.5 mins; P=0.26) glycemic goal range were not significantly different from baseline. However, A1c significantly decreased from baseline at Week 14 (-0.76%±0.18; P=0.0002). At Week 14, Quality of Life (QoL) Total score did not significantly change from baseline (+0.19±0.13; P=0.15). However, Useful (+0.46±0.20; P=0.03), Freeing (+0.92±0.24; P=0.0008), and Difficult ( 0.68±0.28; P=0.02) QoL subdomains significantly improved from baseline at Week 14 Why would they include TIR during sleeping hours for a mealtime insulin product. I’m a fricken dumb old Bass Player and even I can see how that would water down the results of the trial. Dilution is the solution I guess. 🤓
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