Interesting Journals, Studies, etc that cite Technosphere

[harryx1]

These are all issued/published in 2015.

Journal of Nanoscience and Nanotechnology, Volume 15, Number 4
Breathable Medicine: Pulmonary Mode of Drug Delivery
www.ingentaconnect.com/content/asp/jnn/2015/00000015/00000004/art00001?token=0055179ae538c2b6720297d76345f7b2a4a457a41385357496d3f6a4b4b6e6e42576b6427389f47900de8



Nanomedicine: Nanotechnology, Biology and Medicine
Inhalable nanoparticulate powders for respiratory delivery. Invited review
www.sciencedirect.com/science/article/pii/S1549963415000313
... 36 Afrezza®, which is inhalable recombinant insulin contains Technosphere® particles formed
with excipient carrier fumaryl diketopiperazine (FDKP) powder which self assembles through
hydrogen bonding in mildly acidic environment to form microspheres. ...



The role of disposable inhalers in pulmonary drug delivery
informahealthcare.com/doi/abs/10.1517/17425247.2014.952626
... New technologies can, for instance, also be found in the Alexza Staccato for delivery of loxapine
(Adasuve) via drug evaporation and condensation [25] and the Afrezza Technosphere insulin
(Mannkind Corp.), which makes use of self-assembling carrier particles [80]. ...



Afrezza: An inhaled approach to insulin delivery
The purpose of this article is to educate nurse practitioners about Afrezza.
onlinelibrary.wiley.com/doi/10.1002/2327-6924.12247/abstract



Challenges in the delivery of peptide drugs: an industry perspective
www.future-science.com/doi/abs/10.4155/tde.14.111
... They have submitted their Marketing Authorization Application to the FDA. The
technology (Technosphere ® ) is based on a novel excipient diketylpiperizine that
enables the formation of uniform peptide particles with a 2 µm diameter. ...



Solid-state protein formulations
www.future-science.com/doi/abs/10.4155/tde.14.98
... However, this product unfortunately had to be withdrawn from the market because of poor sales
[120]. More recently, MannKind Corporation has developed a platform technology (Technosphere
® ) to deliver a range of proteins via the pulmonary route [121]. ...

[harryx1]

This one is pretty interesting...

Heat-Stable Dry Powder Oxytocin Formulations for Delivery by Oral Inhalation
link.springer.com/article/10.1208/s12249-015-0314-0

[harryx1]

Interesting, this was just posted on ST and it's one listed above...

[harryx1]

Now it's getting interesting...



mnkd.proboards.com/thread/2071/hospital-networks-afrezza

[harryx1]

Mar 25, 2015 9:22:39 GMT -5 harryx1 said:

This one is pretty interesting...

Heat-Stable Dry Powder Oxytocin Formulations for Delivery by Oral Inhalation
link.springer.com/article/10.1208/s12249-015-0314-0

 Thanks to Tinkering on ST for finding this...

www.gtcbio.com/conferences/diabetes-drug-discovery-development-agenda
8th Diabetes Drug Discovery & Development Agenda
April 27-29th, Boston MA

Session: Clinical Drug Development Strategies in Diabetes

FEATURED SPEAKER
2:55 Dry Powder Formulations for the Inhalation of Oxyntomodulin

Andrea Leone-Bay
Vice President Scientific Research
MannKind


Obesity is a rapidly becoming a global epidemic and underlies many disease conditions including diabetes and cardiovascular disease. Current treatment options are limited and are challenged by undesirable side effects. Oxyntomodulin (OXY) is an endogenous peptide hormone that signals satiety in healthy individuals. High circulating OXY concentrations are associated with satiety and low OXY concentrations are associated with a feeling of hunger. This activity profile positions OXY as a potential treatment for obesity. To address this unmet medical need, this presentation will introduce an approach to developing an orally inhaled dry powder OXY product administered using a small, breath-powered inhaler for obesity therapy.

The audience will learn about oxyntomodulin, a potential new obesity therapy and about the administration of peptides by oral inhalation using a simple, patient-friendly approach.

[kball]

Obesity...would be BIG...if you'll pardon the pun

[Deleted]

Was posted back in December, fwiw:

mnkd.proboards.com/thread/1511/8th-diabetes-drug-discovery-development

[harryx1]

Well I guess I missed that one, thanks.

[kc]

I guess we can see the tie-in to where Andrea Leona Bay went to work at Receptor. Does GSK one our new CMO tie into this?

[dejude42]

  technovax.com/TechnoVax_LSHVS13.pdf        Please check page 4. It seems the company Technovax and Mannkind are working together for Cricket usage TechnoVax: The gold standard in vaccine technology

CompanyTechnologiesPartneringServicesPublicationsContact
“Inhaled Powder” Vaccines

“Shelf-Stable, Self-Inhaled, Powderized” VLP Vaccines.

TechnoVax and MannKind Corp. have combined their respective technologies to create a Powder Formulation of VLP Influenza Vaccine for Intrapulmonary Self-Delivery by Inhalation.

No refrigeration is required, and because it is potentially self-administered public exposure is limited. In the event of an emerging pandemic the vaccine could be easily distributed to the population, greatly reducing the spread of the virus!

Advantages

Extended Shelf Life and Elimination of Cold Chain results in improved distribution costs and inventory management.
Best Route of Immunization (mucosal surface – respiratory tract)
Increased Patient Acceptance (inhaled vs. injection)
inhaled-powder
VLP’s are combined with FPDK Excipient Particles for optimized airflow delivery using the Cricket Inhalation Device.

“Seasonal Tetravalent” Influenza VLP Vaccine
“Inhaled Powder” Vaccines
“Universal” Flu Vaccine
RSV Vaccine
© 2016 TechnoVax | Site by Continuum

[cretin11]

dejude that's an interesting slide presentation. I don't see where it says copyright 2016? Slide 6 appears to be from 2013 or earlier.

[mindovermatter]

If stock prices were based on journal publications and patents MNKD would be worth $50 a share!
I believe there is a very good reason why Andrea Leone Bay left Mannkind for Receptor Life Sciences and that is because, unlike Mannkind, it has the resources to see her work come to life instead of just get moth balled. I have no idea if RLS will be successful but look at every partner Mannkind has worked with. Not ONE has been successful.