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Post by uvula on Oct 6, 2015 14:46:08 GMT -5
Type 1 is around 20% of the diabetic population and the pediatric market is quite difficult. It is very common to put children on insulin pumps because that way the adult can control the dosing remotely plus it delivers the basal insulin. Without a pump you would still have to inject daily anyway for the basal plus you would have to get the child to either inject or inhale mealtime insulin. Contrary to what people think the big issue to children isn't injecting itself, it's being different and using an inhaler before every meal qualifies. Why pediatrics? The options currently are pump or injection. Once you in a routine you are unlikely to change so to capture the young adult market you need the pediatric market. Another reason for the pediatric approval would be to treat the pre-diabetes population of which, many are children. Minor point but I do not think this is correct. Most pre-type 2 diabetics are adults. And there are no pre-type 1 diabetics. You go from normal to type 1 without much notice or warning.
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Post by blindhog1 on Oct 7, 2015 9:50:15 GMT -5
Good Morning. Today's FBG is a respectable 87. I'm finding the change in the social media banter refreshing.
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Post by blindhog1 on Oct 12, 2015 6:50:26 GMT -5
Pretty nice Monday with a FBG of 102.
I read Matt's piece on "Timing is Everything" and decided to give it a try. The basic idea is instead of taking Afrezza at the beginning of the meal you'll get better results by waiting 10 minutes into your meal. OK I'll bite....how can I go wrong on a trial.
For my test I picked a Taco Bell Taco Salad. Taco Salad has 74 carbs with the shell. Gusty move you say. Pre meal my BG was 89....took my basic 8 units....one hour later my BG was 92. Amazing
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Post by kball on Oct 12, 2015 8:42:00 GMT -5
Pretty nice Monday with a FBG of 102.
I read Matt's piece on "Timing is Everything" and decided to give it a try. The basic idea is instead of taking Afrezza at the beginning of the meal you'll get better results by waiting 10 minutes into your meal. OK I'll bite....how can I go wrong on a trial.
For my test I picked a Taco Bell Taco Salad. Taco Salad has 74 carbs with the shell. Gusty move you say. Pre meal my BG was 89....took my basic 8 units....one hour later my BG was 92. Amazing
You would seem to fall several standard deviations out of Taco Bells target market as best i can figure though. And no offense. As do i
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Post by blindhog1 on Oct 12, 2015 8:56:56 GMT -5
Pretty nice Monday with a FBG of 102.
I read Matt's piece on "Timing is Everything" and decided to give it a try. The basic idea is instead of taking Afrezza at the beginning of the meal you'll get better results by waiting 10 minutes into your meal. OK I'll bite....how can I go wrong on a trial.
For my test I picked a Taco Bell Taco Salad. Taco Salad has 74 carbs with the shell. Gusty move you say. Pre meal my BG was 89....took my basic 8 units....one hour later my BG was 92. Amazing
You would seem to fall several standard deviations out of Taco Bells target market as best i can figure though. And no offense. As do i You have to understand that for years I considered a Double Whopper w/cheese as a balanced meal.
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Post by compound26 on Oct 12, 2015 17:40:49 GMT -5
Pretty nice Monday with a FBG of 102.
I read Matt's piece on "Timing is Everything" and decided to give it a try. The basic idea is instead of taking Afrezza at the beginning of the meal you'll get better results by waiting 10 minutes into your meal. OK I'll bite....how can I go wrong on a trial.
For my test I picked a Taco Bell Taco Salad. Taco Salad has 74 carbs with the shell. Gusty move you say. Pre meal my BG was 89....took my basic 8 units....one hour later my BG was 92. Amazing
blindhog1. That's a great experiment! Way to go! This proves that Matt's observation and comment in his video and article are accurate. And both your and Matt's experience support Al Mann's claim that "the first Afrezza dose really ought to be taken ten or fifteen minutes after starting to eat." And note that Matt's observation and comment in his video and article regarding the timing and dosage of follow-up doses also support Al Mann's statements below. [Matt gave an example where he was having a five-course Japanese banquet, he took a green dose (8-Unit) Afrezza every forty-five minutes or so and his BG level remained perfect throughout the dinner. And the same approach worked for him at a dinner party, where he even drank sugary cocktails]. Al made his above comment in this interview: An Exclusive Interview with Al Mann, Founder and CEO, Mannkind Corp."SF: Was that when you changed to the new device? AM: No, I think that a problem during the trials was that some patients took their dose of Afrezza even before starting to eat. The trial protocols called for Afrezza to be dosed “at the beginning of the meal,” but sometimes it was taken even before. We need to do additional trials to gain more experience with optimized dosing times. Actual ingestion of food in most meals in the United States except in restaurants takes only about 30 minutes, so I believe that the first Afrezza dose really ought to be taken ten or fifteen minutes after starting to eat.
