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Post by mnholdem on Nov 22, 2015 14:14:27 GMT -5
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Post by peppy on Dec 17, 2015 6:09:01 GMT -5
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Post by longstocking on Dec 29, 2015 19:38:51 GMT -5
Thanks for posting. I am checking this patent site daily now. |
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Post by longstocking on Dec 29, 2015 19:40:32 GMT -5
When searching for "Mannkind" patents on this site, I recently found one patent that comes up for Ironwood Pharm. Do you know who they are and how they might be connected to Mannkind? |
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Post by mnholdem on Dec 29, 2015 20:27:42 GMT -5
You have to search for it in the document. The hit may have simply resulted from a MannKind document or study that is listed as a reference somewhere within the patent document.
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Post by peppy on Mar 6, 2016 20:13:47 GMT -5
patents.justia.com/patent/9259471 Example 11 Oral Administration of Disodium FDKP-Insulin Capsules containing the FDKP salt and insulin are taken before a meal. The exact dosage is patient-specific, but generally on the order of 10-150 units of insulin is administered per dose. This oral insulin formulation is used to replace pre-meal insulin injections in patients with diabetes. Additionally, insulin absorbed through the gastrointestinal tract mimics endogenous insulin secretion. Endogenous insulin is secreted by the pancreas into the portal circulation. Thus, the oral route of insulin administration delivers insulin to the site of action in the liver, offering the potential to control glucose levels while limiting systemic exposure to insulin. Oral insulin delivery using a combination of insulin and the diacid form of FDKP is hindered by the poor solubility of the FDKP diacid in the low PH environment of the gastrointestinal tract. The FDKP salts, however, provide a local buffering effect that facilitates their dissolution in low PH. Read more: mnkd.proboards.com/thread/5250/mannkind-got-oral-insulin-patent?page=1#ixzz42Aw7eeYk |
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