For a longer meal, which is not very common, a second dose might be taken fifty or sixty minutes after starting to eat.
For a long feast that lasts for an hour and a half or more, I suggest a third dose be taken at maybe one and a half hours after start.
Interestingly I believe the size of all those doses should probably be the same for most patients.
Unfortunately the trial protocols called for dosing at the beginning of the meal so we will need to do more trials to be able to gain FDA label approval of optimized dosing."
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Post by blindhog1 on Oct 12, 2015 21:35:59 GMT -5
Compound26, I see you liked my test yesterday. I did too, so I did it again today for lunch and supper. Dosing after 10 minutes into the meal. The results are interesting. Lunch: 11:37 BG 107 took a 4 unit Afrezza. Carb count was 50. 12:30 BG 114 Supper: 5:06 BG 114 took a 8 unit Afrezza. Low Carb count of 22. 5:55 BG 91 My take away is right out of Matt's videos. In one of his video's he said the term unit may get in the way. Dr.'s should probably think in terms of cartridge size. Dr's (and we) should refer to the meal in terms of carb size: Small, Medium and Large and dose accordingly (4,8,12). I realize this is only a guess but we're smart and can get pretty close.
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Post by blindhog1 on Oct 13, 2015 5:32:41 GMT -5
Morning FBG is 88.
No more testing on the dosing times. It is now standard procedure that I dose 10 minutes after my meal begins. Who am I to buck the advise of Matt and Al. I'm getting so close to my next A1C it's beginning to scare me.
Did I mention the 8 pounds I've lost.
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Post by jbe on Oct 13, 2015 8:00:10 GMT -5
This makes sense, a healthy pancreas doesn't start insulin pumping before the meal starts, it activates after the meal starts...Afrezza appears to work best when mimicking a pancreas.
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Post by blindhog1 on Oct 14, 2015 7:25:43 GMT -5
This mornings FBG was 104.
This number is absolutely fantastic considering all the snacks I consumed during last nights debate.
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Post by kball on Oct 14, 2015 9:41:13 GMT -5
This mornings FBG was 104.
This number is absolutely fantastic considering all the snacks I consumed during last nights debate. Buy or Sell Mannkind debate.... Or the Democratic one?
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Post by blindhog1 on Oct 14, 2015 10:00:19 GMT -5
This mornings FBG was 104.
This number is absolutely fantastic considering all the snacks I consumed during last nights debate. Buy or Sell Mannkind debate.... Or the Democratic one? I personally think the MNKD buy or sell debate is a waste of time. It's an exercise in whether you think you made a good decision when you invested. If you didn't do your DD you're a fool. If you have buyers regret then you have a choice to make. If you just want to air your fears in public I have no time to waste listening to you.
I am a user of Afrezza. I know it works.
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Post by blindhog1 on Oct 17, 2015 9:39:31 GMT -5
This mornings FBG was 89.
OK I'm convinced on the dosing 10 minutes after starting a meal. It appears to be the ticket. I read a post on YMB about a guy that waited 6 months for his ENDO to come around. His ENDO has prescribed to 7 others since his conversion. One of the things he is having him do is see a TRAINER. Excellent idea.
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Post by vestful on Oct 17, 2015 9:49:11 GMT -5
Buy or Sell Mannkind debate.... Or the Democratic one? I personally think the MNKD buy or sell debate is a waste of time. It's an exercise in whether you think you made a good decision when you invested. If you didn't do your DD you're a fool. If you have buyers regret then you have a choice to make. If you just want to air your fears in public I have no time to waste listening to you.
I am a user of Afrezza. I know it works.
This post says it all. Short. Sweet. To the point.
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Post by blindhog1 on Oct 18, 2015 9:28:51 GMT -5
This mornings FBG is 107.
I'm just hanging out with these nice numbers and now I've lost 9 pounds. What have I got to look forward to? What could make the next month interesting? Conferences calls? Introductions by Sanofi? Ad campaign for Afrezza? Light reading in my carb book? Nope.
It's the Cubs. I hope not to backslide and binge during the games. I have control. IT'S ALL ABOUT CONTROL.
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